Novel approach to vascular injury by targeting amino acid transporter LAT1
| Project/Area Number |
19590543
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | Kyorin University |
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Principal Investigator |
KOZAKI Koichi Kyorin University, 医学部, 准教授 (80272540)
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| Co-Investigator(Kenkyū-buntansha) |
NAGAI Kumiko 杏林大学, 医学部, 実験助手 (60398592)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | アミノ酸トランスポーター / LAT / 血管平滑筋 / 頚動脈 / ApoE欠損マウス / 頸動脈 |
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| Research Abstract |
LAT1, a transporter providing essential amino acids into the cells, is expressed in the rat aortic smooth muscle cells (RASMC), and also in the carotid artery. LAT1 is necessary for the growth and survival of RASMC. Animal experiments showed that LAT1 plays an important role in the neointima formation after vascular injury in the carotid and femoral artery. Furthermore, we are investigating the role of LAT1 in the development of atherosclerosis and in the function of blood-brain barrier.
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Report
(4 results)
Research Products
(49 results)
