Role of vasoactive substances on the cross-talk between inflammation and coagulation in disseminated intravascular coagulation

• Project/Area Number: 19590549
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Kanazawa University
• Principal Investigator: ASAKURA Hidesaku Kanazawa University, 附属病院, 准教授 (60192936)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: DIC / 血管作動性物質 / 一酸化窒素 / エンドセリン / サイトカイン / 炎症 / 凝固

Research Abstract

LPS または組織因子(TF)で播種性血管内凝固症候群(DIC)モデルを作成し、血管作動性物質である一酸化窒素(NO)やエンドセリン(ET)の役割を評価した。両モデル間で、血管作動性物質は全く異なった役割を果たしていることが明らかになった。血管作動性物質を調節する薬物やPGI2 誘導体をDIC モデルに対して投与するとDIC 病態が変化することが確認され、治療応用が可能ではないかと考えられた。

Research Products

• [Journal Article] 造血器腫瘍と血栓症 (2008)
  • Author(s): 朝倉英策、前川実生、門平靖子
  • Journal Title: 血液フロンティア 18 Pages: 1585-1593
• [Journal Article] リコンビナントトロンボモジュリン (2008)
  • Author(s): 朝倉英策、前川実生
  • Journal Title: 臨床検査 52 Pages: 1581-1586
• [Journal Article] 急性期DIC 診断基準の考え方 (2008)
  • Author(s): 朝倉英策、門平靖子
  • Journal Title: 検査と技術 36 Pages: 1425-1425
• [Journal Article] 抗凝固剤の今と展望 (2008)
  • Author(s): 朝倉英策、門平靖子
  • Journal Title: BIO Clinica 12 Pages: 913-921
• [Journal Article] 動物モデルを用いたDIC/臓器障害研究-最近の話題- (2008)
  • Author(s): 前川実生、朝倉英策
  • Journal Title: 日本血栓止血学会雑誌 19 Pages: 369-377
  • NAID: 10026116286
• [Journal Article] DIC の病態・診断(血栓止血の臨床ー研修医のために) (2008)
  • Author(s): 林朋恵、朝倉英策
  • Journal Title: 日本血栓止血学会雑誌 19 Pages: 344-347
• [Journal Article] Changes in molecular markers of hemostatic and fibrinolytic activation under various sampling conditions using vacuum tube samples from healthy volunteers (2008)
  • Author(s): Omote M, Asakura H, et.al.
  • Journal Title: Thromb Res 123 Pages: 390-395
  • Peer Reviewed
• [Journal Article] Expression of annexin II in human atherosclerotic abdominal aortic aneurysms (2008)
  • Author(s): Hayashi T, Asakura H, et.al.
  • Journal Title: Thromb Res 123 Pages: 274-280
  • Peer Reviewed
• [Journal Article] Increased macrophage colony-stimulating factor levels in patients with Graves' disease (2008)
  • Author(s): Morishita E, Asakura H, et.al.
  • Journal Title: Int J Hematol 88 Pages: 272-277
  • NAID: 10023970229
  • Peer Reviewed
• [Journal Article] Changes of the soluble fibrin monomer complex level during the perioperative period of hip replacement surgery (2008)
  • Author(s): Misaki T, Asakura H, et.al.
  • Journal Title: J Orthop Sci 13 Pages: 419-24
  • NAID: 10024301627
  • Peer Reviewed
• [Journal Article] Expression of annexin II in human atherosclerotic abdominal aortic aneurysms. (2008)
  • Author(s): Hayashi T, Asakura H, et al.
  • Journal Title: Thromb Res 123 Pages: 274-280
  • Peer Reviewed
• [Journal Article] Increased macrophage colony-stimulating factor levels in patients with Graves disease. (2008)
  • Author(s): Morishita E, Asakura H, et al
  • Journal Title: Int J Hematol 88 Pages: 272-277
  • NAID: 10023970229
  • Peer Reviewed
• [Journal Article] Changes in molecular markers of hemostatic and fibrinolytic activation under various sampling conditions using vacuum tube samples from healthy volunteers. (2008)
  • Author(s): Omote M, Asakura H, et al.
  • Journal Title: Thromb Res 123 Pages: 390-395
  • Peer Reviewed
• [Journal Article] Efficacy and safety of recombinant human soluble TM (ART-123) in DIC : results of phase III randomized, double-blind, clinical trial (2007)
  • Author(s): Saito H, Maruyama I, Shimazaki S, YamamotoY, Aikawa N, Ohno R, Hirayama A, Matsuda T, Asakura H, Nakashima M, Aoki N
  • Journal Title: J Thromb Haemost 5 Pages: 31-41
  • Peer Reviewed
• [Journal Article] Successful combined use of tranexamic Acid and unfractionated heparin for life-threatening bleeding associated with intravascular coagulation in a patient with chronic myelogenous leukemia in blast crisis (2007)
  • Author(s): Koseki M, Asakura H, et.al.
  • Journal Title: Int J Hematol 86 Pages: 403-406
  • NAID: 10019533176
  • Peer Reviewed
• [Journal Article] Immature platelet fraction for prediction of platelet engraftment after allogeneic stem cell transplantation (2007)
  • Author(s): Takami A, Asakura H, et.al.
  • Journal Title: Bone Marrow Transplant 39 Pages: 501-507
  • Peer Reviewed
• [Journal Article] Safety and efficacy of foscarnet for preemptive therapy against cytomegalovirus reactivation after unrelated cord blood transplamtation (2007)
  • Author(s): Takami A, Asakura H, et.al.
  • Journal Title: Transplantation Proceedings 39 Pages: 237-239
  • Peer Reviewed
• [Journal Article] DIC 臓器障害のヒエラルキー (2007)
  • Author(s): 朝倉英策、門平靖子、前川実生
  • Journal Title: クリニカ 34 Pages: 236-241
• [Journal Article] DIC の治療とそのトピックス(ダナパロイドナトリウム) (2007)
  • Author(s): 前川実生、朝倉英策
  • Journal Title: Surgery Frontier 14 Pages: 289-294
• [Journal Article] 出血性疾患の実施診療の実際(DIC へのアプローチ) (2007)
  • Author(s): 門平靖子、朝倉英策
  • Journal Title: Medical Practice 24 Pages: 2139-2144
• [Journal Article] 血栓性疾患における凝固検査の最前線 (2007)
  • Author(s): 門平靖子、朝倉英策
  • Journal Title: 日本血栓止血学会雑誌 18 Pages: 127-139
  • NAID: 10026114539
• [Journal Article] DICにおける凝固・線溶・炎症とその制御 (2007)
  • Author(s): 御舘靖雄、朝倉英策
  • Journal Title: 日本検査血液学会雑誌 8 Pages: 127-133
• [Journal Article] DICの病態解析と新しい治療戦略 (2007)
  • Author(s): 門平靖子、朝倉英策
  • Journal Title: 日本救命医療学会雑誌 21 Pages: 87-94
• [Journal Article] DICに対する線溶/抗線溶療法 (2007)
  • Author(s): 門平靖子、朝倉英策
  • Journal Title: 治療学 41 Pages: 289-290
• [Journal Article] Successful combined use of tranexamic acid and unfractionated heparin for life-threatening bleeding associated with intravascular coagulation in apatient with chronic myelogenous leukemia in blast crisis (2007)
  • Author(s): Koseki M, Asakura H, et. al.
  • Journal Title: Int J Hematol 86 Pages: 403-406
  • Peer Reviewed
• [Journal Article] Immature platelet fraction for prediction of platelet engraftment after allogeneic stem cell transplantation (2007)
  • Author(s): Takami A, Asakura H, et. al.
  • Journal Title: Bone Marrow Transplant 39 Pages: 501-507
  • Peer Reviewed
• [Journal Article] Efficacy and safety of recombinant human soluble thrombomodulin (ART-123) in disseminated intravascular coagulation: results of phase III rando mized,double-blind,clinical trial (2007)
  • Author(s): Saito H, Asakura H, et. al.
  • Journal Title: J Thromb Haemost 5 Pages: 31-41
  • Peer Reviewed
• [Presentation] 血小板(数)異常を呈する疾患の病態ならびに診断-播種性血管内凝固症候群の病態と診断- (2008)
  • Author(s): 朝倉英策
  • Organizer: 第55回日本臨床検査医学会シンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2008-11-28
• [Presentation] 播種性血管内凝固症候群の病態と診断(シンポジウム) (2008)
  • Author(s): 朝倉英策
  • Organizer: 日本臨床検査医学会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-11-28
• [Presentation] がんと血栓症の最前線(基礎から臨床まで)-悪性腫瘍(造血器を含む)における血栓・止血異常とその対策- (2008)
  • Author(s): 朝倉英策
  • Organizer: 第31回日本血栓止血学会学術推進SPCシンポジウム
  • Place of Presentation: 大阪
  • Year and Date: 2008-11-20
• [Presentation] 組織因子およびLPS 誘発DIC 動物モデルの病態比較-凝固・線溶、炎症、薬物効果の観点から- (2008)
  • Author(s): 朝倉英策
  • Organizer: 日本血栓止血学会学術標準化委員会シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2008-02-16
• [Presentation] TFおよびLPS誘発DIC動物モデルの病態比較-凝固・稼溶、炎症、薬物効果の観点から- (2008)
  • Author(s): 朝倉 英策
  • Organizer: 日本血栓止血学会学術標準化委員会シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2008-02-16
• [Presentation] DIC治療ガイドラインとその後-血液内科におけるDIC 診断の現状と問題点- (2007)
  • Author(s): 朝倉英策
  • Organizer: 第30回日本血栓止血学会・日本救急医学会合同シンポジウム
  • Place of Presentation: 伊勢
  • Year and Date: 2007-11-16
• [Book] Annual Review 血液(高久史麿, 小澤敬也, 坂田洋一, 金倉譲, 小島勢二編) (2009)
  • Author(s): 朝倉英策
  • Publisher: 中外医学社
• [Book] 今日の治療指針 2009 年版(山口徹、北原光夫、福井次矢 総集編) (2009)
  • Author(s): 朝倉英策
  • Publisher: 医学書院
• [Book] 今日の治療指針(分担 : 播種性血管内凝固症候群) (2009)
  • Author(s): 朝倉英策
  • Publisher: 医学書院
• [Book] 静脈血栓症・肺塞栓症とDIC(斉藤英彦編) (2008)
  • Author(s): 朝倉英策、門平靖子
  • Publisher: 最新医学社
• [Book] 小動物の血栓症・動脈硬化モデル作成法(鈴木宏治編) (2007)
  • Author(s): 前川実生、朝倉英策
  • Publisher: 金芳堂
• [Book] Xa阻害薬のすべて(丸山征郎、池田康夫、坂田洋一編) (2007)
  • Author(s): 門平靖子、朝倉英策
  • Publisher: 先端医学社
• [Book] 小動物の血栓症・動脈硬化モデル作成法(分担:組織因子誘発モデル) (2007)
  • Author(s): 前川 実生、朝倉 英策
  • Publisher: 金芳堂
• [Remarks]
  • URL: http://www.3nai.jp/weblog/archive/category3932.html