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Remnant Lipoprotein Metabolism in Metabolic Syndrome, and the State of Obesity and Hyperlipidemia in Schoolchildren

Research Project

Project/Area Number 19590558
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory medicine
Research InstitutionOsaka University

Principal Investigator

YAMAMURA Taku  Osaka University, 大学院・医学系研究科, 教授 (20132938)

Co-Investigator(Kenkyū-buntansha) ISHIGAMI Masato  大阪大学, 大学院・医学系研究科, 准教授 (10379266)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords脂質異常症 / 高脂血症 / 動脈硬化症 / リポ蛋白 / レムナントリポ蛋白 / メタボリックシンドローム / コレステロール / トリグリセライド / 食後高脂血症 / アポB-48 / 内蔵脂肪 / 肥満
Research Abstract

We studied the clinical significance of remnant lipoprotein cholesterol (RemL-C) determination in metabolic syndrome. The subjects investigated were healthy individuals who underwent medical examinations. Intima-media thickness of the carotid artery determined by B-mode ultrasonography was evaluated as an atherosclerosis marker. Measurement of RemL-C is efficient for the prediction of carotid atherosclerosis. Furthermore, we measured serum lipids and RemL-C in 430 schoolchildren. While 6 children had a high LDL cholesterol level, we found only 2 children with hypertriglyceridemia and one with a high level of RemL-C.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (39 results)

All 2010 2009 2008 2007

All Journal Article (18 results) (of which Peer Reviewed: 10 results) Presentation (13 results) Book (8 results)

  • [Journal Article] アポリポ蛋白B2010

    • Author(s)
      山村卓
    • Journal Title

      日本臨床 68(増刊1)

      Pages: 94-99

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Update of Japanese common LDLR gene mutations and their phenotypes: Mild type mutation L547V might predominate in the Japanese population2009

    • Author(s)
      Miyake Y, Yamamura T, Sakai N, Miyata T, Kokubo Y, Yamamoto A
    • Journal Title

      Atherosclerosis 203

      Pages: 153-160

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chylomicron remnants are increased in the postprandial state in CD36 deficiency2009

    • Author(s)
      Masuda D, Hirano KI, Oku H, Sandoval JC, Kawase R, Yuasa-Kawase M, Yamashita Y, Takada M, Tsubakio-Yamamoto K, Tochino Y, Koseki M, Matsuura F, Nishida M, Kawamoto T, Ishigami M, Hori M, Shimomura I, Yamashita S
    • Journal Title

      J Lipid Res 50

      Pages: 999-1011

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] LDLコレステロールの測定と臨床的意義2009

    • Author(s)
      山村卓
    • Journal Title

      医学と薬学 62

      Pages: 53-60

    • Related Report
      2009 Annual Research Report 2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] RemL-C(レムナントリポ蛋白コレステロール)のホモジニアスアッセイ法2009

    • Author(s)
      石神眞人、山下静也、山村卓
    • Journal Title

      Medical Technology 37

      Pages: 132-137

    • Related Report
      2009 Final Research Report
  • [Journal Article] 身体活動・運動と生活習慣病-運動生理学と最新の予防・治療-V. 運動療法慢性疾患と運動療法脂質異常症2009

    • Author(s)
      石神眞人、山下静也、山村卓
    • Journal Title

      日本臨牀増刊号 67

      Pages: 387-391

    • Related Report
      2009 Final Research Report
  • [Journal Article] Update of Japanese common LDLR gene mutations and their phenotypes : Mild type mutation L547V might predominate in the Japanese population2009

    • Author(s)
      Miyake Y
    • Journal Title

      Atherosclerosis 203

      Pages: 153-160

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic variants in PCSK9 in the Japanese population: Rare genetic variants in PCSK9 might collectively contribute to plasma LDL cholesterol levels in the general population2008

    • Author(s)
      Miyake Y, Kimura R, Kokubo Y, Okayama A, Tomoike H, Yamamura T, Miyata T
    • Journal Title

      Atherosclerosis 196

      Pages: 29-36

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of a homogeneous assay for measuring LDL-cholesterol in hyperlipidemic serum specimens2008

    • Author(s)
      Yamashita S, Nakamura M, Koizumi H, Oku H, C Sandoval J, Tsubakio-Yamamoto K, Kawase M, Masuda D, Koseki M, Matsuura F, Shimomura I, Nishida M, Ishigami M.
    • Journal Title

      J Atheroscler Thromb 15

      Pages: 82-86

    • NAID

      10022608032

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] メタボリードRemL-C試薬によるレムナント/TG比、レムナント/non-HDL-C比測定の有用性2008

    • Author(s)
      山下静也、石神眞人
    • Journal Title

      医学と薬学 59

      Pages: 429-437

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 特定健診の意義と臨床検査2008

    • Author(s)
      山村卓
    • Journal Title

      医療と検査機器・試薬 31

      Pages: 505-510

    • Related Report
      2009 Final Research Report
  • [Journal Article] genetic variants in PCSK9 in the Japanese population2008

    • Author(s)
      Miyake Y
    • Journal Title

      Atherosclerosis 196

      Pages: 29-36

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 特定健診の意義と臨床検査2008

    • Author(s)
      山村 卓
    • Journal Title

      医療と検査機器・試薬 31

      Pages: 505-510

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Development of a homogeneous assay to measure remnant lipoprotein cholesterol2007

    • Author(s)
      Miyauchi K, Kayahara N, Ishigami M, Kuwata H, Mori H, Sugiuchi H, Irie T, Tanaka A, Yamashita S, Yamamura T
    • Journal Title

      Clin Chem 53

      Pages: 2128-2135

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 脂質代謝異常-高脂血症・低脂血症-IV. 脂質代謝異常の臨床高脂血症の管理と治療高脂血症の薬物療法HMG-CoA還元酵素阻害薬(スタチン)2007

    • Author(s)
      山村卓、石神眞人
    • Journal Title

      日本臨牀 65

      Pages: 458-464

    • Related Report
      2009 Final Research Report
  • [Journal Article] Development of a homogeneous assay to measure remnant lipoprotein cholesterol2007

    • Author(s)
      Miyauchi K
    • Journal Title

      Clin Chem 52

      Pages: 2128-2135

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 高脂血症の薬物療法HMG-CoA還元酵素阻害薬(スタチン)2007

    • Author(s)
      山村 卓
    • Journal Title

      日本臨牀 65:

      Pages: 458-464

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 糖尿病とリポ蛋白代謝内臓脂肪蓄積とDyslipidemia2007

    • Author(s)
      石神眞人
    • Journal Title

      内分泌・糖尿病科 24

      Pages: 335-339

    • Related Report
      2007 Annual Research Report
  • [Presentation] メタボリックシンドロームにおけるホモジニアスアッセイ法を用いたレムナントリポ蛋白測定意義に関する研究2009

    • Author(s)
      石神眞人、田口幹泰、西田誠、守山敏樹、山下静也、山村卓
    • Organizer
      第49回日本臨床化学会年次学術集会
    • Place of Presentation
      長崎
    • Year and Date
      2009-09-20
    • Related Report
      2009 Final Research Report
  • [Presentation] レムナント代謝研究の最前線.シンポジウム「リポ蛋白・脂質研究の最前線」2009

    • Author(s)
      山村卓、石神眞人
    • Organizer
      第56回日本臨床検査医学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2009-08-28
    • Related Report
      2009 Final Research Report
  • [Presentation] シンポジウム「リポ蛋白・脂質研究の最前線」レムナント代謝研究の最前線2009

    • Author(s)
      山村卓, 石神眞人
    • Organizer
      第56回日本臨床医学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2009-08-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] Clinical significance of remnant lipoprotein cholesterol determination in an apparently healthy population-Studies with a newly developed homogeneous assay2009

    • Author(s)
      Ishigami M, Taguchi M, Nishida M, Moriyama T, Yamashita S, Yamamura T
    • Organizer
      第41回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      山口
    • Year and Date
      2009-07-18
    • Related Report
      2009 Final Research Report
  • [Presentation] Clinical significance of remnant lipoprotein cholesterol determination in metabolic syndrome-Studies with a newly developed homogeneous assay-2009

    • Author(s)
      山村卓
    • Organizer
      XV International Symposium on Atherosclerosis 2009
    • Place of Presentation
      Boston, USA
    • Year and Date
      2009-07-16
    • Related Report
      2009 Final Research Report
  • [Presentation] メタボ健診と高脂血症、糖尿病2008

    • Author(s)
      山村卓
    • Organizer
      第48回日本臨床化学会年次学術集会主催市民フォーラム「メタボ健診と健康管理」
    • Place of Presentation
      浜松
    • Year and Date
      2008-08-31
    • Related Report
      2009 Final Research Report
  • [Presentation] 新規ホモジニアスアッセイ法を用いたメタボリックシンドロームにおけるレムナント測定意義に関する研究2008

    • Author(s)
      石神眞人、田口幹泰、西田誠、守山敏樹、山下静也、山村卓
    • Organizer
      第48回日本臨床化学会年次学術集会
    • Place of Presentation
      浜松
    • Year and Date
      2008-08-29
    • Related Report
      2009 Final Research Report
  • [Presentation] 食後高脂血症の病態解析-糖負荷およびテストミール負荷試験における新規検査試薬を用いた外因性および内因性リポタンパク代謝の検討-2008

    • Author(s)
      石神眞人、岸清彦、覚野綾子、田口幹泰、山下静也、山村卓
    • Organizer
      第40回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      つくば
    • Year and Date
      2008-07-11
    • Related Report
      2009 Final Research Report
  • [Presentation] メタボリックシンドロームにおけるレムナントリポ蛋白測定意義に関する研究-新規ホモジニアスアッセイ法を用いた検討-2008

    • Author(s)
      田口幹泰、石神眞人、西田誠、守山敏樹、山下静也、山村卓
    • Organizer
      第40回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      つくば
    • Year and Date
      2008-07-11
    • Related Report
      2009 Final Research Report
  • [Presentation] パネルディスカッション「特定健診への臨床検査関係職種としての関わり-特に保健指導について-」2008

    • Author(s)
      山村卓
    • Organizer
      第7回未病臨床検査セミナー
    • Place of Presentation
      大阪
    • Year and Date
      2008-06-28
    • Related Report
      2009 Final Research Report
  • [Presentation] 新規ホモジニアスアッセイ法を用いたメタボリックシンドロームにおけるレムナント測定意義に関する研究2008

    • Author(s)
      山村 卓
    • Organizer
      第55回日本臨床検査医学会学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Annual Research Report
  • [Presentation] 高脂血症2007

    • Author(s)
      山村卓
    • Organizer
      第54回日本臨床検査医学会学術集会主催市民公開講座「メタボリックシンドロームとはどんな病気ですか?」
    • Place of Presentation
      大阪
    • Year and Date
      2007-11-25
    • Related Report
      2009 Final Research Report
  • [Presentation] 新規遺伝子変異(c.648delTおよびIVS3+20A>C)の複合ヘテロ接合体を有するリポ蛋白リパーゼ欠損症の一例2007

    • Author(s)
      山村 卓
    • Organizer
      第54回日本臨床検査医学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2007 Annual Research Report
  • [Book] 内科学症例図説2009

    • Author(s)
      山村卓
    • Publisher
      朝倉書店
    • Related Report
      2009 Final Research Report
  • [Book] 内分泌代謝疾患・糖尿病診療マニュアル2009

    • Author(s)
      山村卓
    • Publisher
      医薬ジャーナル社
    • Related Report
      2009 Final Research Report
  • [Book] 内科学症例図説 (高脂血症 (脂質異常症) を分担)2009

    • Author(s)
      山村卓
    • Total Pages
      638
    • Publisher
      朝倉書店
    • Related Report
      2009 Annual Research Report
  • [Book] 脂質異常症(高脂血症)2008

    • Author(s)
      山村卓、石神眞人
    • Publisher
      最新医学社
    • Related Report
      2009 Final Research Report
  • [Book] 脂質異常症(高脂血症)2008

    • Author(s)
      石神眞人、山村卓、山下静也
    • Publisher
      最新医学社
    • Related Report
      2009 Final Research Report
  • [Book] 脂質異常症(高脂血症)改訂第2版2008

    • Author(s)
      山村 卓
    • Total Pages
      495
    • Publisher
      HMG-CoA還元酵素阻害薬
    • Related Report
      2008 Annual Research Report
  • [Book] 新版健康食品学2007

    • Author(s)
      山村卓
    • Publisher
      健康食品管理士認定協会
    • Related Report
      2009 Final Research Report
  • [Book] 新版健康食品学第3版分担執筆2007

    • Author(s)
      山村 卓
    • Total Pages
      568
    • Publisher
      健康食品管理士認定協会
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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