• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of new chemotherapies against liver cancer on the basis of levels of transcription factor ID2

Research Project

Project/Area Number 19590536
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied pharmacology
Research InstitutionYamaguchi University

Principal Investigator

IIZUKA Norio  Yamaguchi University, 大学院・医学系研究科, 准教授 (80332807)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
KeywordsID2 / 肝癌 / 転移 / 抗がん剤 / 門脈浸潤
Research Abstract

肝癌(HCC)細胞におけるID2の発現量がヒストン脱アセチル化酵素(HDAC)阻害剤(ソディウムブチレート及びトリコスタチンA)の感受性と関連することを見出し、国内(第31回日本分子生物学会年会)および国際学会(The 19^(th) Conference of the Asian Pacific Association for the Study of the Liver)で発表し、現在、論文を投稿準備中である。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (20 results)

All 2009 2008 2007

All Journal Article (15 results) (of which Peer Reviewed: 5 results) Presentation (5 results)

  • [Journal Article] Methylation of multiple genes as molecular markers for diagnosis of a small, well-differentiated hepatocellular carcinoma2009

    • Author(s)
      Moribe T, Iizuka N, et.al.
    • Journal Title

      Int J Cancer 125(2)

      Pages: 388-397

    • Related Report
      2008 Final Research Report
  • [Journal Article] Rapid and quantitative detection of CpG-methylation status using TaqMan PCR combined with methyl-binding-domain polypeptide2009

    • Author(s)
      Kimura N, Moribe T, Iizuka N, et.al.
    • Journal Title

      Clin Biochem 28(Epub ahead of print)

    • Related Report
      2008 Final Research Report
  • [Journal Article] Identification of novel aberrant methylation of BASP1 and SRD5A2 for early diagnosis of hepatocellular carcinoma by genome-wide search2008

    • Author(s)
      Moribe T, Iizuka N, et.al.
    • Journal Title

      Int J Oncol 33(5)

      Pages: 949-58

    • Related Report
      2008 Final Research Report
  • [Journal Article] Glycolysis module activated by hypoxia-inducible factor 1alpha is related to the aggressive phenotype of hepatocellular carcinoma2008

    • Author(s)
      Hamaguchi T, Iizuka N, et.al.
    • Journal Title

      Int J Oncol 33(4)

      Pages: 725-31

    • Related Report
      2008 Final Research Report
  • [Journal Article] Relation between serum levels of cell-free DNA and inflammation status in hepatitis C virus-related hepatocellular carcinoma2008

    • Author(s)
      Iida M, Iizuka N, et.al.
    • Journal Title

      Oncol Rep 20(4)

      Pages: 761-5

    • Related Report
      2008 Final Research Report
  • [Journal Article] Translational microarray systems for outcome prediction of hepatocellular carcinoma2008

    • Author(s)
      Iizuka N, Hamamoto Y, Tsunedomi R, Oka M.
    • Journal Title

      Cancer Sci(Review) 99(4)

      Pages: 659-65

    • NAID

      10024004482

    • Related Report
      2008 Final Research Report
  • [Journal Article] A three-gene predictor for early intrahepatic recurrence of hepatocellular carcinoma after curative hepatectomy2008

    • Author(s)
      Somura H, Iizuka N, et.al.
    • Journal Title

      Oncol Rep 19(2)

      Pages: 489-95

    • Related Report
      2008 Final Research Report
  • [Journal Article] Decreased ID2 Promotes Metastatic Potentials of Hepatocellular Carcinoma by Altering Secretion of Vascular Endothelial Growth Factor2008

    • Author(s)
      Tsunedomi R, Iizuka N, et.al.
    • Journal Title

      Clin Cancer Res 11

      Pages: 1023-1031

    • Related Report
      2008 Final Research Report
  • [Journal Article] Glycolysis module activated by hypoxia-inducible factor 1alpha is related to the aggressive phenotype of hepatocellular carcinoma.2008

    • Author(s)
      Hamaguchi, et al
    • Journal Title

      International Journal of Oncology 33

      Pages: 725-731

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relation between serum levels of cell-free DNA and inflammation status in hepatitis C virus-related hepatocellular carcinoma.2008

    • Author(s)
      Iida, et al
    • Journal Title

      Oncology Reports 20

      Pages: 761-765

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Translational microarray systems for outcome prediction of hepatocellular carcinoma.2008

    • Author(s)
      Iizuka, et al
    • Journal Title

      Cancer Science 99

      Pages: 659-665

    • NAID

      10024004482

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Decreased ID2 Promotes Metastatic Potentials of Hepatocellular Carcinoma by Altering Secretion of Vascular Endothelial Growth Factor.2008

    • Author(s)
      Tsunedomi R,, et. al.
    • Journal Title

      Clin Cancer Res 14

      Pages: 1023-1031

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A three-gene predictor for early intrahepatic recurrence of hepatocellular carcinoma after curative hepatectomy.2008

    • Author(s)
      Somura H, et. al.
    • Journal Title

      Oncol Rep 19

      Pages: 489-495

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Circulating cell-free DNA as a predictive marker for distant metastasis of hepatitis C virus-related hepatocellular carcinoma.2007

    • Author(s)
      Tokuhisa Y, et. al.
    • Journal Title

      Br J Cancer 97

      Pages: 1399-1403

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Resampling based on geographic patterns of hepatitis virus infection reveals a common gene signature for early intrahepatic recurrence of hepatocellular carcinoma.2007

    • Author(s)
      Uchimura S, et. al.
    • Journal Title

      Anticancer Res 27

      Pages: 3323-3330

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 肝細胞癌におけるID2レベルとヒストン脱アセチル化酵素阻害剤感受性2009

    • Author(s)
      原田紗和子、飯塚徳男, 他
    • Organizer
      第111回山口大学医学会学術講演会
    • Place of Presentation
      宇部
    • Year and Date
      2009-02-21
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Influence of the ID2 on the anti-tumor activity of histone deacetylase inhibitor in hepatocellular carcinoma cells2009

    • Author(s)
      Tsunedomi R, Iizuka N, et.al.
    • Organizer
      The 19^<th>Conference of the Asian Pacific Associationfor the Study of the Liver (APASL)
    • Place of Presentation
      Hong Kong, China
    • Related Report
      2008 Final Research Report
  • [Presentation] Influence of the ID2 on the anti-tumor activity of histone deacetylase inhibitor in hepatocellular carcinoma cells2009

    • Author(s)
      Ryouichi Tsunedomi
    • Organizer
      The 19^<th> Conference of the Asian Pacific Association for the Study of the Liver (APASL)
    • Place of Presentation
      Hong Kong, China
    • Related Report
      2008 Annual Research Report
  • [Presentation] Intracellular ID2 levels and histone deacetylase inhibitors in hepatocellular carcinoma cells2008

    • Author(s)
      Harada S, Iizuka N et.al.
    • Organizer
      第31回日本分子生物学会年会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-28
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] ID2 Level Relates to Prognosis and Metastatic Potentials of Hepatocellular Carcinoma.2007

    • Author(s)
      Tsunedomi R, et. al.
    • Organizer
      15^<th> United European Gastroenterology Week(UEGW)
    • Place of Presentation
      Paris,FRANCE,
    • Year and Date
      2007-10-30
    • Related Report
      2007 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi