• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Epidemiologic and pharmacogenetic study of adverse drug reactions in 10,000 subjects of participants in a health screening program or patients with epilepsy

Research Project

Project/Area Number 19590539
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied pharmacology
Research InstitutionKumamoto University

Principal Investigator

NAKAGAWA Kazuko  Kumamoto University, 大学院・医学薬学研究部, 教授 (20284747)

Co-Investigator(Kenkyū-buntansha) HORI Masaharu  熊本大学, 大学院・医学薬学研究部, 助教 (30433014)
佐藤 圭三  熊本大学, 大学院・医学薬学研究部, 准教授 (00315293)
Co-Investigator(Renkei-kenkyūsha) SATO Keizo  熊本大学, 大学院・医学薬学研究部, 准教授 (00315293)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords医薬品副作用 / 薬学 / 臨床 / 薬理遺伝学 / トランスレーショナルリサーチ
Research Abstract

1)人間ドック受診者の副作用調査から、女性は男性に比べて副作用の発現頻度が2.5倍高いことを明らかにした。2)抗てんかん薬の効果や副作用に係る遺伝要因を明らかにして、「遺伝情報に基づくてんかんの個別化治療法の開発(代表 : 弘前大学兼子直教授)」を展開中である。3)熊本大学育薬フロンティアセンター(H20年設置)と熊本県下700の薬局を結ぶ副作用調査網を構築中であり、今後、本システムを用いた独自の副作用調査を展開する。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (90 results)

All 2009 2008 2007 Other

All Journal Article (43 results) (of which Peer Reviewed: 43 results) Presentation (45 results) Remarks (2 results)

  • [Journal Article] Two novel CYP2D6*10 haplotypes as possible causes of a poor metabolic phenotype in Japanese2009

    • Author(s)
      Matsunaga M., 他11名
    • Journal Title

      Drug Metab Dispos 34

      Pages: 699-701

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of polymorphic variations in tumor necrosis factor alpha and occupational exposure to grain dust on longitudinal decline in pulmonary function2009

    • Author(s)
      Pahwa P., 他3名
    • Journal Title

      J Agromedicine 14

      Pages: 215-21

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of paraoxonase-1 in induced sputum from healthy volunteers2009

    • Author(s)
      Umemoto Y., 他4名
    • Journal Title

      Free Rad Biol Med 46

      Pages: 699-699

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association between combinations of glutathione-S-transferase M1, T1 and P1 genotypes and non-alcoholic fatty liver disease.2009

    • Author(s)
      Hori M
    • Journal Title

      Liver International 29

      Pages: 164-168

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two novel CYP2D6*10 haplotypes as possible causes of a poor metabolic phenotype in Japanese.2009

    • Author(s)
      Matsunaga M
    • Journal Title

      Drug metabolism and disposition : the biological fate of chemicals 37

      Pages: 699-701

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of paraoxonase-1 in induced sputum from healthy volunteers.2009

    • Author(s)
      Umemoto Y
    • Journal Title

      Free Radical Biology & Medicine 46

      Pages: 699-699

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of CYP2C19 polymorphisms on the efficacy of clobazam therapy2008

    • Author(s)
      Seo T., 他6名
    • Journal Title

      Pharmacogenomics 9

      Pages: 527-537

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Population estimation of the effects of cytochrome P450 2C19 and 3A5 polymorphisms on zonisamide clearance2008

    • Author(s)
      Okada Y., 他6名
    • Journal Title

      Ther Drug Monit 30

      Pages: 540-543

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association between SCN1A polymorphism and carbamazepine-resistant epilepsy2008

    • Author(s)
      Abe T., 他5名
    • Journal Title

      BrJ Clin Pharmacol 66

      Pages: 304-307

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Glutathione-S-transferase (GST) M1 null genotype and combined GSTM1 and GSTT1 null genotypes are risk factors for elevated serum γ-glutamyltransferase in valproic acid-treated patients2008

    • Author(s)
      Fukushima Y., 他5名
    • Journal Title

      Clin Chim Acta 389

      Pages: 98-102

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] ABCC2 haplotype is not associated with drug-resistant epilepsy2008

    • Author(s)
      Seo T., 他5名
    • Journal Title

      J Pharm Pharmacol 60

      Pages: 631-635

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Potential relationships between transaminase abnormality and valproic acid clearance or serum carnitine concentrations in Japanese epileptic patients2008

    • Author(s)
      Goto S., 他8名
    • Journal Title

      J Pharm Pharmacol 60

      Pages: 267-272

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Applicability of new spin trap agent, 2-diphenylphosphinoyl-2-methyl-3, 4-dihydro- 2H-pyrrole N-Oxide2008

    • Author(s)
      Karakawa T., 他10名
    • Journal Title

      in biological system. Biochem Biophys Res Commun 370

      Pages: 93-97

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Superoxide scavenging activity of pirfenidone-iron complex2008

    • Author(s)
      Mitani Y., 他10名
    • Journal Title

      Biochem Biophys Res Commun 372

      Pages: 19-23

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A preliminary investigation of the association between haptoglobin polymorphism, serum ferritin concentration and fatty liver disease2008

    • Author(s)
      Nakagawa T., 他5名
    • Journal Title

      Clinica Chimica Acta 398

      Pages: 34-38

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association between combinations of glutathione-S-transferase M1, T1, and P1 genotypes and non-alcoholic fatty liver disease2008

    • Author(s)
      Hori M., 他6名
    • Journal Title

      Liver Int 29

      Pages: 164-168

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Glutathione S-transferase A1 polymorphism as a risk factor for smoking-related type 2 diabetes in Japanese2008

    • Author(s)
      Oniki K., 他6名
    • Journal Title

      Toxicol Lett 178

      Pages: 143-145

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association between glutathione S-transferase A1, M1 and T1 polymorphisms and hypertension2008

    • Author(s)
      Oniki K., 他6名
    • Journal Title

      Pharmacogenet Genomics 18

      Pages: 275-277

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association between cytochrome P450 3A5 polymorphism and the lung function in Saskatchewan grain workers2008

    • Author(s)
      Seo T., 他8名
    • Journal Title

      Pharmacogenet Genomics 18

      Pages: 487-493

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interactive effect of paraoxonase-1 Q192R polymorphism and smoking history on the lung function decline in grain workers2008

    • Author(s)
      Seo T., 他6名
    • Journal Title

      Ann Epidemiol 18

      Pages: 330-334

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Population estimation of the effects of cytochrome P450 2C19 and 3A5 polymorphisms on zonisamide clearance.2008

    • Author(s)
      Okada Y
    • Journal Title

      Therapeutic Drug Monitoring 30

      Pages: 540-543

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between SCN1A polymorphism and carbamazepine-resistant epilepsy.2008

    • Author(s)
      AbeT
    • Journal Title

      British Journal of Clinical Pharmacology 66

      Pages: 304-307

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ABCC2 haplotype is not associated with drug-resistant epilepsy.2008

    • Author(s)
      Seo T
    • Journal Title

      The Journal of Pharmacy and Pharmacology 60

      Pages: 631-635

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of CYP2C19 polymorphisms on the efficacy of clobazam therapy.2008

    • Author(s)
      Seo T
    • Journal Title

      Pharmacogenomics 9

      Pages: 527-537

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between combinations of glutathione-S-transferase M1, T1, and P1 genotypes and non-alcoholic fatty liver disease.2008

    • Author(s)
      Hori M
    • Journal Title

      Official Journal of the International Association for the Study of the Liver 29

      Pages: 164-168

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between glutathione S-transferase A1, M1 and T1 polymorphisms and hypertension.2008

    • Author(s)
      Oniki K
    • Journal Title

      Pharmacogenetics and Genomics 18

      Pages: 275-277

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Applicability of new spin trap agent, 2-diphenylphosphinoy1-2-methy1-3, 4-dihydro-2H-pyrrole N-Oxide, in biological system.2008

    • Author(s)
      Karakawa T
    • Journal Title

      Biochemical and Biophysical Research Communications 370

      Pages: 93-97

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Superoxide scavenging activity of pirfenidone-iron complex.2008

    • Author(s)
      Mitani Y
    • Journal Title

      Biochemical and Biophysical Rresearch Communications 372

      Pages: 19-23

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interactive effect of smoking and paraoxonase-1 genotype on the lung function decline.2008

    • Author(s)
      Seo T
    • Journal Title

      Annals of Epidemiology 18

      Pages: 330-334

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Influence of valproic acid clearance and serum carnitine concentrations on mild liver dysfunction in Japanese epileptic patients.2008

    • Author(s)
      Goto S
    • Journal Title

      The Journal of Pharmacy and Pharmacology 60

      Pages: 267-272

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Glutathione-S-transferase (GST) M1 null genotype and combined GSTM1 and GSTT1 null genotypes are risk factors for elevated serum γ-glutamyltransferase in valproic acid-treated patients.2008

    • Author(s)
      Fukushima Y
    • Journal Title

      International Journal of Clinial Chemistry 389

      Pages: 98-102

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Combined glutathione-S-transferase M1 and T1 null genotypes as a risk factor for carbamazepine-induced mild hepatotoxicity2007

    • Author(s)
      Ueda K., 他6名
    • Journal Title

      Pharmacogenomics 8

      Pages: 435-442

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Population estimation of the effects of cytochrome P450 2C9 and 2C19 polymorphisms on phenobarbital clearance in Japanese2007

    • Author(s)
      Goto S., 他6名
    • Journal Title

      Ther Drug Monit 29

      Pages: 118-121

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The effect of Shoseiryuto, a traditional Japanese medicine, on cytochrome P450s, N-acetyltransferase 2 and xanthine oxidase in extensive or intermediate metabolizers of CYP2D62007

    • Author(s)
      Nakao M., 他7名
    • Journal Title

      Eur J Clin Pharmacol 63

      Pages: 345-353

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Combined glutathione-S-transferase T1 and M1 positive genotypes afford protection against type 2 diabetes in Japanese2007

    • Author(s)
      Hori M., 他6名
    • Journal Title

      Pharmacogenomics 8

      Pages: 1307-1314

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Glutathione-S-transferase (GST) M1 null genotype and combined GSTM1 and GSTT1 null genotypes as a risk factor for alcoholic mild liver dysfunction2007

    • Author(s)
      Oniki K., 他5名
    • Journal Title

      Clin Pharm Ther 81

      Pages: 634-635

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association between paraoxonase-1 Q192R polymorphism and lung function among Saskatchewan grain handlers2007

    • Author(s)
      Seo T., 他7名
    • Journal Title

      Pharmacogenomics 8

      Pages: 901-908

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Influence of paraoxonase-1 Q192R polymorphism on the lung function in Saskatchewan grain handlers2007

    • Author(s)
      Seo T
    • Journal Title

      Pharmacogenomics 8

      Pages: 901-908

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Combined glutathione-S-transferase T1 and M1 positive genotypes afford protection against type 2 diabetes in Japanese.2007

    • Author(s)
      Hori M
    • Journal Title

      Pharmacogenomics 8

      Pages: 1307-1314

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Combined glutathione-S-transferase M1 and T1 null genotypes as a risk factor for alcoholic mild liver dysfunction.2007

    • Author(s)
      Oniki K
    • Journal Title

      Clinical Pharmacology and Therapeutics 81

      Pages: 634-635

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Population estimation of the effects of cytochrome P450 2C9 and 2C19 polymorphisms on phenobarbital clearance in Japanese.2007

    • Author(s)
      Goto S
    • Journal Title

      Therapeutic Drug Monitoring 29

      Pages: 118-121

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effect of Shoseiryuto,a traditional Japanese medicine,on cytochrome P450s,N-acetyltransferase 2 and xanthine oxidase in extensive or intermediate metabolizers of CYP2D6.2007

    • Author(s)
      Nakao M
    • Journal Title

      European Journal of Clinical Pharmacology 63

      Pages: 345-353

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Combined glutathione-S-transferase M1 and T1 null genotypes as a risk factor for carbamazepine-induced mild hepatotoxicity.2007

    • Author(s)
      Ueda K
    • Journal Title

      Pharmacogenomics 8

      Pages: 435-442

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 個別化医療をリードする育薬フロンティアセンター研究拠点形成2008

    • Author(s)
      中川和子
    • Organizer
      第2回薬学研究フォーラムin東京
    • Place of Presentation
      東京都
    • Related Report
      2008 Final Research Report
  • [Presentation] 抗てんかん薬服用による体重増加に及ぼすCytochrome P450 2C19遺伝子型の影響2008

    • Author(s)
      安部智英
    • Organizer
      第29回日本臨床薬理学会年会
    • Place of Presentation
      東京都
    • Related Report
      2008 Final Research Report
  • [Presentation] Personalized Medicine at the Centerf or Clinical Pharmaceutical Sciences(CCPS)2008

    • Author(s)
      Irie T.
    • Organizer
      6th Kumamoto University Forum
    • Place of Presentation
      Surabaya Indonesia
    • Related Report
      2008 Final Research Report
  • [Presentation] 薬物有害反応危険因子としての性差の検討2008

    • Author(s)
      高石千聖
    • Organizer
      第23回日本薬物動態学会年会
    • Place of Presentation
      熊本市
    • Related Report
      2008 Final Research Report
  • [Presentation] 抗てんかん薬による肝障害におけるミトコンドリアSOD遺伝子多型の影響2008

    • Author(s)
      出口真理子
    • Organizer
      第23回日本薬物動態学会年会
    • Place of Presentation
      熊本市
    • Related Report
      2008 Final Research Report
  • [Presentation] 桂枝茯苓丸が薬物代謝酵素(cytochrome P450 1A2, 2D6, 3A, N-acetyltransferase, xanthineoxidase)に及ぼす影響2008

    • Author(s)
      藤村洋平
    • Organizer
      第23回日本薬物動態学会年会
    • Place of Presentation
      熊本市
    • Related Report
      2008 Final Research Report
  • [Presentation] 難治てんかんにおけるMDR1・MRP2遺伝子多型解析2008

    • Author(s)
      吉田秀一
    • Organizer
      第42回日本てんかん学会
    • Place of Presentation
      東京都
    • Related Report
      2008 Final Research Report
  • [Presentation] Development of Individualized Medicine for Epilepsy Based on Genetic Polymorphisms2008

    • Author(s)
      Kaneko S.
    • Organizer
      7th Asian & Oceanian Epilepsy Congress
    • Place of Presentation
      Xiamen China
    • Related Report
      2008 Final Research Report
  • [Presentation] Development of Individualized Medicine for Epilepsy Based on Genetic Polymorphisms.2008

    • Author(s)
      Kaneko S
    • Organizer
      7th Asian & Oceanian Epilepsy Congress
    • Place of Presentation
      アモイ, 中国
    • Related Report
      2008 Annual Research Report
  • [Presentation] Superoxide scavenging activity of pirfenidone-iron complex.2008

    • Author(s)
      Mitani Y
    • Organizer
      A Joint Conference of the 13th In Vivo ESR/EPR Spectroscopy & Imaging and the 10th International EPR Spin Trapping/Spin Labeling : Biomedical Redox Navigation (EPR2008)
    • Place of Presentation
      福岡県福岡市
    • Related Report
      2008 Annual Research Report
  • [Presentation] Applicability of new spin trap agent, 2-diphenylphosphinoyl-2-methyl-3, 4-dihydro-2H-pyrrole N-oxide, in biological system.2008

    • Author(s)
      Karakawa T
    • Organizer
      A Joint Conference of the 13th In Vivo ESR/EPR Spectroscopy & Imaging and the 10th International EPR Spin Trapping/Spin Labeling : Biomedical Redox Navigation (EPR2008)
    • Place of Presentation
      福岡県福岡市
    • Related Report
      2008 Annual Research Report
  • [Presentation] Carboxy-PTIOを用いたin vitroでの新規-酸化窒素検出法の評価2008

    • Author(s)
      橋口直隆
    • Organizer
      第47回電子スピンサイエンス学会年会
    • Place of Presentation
      福岡県福岡市
    • Related Report
      2008 Annual Research Report
  • [Presentation] ニューキノロン系抗菌薬由来スーパーオキシドラジカル生成の酵素学的反応機序の検討2008

    • Author(s)
      北窓正孝
    • Organizer
      第47回電子スピンサイエンス学会年会
    • Place of Presentation
      福岡県福岡市
    • Related Report
      2008 Annual Research Report
  • [Presentation] 難治てんかんにおけるMDR1・MRP2遺伝子多型解析2008

    • Author(s)
      吉田秀一
    • Organizer
      第42回日本てんかん学会
    • Place of Presentation
      東京都新宿区
    • Related Report
      2008 Annual Research Report
  • [Presentation] Association between high-risk genotypes of glutathione S-transferases and type 2 diabetes mellitus, non-alcoholic fatty liver disease and hypertension.2008

    • Author(s)
      Nakagawa K
    • Organizer
      The Sixth International Symposium : Public Health and the Agricultural Rural Ecosystem
    • Place of Presentation
      サスカツーン, カナダ
    • Related Report
      2008 Annual Research Report
  • [Presentation] Effects of Genetic Polymorphisms And Occupational Exposure to Canary Seed Dust on Longitudinal decline in pulmonary function.2008

    • Author(s)
      Pahwa P
    • Organizer
      The Sixth International Symposium : Public Health and the Agricultural Rural Ecosystem
    • Place of Presentation
      サスカツーン, カナダ
    • Related Report
      2008 Annual Research Report
  • [Presentation] 桂枝茯苓丸が薬物代謝酵素(cytochrome P450 1A2, 2D6, 3A, N-acetyltransferase, xanthine oxidase)に及ぼす影響2008

    • Author(s)
      藤村洋平
    • Organizer
      第23回日本薬物動態学会年会
    • Place of Presentation
      熊本県熊本市
    • Related Report
      2008 Annual Research Report
  • [Presentation] 肥満に伴う血清脂質・トランスアミナーゼ値異常に及ぼすミクロゾームトリグリセリド転移蛋白遺伝子多型の影響2008

    • Author(s)
      濱本愛
    • Organizer
      第23回日本薬物動態学会年会
    • Place of Presentation
      熊本県熊本市
    • Related Report
      2008 Annual Research Report
  • [Presentation] Carboxy-PTIOを用いたin vitroでの新規-酸化窒素検出法の評価2008

    • Author(s)
      田中圭祐
    • Organizer
      第23回日本薬物動態学会年会
    • Place of Presentation
      熊本県熊本市
    • Related Report
      2008 Annual Research Report
  • [Presentation] 2型糖尿病の発症に関するmethylenetetrahydrofolate reductaseA1298C遺伝子多型の影響2008

    • Author(s)
      下益田正嗣
    • Organizer
      第23回日本薬物動態学会年会
    • Place of Presentation
      熊本県熊本市
    • Related Report
      2008 Annual Research Report
  • [Presentation] 抗てんかん薬による肝障害におけるミトコンドリア-SOD遺伝子多型の影響2008

    • Author(s)
      出口真理子
    • Organizer
      第23回日本薬物動態学会年会
    • Place of Presentation
      熊本県熊本市
    • Related Report
      2008 Annual Research Report
  • [Presentation] ニューキノロン系抗菌薬由来スーパーオキシドラジカル生成の酵素学的反応機序の検討2008

    • Author(s)
      北窓正孝
    • Organizer
      第23回日本薬物動態学会年会
    • Place of Presentation
      熊本県熊本市
    • Related Report
      2008 Annual Research Report
  • [Presentation] ラジカル補足剤2-diphenylphosphinoyl-2-methyl-3, 4-dihydro-2H-pyrrole N-oxideを用いた新規酸化ストレスマーカー測定法の検討2008

    • Author(s)
      井原啓子
    • Organizer
      第23回日本薬物動態学会年会
    • Place of Presentation
      熊本県熊本市
    • Related Report
      2008 Annual Research Report
  • [Presentation] 新規抗線維化薬PirfenidoneのSuperoxide消去活性の検討2008

    • Author(s)
      三谷佳弘
    • Organizer
      第23回日本薬物動態学会年会
    • Place of Presentation
      熊本県熊本市
    • Related Report
      2008 Annual Research Report
  • [Presentation] Mitochondrial superoxide dismutase遺伝子多型および飲酒が高血圧発症に及ぼす影響2008

    • Author(s)
      中川武裕
    • Organizer
      第23回日本薬物動態学会年会
    • Place of Presentation
      熊本県熊本市
    • Related Report
      2008 Annual Research Report
  • [Presentation] 薬物有害反応危険因子としての性差の検討2008

    • Author(s)
      高石千聖
    • Organizer
      第23回日本薬物動態学会年会
    • Place of Presentation
      熊本県熊本市
    • Related Report
      2008 Annual Research Report
  • [Presentation] 新規ラジカル補足剤2-diphenylphosphinoyl-2-methyl-3, 4-dihydro-2H-pyrrole N-oxideの有用性の検討2008

    • Author(s)
      辛川知弘
    • Organizer
      第23回日本薬物動態学会年会
    • Place of Presentation
      熊本県熊本市
    • Related Report
      2008 Annual Research Report
  • [Presentation] Glutathione S-transferase遺伝子変異が日本人及びカナダ人の肺機能に及ぼす影響2008

    • Author(s)
      梅本雄一郎
    • Organizer
      第23回日本薬物動態学会年会
    • Place of Presentation
      熊本県熊本市
    • Related Report
      2008 Annual Research Report
  • [Presentation] 抗てんかん薬服用による体重増加に及ぼすCYP2C19遺伝子型の影響2008

    • Author(s)
      安部智英
    • Organizer
      第23回日本薬物動態学会年会
    • Place of Presentation
      熊本県熊本市
    • Related Report
      2008 Annual Research Report
  • [Presentation] Mitochondrial superoxide dismutase遺伝子多型が高血圧発症に及ぼす影響〜飲酒との相互作用に関する検討〜2008

    • Author(s)
      中川武裕
    • Organizer
      第29回日本臨床薬理学会年会
    • Place of Presentation
      東京都新宿区
    • Related Report
      2008 Annual Research Report
  • [Presentation] 抗てんかん薬服用による体重増加に及ぼすCytochrome P450 2C19遺伝子型の影響2008

    • Author(s)
      安部智英
    • Organizer
      第29回日本臨床薬理学会年会
    • Place of Presentation
      東京都新宿区
    • Related Report
      2008 Annual Research Report
  • [Presentation] 個別化医療をリードする育薬フロンティアセンター研究拠点形成2008

    • Author(s)
      中川和子
    • Organizer
      第2回薬学研究フォーラムin東京
    • Place of Presentation
      東京都渋谷区
    • Related Report
      2008 Annual Research Report
  • [Presentation] てんかんの治療抵抗性に及ぼす薬物トランスポーター (ABCC2) 遺伝子多型の影響2007

    • Author(s)
      瀬尾 享志
    • Organizer
      第1回トランスポーター研究会九州支部会in Kumamoto
    • Place of Presentation
      熊本県熊本市
    • Year and Date
      2007-11-24
    • Related Report
      2007 Annual Research Report
  • [Presentation] SCN1A遺伝子多型が抗てんかん薬治療に及ぼす影響2007

    • Author(s)
      安部 智英
    • Organizer
      第1回トランスポーター研究会九州支部会in Kumamoto
    • Place of Presentation
      熊本県熊本市
    • Year and Date
      2007-11-24
    • Related Report
      2007 Annual Research Report
  • [Presentation] ニューキノロン系抗菌薬の副作用発現におけるフリーラジカルの影響2007

    • Author(s)
      村本洋介
    • Organizer
      第28回日本臨床薬理学会年会
    • Place of Presentation
      宇都宮市
    • Related Report
      2008 Final Research Report
  • [Presentation] Cytochrome P450 2C19 遺伝子多型のクロバザム治療への影響に関する薬物動態・薬力学的検討2007

    • Author(s)
      瀬尾 享志
    • Organizer
      第34回日本小児臨床薬理学会
    • Place of Presentation
      熊本県熊本市
    • Related Report
      2007 Annual Research Report
  • [Presentation] 抗てんかん薬治療におけるSCN1A遺伝子多型の影響2007

    • Author(s)
      安部 智英
    • Organizer
      第34回日本小児臨床薬理学会
    • Place of Presentation
      熊本県熊本市
    • Related Report
      2007 Annual Research Report
  • [Presentation] ゾニサミドの体内動態に影響を及ぼす因子の検討2007

    • Author(s)
      岡田 祐輔
    • Organizer
      第34回日本小児臨床薬理学会
    • Place of Presentation
      熊本県熊本市
    • Related Report
      2007 Annual Research Report
  • [Presentation] Cytochrome P450 345 遺伝子多型がカナダ穀物取扱作業者の呼吸機能に及ぼす影響2007

    • Author(s)
      瀬尾 享志
    • Organizer
      第28回日本臨床薬理学会年会
    • Place of Presentation
      栃木県宇都宮市
    • Related Report
      2007 Annual Research Report
  • [Presentation] カナダ穀物取扱作業者の呼吸機能低下に与える Paraoxnase-1 Q192R 遺伝子多型の影響2007

    • Author(s)
      瀬尾 享志
    • Organizer
      第28回日本臨床薬理学会年会
    • Place of Presentation
      栃木県宇都宮市
    • Related Report
      2007 Annual Research Report
  • [Presentation] グルタチオンS転移酵素T1,M1遺伝子欠損が糖尿病の発症に及ぼす影響2007

    • Author(s)
      鬼木 健太郎
    • Organizer
      第28回日本臨床薬理学会年会
    • Place of Presentation
      栃木県宇都宮市
    • Related Report
      2007 Annual Research Report
  • [Presentation] 気道内 Paraoxonase-1 (PON1) 活性の証明と PON1 遺伝子多型が呼吸機能に及ぼす影響に関する研究2007

    • Author(s)
      梅本 雄一郎
    • Organizer
      第28回日本臨床薬理学会年会
    • Place of Presentation
      栃木県宇都宮市
    • Related Report
      2007 Annual Research Report
  • [Presentation] 人間ドック受診者を対象とした副作用発現における性差の検討2007

    • Author(s)
      高石 千聖
    • Organizer
      第28回日本臨床薬理学会年会
    • Place of Presentation
      栃木県宇都宮市
    • Related Report
      2007 Annual Research Report
  • [Presentation] Cytochrome P450 2C19 遺伝子多型のクロバザム治療への影響に関する薬物動態・薬力学的検討2007

    • Author(s)
      瀬尾 享志
    • Organizer
      第28回日本臨床薬理学会年会
    • Place of Presentation
      栃木県宇都宮市
    • Related Report
      2007 Annual Research Report
  • [Presentation] ニューキノロン系抗菌薬の副作用発現におけるフリーラジカルの影響2007

    • Author(s)
      村本 洋介
    • Organizer
      第28回日本臨床薬理学会年会
    • Place of Presentation
      栃木県宇都宮市
    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://www.pharm.kumamoto-u.ac.jp/Labs/tiryougaku/index.html

    • Related Report
      2008 Final Research Report
  • [Remarks] 育薬フロンティアセンターの紹介

    • URL

      http://www.pharm.kumamoto-u.ac.jp/details/index.php?id=416

    • Related Report
      2008 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi