Mechanisms of Goiter Development in Patients with Thyroglobulin Mutations
| Project/Area Number |
19590569
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Dokkyo Medical University |
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Principal Investigator |
IEIRI Tamio Dokkyo Medical University, 医学部, 教授 (80049220)
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| Co-Investigator(Kenkyū-buntansha) |
菱沼 昭 獨協医科大学, 医学部, 准教授 (40201727)
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| Co-Investigator(Renkei-kenkyūsha) |
HISHINUMA Akira 獨協医科大学, 医学部, 准教授 (40201727)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | サイログロブリン異常症 / 甲状腺ホルモン合成障害 / びまん性甲状腺腫 / 細胞内輸送障害 / 定量RT-PCR / 遺伝子発現 / 細胞増殖 / MEK-MAPK経路 / アポトーシス / サイログロブリン / 遺伝子異常症 / 甲状腺腫 / 小胞体貯蔵病 / 分子シャペロン |
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| Research Abstract |
One of the major causes of congenital thyroid dyshormonogenesis is thyroglobulin gene. Until recently mutations of Tg gene were believed rare. However, upon understanding of clinical characteristics, an increasing number of Tg mutations were identified. Adult patients present huge goiter with normal or subclinical hypothyroidism and frequently develop thyroid cancer. We studied gene expression profile of surgically removed patients' thyroid tissues and cultured cells expressing abnormal thyroglobulin in vitro. Several genes were identified which play a significant role in cell proliferation.
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Report
(4 results)
Research Products
(41 results)
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[Journal Article]2009
Author(s)
菱沼昭, 家入蒼生夫
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Journal Title
内分泌病理学 最近の進歩2008(医学の世界社)
Pages: 73-79
Related Report
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[Journal Article] A novel homozygous missense mutation of the dual oxidase 2 (DUOX2) gene in an adult patient with large goiter.2008
Author(s)
Ohye H, Fukata S, Hishinuma A, Kudo T, Nishihara E, ItoM, Kubota S, Amino N, Ieiri T, Kuma K, Miyauchi A
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Journal Title
Thyroid 10(5)
Pages: 561-566
Related Report
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[Journal Article] Thyroglobulin gene mutations producing defective intracellular transport of thyroglobulin are associated with increased thyroldal type 2 10dothyronine delodinase activity.2007
Author(s)
Kanou Y, Hishinuma A, Tsunekawa K, Seki K, MIzuno Y, Fujisawa H, Imai T, Miura Y, Nagasaka T, Yamada C, Ieiri T, Murakami A, Murata Y.
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Journal Title
J Clin EndocrinoI Metab 92(4)
Pages: 1451-1457
Related Report
Peer Reviewed
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