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Measurement of soluble FcγRIIIa^<Mφ> in plasma as a novel marker for unstable plaques in atherosclerosis

Research Project

Project/Area Number 19590575
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory medicine
Research InstitutionKansai Medical University

Principal Investigator

MASUDA Midori  Kansai Medical University, 医学部, 講師 (50173753)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords動脈硬化 / FcγレセプターIIIa / CD16 / ELISA / 臨床検査 / マクロファージ / 可溶性FcγレセプターIIIa
Research Abstract

動脈硬化症を来たすプロセスでは、特に酸化変性LDLがMφに際限なく取り込まれて動脈硬化の初期病変である泡沫細胞の集積をもたらし、ついには多量の脂質を含む不安定なプラークとなる。本研究は、申請者が開発したMφ型sFcγRIIIa^<Mφ>測定法の不安定プラーク検出法への応用を目的とするものである。すなわち、不安定プラークでは多量の脂質と共に活性化したMφが観察されることから、生体内におけるMφ活性の測定が不安定プラークの検出に有用と考えられる。血漿sFcγRIIIa^Mは、健常者では加齢とともに増加した。成人病検診症例では動脈硬化症のリスクファクターが増すに従い増加し、頸動脈エコー検査のIMTとよく相関した。虚血性心疾患症例では明らかな高値を示し、冠動脈の有意狭窄数が増すに従い増加した。頸動脈エコー検査施行患者では低エコープラーク群で最も高く、プラークの最大径と正の相関を示し、sFcγRIIIa^M測定が新しい不安定プラーク検出法になる可能性が示唆された。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (17 results)

All 2010 2009 2008 2007

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (13 results) Book (2 results)

  • [Journal Article] Soluble FcγRIIIa^<Mφ> levels in plasma correlate with carotid maximum intima-media thickness (IMT) in subjects with annual medical checkup2008

    • Author(s)
      Midori Masuda, Katsuya Amano, Shi Yan Hong, Noriko Nishimura, Masayoshi Fukui, Masamichi Yoshika, Yutaka Komiyama, Hiroya Masaki, Toshiji Iwasaka, Hakuo Takahashi
    • Journal Title

      Mol. Med. 14 (7-8)

      Pages: 436-442

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Soiubie FcγRIiIa^<Mφ> ieveis in piasma correiate with carotid maximum intima-media thickness (iMT) in subjects with annuai medicai checkup.2008

    • Author(s)
      Midori Masuda, et, al.
    • Journal Title

      Mol. Med. 14

      Pages: 436-442

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 頸動脈エコー検査施行患者における可溶性Fc(c)cRIIIa^Mの増加2010

    • Author(s)
      桝田緑, 横井豊彦, 正木浩哉, 高橋伯夫
    • Organizer
      第57回日本臨床検査医学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] Measurement of soluble FcγRIIIa and soluble FcγRIIIa^<Mφ> in urine from patients with proteinuria2010

    • Author(s)
      Midori Masuda, Satoshi Morimoto, Shi Yan Hong, Tatsuyoshi Morita, Noriko Nishimura, Nobuyuki Takahashi, Hiroya Masaki, Keiko Kouno, Toyohiko Yokoi, Masamichi Yoshika, Yutaka Komiyama, Toshiji Iwasaka, Hakuo Takahashi
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      Kobe, Japan
    • Related Report
      2008 Final Research Report
  • [Presentation] Increase of soluble FcγRIIIs levels in urine from patients with nephritis2009

    • Author(s)
      Midori MASUDA, Hakuo TAKAHASHI
    • Organizer
      第39回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪
    • Related Report
      2008 Final Research Report
  • [Presentation] 腎生検施行患者における3種の尿中可溶性FcγRIIIsの増加2009

    • Author(s)
      桝田緑, 正木浩哉, 高橋伯夫
    • Organizer
      第56回日本臨床検査医学会学術集会
    • Place of Presentation
      札幌
    • Related Report
      2008 Final Research Report
  • [Presentation] 本学付属病院における下肢動脈エコー検査の症例検討2009

    • Author(s)
      横井豊彦, 正木浩哉, 清水俊宏, 岡本恵, 吉賀正亨, 桝田緑, 小宮山豊, 高橋伯夫
    • Organizer
      第56回日本臨床検査医学会学術集会
    • Place of Presentation
      北海道
    • Related Report
      2008 Final Research Report
  • [Presentation] Measurement of soluble FcγRIIIa and soluble FcγRIIIa^<Mφ> in urine2008

    • Author(s)
      Midori MASUDA, Hakuo TAKAHASHI
    • Organizer
      第38回日本免疫学会総会・学術集会
    • Place of Presentation
      京都
    • Related Report
      2008 Final Research Report
  • [Presentation] 尿中可溶性FcγRIIIaおよび可溶性FcgRIIIa^<Mφ>の測定2008

    • Author(s)
      桝田緑, 正木浩哉, 高橋伯夫
    • Organizer
      第55回日本臨床検査医学会学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Final Research Report
  • [Presentation] 尿中可溶性FcγRIIIaおよび可溶性FcγRIIIa^<Mφ>の測定2008

    • Author(s)
      桝田緑, 正木浩哉, 高橋伯夫
    • Organizer
      第55回日本臨床検査医学会学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Annual Research Report
  • [Presentation] Measurement of solubie Fcγ RIIIa and soluble FcγRIIIa^<Mφ>in urine2008

    • Author(s)
      M. Masuda, H. Takahashi
    • Organizer
      第38回日本免疫学会総会・学術集会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] 関節リウマチ患者のNKT細胞におけるFcγRIIIa発現量の変化2007

    • Author(s)
      桝田緑, 吉賀正亨, 小宮山豊, 高橋伯夫
    • Organizer
      第54回日本臨床検査医学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2008 Final Research Report
  • [Presentation] Expression of FcγRIIIa on NKT cell from RA patients2007

    • Author(s)
      Midori MASUDA, Hakuo TAKAHASHI
    • Organizer
      第37回日本免疫学会総会・学術集会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] Soluble Fcγ receptor type IIIa derived from NK cells in plasma as a novel marker for the inflammatory activity in rheumatoid arthritis2007

    • Author(s)
      Midori Masuda, Shigeo Miyashima, Shi Yan Hong, Noriko Nishimura, Masamichi Yoshika, Yutaka Komiyama, Hirokazu Iida, Hakuo Takahashi
    • Organizer
      13th International Congress of Immunology
    • Place of Presentation
      Rio de Janeiro, Brazil
    • Related Report
      2008 Final Research Report
  • [Presentation] Fractalkine とCD16陽性細胞 _Stevens-Johnson 症候群TENにおける新たな表皮障害機構2007

    • Author(s)
      藤山幹子, 井上有紀子, 白方裕司, 丸山美鈴, 桝田緑, 高橋伯夫, 佐山浩二, 橋本公二
    • Organizer
      第32回日本研究皮膚科学会年次学術大会・総会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Book] Soluble Fcγ receptor type IIIa in plasma as a novel marker for the inflammatory activity in rheumatoid arthritis2007

    • Author(s)
      Midori Masuda, Shigeo Miyashima, Shi Yan Hong, Noriko Nishimura, Masamichi Yoshika, Yutaka Komiyama, Hirokazu Iida, Hakuo Takahashi
    • Publisher
      Medimond S.r.l.
    • Related Report
      2008 Final Research Report
  • [Book] 13th International Congress of Immunology2007

    • Author(s)
      Jorge Kalil, et. al. eds.
    • Total Pages
      603
    • Publisher
      Medimond S.r.l.,Italy
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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