Pathogenesis of malignant pleural mesothelioma
| Project/Area Number |
19590547
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Chiba University |
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Principal Investigator |
廣島 健三 Chiba University, 大学院・医学研究院, 准教授 (80218833)
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| Co-Investigator(Kenkyū-buntansha) |
NAKATANI Yukio 千葉大学, 大学院・医学研究院, 教授 (20137037)
TOMONAGA Tsuyoshi 医薬基盤研究所, 基盤的研究部プロテオームリサーチプロジェクト, プロジェクトリーダー (80227644)
TANIZAWA Tohru 千葉大学, 医学部・付属病院, 准教授 (00227232)
SUZUKI Makoto 千葉大学, 大学院・医学研究院, 講師 (80312940)
OIDE Takashi 千葉大学, 大学院・医学研究院, 助教 (00422246)
YONEMORI Yoko 千葉大学, 大学院・医学研究院, 助教 (10422247)
伊豫田 明 北里大学, 医学部, 講師 (10302548)
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| Co-Investigator(Renkei-kenkyūsha) |
IYODA Akira 北里大学, 医学部, 講師 (10302548)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 中皮腫 / 壁側胸膜 / 臓側胸膜 / mesothelioma in situ / epithelial membrane antigen / (EMA) / GLUT-1 / 2時元電気泳動 / 2-D DIGE / 2次元電気泳動 / mesotheliomainsitu / epithelialmembraneantigen / 2-DDIGE |
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| Research Abstract |
早期の胸膜中皮腫は腫瘍細胞が胸膜表面に一層性あるいは乳頭状に認められ, 壁側胸膜と臓側胸膜の両方に腫瘍が進展している. 中皮腫は早期に腫瘍を摘出しても過半数は3年以内に死亡する. 5年以上生存した症例はいずれも上皮型であり, desmoplasiaや壊死を認めず, 腫瘍細胞の細胞増殖能は低く, 癌抑制遺伝子のプロモーター領域のメチル化の頻度は低い. このような特徴をもつ中皮腫が胸膜肺全摘術の適応になる.
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Report
(3 results)
Research Products
(60 results)
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[Journal Article] Malignant pleural mesothelioma : A clinicopathological study of sixteen extrapleural pneumonectomy cases with special reference to early stage features2009
Author(s)
Hiroshima K, Yusa T, Kameya T, Ito I, Kaneko K, Kadoyama C, Kishi H, Saitoh Y, Ozaki D, Itami M, Iwata T, Iyoda A, Kawai T, Yoshino I, Nakatani Y.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Aberrant methylation of CXCL12 in non-small cell lung cancer is associated with an unfavorable prognosis2008
Author(s)
Suzuki M, Mohamed S, Nakajima T, Kubo R, Tian L, Fujiwara T, Suzuki H, Nagato K, Chiyo M, Motohashi S, Yasufuku K, Iyoda A, Yoshida S, Sekine Y, Shibuya K, Hiroshima K, Nakatani Y, Yoshino I, Fujisawa T.
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Journal Title
Int J Oncol. 33
Pages: 113-119
Related Report
Peer Reviewed
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[Presentation] 中皮腫の克服を目指して基礎と臨床の最前線肉眼的に腫瘤を認めない早期胸膜中皮腫の検討2008
Author(s)
廣島健三, 由佐俊和, 柴崎正巳, 兼子耕, 岸宏久, 斉藤忠, 伊藤以知郎, 山川久美, 前澤直樹, 伊丹真紀子, 尾崎大介, 亀井敏昭, 吉野一郎, 中谷行雄
Organizer
第47回日本臨床細胞学会総会(秋期大会)
Place of Presentation
東京
Year and Date
2008-11-15
Related Report
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[Presentation] Microscopic malignant pleural mesothelioma2008
Author(s)
Hiroshima K, Yusa T, Tanizawa T, Yonemori Y, Oide T, Kameya T, Ito I, Kaneko K, Kishi H, Ozaki D, Itami M, Kawai T, Nakatani Y.
Organizer
27th International Congress of the International Academy of Pathology
Place of Presentation
ギリシア, アテネ
Year and Date
2008-10-16
Related Report
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[Presentation] Early detection of malignant pleural mesothelioma2008
Author(s)
Hiroshima K, Yusa T, Kameya T, Kadoyama C, Saitoh Y, Iwata T, Tada Y, Shimada H, Tagawa M, Nakatani Y.
Organizer
9th International Mesothelioma Interest Group Conference
Place of Presentation
オランダ, アムステルダム
Year and Date
2008-09-25
Related Report
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[Presentation] Pathological study of malignant pleural mesothelioma resected with extrapleural pneumonectomy2007
Author(s)
Hiroshima K, Yusa T, Kameya T, Ito I, Kawai T, Kaneko K, Kadoyama C, Kishi H, Fujisawa T, Nakatani Y.
Organizer
12th World Conference on Lung Cancer
Place of Presentation
韓国, ソウル
Year and Date
2007-09-03
Related Report
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