Development of new chemotherapies against liver cancer on the basis of levels of transcription factor ID2

• Project/Area Number: 19590536
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied pharmacology
• Research Institution: Yamaguchi University
• Principal Investigator: IIZUKA Norio Yamaguchi University, 大学院・医学系研究科, 准教授 (80332807)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: ID2 / 肝癌 / 転移 / 抗がん剤 / 門脈浸潤

Research Abstract

肝癌(HCC)細胞におけるID2の発現量がヒストン脱アセチル化酵素(HDAC)阻害剤(ソディウムブチレート及びトリコスタチンA)の感受性と関連することを見出し、国内(第31回日本分子生物学会年会)および国際学会(The 19^(th) Conference of the Asian Pacific Association for the Study of the Liver)で発表し、現在、論文を投稿準備中である。

Research Products

• [Journal Article] Methylation of multiple genes as molecular markers for diagnosis of a small, well-differentiated hepatocellular carcinoma (2009)
  • Author(s): Moribe T, Iizuka N, et.al.
  • Journal Title: Int J Cancer 125(2) Pages: 388-397
• [Journal Article] Rapid and quantitative detection of CpG-methylation status using TaqMan PCR combined with methyl-binding-domain polypeptide (2009)
  • Author(s): Kimura N, Moribe T, Iizuka N, et.al.
  • Journal Title: Clin Biochem 28(Epub ahead of print)
• [Journal Article] Identification of novel aberrant methylation of BASP1 and SRD5A2 for early diagnosis of hepatocellular carcinoma by genome-wide search (2008)
  • Author(s): Moribe T, Iizuka N, et.al.
  • Journal Title: Int J Oncol 33(5) Pages: 949-58
• [Journal Article] Glycolysis module activated by hypoxia-inducible factor 1alpha is related to the aggressive phenotype of hepatocellular carcinoma (2008)
  • Author(s): Hamaguchi T, Iizuka N, et.al.
  • Journal Title: Int J Oncol 33(4) Pages: 725-31
• [Journal Article] Relation between serum levels of cell-free DNA and inflammation status in hepatitis C virus-related hepatocellular carcinoma (2008)
  • Author(s): Iida M, Iizuka N, et.al.
  • Journal Title: Oncol Rep 20(4) Pages: 761-5
• [Journal Article] Translational microarray systems for outcome prediction of hepatocellular carcinoma (2008)
  • Author(s): Iizuka N, Hamamoto Y, Tsunedomi R, Oka M.
  • Journal Title: Cancer Sci(Review) 99(4) Pages: 659-65
  • NAID: 10024004482
• [Journal Article] A three-gene predictor for early intrahepatic recurrence of hepatocellular carcinoma after curative hepatectomy (2008)
  • Author(s): Somura H, Iizuka N, et.al.
  • Journal Title: Oncol Rep 19(2) Pages: 489-95
• [Journal Article] Decreased ID2 Promotes Metastatic Potentials of Hepatocellular Carcinoma by Altering Secretion of Vascular Endothelial Growth Factor (2008)
  • Author(s): Tsunedomi R, Iizuka N, et.al.
  • Journal Title: Clin Cancer Res 11 Pages: 1023-1031
• [Journal Article] Glycolysis module activated by hypoxia-inducible factor 1alpha is related to the aggressive phenotype of hepatocellular carcinoma. (2008)
  • Author(s): Hamaguchi, et al
  • Journal Title: International Journal of Oncology 33 Pages: 725-731
  • Peer Reviewed
• [Journal Article] Relation between serum levels of cell-free DNA and inflammation status in hepatitis C virus-related hepatocellular carcinoma. (2008)
  • Author(s): Iida, et al
  • Journal Title: Oncology Reports 20 Pages: 761-765
• [Journal Article] Translational microarray systems for outcome prediction of hepatocellular carcinoma. (2008)
  • Author(s): Iizuka, et al
  • Journal Title: Cancer Science 99 Pages: 659-665
  • NAID: 10024004482
• [Journal Article] Decreased ID2 Promotes Metastatic Potentials of Hepatocellular Carcinoma by Altering Secretion of Vascular Endothelial Growth Factor. (2008)
  • Author(s): Tsunedomi R,, et. al.
  • Journal Title: Clin Cancer Res 14 Pages: 1023-1031
  • Peer Reviewed
• [Journal Article] A three-gene predictor for early intrahepatic recurrence of hepatocellular carcinoma after curative hepatectomy. (2008)
  • Author(s): Somura H, et. al.
  • Journal Title: Oncol Rep 19 Pages: 489-495
  • Peer Reviewed
• [Journal Article] Circulating cell-free DNA as a predictive marker for distant metastasis of hepatitis C virus-related hepatocellular carcinoma. (2007)
  • Author(s): Tokuhisa Y, et. al.
  • Journal Title: Br J Cancer 97 Pages: 1399-1403
  • Peer Reviewed
• [Journal Article] Resampling based on geographic patterns of hepatitis virus infection reveals a common gene signature for early intrahepatic recurrence of hepatocellular carcinoma. (2007)
  • Author(s): Uchimura S, et. al.
  • Journal Title: Anticancer Res 27 Pages: 3323-3330
  • Peer Reviewed
• [Presentation] 肝細胞癌におけるID2レベルとヒストン脱アセチル化酵素阻害剤感受性 (2009)
  • Author(s): 原田紗和子、飯塚徳男, 他
  • Organizer: 第111回山口大学医学会学術講演会
  • Place of Presentation: 宇部
  • Year and Date: 2009-02-21
• [Presentation] Influence of the ID2 on the anti-tumor activity of histone deacetylase inhibitor in hepatocellular carcinoma cells (2009)
  • Author(s): Tsunedomi R, Iizuka N, et.al.
  • Organizer: The 19^<th>Conference of the Asian Pacific Associationfor the Study of the Liver (APASL)
  • Place of Presentation: Hong Kong, China
• [Presentation] Influence of the ID2 on the anti-tumor activity of histone deacetylase inhibitor in hepatocellular carcinoma cells (2009)
  • Author(s): Ryouichi Tsunedomi
  • Organizer: The 19^<th> Conference of the Asian Pacific Association for the Study of the Liver (APASL)
  • Place of Presentation: Hong Kong, China
• [Presentation] Intracellular ID2 levels and histone deacetylase inhibitors in hepatocellular carcinoma cells (2008)
  • Author(s): Harada S, Iizuka N et.al.
  • Organizer: 第31回日本分子生物学会年会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-28
• [Presentation] ID2 Level Relates to Prognosis and Metastatic Potentials of Hepatocellular Carcinoma. (2007)
  • Author(s): Tsunedomi R, et. al.
  • Organizer: 15^<th> United European Gastroenterology Week(UEGW)
  • Place of Presentation: Paris,FRANCE,
  • Year and Date: 2007-10-30