Standardization of tailor-made chemotherapy based on pharmacokinetics and pharmacogenomics

• Project/Area Number: 19590533
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied pharmacology
• Research Institution: Kyoto University
• Principal Investigator: ISHIGURO Hiroshi 京都大学, 医学研究科, 特定講師 (20422925)
• Co-Investigator(Kenkyū-buntansha): YANO Ikuko 京都大学, 薬学研究科, 准教授 (50273446) ; YANAGIHARA Kazuhiro 京都大学, 医学研究科, 准教授 (70332731)
• Project Period (FY): 2007 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2007: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 臨床薬理学 / 薬理遺伝学

Research Abstract

Anti-neoplastics metabolized by liver has not only with narrow safety margin but also large inter-individual variation in pharmacokinetics. Dosing based on the knowledge of pharmacogenomics, drug interaction and pharmacokinetics are the most simple and reliable methods. We have conducted several investigator-initiated clinical pharmacology trial under approval of ethics committee of Kyoto University Hospital and searched for possibility for minimizing inter-individual variation in pharmacokinetics.

Research Products

• [Journal Article] Dose-escalation and pharma cokinetic study of nanoparticle curcumin, a potentialanti cancer agent with improved bioavailability, in healthy human volunteers (2012)
  • Author(s): Kanai M, Ishiguro H(8番目), et al
  • Journal Title: Cancer Chemother Pharmacol Volume: Vol.69 Issue: 1 Pages: 65-70
  • DOI: 10.1007/s00280-011-1673-1
  • Peer Reviewed
• [Journal Article] Temporaryblood pressure drop after bevacizumab administration is associated with clinical course of advanced colorectal cancer (2011)
  • Author(s): Kanai M, Ishiguro H(2番目), et al
  • Journal Title: Br, J Cancer Volume: Vol.105 Issue: 11 Pages: 1693-6
  • DOI: 10.1038/bjc.2011.398
  • Peer Reviewed
• [Journal Article] Degree of freezing does not affect efficacy of frozen gloves for prevention of do cetaxel-induced nail toxicity in breast cancer patients (2011)
  • Author(s): Ishiguro H(1番目), Yano I, Yanagihara K, et al
  • Journal Title: Support Care Cancer Volume: (in press) Issue: 9 Pages: 2017-2024
  • DOI: 10.1007/s00520-011-1308-4
  • NAID: 120004873705
  • Peer Reviewed
• [Journal Article] Correlation be tween docetaxel-induced skin toxicity and the use of steroids and H2 blockers : A multi-in stitution survey (2011)
  • Author(s): Kawaguchi K, Ishiguro H(2番目), et al
  • Journal Title: Breast Cancer ResTreat Volume: Vol.130 Issue: 2 Pages: 627-34
  • DOI: 10.1007/s10549-011-1641-9
  • Peer Reviewed
• [Journal Article] Determining circulating endothelial cells using CellSearch system during preoperative systemic chemotherapy in breast cancer patients (2011)
  • Author(s): Ali AM, Ueno T, Tanaka S, Takada M, Ishiguro H, Abdellah AZ, Toi M
  • Journal Title: Eur J Cancer Volume: 47 Issue: 15 Pages: 2265-2272
  • DOI: 10.1016/j.ejca.2011.06.015
  • Peer Reviewed
• [Journal Article] Economic evaluation of the 21-gene signature (Oncotype DX[○!R]) in lymphnode-negative/positive, hormone receptor-positive early-stage breast cancer based on Japanese validation study (JBCRG-TR03) (2011)
  • Author(s): Kondo M, Hoshi SL, Ishiguro H, et al
  • Journal Title: Breast Cancer Research and Treatment Volume: 127 Pages: 739-749
  • Peer Reviewed
• [Journal Article] 医療に関する達成動機尺度の開発がん医療インフォームド・コンセントの観察研究にむけて (2011)
  • Author(s): 八田太一、成田慶一、石黒洋, 他
  • Journal Title: 心身医学 Volume: 51 Pages: 73-79
  • NAID: 110008006729
  • Peer Reviewed
• [Journal Article] 化学療法副作用情報室(抗がん薬による皮膚・粘膜障害の予防) (2011)
  • Author(s): 石黒洋
  • Journal Title: Cancer Board乳癌 Volume: 4.1 Pages: 75-77
• [Journal Article] 骨転移がん患者に対するEORTCQOL調査モジュールEORTCQLQ-BM22日本語版について (2011)
  • Author(s): 佐藤威文、小林国彦、石黒洋, 他
  • Journal Title: 泌尿器外科 Volume: 24 Pages: 1319-1320
• [Journal Article] Phase II study of S-1 and docetaxel for previously treated patients with locally advanced or metastatic non-small-cell lung cancer (2010)
  • Author(s): Yanagihara K, Ishiguro H(7番目), et al
  • Journal Title: Cancer Chemother Pharmacol Volume: Vol.66 Issue: 5 Pages: 13-8
  • DOI: 10.1007/s00280-009-1239-7
  • NAID: 120002515188
  • Peer Reviewed
• [Journal Article] The Breast Cancer Working Group presentation was divided into three sections : the epidemiology, pathology and treatment of breast cancer (2010)
  • Author(s): Toi M, , Ishiguro H(12番目), et al
  • Journal Title: Jpn J Clin Oncol Volume: Vol.40 Issue: Supplement 1 Pages: 13-8
  • DOI: 10.1093/jjco/hyq122
  • Peer Reviewed
• [Journal Article] Associations between glutathione S-trans ferase pi Ile105Val and glyoxylate aminotransferase Pro11Leu and Ile340Met polymorphisms and early-onset oxaliplatin-induced neuropathy (2010)
  • Author(s): Kanai M, Ishiguro H(12番目), Yanagihara K, etal
  • Journal Title: Cancer Epidemiol Volume: Vol.34 Issue: 2 Pages: 189-93
  • DOI: 10.1016/j.canep.2010.02.008
  • Peer Reviewed
• [Journal Article] The Breast Cancer Working Group presentation was divided into three sections : the epidemiology, pathology and treatment of breast cancer (2010)
  • Author(s): Toi M, Ohashi Y, Ishiguro H, et al
  • Journal Title: Japanese Journal of Clinical Oncology Volume: 40, Suppl.1
  • Peer Reviewed
• [Journal Article] The European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire for Japanese patients with bone metastases--The Japanese version of the EORTC QLQ-BM22 (2010)
  • Author(s): Sato T, Kabayashi K, Ishiguro H, et al
  • Journal Title: Japanese Journal of Cancer and Chemotherapy Volume: 37 Pages: 1507-1512
  • Peer Reviewed
• [Journal Article] 化学療法副作用情報室(副作用発現に影響を及ぼす薬物相互作用) (2010)
  • Author(s): 石黒洋
  • Journal Title: Cancer Board乳癌 Volume: 3.2 Pages: 165-167
• [Journal Article] 化学療法副作用情報室(発熱性好中球減少の予防) (2010)
  • Author(s): 石黒洋
  • Journal Title: Cancer Board乳癌 Volume: 3.1 Pages: 80-82
• [Journal Article] TC療法:現在のコンセンサス臨床エビデンスからの視点によるTC療法の展開 (2010)
  • Author(s): 柏葉匡寛、石黒洋、大野真司, 他
  • Journal Title: Cancer Board乳癌 Volume: 3.1 Pages: 28-38
• [Journal Article] 化学療法における貧血の診断と治療 (2010)
  • Author(s): 森由希子、北野俊行、石黒洋
  • Journal Title: 腫瘍内科 Volume: 5 Pages: 309-314
• [Journal Article] Associations between glutathione S-transferase pi Ile105Val and glyoxylate aminotransferase ProllLeu and Ile340Met polymorphisms and early-onset oxaliplatin-induced neuropathy (2010)
  • Author(s): Kanai M, Yoshioka A, Ishiguro H (12番目/16人), et al
  • Journal Title: Cancer Epidemiol Vol. 34 Pages: 189-93
  • Peer Reviewed
• [Journal Article] Economic evaluation of intensive chemotherapy with prophylactic granulocyte colony-stimulating factor for patients with high-risk early breast cancer in Japan (2010)
  • Author(s): Ishiguro H (1番目/8人), Kondo M, Hoshi SL, et al
  • Journal Title: Clin Ther Vol. 32 Pages: 311-26
  • Peer Reviewed
• [Journal Article] Associations between glutathione S-transferase pi Ile(105)Val and glyoxylate aminotransferase Pro(11)Leu and Ile(340)Met polymorphisms and early-onset oxaliplatin-induced neuropathy (2010)
  • Author(s): Kanai M, Yoshioka A, Ishiguro H, et al
  • Journal Title: Cancer Epidemiology 34 Pages: 189-193
  • Peer Reviewed
• [Journal Article] Economic evaluation of intensive chemotherapy with (2010)
  • Author(s): Ishiguro H, Kondo M, Hoshi S, et
  • Journal Title: Clinical Therapeutics 32 Pages: 311-326
  • Peer Reviewed
• [Journal Article] Phase II study of S-1 and docetaxel for previously treated patients with locally advanced or metastatic non-small cell lung cancer (2010)
  • Author(s): Yanagihara K, Yoshimura K, Ishiguro H, et al.
  • Journal Title: Cancer Chemotherapy and Pharmacology
  • NAID: 120002515188
  • Peer Reviewed
• [Journal Article] A history of smoking is inversely correlated with the incidence of gemcitabine-induced neutropenia (2009)
  • Author(s): Kanai M, Ishiguro H(11番目), Yanagihara K, etal
  • Journal Title: Ann Oncol Volume: Vol.20 Issue: 8 Pages: 1397-401
  • DOI: 10.1093/annonc/mdp008
  • Peer Reviewed
• [Journal Article] Drug interactions inmedical oncology(in Japanese) (2009)
  • Author(s): Ishiguro H(1番目), et al
  • Journal Title: JapaneseJournal of Cancer and Chemotherapy Volume: Vol.36 Pages: 879-85
  • Peer Reviewed
• [Journal Article] A history of smoking is inversely correlated with the incidence of gemcitabine-induced neutropenia (2009)
  • Author(s): Kanai M, Morita S, Ishiguro H (11番目/15人), et al
  • Journal Title: Ann Oncol Vol. 20 Pages: 1397-401
  • Peer Reviewed
• [Journal Article] Premedication with 20mg dexamethasone effecyively prevents relapse of skin rash associated gemcitabine monotherapy (2009)
  • Author(s): Kanai k, Matsumoto S, Ishiguro H, et al
  • Journal Title: Annals of Oncology 21 Pages: 189-190
  • Peer Reviewed
• [Journal Article] Important Drug Interactions for Clinical Oncologists (2009)
  • Author(s): Ishiguro H, Yano I, Toi M
  • Journal Title: Frontiers in Drug Design & Discovery 4 Pages: 97-121
  • Peer Reviewed
• [Journal Article] Pharmacogenomic Considerations in Breast Cancer Management (2009)
  • Author(s): Ishiguro H, Yano I, Toi M
  • Journal Title: Frontiers in Drug Design & Discovery 4 Pages: 122-134
  • Peer Reviewed
• [Journal Article] A history of smoking is inversely correlated with the incidence of gemcitabine-induced neutropenia (2009)
  • Author(s): Kanai k, Morita S, Ishiguro H, et al
  • Journal Title: Annals of Oncology 20 Pages: 1397-1401
  • Peer Reviewed
• [Journal Article] がん薬物療法に重要な薬物相互作用-Important Drug Interactions in Medical Oncology- (2009)
  • Author(s): 石黒洋、越路みのり、森實敏夫, 他
  • Journal Title: 癌と化学療法 36 Pages: 56-58
  • Peer Reviewed
• [Journal Article] 乳がん化学療法FEC100におけるG-CSF製剤の使用評価 (2009)
  • Author(s): 藤澤浩美、橋田亨、石黒洋, 他
  • Journal Title: 医療薬学 35 Pages: 31-36
  • NAID: 110007022556
  • Peer Reviewed
• [Journal Article] On going clinical study : JBCRG-M01 (2009)
  • Author(s): 石黒洋
  • Journal Title: Cancer Board乳癌 2(2) Pages: 153-153
• [Journal Article] 乳癌の抗癌薬治療における心毒性 (2009)
  • Author(s): 南博信、Stephan Zbinden、石黒洋、
  • Journal Title: Cancer Board乳癌 2(2) Pages: 144-151
• [Journal Article] 化学療法副作用情報室:発熱性好中球減少の治療 (2009)
  • Author(s): 石黒洋
  • Journal Title: Cancer Board乳癌 2(2) Pages: 130-132
• [Journal Article] 化学療法副作用情報室:遅発性悪心・嘔吐対策 (2009)
  • Author(s): 石黒洋
  • Journal Title: Cancer Board乳癌 2 Pages: 56-58
• [Journal Article] A history of smoking is inversely correlated with the incidence of gemcitabine-induced neutropenia (2009)
  • Author(s): Kanai k, Morita S, Ishiguro H, et al
  • Journal Title: Annals of Oncology
  • Peer Reviewed
• [Journal Article] 乳がん化学療法FEC100におけるG-CSF製剤の使用評価 (2009)
  • Author(s): 藤澤浩美, 橋田亨, 石黒洋, 他
  • Journal Title: 医療薬学 35 Pages: 31-36
  • NAID: 110007022556
  • Peer Reviewed
• [Journal Article] Prolonged neutropenia after dose-dense chemo the rapy with pegfilgrastim (2008)
  • Author(s): Ishiguro H(1番目), Yanagihara K, et al
  • Journal Title: Ann Oncol Volume: Vol.19 Issue: 5 Pages: 1019-20
  • DOI: 10.1093/annonc/mdn051
  • Peer Reviewed
• [Journal Article] Prolonged neutropenia after dose-dense chemotherapy with pegfilgrastim (2008)
  • Author(s): Ishiguro H (1番目/9人), Kitano T, Yoshibayashi H, et al
  • Journal Title: Ann Oncol Vol. 19 Pages: 1019-1019
  • Peer Reviewed
• [Journal Article] Economic evaluation of 21-gene reverse transcriptase-polymerase chain reaction assay in lymph-node-negative, estrogen-receptor-positive, early-stage breast cancer in Japan (2008)
  • Author(s): Kondo M, Hoshi SL, Ishiguro H (3番目/5人), et al
  • Journal Title: Breast Cancer Res Treat Vol. 112 Pages: 175-87
  • Peer Reviewed
• [Journal Article] Safety and Efficacy of Modified FOLFOX6 for Treatment of Metastatic or Locally Advanced Colorectal Cancer -A Single-Institution Outcome study (2008)
  • Author(s): Matsumoto S, Nishimura T, Ishiguro H, et al
  • Journal Title: Chemotherapy 54 Pages: 395-403
  • Peer Reviewed
• [Journal Article] Prolonged neutropenia after dose-dense chemotherapy with pegfilgrastim (2008)
  • Author(s): Ishiguro H, Kitano T, Yoshibayashi H, et al
  • Journal Title: Annals of Oncology 19 Pages: 1019-20
  • Peer Reviewed
• [Journal Article] Economic evaluation of 21-gene reverse transcription-polymerase chain reaction assay in lymph-node-negative, estrogen-receptor-positive, early breast cancer in Japan (2008)
  • Author(s): Kondo M, Hoshi S, Ishiguro H, et al
  • Journal Title: Breast Cancer Research and Treatment 112 Pages: 175-87
  • Peer Reviewed
• [Journal Article] 妊娠中に発見された悪性腫瘍の取り扱い : 妊娠中に発見される乳癌 (2008)
  • Author(s): 山城大秦, 石黒洋, 戸井雅和
  • Journal Title: 産婦人科の実際 57 Pages: 669-75
• [Journal Article] DocetaxelとCyclophosphamide併用術前化学療法が著効した乳癌の1例 (2008)
  • Author(s): 芳林浩史, 石黒洋, 高田正泰, 他
  • Journal Title: 癌と化学療法 35 Pages: 987-90
  • Peer Reviewed
• [Journal Article] Pharmacogenomics for Cancer Therapy : ホルモン療法のPhamacogenomics (2008)
  • Author(s): 石黒洋
  • Journal Title: がん分子標的治療 6 Pages: 166-71
• [Journal Article] 化学療法副作用情報室 : 急性の悪心・嘔吐対策 (2008)
  • Author(s): 石黒洋
  • Journal Title: Cancer Board乳癌 1 Pages: 48-50
• [Journal Article] Breast and Endocrine Tumor 乳腺・内分泌腫瘍治療について (2008)
  • Author(s): 高田正泰, 石黒洋, 戸井雅和
  • Journal Title: 癌と化学療法 35 Pages: 2344-50
  • Peer Reviewed
• [Journal Article] 補助化学療法 : 乳がんに対する補助薬物療法 (2008)
  • Author(s): 芳林浩史, 石黒洋, 戸井雅和
  • Journal Title: 腫瘍内科 2 Pages: 500-9
• [Journal Article] Prolonged neutropenia after dose-dense chemotherapy with pegfilgrastim (2008)
  • Author(s): Ishiguro H, Kitano T, Yoshibayashi H, et. al.
  • Journal Title: Annals of Oncology (on line)
  • Peer Reviewed
• [Journal Article] Economic evaluation of 21-gene reverse transcription-polymerase chain reaction assay in lymph-node-negative, estrogen-receptor-positive, early breast cancer in Japan (2007)
  • Author(s): Kondo M, Hoshi S, Ishiguro H, et. al.
  • Journal Title: Breast Cancer Research and Treatment (on line)
  • Peer Reviewed
• [Journal Article] Clinical outcome of gemcitabine/S-1 combination therapy for advanced pancreatic cancer (2007)
  • Author(s): Yamauchi J, Kanai M, Ishiguro H, et. al.
  • Journal Title: Pancreas 36 Pages: 327-8
  • Peer Reviewed
• [Journal Article] Prevalence and incidence of anemia in Japanese cancer patients receiving outpatient chemotherapy (2007)
  • Author(s): Kitano T, Tada H, Ishiguro H, et. al.
  • Journal Title: International Journal for Hematology 86 Pages: 37-41
  • NAID: 10018515509
  • Peer Reviewed
• [Journal Article] Retrospective analysis of 27 consecutive patients treated with docetaxel/nedaplatin combination therapy as a second-line regimen for advanced esophageal cancer (2007)
  • Author(s): Kanai M, Matsumoto S, Ishiguro H, et. al.
  • Journal Title: International Journal of Clinical Oncology 12 Pages: 224-7
  • Peer Reviewed
• [Journal Article] 外来化学療法と副作用対策:入院化学療法から外来化学療法へ (2007)
  • Author(s): 石黒洋、柳原一広
  • Journal Title: 腫瘍内科 1 Pages: 213-8
• [Presentation] Degree of freezing does not affect frozen glove efficacy for prevention of docetaxel-induced nail toxicity in breast cancer patients (2011)
  • Author(s): Ishiguro H, Yanagihara K, et al
  • Organizer: Multinational Associationof Supportive Care in Cancer(MASCC)
  • Place of Presentation: Athens, Greece
  • Year and Date: 2011-06-24
• [Presentation] A double-blind, randomized, multicenter study regarding the effects of solution for gemcitabine on frequency and degree of vascular pain in patients with cancer (2011)
  • Author(s): Nagai H, Ishiguro H, et al
  • Organizer: American Society of Clinical Oncology(ASCO)
  • Place of Presentation: Publish-only
• [Presentation] Prevention of Chemo the rapy Induced Nausea and Vomiting by Olanzapine in Japanese Patients with Early BreastCancer. (2011)
  • Author(s): Nishimura T, Ishiguro H, et al
  • Organizer: The 22nd International Congress onAnti-Cancer Treatment(ICACT)
  • Place of Presentation: Paris, France
• [Presentation] Prevention of Chemotherapy Induced Nausea and Vomiting by Olanzapine in Japanese Patients with Early Breast Cancer (2011)
  • Author(s): Nishimura T, Ishiguro H, Sugie T, et al
  • Organizer: 22^<nd> International Congress on Anti-Cancer Treatment (ICACT)
  • Place of Presentation: Paris, France
• [Presentation] Breast cancer clinical trail design in the era of personalized medicine(Invitedspeaker) (2010)
  • Author(s): Ishiguro H
  • Organizer: Frontiers in Gynecologic Oncology
  • Place of Presentation: Taichung, TAIWAN
  • Year and Date: 2010-12-19
• [Presentation] Breast cancer clinical trail design in the era of personalized medicine (2010)
  • Author(s): Ishiguro H
  • Organizer: Frontiers in Gynecologic Oncology
  • Place of Presentation: Taichung, TAIWAN, R.O.C(招待講演)
  • Year and Date: 2010-12-19
• [Presentation] 安全にがん薬物療法を行うために (2010)
  • Author(s): 石黒洋
  • Organizer: 日本乳癌学会第8回近畿地方会教育セミナー
  • Place of Presentation: 国際会議場、京都(招待講演)
  • Year and Date: 2010-12-04
• [Presentation] 分子表的治療の有効性の検証と新しい進歩抗悪性腫瘍薬による重篤な心毒性の予防 (2010)
  • Author(s): 石黒洋
  • Organizer: 第18回日本乳癌学会学術総会シンポジウム
  • Place of Presentation: 札幌芸術文化の館、札幌(招待講演)
  • Year and Date: 2010-06-25
• [Presentation] Important Drug Interaction for Clinical Oncologist (2010)
  • Author(s): Ishiguro H
  • Organizer: BIT Life Sciences' 3^<rd> World CancerCongress
  • Place of Presentation: Singapore
  • Year and Date: 2010-06-23
• [Presentation] Important Drug Interaction for Clinical Oncologist (2010)
  • Author(s): Ishiguro H
  • Organizer: BIT Life Sciences' 3rd World Cancer Congress-2010
  • Place of Presentation: Singapore(招待講演)
  • Year and Date: 2010-06-23
• [Presentation] 抗悪性腫瘍薬治療における薬物動態のばらつきを考える-抗がん剤治療は、副作用がないと効果も期待できないのか- (2010)
  • Author(s): 石黒洋
  • Organizer: 日本血液学会第93回近畿血液学地方会特別講演
  • Place of Presentation: テイジンホール、大阪(招待講演)
  • Year and Date: 2010-06-19
• [Presentation] Development of the Japanese version of the HRQOL instrument for patients with bone metastasis : EORTC QLQ-BM22 (2010)
  • Author(s): Shimozuma K, Satoh T, Ishiguro H, et al
  • Organizer: 17th Annual Conference, International Society for Quality of Life Research
  • Place of Presentation: London, England
• [Presentation] Clinical Oncologist (2009)
  • Author(s): Ishiguro H, et al
  • Organizer: The 20th Asia Pacific Cancer Conference
  • Place of Presentation: Tsukuba, Japan
  • Year and Date: 2009-11-13
• [Presentation] Inter-ethnic variation in the Pharmacodynamic Parrameters of Aromatase Inhibitors : A Retrospective Observational Study (2009)
  • Author(s): Ishiguro H (1番目/6人), Park BW, Bando H, et al
  • Organizer: 20^<th> Asia Pacific Cancer Conference
  • Place of Presentation: Tsukuba Japan
  • Year and Date: 2009-11-13
• [Presentation] Inter-ethnic variation in the pharmacodynamic parameters of aromatase inhibitors : A prospective observational study (2009)
  • Author(s): Ishiguro H, Park BW, Bando H, et al.
  • Organizer: 20th Asia Pacific Cancer Conference
  • Place of Presentation: Tsukuba, Japan
  • Year and Date: 2009-11-13
• [Presentation] Right drugs for right target at right dose (2009)
  • Author(s): 石黒洋
  • Organizer: 第47回日本乳癌学会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-23
• [Presentation] 乳癌骨転移に対する集学的治療 (2009)
  • Author(s): 杉江知治、高田正泰、石黒洋, 他
  • Organizer: 第47回日本癌治療学会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2009-10-23
• [Presentation] 新薬導入による乳癌治療の新たなる展開Right drugs for right target at right dose (2009)
  • Author(s): 石黒洋
  • Organizer: 第47回日本癌治療学会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2009-10-23
• [Presentation] 原発不明癌の治療方針 (2009)
  • Author(s): 杉江知治、芳林浩史、石黒洋, 他
  • Organizer: 第64回日本消化器外科学会総会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2009-07-18
• [Presentation] 転移性乳癌に対する治療戦略UGT1A1遺伝子多型を考慮したCPT/S-1併用療法の第I/II相臨床試験(JBCRG-M01) (2009)
  • Author(s): 佐治重衡、石黒洋、岩田広治, 他
  • Organizer: 第17回 日本乳癌学会学術総会
  • Place of Presentation: ホテル日航東京・ホテルグランパシフィックLE DAIBA
  • Year and Date: 2009-07-04
• [Presentation] 乳癌における治療効果予測因子の現状と今後の展望分子標的薬の効果予測因子 (2009)
  • Author(s): 戸井雅和、上野貴之、石黒洋, 他
  • Organizer: 第17回日本乳癌学会学術総会
  • Place of Presentation: ホテル日航東京・ホテルグランパシフィックLE DAIBA
  • Year and Date: 2009-07-03
• [Presentation] 術前化学療法の適応、レジメン、手術タイミングの比較検討(39施設へのアンケートによる調査結果から) (2009)
  • Author(s): 加藤大典、戸井雅和、石黒洋, 他
  • Organizer: 第17回日本乳癌学会学術総会
  • Place of Presentation: ホテル日航東京・ホテルグランパシフィックLE DAIBA
  • Year and Date: 2009-07-03
• [Presentation] ホルモン受容体陰性乳癌の術後補助化学療法と再発形式(多施設アンケート調査結果) (2009)
  • Author(s): 杉江知治、戸井雅和、石黒洋, 他
  • Organizer: 第17回日本乳癌学会学術総会
  • Place of Presentation: ホテル日航東京・ホテルグランパシフィックLE DAIBA
  • Year and Date: 2009-07-03
• [Presentation] 原発性乳癌症例における循環血液中腫瘍細胞(CTC)の検討 (2009)
  • Author(s): 上野貴之、杉江知治、石黒洋, 他
  • Organizer: 第17回日本乳癌学会学術総会
  • Place of Presentation: ホテル日航東京・ホテルグランパシフィックLE DAIBA
  • Year and Date: 2009-07-03
• [Presentation] Correlation between docetaxel-induced skin toxicity and the use of steroid and H_2 blockers : A multi-institution survey (2009)
  • Author(s): Kawaguchi K, Ishiguro H (2番目/10人), Morita S, et al
  • Organizer: American Society of Clinical Oncology Annual Meeting 2009
  • Place of Presentation: Orlando, USA
  • Year and Date: 2009-05-31
• [Presentation] Correlation between docetaxel-induced skin toxicity and the use of steroids and H2 blockers : A multi-institution survey. (2009)
  • Author(s): Kawaguchi K, Ishiguro H, Morita S, et al.
  • Organizer: The American Society of Clinical Oncology Annual Meeting 2009
  • Place of Presentation: Orlando, USA
  • Year and Date: 2009-05-31
• [Presentation] 市販後の当院におけるElrotinib使用症例の検討 (2009)
  • Author(s): 永井宏樹, 柳原一広, 石黒洋, 他
  • Organizer: 日本臨床腫瘍学会総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2009-03-21
• [Presentation] Correlation bet weendocetaxel-induced skin toxicity and the use of steroid and H2 blockers (2009)
  • Author(s): Kawaguchi K, Ishiguro H, et al
  • Organizer: American Society of Clinical Oncology(ASCO)
  • Place of Presentation: Orlando, FL, USA
• [Presentation] 臨床腫瘍医の育成はどうあるべきか : 本邦での現状と今後の課題これからのがん医療を支える医療人をどう育成するか (2008)
  • Author(s): 柳原一広, 金井雅史, 石黒洋, 他
  • Organizer: 日本癌治療学会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2008-11-01
• [Presentation] 術前化学療法の現状と展望 乳腺 : 抗腫瘍効果の予測、モニタリングについて (2008)
  • Author(s): 戸井雅和, 高田正泰, 石黒洋, 他
  • Organizer: 日本癌治療学会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2008-10-30
• [Presentation] 分子標的治療の現状と展望 抗HER療法とその効果予測 (2008)
  • Author(s): 上野貴之, 杉江知治, 石黒洋, 他
  • Organizer: 日本乳癌学会学術総会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2008-09-27
• [Presentation] 乳癌の脳転移における治療戦略への考察 (2008)
  • Author(s): 竹内恵, 高田正泰, 石黒洋, 他
  • Organizer: 日本乳癌学会学術総会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2008-09-26
• [Presentation] Development of a novel information technology (IT) system using the electronic medical record (EMR) in daily clinical practice (2007)
  • Author(s): Matsumoto S, Nishimura T, Ishiguro H, et. al.
  • Organizer: American Society of Clinical Oncology Annual Meeting
  • Place of Presentation: Chicago, IL, USA
• [Book] エビデンスに基づいたがん薬物療法エキスパートマニュアル (2012)
  • Author(s): 石黒洋, 他
  • Total Pages: 533
  • Publisher: 総合医学社
• [Book] 乳癌レビュ (2012)
  • Author(s): 石黒洋, 他
  • Total Pages: 296
  • Publisher: メディカルレビュー社
• [Book] 抗がん剤の開発戦略と承認申請のポイント (2011)
  • Author(s): 石黒洋, 他
  • Total Pages: 377
  • Publisher: 技術情報協会
• [Book] 外来がん化学療法マニュアル (2011)
  • Author(s): 石黒洋, 他
  • Total Pages: 458
  • Publisher: 文光堂
• [Book] 抗がん剤の開発戦略と承認申請のポイント (2011)
  • Author(s): 石黒洋、戸井雅和
  • Total Pages: 377
  • Publisher: 技術情報協会
• [Book] 外科研修マニュアル (2009)
  • Author(s): 石黒洋, 他
  • Total Pages: 538
  • Publisher: 南江堂
• [Book] 乳癌レビュ (2009)
  • Author(s): 石黒洋, 他
  • Total Pages: 220
  • Publisher: メディカルレビュー社
• [Book] What's New in Oncology (2009)
  • Author(s): 石黒洋, 他
  • Total Pages: 658
  • Publisher: 南山堂
• [Book] Frontiers in DrugDesign & Discovery (2009)
  • Author(s): Ishiguro H, et al
  • Publisher: BENTHAM SCIENCEPUBLISHERES LTD
• [Book] Bentham Frontiers in Drug Design & Discovery(Important Drug Interactions for Clinical Oncologists) (2009)
  • Author(s): Ishiguro H, Yano I, Toi M
  • Publisher: Science Publishers Ltd
• [Book] Pharmacogenomic Considerations(Breast Cancer Management, in Frontiers in Drug Design & Discovery) (2009)
  • Author(s): Ishiguro H, Yano I, Toi M.
  • Publisher: Bentham Science Publishers Ltd
• [Book] 乳癌レビュー2009 (2009)
  • Author(s): 戸井雅和, 石黒洋
  • Total Pages: 217
  • Publisher: メディカルレビュー社
• [Book] 乳癌レビュー2009 (2009)
  • Author(s): 戸井雅和、石黒洋, 他
  • Total Pages: 217
  • Publisher: メディカルレビュー社
• [Book] What's New in Oncology がん治療エッセンシャルガイド (2009)
  • Author(s): 佐藤隆美、石黒洋, 他
  • Total Pages: 658
  • Publisher: 南山堂
• [Book] 外来がん化学療法マニュアル (2009)
  • Author(s): 佐々木康綱、石黒洋, 他
  • Total Pages: 445
  • Publisher: 文光堂
• [Book] 外科研修マニュアル改訂第2版 (2009)
  • Author(s): 京都大学医学研究科外科学教室
  • Total Pages: 564
  • Publisher: 南江堂
• [Book] 乳癌レビュー2009 (2009)
  • Author(s): 戸井雅和, 石黒洋, 他
  • Total Pages: 217
  • Publisher: メディカルレビュー社
• [Book] インフォームドコンセントのための図説シリーズ乳がん薬物療法 (2008)
  • Author(s): 石黒洋, 他
  • Total Pages: 92
  • Publisher: 医薬ジャーナル社
• [Book] オスラ-Medical Handbook (2008)
  • Author(s): 石黒洋, 他
  • Total Pages: 1046
  • Publisher: エルゼビア・ジャパン
• [Book] インフォームドコンセントのための図説シリーズ (2007)
  • Author(s): 戸井雅和、石黒洋、他
  • Total Pages: 92
  • Publisher: 医薬ジャーナル社
• [Book] がん化学療法と患者ケア 改訂第2版 (2007)
  • Author(s): 福島雅典、柳原一広、石黒洋、他
  • Publisher: 医学芸術社