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Gene expression profiling in the obesity model rats

Research Project

Project/Area Number 19590531
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied pharmacology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

IMAI Jyunichi  Tokyo Medical and Dental University, 医学部, 准教授 (70376739)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords肥満 / 生活習慣病 / 動物モデル / メタボリックシンドローム / 遺伝子発現プロファイル
Research Abstract

肥満モデルラットを通常ラットと比較して、複数の組織において両者間で発現レベルが有意に変化している肥満関連遺伝子群を特定した。これらの遺伝子群によるデータセットは、クラスタ分析により両者を明確に区別することができ、「肥満のメカニズムの解明」、「抗肥満薬の評価系」、「肥満治療薬標的分子の探索」、「食物の安全性評価」などに使用できる可能性がある。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report

Research Products

(19 results)

All 2008 2007

All Journal Article (19 results) (of which Peer Reviewed: 19 results)

  • [Journal Article] Human protein factory for converting the transcriptome into an in vitro-expressed proteome2008

    • Author(s)
      Goshima N, Kawamura Y, Fukumoto A, Miura A, Honma R, Satoh R, Wakamatsu A, Yamamoto J, Kimura K, Nishikawa T, Andoh T, lida Y, Ishikawa K, Ito E, Kagawa N, Kaminaga C, Kanehori K, Kawakami B, Kenmochi K, Kimura R, Kobayashi M, Kuroita T, Kuwayama H, Maruyama Y, Matsuo K, Minami K, Mitsubori M, Mori M, Morishita R, Murase A, Nishikawa A, Nishikawa S, Okamoto T, Sakagami N, Sakamoto Y, Sasaki Y, Seki T, Sono S, Sugiyama A, Sumiya T, Takayama T, Takayama Y, Takeda H, Togashi T, Yahata K, Yamada H, Yanagisawa Y, Endo Y, Imamoto F, Kisu Y, Tanaka S, Isogai T, Imai J, Watanabe S, Nomura N.
    • Journal Title

      Nat. Methods 5

      Pages: 1011-1017

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Application of quantitative gene expression analysis for pertussis vaccine safety control.2008

    • Author(s)
      Hamaguchi I, Imai J, Momose H, Kawamura M, Mizukami T, Naito S, Maeyama J, Masumi A, Kuramitsu M, Takizawa K, Kato H, Mizutani T, Horiuchi Y, Nomura N, Watanabe S, Yamaguchi K.
    • Journal Title

      Vaccine 26

      Pages: 4686-4696

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article]2008

    • Author(s)
      Fujita N, Imai J, Suzuki T, Yamada M, Ninomiya K, Miyamoto K, Iwasaki R, Morioka H, Matsumoto M, Chiba K, Watanabe S, Suda T, Toyama Y, Miyamoto T.
    • Journal Title

      Biochem Biophys Res Commun 372

      Pages: 367-372

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Application of DNA microarray technology to influenza A/Vietnam/1194/2004 (H5N1) vaccine safety evaluation2008

    • Author(s)
      Mizukami T, Imai J, Hamaguchi I, Kawamura M, Momose H, Naito S, Maeyama J, Masumi A, Kuramitsu M, Takizawa K, Nomura N, Watanabe S, Yamaguchi K.
    • Journal Title

      Vaccine 26

      Pages: 2270-2283

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] NOTCH3 signaling pathway plays crucial roles in the proliferation of ErbB2-negative human breast cancer cells2008

    • Author(s)
      Yamaguchi N, Oyama T, Ito E, Satoh H, Azuma S, Hayashi M, Shimizu K, Honma R, Yanagisawa Y, Nishikawa A, Kawamura M, Imai J, Ohwada S, Tatsuta K, Inoue J, Semba K, Watanabe S.
    • Journal Title

      Cancer Res 68

      Pages: 1881-1888

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] FoxAl as a lineage-specific oncogene in luminal type breast cancer2008

    • Author(s)
      Yamaguchi N, Ito E, Azuma S, Honma R, Yanagisawa Y, Nishikawa A, Kawamura M, Imai J, Tatsuta K, Inoue J, Semba K, Watanabe S.
    • Journal Title

      Biochem Biophys Res Commun 365

      Pages: 711-717

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Human protein factory for converting the transcriptome into an in vitro-expressed proteome, .2008

    • Author(s)
      Goshima N., et al.
    • Journal Title

      Nat. Methods. 5

      Pages: 1011-1017

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Application of quantitative gene expression analysis for pertussis vaccine safety control.2008

    • Author(s)
      Hamaguchi I., et al.
    • Journal Title

      Vaccine. 26

      Pages: 4686-4689

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vascular endothelial growth factor-A is a survival factor for nucleus pulposus cells in the intervertebral disc.2008

    • Author(s)
      Fujita N., et al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 372

      Pages: 367-372

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Application of DNA microarray technology to influenza A/Vietnam/1194/2004 (H5N1)vaccine safety evaluation.2008

    • Author(s)
      Mizukami T., et al.
    • Journal Title

      Vaccine. 26

      Pages: 2270-2283

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NOTCH3 signaling pathway plays crucial roles in the proliferation of ErbB2-negative human breast cancer cells.2008

    • Author(s)
      Yamaguchi N., et. al,
    • Journal Title

      Cancer Research 68

      Pages: 1881-1888

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FoxA1 as a lineage-specific oncogene in luminal type breast cancer.2008

    • Author(s)
      Yamaguchi N., et. al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 365

      Pages: 711-717

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Osteoclastic activity induces osteomodulin expression in osteoblasts2007

    • Author(s)
      Ninomiya K, Miyamoto T, Imai J, Fujita N, Suzuki T, Iwasaki R, Yagi M, Watanabe S, Toyama Y, Suda T.
    • Journal Title

      Biochem Biophys Res Commun 362

      Pages: 460-466

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Knock down of hSNF5/Inil causes cell cycle arrest and apoptosis in a p53-dependent manner2007

    • Author(s)
      Kato H, Honma R, Sanda T, Fujiwara T, Ito E, Yanagisawa Y, Imai J, Okamoto T, Watanabe S.
    • Journal Title

      Biochem Biophys Res Commun 361

      Pages: 580-585

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel clusters of highly expressed genes accompany genomic amplification in breast cancers2007

    • Author(s)
      Ito E, Honma R, Yanagisawa Y, Imai J, Azuma S, Oyama T, Ohwada S, Akiyama T, Nomura N, Inoue J, Watanabe S, Semba K.
    • Journal Title

      FEBS Lett 581

      Pages: 3909-3914

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Two vaccine toxicity-related genes Agp and Hpx could prove useful for pertussis vaccine safety control2007

    • Author(s)
      Hamaguchi I, Imai J, Momose H, Kawamura M, Mizukami T, Kato H, Naito S, Maeyama J, Masumi A, Kuramitsu M, Takizawa K, Mochizuki M, Ochiai M, Yamamoto A, Horiuchi Y, Nomura N, Watanabe S, Yamaguchi K.
    • Journal Title

      Vaccine 25

      Pages: 3355-3364

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Osteoclastic activity induces osteomodulin expression in osteoblasts.2007

    • Author(s)
      Ninomiya K., et. al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 362

      Pages: 460-466

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Knock down of hSNF5/Ini1 causes cell cycle arrest and apoptosis in ap53-dependent manner.2007

    • Author(s)
      Kato H., et. al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 361

      Pages: 580-585

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel clusters of highly expressed genes accompany genomicamplification in breast cancers.2007

    • Author(s)
      Ito E., et. al.
    • Journal Title

      FEBS Lett. 581

      Pages: 3909-3914

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed

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Published: 2007-03-31   Modified: 2016-04-21  

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