Development of the detecting system for Core1 synthetases; forthe development of glyco-cancer marker

• Project/Area Number: 19590580
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: National Institute of Advanced Industrial Science and Technology
• Principal Investigator: TACHIBANA Koichi National Institute of Advanced Industrial Science and Technology, セルエンジニアリング研究部門, 主任研究員 (80216986)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2007: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
• Keywords: 糖鎖 / 癌

Research Abstract

癌特異的糖鎖抗原の多くの形成に関わるコア1型糖鎖合成酵素を制御する特異的シャペロンCosmc に対する特異モノクローナル抗体を作製した。この抗体は癌組織標本の解析やコア1合成酵素の機能解析に役立つことが期待される。