Analysis of the molecular mechanism underlying the T-cell regulatory function of regulatory dendritic cells

• Project/Area Number: 19590505
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Immunology
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: SATO Katsuaki The Institute of Physical and Chemical Research, 樹状細胞機能研究チーム, チームリーダー (40301147)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2007: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 樹状細胞 / T細胞 / 免疫寛容 / 制御性樹状細胞 / アネルギーT細胞 / 制御性T細胞 / 免疫機能分子 / 制御制樹状細胞 / 制御制T細胞

Research Abstract

本研究課題では制御性樹状細胞のT細胞機能制御機構におけるCD200受容体(CD200R; CD200 receptor)分子群であるCD200R3の役割について検討を行った。その結果、CD200R3は制御性樹状細胞のT細胞アナジー誘導機構とCD4^+CD25^+Foxp3^+制御性細胞誘導機構に関与する特異的発現機能分子であることが明らかとなった。

Research Products

• [Journal Article] Naturally occurring regulatory dendritic cells regulate murine cutaneous chronic graft-versus-host disease (2009)
  • Author(s): Sato, K., Eizumi, K., Fukaya, T., Fujita, S., Sato, Y., Takagi, H., Yamamoto, M., Yamashita, N., Hijikata, A., Kitamura, H., Ohara, O., Yamasaki, S., Saito, T., and Sato, K.
  • Journal Title: Blood 113(19) Pages: 4780-4789
  • Peer Reviewed
• [Journal Article] Regulatory dendritic cells protect against allergic airway inflammation in a murine athmatic model, Regulatory dendritic cells protect against allergic airway inflammation in a murine athmatic model (2008)
  • Author(s): .Fujita, S., Yamashita, N., Ishii, Y., Sato, Y., Sato, K., Eizumi, K., Fukaya, T., Nozawa, R., Takamoto, Y., Yamashita, N., Taniguchi, M. and Sato, K.
  • Journal Title: J. Allergy Clin. Immunol. 121(1) Pages: 95-104
  • Peer Reviewed
• [Journal Article] Regulatory dendritic cells protect against allergic airway inflammation in a murine athmatic model (2008)
  • Author(s): Fujita, S., et al.
  • Journal Title: J.Allergy Clin.Immunol. 121(1) Pages: 95-104
  • Peer Reviewed
• [Journal Article] Regulatory dendritic cells protect against cutaneous chronic graft-versus-host disease mediated through CD4^+CD25^+Foxp3^+ regulatory T cells (2007)
  • Author(s): Fujita, S., Sato, Y., Sato, K., Eizumi, K., Fukaya, T., Kubo, M., Yamashita, N. and Sato, K.
  • Journal Title: Blood 110(10) Pages: 3793-3803
  • Peer Reviewed
• [Journal Article] Dendritic cells-Nature and classification (2007)
  • Author(s): Sato, K. and Fujita, S.
  • Journal Title: Allergol. Int. 56(3) Pages: 183-191
  • NAID: 10019815071
  • Peer Reviewed
• [Journal Article] Dendritic cells-Nature and classification (2007)
  • Author(s): Sato, K., et al.
  • Journal Title: Allergol.Int. 56(3) Pages: 183-191
  • NAID: 10019815071
  • Peer Reviewed
• [Journal Article] Regulatory dendritic cells protect against cutaneous chronic graft-versus-host disease mediated through CD4^+CD25^+Foxp3^+T cells (2007)
  • Author(s): Fujita, S., et al.
  • Journal Title: Blood 110(10) Pages: 3793-3803
  • Peer Reviewed
• [Presentation] Crucial role of CD200R3 in the induction of peripheral tolerance by regulatory dendritic cells (2008)
  • Author(s): 江泉香里、佐藤馨、深谷知宏、藤田成晴、高木秀明、山下直秀、土方敦司、北村浩、小原收、山崎晶、斉藤隆、佐藤克明
  • Organizer: 第38回日本免疫学会総会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-02
• [Presentation] Naturally occurring regulatory dendritic cells induce regulatory T cell-mediated peripheral tolerance (2008)
  • Author(s): 佐藤馨、江泉香里、深谷知宏、藤田成晴、高木秀明、山下直秀、佐藤克明
  • Organizer: 第38回日本免疫学会総会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-02
• [Presentation] Regulatory dendritic cells induce antigen-specific extrathymic peripheral generation of CD4^+CD25^+Foxp3^+regulatory T cells (2007)
  • Author(s): 藤田成晴、佐藤馨、山下直秀、佐藤克明
  • Organizer: 第37回日本免疫学会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-21
• [Presentation] Regulatory dendritic cells induce antigen-specific extrathymic peripheral generation of CD4^+CD25^+Foxp3^+ regulatory T cells (2007)
  • Author(s): 藤田成晴, 他
  • Organizer: 第37回日本免疫学会
  • Place of Presentation: グランドプリンスホテル新高輪・東京都
  • Year and Date: 2007-11-21
• [Presentation] Impact of immunostimulatory and regulatory DCs on T cell?polarization in the control of TH2-mediated allergic immunity (2007)
  • Author(s): 藤田成晴、山下直秀、山下直美、佐藤克明
  • Organizer: 第18回日本樹状細胞研究会
  • Place of Presentation: 兵庫
  • Year and Date: 2007-05-25
• [Presentation] Impact of immunostimulatory and regulatory DCs on T cell-polarization in the control of T_H2-mediated allergic immunity (2007)
  • Author(s): 藤田成晴, 他
  • Organizer: 第18回日樹状細胞研究会
  • Place of Presentation: 兵庫県立淡路夢舞台国際会議場・淡路市
  • Year and Date: 2007-05-25
• [Book] 「樹状細胞の抗原提示・T細胞との相互作用」肝胆膵 58(2)、175-183 (2009)
  • Author(s): 佐藤克明
  • Publisher: アークメディア
• [Book] 「気管支喘息の樹状細胞を用いた免疫細胞療法」呼吸 27(10)、953-957 (2008)
  • Author(s): 佐藤克明
  • Publisher: Respiration Research Foundation
• [Book] 「制御性樹状細胞を介する免疫応答コントロール」実験医学 26(20)、89-95 (2008)
  • Author(s): 佐藤克明
  • Publisher: 羊土社
• [Book] 「制御性T細胞誘導樹状細胞」臨床免疫・アレルギー科 50(1)、25-31 (2008)
  • Author(s): 佐藤克明
  • Publisher: 科学評論社
• [Book] 「樹状細胞によるIgE産生調節」臨床免疫・アレルギー科 48(3)、223-229 (2007)
  • Author(s): 佐藤克明、藤田成晴
  • Publisher: 科学評論社
• [Book] 臨床免疫・アレルギー科「樹状細胞によるIgE産生調節」 (2007)
  • Author(s): 佐藤克明, 他
  • Total Pages: 346
  • Publisher: 科学評論社
• [Remarks]
  • URL: http://web.rcai.riken.jp/en/labo/cell
• [Remarks]
  • URL: http://web.rcai.riken.jp/en/labo/cell/