| Project/Area Number |
19590604
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Kinki University |
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Principal Investigator |
MASAKI Hideyuki Kinki University, 医学部, 講師 (90247982)
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| Co-Investigator(Kenkyū-buntansha) |
高崎 智彦 国立感染症研究所, ウイルス1部, 室長 (20221351)
倉根 一郎 国立感染症研究所, ウイルス1部, 部長 (90278656)
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| Co-Investigator(Renkei-kenkyūsha) |
KONISHI Eiji 神戸大学, 大学院・保健学研究科, 准教授 (40135786)
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| Research Collaborator |
SATOH Mayumi 神戸大学, 大学院・保健学研究科, 大学院生
KUWAHARA Miwa 神戸大学, 大学院・保健学研究科, 大学院生
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| Project Period (FY) |
2007 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ウエストナイルウイルス / E蛋白質 / 成分ワクチン / 組換えワクチン / CTL / cross-presentation / 中和抗体 / 感染防御 / 感染防護 |
|---|
| Research Abstract |
West Nile virus (WNV) is the human-infectious virus, which sometimes causes lethal encephalitis/meningitis, and the vaccine for human use has not been developed yet. Based on the findings concerning its relative viruses, it is anticipated that the envelope (E) protein should induce protective immunity. In the present study, we have established several recombinant WNV E protein expression systems and the CTL target cells in order to develop the recombinant component vaccine against WNV infection, which induces not only neutralizing antibody but also CTL, using recombinant WNV E protein combined with cross-presentation inducing adjuvant.
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