| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Research Abstract |
LAT1, a transporter providing essential amino acids into the cells, is expressed in the rat aortic smooth muscle cells (RASMC), and also in the carotid artery. LAT1 is necessary for the growth and survival of RASMC. Animal experiments showed that LAT1 plays an important role in the neointima formation after vascular injury in the carotid and femoral artery. Furthermore, we are investigating the role of LAT1 in the development of atherosclerosis and in the function of blood-brain barrier.
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