Remnant Lipoprotein Metabolism in Metabolic Syndrome, and the State of Obesity and Hyperlipidemia in Schoolchildren
| Project/Area Number |
19590558
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Osaka University |
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Principal Investigator |
YAMAMURA Taku Osaka University, 大学院・医学系研究科, 教授 (20132938)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIGAMI Masato 大阪大学, 大学院・医学系研究科, 准教授 (10379266)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 脂質異常症 / 高脂血症 / 動脈硬化症 / リポ蛋白 / レムナントリポ蛋白 / メタボリックシンドローム / コレステロール / トリグリセライド / 食後高脂血症 / アポB-48 / 内蔵脂肪 / 肥満 |
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| Research Abstract |
We studied the clinical significance of remnant lipoprotein cholesterol (RemL-C) determination in metabolic syndrome. The subjects investigated were healthy individuals who underwent medical examinations. Intima-media thickness of the carotid artery determined by B-mode ultrasonography was evaluated as an atherosclerosis marker. Measurement of RemL-C is efficient for the prediction of carotid atherosclerosis. Furthermore, we measured serum lipids and RemL-C in 430 schoolchildren. While 6 children had a high LDL cholesterol level, we found only 2 children with hypertriglyceridemia and one with a high level of RemL-C.
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Report
(4 results)
Research Products
(39 results)
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[Journal Article] Chylomicron remnants are increased in the postprandial state in CD36 deficiency2009
Author(s)
Masuda D, Hirano KI, Oku H, Sandoval JC, Kawase R, Yuasa-Kawase M, Yamashita Y, Takada M, Tsubakio-Yamamoto K, Tochino Y, Koseki M, Matsuura F, Nishida M, Kawamoto T, Ishigami M, Hori M, Shimomura I, Yamashita S
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Journal Title
J Lipid Res 50
Pages: 999-1011
Related Report
Peer Reviewed
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[Journal Article] Evaluation of a homogeneous assay for measuring LDL-cholesterol in hyperlipidemic serum specimens2008
Author(s)
Yamashita S, Nakamura M, Koizumi H, Oku H, C Sandoval J, Tsubakio-Yamamoto K, Kawase M, Masuda D, Koseki M, Matsuura F, Shimomura I, Nishida M, Ishigami M.
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Journal Title
J Atheroscler Thromb 15
Pages: 82-86
NAID
Related Report
Peer Reviewed
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