Biochemical and physiological analysis of the effects of abdominal fat accumulation on vascular endothelial function among healthy populations

• Project/Area Number: 19590626
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Nagoya University
• Principal Investigator: KONDO Takaaki Nagoya University, 医学部・保健学科, 教授 (00195900)
• Co-Investigator(Kenkyū-buntansha): UEYAMA Jun 名古屋大学, 医学部・保健学科, 准教授 (00397465)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 酸化ストレス / 血管内皮機能 / 内臓脂肪 / 一酸化窒素 / プレチスモグラフ / 腹部脂肪 / カロテノイド / 炎症指標

Research Abstract

Abdominal fat accumulation was associated with an increase in the serum levels of oxidative stress markers or decline in the antioxidative micronutrient levels. Due to a great intra- and inter-individual variability of the vasculo-endothelial responses, however, incorporation of a larger number of subjects or high-risk population seems to be required to determine the influence of abdominal fat accumulation on the endothelial function.

Research Products

• [Journal Article] Body mass index and all-cause mortality among Japanese older adults : findings from the Japan Collaborative Cohort Study. (2010)
  • Author(s): Tamakoshi A, Yatsuya H, Lin Y, Tamakoshi K, Kondo T, Suzuki S, Yagyu K, Kikuchi S for the JACC Study Group.
  • Journal Title: Obesity 18(2) Pages: 362-369
  • Peer Reviewed
• [Journal Article] Measurement of forearm blood flow of healthy young men and women using strain-gauge plethysmography. (2010)
  • Author(s): Kondo T, Yamada C, Furuta T, Yoshitake J, Shirotori A, Okada Y, Kimata A, Yamamoto K, Ueyama J, Sakakibara H, Fukaya Y.
  • Journal Title: Bull Aichi Bunkyo Women's Coll 31 Pages: 27-34
  • NAID: 40018709584
  • Peer Reviewed
• [Journal Article] Body mass index and all-cause mortality among Japanese older adults : findings from the Japan Collaborative Cohort Study (2010)
  • Author(s): Tamakoshi Akiko
  • Journal Title: Obesity Volume: 18 Pages: 362-369
  • Peer Reviewed
• [Journal Article] Use of waist circumference and ultrasonographic assessment of abdominal fat distribution in predicting metabolic risk factors in healthy Japanese adults. (2009)
  • Author(s): Kondo T, Abe M, Ueyama J, Kimata A, Yamamoto K, Hori Y.
  • Journal Title: J Physiol Anthropol 28 Pages: 7-14
  • NAID: 110007043811
  • Peer Reviewed
• [Journal Article] Multilevel analyses of effects of variation in body mass index on serum lipid concentrations in middle-aged Japanese men. (2009)
  • Author(s): Kondo T, Kimata A, Yamamoto K, Ueyama S, Ueyama J, Yatsuya H, Tamakoshi K, Hori Y.
  • Journal Title: Nagoya J Med Sci 71 Pages: 19-28
  • NAID: 110007020097
  • Peer Reviewed
• [Journal Article] Effects of short-term variation in body mass index on blood pressure in middle-aged Japanese male workers. (2009)
  • Author(s): Kondo T, Kimata A, Yamamoto K, Ueyama S, Ueyama J, Hori Y.
  • Journal Title: J Health Sci 55 Pages: 62-71
  • NAID: 110007055932
  • Peer Reviewed
• [Journal Article] Measurement of forearm blood flow of healthy young men and women using strain-gauge plethysmography (2009)
  • Author(s): Kondo Takaaki
  • Journal Title: Bulletin of Aichi Bunkyo Women's College Volume: 31 Pages: 27-34
  • NAID: 40018709584
  • Peer Reviewed
• [Journal Article] Use of waist circumference and ultrasonographic assessment of abdominal fat distribution in predicting metabolic risk factors in healthy Japanese adults (2009)
  • Author(s): Kondo Takaaki
  • Journal Title: Journalof Physiological Anthropology 28 Pages: 7-14
  • NAID: 110007043811
  • Peer Reviewed
• [Journal Article] Association of serum NO_x level with clustering of metabolic syndrome components in middle-aged and elderly general population in Japan. (2008)
  • Author(s): Ueyama J, Kondo T, Imai R, Kimata A, Yamamoto K, Suzuki K, Inoue T, Ito Y, Miyamoto K, Hasegawa T, Hamajima N.
  • Journal Title: Environ Health Prev Med 13 Pages: 36-42
  • NAID: 10026956635
  • Peer Reviewed
• [Journal Article] Acute effect of exercise on blood pressure among fitness facility users, with special reference to influence of body mass index (2008)
  • Author(s): Kondo Takaaki
  • Journal Title: Bulletin of Aichi Bunkyo Women's College 29 Pages: 27-37
  • NAID: 40016591824
  • Peer Reviewed
• [Journal Article] Association of serum NO_x level with clustering of metabolic syndrome components in middle-aged and elderly general population in Japan (2008)
  • Author(s): Ueyama Jun
  • Journal Title: Environmental Health and Preventive Medicine 13 Pages: 36-42
  • NAID: 10026956635
  • Peer Reviewed
• [Journal Article] Serum total cholesterol levels and risk of mortality from stroke and coronary heart disease in Japanese : the JACC study. (2007)
  • Author(s): Cui R, Iso H, Toyoshima H, Date C, Yamamoto A, Kikuchi S, Kondo T, Watanabe Y, Koizumi A, Inaba Y, Tamakoshi A, the JACC Study Group.
  • Journal Title: Atherosclerosis 194 Pages: 415-420
  • Peer Reviewed
• [Journal Article] Lack of effect of aerobic physical exercise on endothelium-derived nitric oxide concentrations in healthy young subjects. (2007)
  • Author(s): Yamamoto K, Kondo T, Kimata A, Ueyama J, Shirotori A, Okada Y, Sakui D, Nakashima M, Yamada S.
  • Journal Title: Nagoya J Med Sci 69 Pages: 167-172
  • NAID: 110006611669
  • Peer Reviewed
• [Journal Article] Association of a polymorphism in the ornithine decarboxylase gene with whole blood polyamine concentrations in a non-smoking healthy population. (2007)
  • Author(s): Kondo T, Hamajima N, Nishio K, Ishida Y, Imai R, Ueyama J, Torita S, Kasai Y, Yamamoto R, Suzuki K, Ito Y.
  • Journal Title: J Health Sci 53 Pages: 406-412
  • NAID: 110006366920
  • Peer Reviewed
• [Journal Article] Lack of effect of aerobic physical exercise on endothelium-derived nitric oxide concentrations in healthy young subjects (2007)
  • Author(s): Yamamoto Kanami
  • Journal Title: Nagoya Journal of Medical Science 69 Pages: 167-172
  • Peer Reviewed
• [Journal Article]
  • Peer Reviewed
• [Presentation] 健常成人集団における血清8-iso-PGF_<2α>と骨密度との関連 (2009)
  • Author(s): 近藤高明, 上山純, 木全明子, 山本佳那実, 鈴木康司, 井上孝, 伊藤宜則, 浜島信之, 長谷川幸治
  • Organizer: 第79回日本衛生学会総会
  • Place of Presentation: 東京
  • Year and Date: 2009-03-30
• [Presentation] 男性健常成人集団における血中polyamine 値の分布とmetabolic risk factorとの関連性 (2008)
  • Author(s): 山本佳那実, 近藤高明, 木全明子, 高木健次
  • Organizer: 第78回日本衛生学会総会
  • Place of Presentation: 熊本
  • Year and Date: 2008-03-29
• [Presentation] 健常成人集団でのCETP TaqIB 遺伝多型と血管内皮由来NO (2008)
  • Author(s): 近藤高明, 上山純, 吉武順子, 木全明子, 山本佳那実, 鈴木康司, 井上孝, 伊藤宜則, 浜島信之
  • Organizer: 濃度との関連性
  • Place of Presentation: 熊本
  • Year and Date: 2008-03-29
• [Presentation] 健常成人男性集団で体重が血圧値にあたえる影響-経年的測定データの多重レベル解析 (2007)
  • Author(s): 近藤高明, 堀容子, 玉腰浩司, 八谷寛, 豊嶋英明
  • Organizer: 第66回日本公衆衛生学会総会
  • Place of Presentation: 松山
  • Year and Date: 2007-10-23
• [Presentation] 一般中高年集団を対象としたメタボリック症候群の危険因子と血中一酸化窒素代謝産物の解析 (2007)
  • Author(s): 上山純, 近藤高明, 今井亮太, 鈴木康司, 井上孝, 伊藤宜則, 宮本謙一, 長谷川高明, 濱島信之
  • Organizer: 第77回日本衛生学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2007-04-01
• [Remarks] ホームページ等
  • URL: http://homepage2.nifty.com/takaaki/environ.html
• [Remarks]
  • URL: http://kenpro.mynu.jp:8001/Profiles/0006/0000615/profile.html