Role of transcription repressor Bach1 in cardiovascular diseases

• Project/Area Number: 19590561
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Hiroshima University
• Principal Investigator: ISHIDA Takafumi Hiroshima University, 大学院・医歯薬学総合研究科, 講師 (40346482)
• Co-Investigator(Kenkyū-buntansha): 大島 哲也 広島大学, 大学院・医歯薬学総合研究科, 准教授 (40233100) ; 田代 聡 広島大学, 原爆放射線医科学研究所, 教授 (20243610)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2007: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
• Keywords: 酸化ストレス / 動脈硬化 / 血管

Research Abstract

本研究は酸化ストレス応答を制御する転写因子Bach1の心血管疾患における役割を研究するために行われた。1) ヒト血管平滑筋細胞および内皮細胞においてBach1がヘムオキシゲナーゼ1(HO-1)の発現を制御していること、2) Bach1による転写応答、特にHO-1の発現調節が圧負荷による心肥大形成に関与していること、3) Bach1欠損はHO-1の発現を介して動脈硬化形成を抑制していること、4) Bach1が心筋梗塞後の左室リモデリングにおいて重要な役割を果たしていることが明らかとなり、Bach1が心血管疾患の病態に深く関与していることが示唆された。

Research Products

• [Journal Article] Angiotensin IIinduced osteopontin expression in vascular smooth muscle cells involves Gq/11, Ras, ERK, Src and Ets-1 (2008)
  • Author(s): Abe K, Nakashima H, Ishida M, Miho N, Sawano M, oe NN, Kurabayashi M, Chayama K, Yoshizumi M, Ishida T
  • Journal Title: Hypertens Res 31 Pages: 987-998
  • Peer Reviewed
• [Journal Article] Ablation of the bachl gene leads to the suppression of atherosclerosis in bachl and apolipoprotein E double knockout mice (2008)
  • Author(s): Watari Y, Yamamoto Y, Brydun A, Ishida T, Mito S, Yoshizumi M, Igarashi K, Chayama K, Ohshima T, Ozono R
  • Journal Title: Hypertens Res 31 Pages: 783-792
  • Peer Reviewed
• [Journal Article] Angiotensin II-induced osteopontin expression in vascular smooth muscle cells in volves Gq/ll, Ras, ERK, Src and Ets-1. (2008)
  • Author(s): Keiko Abe
  • Journal Title: Hypertension Research 31 Pages: 987-998
  • Peer Reviewed
• [Journal Article] Ablation of the bach1 gene leads to the suppression of atherosclerosis in bach1 and apolipoprotein E double knockout mice. (2008)
  • Author(s): Yuichiro Watari
  • Journal Title: Hypertension Research 31 Pages: 783-792
  • Peer Reviewed
• [Journal Article] Angiotensin II-induced Osteopontin Expression in Vascular Smooth Muscle Cells Involves G_q/11, Ras, ERK, Src and Ets-1 (2008)
  • Author(s): Keiko Abe
  • Journal Title: Hypertension Reasearch (In press)
  • Peer Reviewed
• [Journal Article] Ablation of the Bach1 gene Ieads to the suppression of atherosclerosis in Bach1 and ApoE double knockout mice (2008)
  • Author(s): Yuichiro Watari
  • Journal Title: Hypertension Reasearch (In press)
  • Peer Reviewed
• [Journal Article] Nifedipine Interferes with Migration of Vascular Smooth Muscle Cells via Inhibition of Pyk2-Src Axis
  • Author(s): Soe NN, Ishida T, Ishida M, Sawano M, Abe K, Miho N, Chayama K, Kihara Y, Yoshizumi M
  • Journal Title: J Atheroscler Thromb (In press)
  • NAID: 10025765621
  • Peer Reviewed
• [Journal Article] Nifedipine Interferes with Migration of Vascular Smooth Muscle Cellsvia Inhibition of Pyk2-Src Axis.
  • Author(s): Nwe Nwe Soe
  • Journal Title: Journal of Atherosclerosis and Thrombosis (In press)
  • Peer Reviewed
• [Presentation] Increased leukocyte Rhokinase (ROCK) activity and endothelialdysfunction in cigarette smoking (2009)
  • Author(s): Hidaka T
  • Organizer: 第73回日本循環器学会総会・学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-03-22
• [Presentation] Usefulness of 64-slice multidetector-row computed tomographyin the simultaneous evaluation of aorticvalve area and coronary artery disease (2009)
  • Author(s): Utsunomiya H
  • Organizer: 第73回日本循環器学会総会・学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-03-22
• [Presentation] Low-intensity pulsed ultrasound(LIPUS)enhanced angiogenesis in a rat hindlimb ischemia model, VEGF-A expression andmobilization in HUVEC (2009)
  • Author(s): Hidaka T
  • Organizer: 第73回日本循環器学会総会・学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-03-21
• [Presentation] Coronary plaquestabilization by intensive statin therapydecreasing serum LDL/HDL cholesterolratio on multislice computed tomographicangiography (2009)
  • Author(s): Kitagawa T
  • Organizer: 第73回日本循環器学会総会・学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-03-21
• [Presentation] Role of Src and Cas in dorsal ruffling, lamellipodia and migration in vascular smoothmuscle cells (2009)
  • Author(s): Soe NN
  • Organizer: 第73回日本循環器学会総会・学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-03-20
• [Presentation] Evaluation of coronarycalcium and noncalcified plaquecharacteristics in patients with acutecoronary syndrome by multislice computed tomography (2009)
  • Author(s): Kitagawa T
  • Organizer: 第73回日本循環器学会総会・学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-03-20
• [Presentation] Lower high molecular weightadiponectin level is associated withunstable coronary plaques as detected bymulty-detector computed tomography (2009)
  • Author(s): Kunita E
  • Organizer: 第73回日本循環器学会総会・学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-03-20
• [Presentation] Prediction of heart failuredeath in hemodialysis patients bymyocardial washout rate of technetium99m sestamibi (2009)
  • Author(s): Tadehara F
  • Organizer: 第73回日本循環器学会総会・学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-03-20
• [Presentation] Nonosbstructive aorticvalve calcification and cardiovascular riskfactors as predictors of coronary arteryatherosclerosis assessed by 64-slicemultidetector-row computed tomography (2009)
  • Author(s): Ustunomiya H
  • Organizer: 第73回日本循環器学会総会・学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-03-20
• [Presentation] Feasibility and optimization of aortic valve planimetry using retrospective ECG-gated 64-slice multidetector-row computed tomography (2009)
  • Author(s): Utsunomiya H
  • Organizer: 第73回日本循環器学会総会・学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-03-20
• [Presentation] Role of Src and Its Substrates in Vascular Smooth Muscle Cell Migration. (2009)
  • Author(s): Nwe Nwe Soe
  • Organizer: 第73回日本循環器学会総会・学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-03-20
• [Presentation] バトルセッションーキレーション治療による動脈硬化予防「キレート療法の根拠を検証する一鉄と酸化ストレスの血管に対する作用」 (2008)
  • Author(s): 石田隆史
  • Organizer: 第8回日本抗加齢医学会総会
  • Place of Presentation: 東京
  • Year and Date: 2008-06-07
• [Presentation] c-Src and Its Substrates Play A Pivotal Role in Migration of Vascular Smooth Muscle Cells (2008)
  • Author(s): Nwe Nwe Soe
  • Organizer: Arteriosclerosis, Thrombosis and Vascular Biology Annual Conference 2008
  • Place of Presentation: 米国 Atlanta
  • Year and Date: 2008-04-18
• [Presentation] Role of HIF-1-dependent expressionof the VLDL receptor in the progression ofatherosclerosis (2008)
  • Author(s): Abe K
  • Organizer: 第72回日本循環器学会総会・学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2008-03-29
• [Presentation] c-Src and Its Substrates Play aPivotal Role in Migration of Vascular3mooth Muscle Cells (2008)
  • Author(s): Soe NN
  • Organizer: 日本動脈硬化学会学術集会
  • Place of Presentation: 筑波
• [Presentation] c-Src and Its Substrates Play a Pivotal Role in Migration of Vascular Smooth Muscle Cells. Arterioscelrosis (2008)
  • Author(s): Soe NN
  • Organizer: Thrombosis and Vascular Biology Annual Conference 2008
  • Place of Presentation: Atlanta, USA
• [Presentation] Angiotensin II-induced osteopontin expression in vascular smooth muscle cells involves Gq/11, Ras, ERK, Src and Ets-1 (2007)
  • Author(s): 阿部恵子
  • Organizer: American Heart Association Scientific Sessions 2007
  • Place of Presentation: Orlando, USA
  • Year and Date: 2007-11-16
• [Presentation] Angiotensin IIによるOsteopontinの発現にはGq/11 Src, Ras, ERKが関与する (2007)
  • Author(s): 外間梨沙
  • Organizer: 第30回日本高血圧学会
  • Place of Presentation: 沖縄
  • Year and Date: 2007-10-25
• [Presentation] Nefedipineの血管平滑筋細胞遊走・肥大およびその細胞内シグナル伝達機構におよぼす作用 (2007)
  • Author(s): 澤野真理子
  • Organizer: 第30回日本高血圧学会
  • Place of Presentation: 沖縄
  • Year and Date: 2007-10-25
• [Presentation] Hypoxia、Induces the Expression of Very Low-Density Lipoprotein Receptor in Human Macrophages and Vascular Smooth Muscle Cells via a HIF-1-Dependent Mechanism (2007)
  • Author(s): 阿部恵子
  • Organizer: 第30回日本動脈硬化学会
  • Place of Presentation: 大阪
  • Year and Date: 2007-07-13
• [Presentation] Angiotensin II-induced Osteopontin Expression in Vascular Smooth Muscle Cells involves Gq/11, Ras, ERK, Src, Ets-1 and c-Fos (2007)
  • Author(s): Abe K
  • Organizer: Scientific Sessions of American Heart Association
  • Place of Presentation: Orlando, USA
• [Presentation] Angiotensin IIによるOsteopontinの発現にはG_<q/11>, Src, Ras, ERKが関与する (2007)
  • Author(s): 外間梨沙
  • Organizer: 第30回日本高血圧学会総会
  • Place of Presentation: 沖縄
• [Presentation] Nifedipineの血管平滑筋細胞遊走・肥大およびその細胞内シグナル伝達機構におよぼす作用 (2007)
  • Author(s): 澤野真理子
  • Organizer: 第30回日本高血圧学会総会
  • Place of Presentation: 沖縄
• [Presentation] Hypoxia Induces theExpression of Very Low-DensityLipoprotein Receptor in HumanMacrophages and Vascular Smooth MuscleCells via a HIF-1 Dependent Mechanism (2007)
  • Author(s): Keiko Abe
  • Organizer: 日本動脈硬化学会学術集会
  • Place of Presentation: 大阪
• [Book] 「β遮断薬の心筋に対する作用」β遮断薬のすべて 第3版(荻原俊男、築山久一郎、松崎益徳、島田和幸編) (2009)
  • Author(s): 石田隆史、木原康樹
  • Publisher: 先端医学社