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Neurotoxicity of perinatal hypothyroidism in rats : Developmentsof brain function diagnosis by fMRI

Research Project

Project/Area Number 19590619
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionHokkaido University

Principal Investigator

WADA Hiromi  Hokkaido University, 大学院・文学研究科, 教授 (90191832)

Co-Investigator(Kenkyū-buntansha) KIDA Ikuhiro  北海道大学, 大学院・歯学研究科, 助教 (60374716)
Research Collaborator YONEZAKI Kumiko  北海道大学, 大学院・文学研究科, 博士後期課程院生
HASEGAWA Masashi  北海道大学, 大学院・文学研究科, 修士課程院生
YUMOTO Shoko  北海道大学, 大学院・文学研究科, 修士課程院生
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords甲状腺ホルモン / メチマゾール / ラット / プレパルス・インヒビション / MRI / 水迷路 / DRL / 環境ホルモン / 注意障害 / 衝動性 / ADHD
Research Abstract

甲状腺ホルモンを阻害されたラットは、行動を抑制できず、衝動的な傾向が観察された。新たなターゲットに、すばやく注意を切り替えることもできない。音刺激に対する閾値が上昇している可能性がある一方で、音に対する驚愕反射が増大しパニック傾向が見られた。空間的な位置関係に関する作業記憶の形成に、障害が見られた。海馬、脳の体積が縮小したが、海馬/脳の体積比には影響がなかった。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (47 results)

All 2009 2008 2007

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (25 results) Book (10 results)

  • [Journal Article] Hypothyroidism gives rise to panictendencies in response to auditorystartle stimuli in the rat:neurotoxicological potential ofpersistent organic pollutants2008

    • Author(s)
      Wada H, Yumoto S, and Iso H.
    • Journal Title

      Organohalogen Compounds 70

      Pages: 1016-1019

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The deficit ofbehavioural inhibition is not improvedby methylphenidate in hypothyroid rats2008

    • Author(s)
      Hasegawa M and Wada H.
    • Journal Title

      Organohalogen Compounds 70

      Pages: 1363-1366

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impulsiveness ofhypothyroid rats shown in non-rewardedtrials2008

    • Author(s)
      Yonezaki K and Wada H.
    • Journal Title

      Organohalogen Compounds 70

      Pages: 2439-2442

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hypothyroidism gives rise to panic tendencies in response to auditory startle stimuli in the rat : neurotoxicological potential of Persistent organic pollutants2008

    • Author(s)
      Wada H
    • Journal Title

      Organohalogen Compounds 70

      Pages: 1016-1019

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The deficit of behavioural inhibition is not improved by methvlphenidate in hypothyroid rats2008

    • Author(s)
      Hasegawa M
    • Journal Title

      Organohalogen Compounds 70

      Pages: 1363-1366

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impulsiveness of hypothyroid rats shown in non-rewarded trials2008

    • Author(s)
      Yonezaki K
    • Journal Title

      Organohalogen Compounds 70

      Pages: 2439-2442

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypothyroidismdisrupts prepulse inhibition ofauditory startle response in rats2007

    • Author(s)
      Wada H. and Iso H.
    • Journal Title

      Organohalogen Compounds 69

      Pages: 2976-2979

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inability ofhypothyroid rats to shift attentionquickly in a target detection task2007

    • Author(s)
      Hasegawa M and Wada H.
    • Journal Title

      Organohalogen Compounds 69

      Pages: 2972-2975

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Deficiency ofbehavioral inhibition in hypothyroidrats : A pilot study2007

    • Author(s)
      Yonezaki K and Wada H.
    • Journal Title

      OrganohalogenCompounds 69

      Pages: 2980-2983

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hypothyroidism disrupts prepulse inhibition of auditory startle response in rats2007

    • Author(s)
      WADA H.
    • Journal Title

      Organohalogen Compounds (CD-ROM) 69

      Pages: 2976-2979

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inability of hypothyroid rats to shift attention quickly in a target detection task2007

    • Author(s)
      Hasegawa M.
    • Journal Title

      Organohalogen Compounds (CD-ROM) 69

      Pages: 2972-2975

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deficiency of behavioral inhibition in hypothyroid rats: A pilot study2007

    • Author(s)
      Yonezaki K.
    • Journal Title

      Organohalogen Compounds (CD-ROM) 69

      Pages: 2980-2983

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Hypothyroidism gives rise topanic tendencies in response toauditory startle stimuli in therat:Neurotoxicological potential ofpersistent organic pollutants2008

    • Author(s)
      Wada H
    • Organizer
      DIOXIN2008
    • Place of Presentation
      BirminghamInternational Convention Center,Birmingham, UK
    • Year and Date
      2008-08-19
    • Related Report
      2008 Final Research Report
  • [Presentation] The deficit of behaviouralinhibition is not improved bymethylphenidate in hypothyroid rats2008

    • Author(s)
      Hasegawa M
    • Organizer
      DIOXIN 2008
    • Place of Presentation
      Birmingham International ConventionCenter, Birmingham, UK
    • Year and Date
      2008-08-19
    • Related Report
      2008 Final Research Report
  • [Presentation] Impulsiveness ofhypothyroid rats shown innon-rewardedtrials2008

    • Author(s)
      Yonezaki K
    • Organizer
      DIOXIN 2008
    • Place of Presentation
      BirminghamInternational Convention Center,Birmingham, UK.
    • Year and Date
      2008-08-19
    • Related Report
      2008 Final Research Report
  • [Presentation] Hypothyroidism gives rise to panic tendencies in response to auditory startle stimuli in the rat : neurotoxicological potential of persistent organic pollutants2008

    • Author(s)
      Wada H
    • Organizer
      Dioxin 2008
    • Place of Presentation
      Birmingham International Convention Center, Birmingham, UK
    • Year and Date
      2008-08-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] The deficit of behavioural inhibition is not improved by methylphenidate in hvpothyroid rats2008

    • Author(s)
      Hasegawa M
    • Organizer
      Dioxin 2008
    • Place of Presentation
      Birmingham International Convention Center, Birmingham, UK
    • Year and Date
      2008-08-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] Imnulsiveness of hvnothvroid rats shown in non-rewardedtrials2008

    • Author(s)
      Yonezaki K
    • Organizer
      Dioxin 2008
    • Place of Presentation
      Birmingham International Convention Center, Birmingham, UK
    • Year and Date
      2008-08-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] The effects of perinatalhypothyroidism on the attentionability in rats2008

    • Author(s)
      Hasegawa M
    • Organizer
      International Congress of Psychology
    • Place of Presentation
      International Congress Center Berlin,Berlin, Germany.
    • Year and Date
      2008-07-23
    • Related Report
      2008 Final Research Report
  • [Presentation] The effects of perinatal hypothyroidism on the attention ability in rats2008

    • Author(s)
      Hasegawa M
    • Organizer
      International Congress of Psychology
    • Place of Presentation
      International Congress Center Berlin, Berlin, Germany
    • Year and Date
      2008-07-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] Developmental effects ofhypothyroidism on prepulse inhibitionin the rat2008

    • Author(s)
      Wada H
    • Organizer
      10^<th>InternationalSymposium of Neurobehavioral Methodsand Effects in Occupational andEnvironmental Health
    • Place of Presentation
      Hotel Ramada Herradura, San Jose,Costa Rica.
    • Year and Date
      2008-06-11
    • Related Report
      2008 Final Research Report
  • [Presentation] Developmental effects of hypothyroidism on prepulse inhibition in the rat2008

    • Author(s)
      Wada H
    • Organizer
      International Symposium of Neurobehavioral Methods and Effects in Occupational and Environmental Health
    • Place of Presentation
      Hotel Ramada Herradura, San Jose, Costa Rica
    • Year and Date
      2008-06-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] Developmental effects of hypothyroidism on auditory startle response in rats2007

    • Author(s)
      WADA H.
    • Organizer
      第10回環境ホルモン学会
    • Place of Presentation
      さいたま市,大宮 ソニック シティー
    • Year and Date
      2007-12-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] 甲状腺ホルモン阻害によるラットの衝動性への影響2007

    • Author(s)
      米崎 久美子
    • Organizer
      第10回環境ホルモン学会
    • Place of Presentation
      さいたま市,大宮 ソニック シティー
    • Year and Date
      2007-12-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] Effects of perinatal hypothyroidism on hippocampal volumes in rats2007

    • Author(s)
      Hasegawa M.
    • Organizer
      第10回環境ホルモン学会
    • Place of Presentation
      さいたま市,大宮 ソニック シティー
    • Year and Date
      2007-12-10
    • Related Report
      2007 Annual Research Report
  • [Presentation] 甲状腺ホルモン攪乱作用と次世代影響IV-プレパルス・インヒビションによる検討-2007

    • Author(s)
      和田 博美
    • Organizer
      第67回日本動物心理学会
    • Place of Presentation
      東京,早稲田大学
    • Year and Date
      2007-10-07
    • Related Report
      2007 Annual Research Report
  • [Presentation] 妊娠ラットの甲状腺ホルモン阻害と次世代行動障害I-ビジランス課題を用いた注意障害の解析-2007

    • Author(s)
      長谷川 征史
    • Organizer
      第67回日本動物心理学会
    • Place of Presentation
      東京,早稲田大学
    • Year and Date
      2007-10-07
    • Related Report
      2007 Annual Research Report
  • [Presentation] 甲状腺ホルモン阻害ラットにおけるDRLスケジュールの学習I-強化率とIRT分布の分析-2007

    • Author(s)
      米崎 久美子
    • Organizer
      第67回日本動物心理学会
    • Place of Presentation
      東京,早稲田大学
    • Year and Date
      2007-10-07
    • Related Report
      2007 Annual Research Report
  • [Presentation] 脳発達期の甲状腺ホルモン阻害は注意障害を引き起こすか?-ターゲット検出課題によるラットの行動分析-2007

    • Author(s)
      長谷川 征史
    • Organizer
      第71回日本心理学会
    • Place of Presentation
      東京,東洋大学
    • Year and Date
      2007-09-18
    • Related Report
      2007 Annual Research Report
  • [Presentation] Hypothyroidism disrupts prepulse inhibition of auditory startle response in rats2007

    • Author(s)
      WADA H.
    • Organizer
      DIOXIN 2007
    • Place of Presentation
      Tokyo, JAPAN ホテル オークラ 東京
    • Year and Date
      2007-09-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] Inability of hypothyroid rats to shift attention quickly in a target detection task2007

    • Author(s)
      Hasegawa M.
    • Organizer
      DIOXIN 2007
    • Place of Presentation
      Tokyo, JAPAN ホテル オークラ 東京
    • Year and Date
      2007-09-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] Deficiency of behavioral inhibition in hypothyroid rats: A pilot study2007

    • Author(s)
      Yonezaki K.
    • Organizer
      DIOXIN 2007
    • Place of Presentation
      Tokyo, JAPAN ホテル オークラ 東京
    • Year and Date
      2007-09-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] Hypothyroidism disruptsprepulse inhibition of auditorystartle response in rats2007

    • Author(s)
      Wada H
    • Organizer
      DIOXIN 2007
    • Place of Presentation
      Hotel Okura, Tokyo,Japan.
    • Year and Date
      2007-09-03
    • Related Report
      2008 Final Research Report
  • [Presentation] Inability of hypothyroidrats to shift attention quickly in atarget detection task2007

    • Author(s)
      Hasegawa M
    • Organizer
      DIOXIN 2007
    • Place of Presentation
      Hotel Okura, Tokyo,Japan
    • Year and Date
      2007-09-03
    • Related Report
      2008 Final Research Report
  • [Presentation] Deficiency of behavioralinhibition in hypothyroid rats : Apilot study2007

    • Author(s)
      Yonezaki K
    • Organizer
      DIOXIN 2007
    • Place of Presentation
      Hotel Okura, Tokyo,Japan
    • Year and Date
      2007-09-03
    • Related Report
      2008 Final Research Report
  • [Presentation] Hypothyroid rats showedgreater startle response to auditorystimulus2007

    • Author(s)
      Wada H
    • Organizer
      11th InternationalNeurotoxicology Association
    • Place of Presentation
      Asilomar Conference Center,Pacific Grove, CA, USA
    • Year and Date
      2007-06-14
    • Related Report
      2008 Final Research Report
  • [Presentation] Hypothyroid rats showed greater startle response to auditory stimulus2007

    • Author(s)
      WADA H.
    • Organizer
      11th International Neurotoxicology Association
    • Place of Presentation
      Pacific Grove, CA, USA Asilomar Conference Center
    • Year and Date
      2007-06-12
    • Related Report
      2007 Annual Research Report
  • [Book] 認知心理学-心のメカニズムを解き明かす2009

    • Author(s)
      和田博美
    • Publisher
      ミネルヴァ書房(印刷中)
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Book] 子どものこころを育む発達科学2009

    • Author(s)
      和田博美
    • Publisher
      北大路書房
    • Related Report
      2008 Final Research Report
  • [Book] Persistent organic pollutants (POPS) research in Asia2008

    • Author(s)
      Wada H
    • Publisher
      Yumoto S, and Iso H, ISEBU
    • Related Report
      2008 Final Research Report
  • [Book] Persistent organic pollutants (POPS) research in Asia2008

    • Author(s)
      Hasegawa M, Kida I, and Wada H
    • Publisher
      ISEBU
    • Related Report
      2008 Final Research Report
  • [Book] Persistent organic pollutants (POPS) research in Asia2008

    • Author(s)
      Yonezaki K, and Wada H
    • Publisher
      ISEBU
    • Related Report
      2008 Final Research Report
  • [Book] Persistent organic pollutants (POPS) research in Asia2008

    • Author(s)
      Wada H
    • Publisher
      ISEBU
    • Related Report
      2008 Annual Research Report
  • [Book] Persistent organic pollutants (POPS) research in Asia2008

    • Author(s)
      Hasegawa M
    • Publisher
      ISEBU
    • Related Report
      2008 Annual Research Report
  • [Book] Persistent organic pollutants (POPS) research in Asia2008

    • Author(s)
      Yonezaki K
    • Publisher
      ISEBU
    • Related Report
      2008 Annual Research Report
  • [Book] 子どものこころを育む発達科学2008

    • Author(s)
      和田博美
    • Publisher
      北大路出版
    • Related Report
      2008 Annual Research Report
  • [Book] 子どもの心を育む2008

    • Author(s)
      和田 博美
    • Total Pages
      220
    • Publisher
      北大路書房
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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