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The effects of metabolic syndrome on cardiovascular diseases in Japanese general population

Research Project

Project/Area Number 19590639
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionSapporo Medical University

Principal Investigator

SAITOH Shigeyuki  Sapporo Medical University, 医学部, 講師 (60253994)

Co-Investigator(Kenkyū-buntansha) OHNISHI Hirohumi  札幌医科大学, 医学部, 講師 (20359996)
MIYAZAKI Yoshinori  札幌医科大学, 医学部, 講師 (00372813)
SHIMAMOTO Kazuaki  札幌医科大学, 医学部, 教授 (40136940)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords代謝症候群 / 循環器・高血圧 / 糖尿病 / 脂質 / 疫学 / メタボリックシンドローム / 心血管疾患
Research Abstract

メタボリックシンドローム(MetS)は軽症でも動脈硬化危険因子が集積することにより循環器疾患発症を増し、その背景は腹部肥満とする病態である。しかしながらMetSが日本人の死因の上位を占める心血管疾患の発症にどのように関与するは不明である。本研究では地域一般住民を対象とした疫学研究からこの点を検討し、日本人でもMetSは循環器疾患の発症リスクを約2倍程度上昇させ、糖尿病や高血圧の強力な発症要因となっていることを明らかにした。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (39 results)

All 2009 2008 2007

All Journal Article (17 results) (of which Peer Reviewed: 17 results) Presentation (15 results) Book (7 results)

  • [Journal Article] Uric acid and left ventricular hypertrophy2009

    • Author(s)
      Saitoh S
    • Journal Title

      Circ J 73

      Pages: 624-625

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] メタボリックシンドローム、危険因子集積と尿中微量アルブミンとの関連-端野・壮瞥町研究-2008

    • Author(s)
      大西浩文, 斎藤重幸, 赤坂憲, 三俣兼人, 千葉瑞恵, 古堅真, 古川哲章, 森満, 島本和明
    • Journal Title

      日循予防誌 43

      Pages: 132-138

    • NAID

      10029554639

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The INTERMAP Research Group. Dietary intake and urinary excretion of selenium in the Japanese adult population : the INTERMAP study Japan2008

    • Author(s)
      Yoneyama S, Miura K, Itai k, Yoshita K, Niagara H, Shinmura T, Okayama A, Sakata K, Saitoh S, Ueshima H, Elliott P, Stamler J
    • Journal Title

      European J of Clinical Nutrition 62

      Pages: 1187-1193

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Incidence of hypertension in individuals with abdominal obesity in rural Japanese population : The Tanno and Sobetsu study2008

    • Author(s)
      Ohnishi H, Saitoh S, Akasaka H, Mitsumata K, Chiba M, Frugen M, Mori M, Shimamoto K
    • Journal Title

      Hypertens. Research 31

      Pages: 1385-1390

    • NAID

      10024360874

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differences in insulin action and secretion, plasma lipids and blood pressure levels between impaired fasting glucose and impaired glucose tolerance in Japanese subjects2008

    • Author(s)
      Miyazaki Y, Akasaka H, Ohnishi H, Saitoh S, DeFronzo RA, Shimamoto K
    • Journal Title

      Hypertens. Research 31

      Pages: 1357-1363

    • NAID

      10024360749

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 地域一般住民高齢者におけるメタボリックシンドローム, インスリン抵抗性と尿中微量アルブミンとの関連-端野・壮瞥町研究2008

    • Author(s)
      田辺谷徹也, 大西浩文, 斎藤重幸, 赤坂憲, 三俣兼人, 千葉瑞恵, 古堅真, 森満, 島本和明
    • Journal Title

      日老医誌 45

      Pages: 302-307

    • NAID

      10021925543

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] relationship of elevated casual blood glucose level with coronary heart disease, Cardiovascular disease and all cause mortality in a representative sample off the Japanese population2008

    • Author(s)
      Kadowaki S, Okamura T, Hozawa A, Kadowaki T, Murakami Y, Nakamura K, Saitoh S, Nakmaura Y, Akasaka T, Kita Y, Ueshima H
    • Journal Title

      NIPPON DATA80 Diabetologia 51

      Pages: 575-582

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rosiglitazone and pioglitazone similarly improve insulin sensitivity and secretion, glucose tolerance and adipocytokines in type 2 diabetic patients2008

    • Author(s)
      Miyazaki Y, DeFronzo RA
    • Journal Title

      Diabetes Obes Metab 10

      Pages: 1204-1211

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Incidence of hypertension in individuals with abdominal obesity in rural Japanese population : The Tanno and Sobetsu study2008

    • Author(s)
      Ohnishi H
    • Journal Title

      Hypertens. Research 31

      Pages: 1385-1390

    • NAID

      10024360874

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differences in insulin action and secretion, plasma lipids and blood pressure levels between impaired fasting glucose and impaired glucose tolerance in Japanese subjects.2008

    • Author(s)
      Miyazaki Y
    • Journal Title

      Hypertens. Research 31

      Pages: 1357-1363

    • NAID

      10024360749

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 地域一般住民高齢者におけるメタボリックシンドローム, インスリン抵抗性と尿中微量アルブミンとの関連-端野・壮瞥町研究2008

    • Author(s)
      田辺谷徹也
    • Journal Title

      日本老年医学会雑誌 45

      Pages: 302-307

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Influence of Hypertension on the Incidence of Cardiovascular Disease in Two Rural Communities in Japan : Tanno-Sobetsu Study2007

    • Author(s)
      Obara F, Saitoh S, Takagi S, Shimamoto K
    • Journal Title

      Hypertens. Research 30

      Pages: 677-682

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Visceral obesity in Japanese patients with metabolic syndrome : Reappraisal of diagnostic criteria by CT scan2007

    • Author(s)
      Eguchi M, Tsutihashi K, Saitoh S, Odawara Y, Hirano T, Nakata T, Miura T, Ura N, Kareyama M, Shimamoto K
    • Journal Title

      Hypertens. Research 30

      Pages: 315-324

    • NAID

      10019576488

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between visceral fail and cardiovascular disease risk factors : The Tanno-Sobetsu study2007

    • Author(s)
      Chiba Y, Saitoh S, Takagi S, Ohonishi H, Katoh N, Ohohata J, Nakagawa M, Shimamoto K
    • Journal Title

      Hypertens. Research 30

      Pages: 229-236

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] メタボリックシンドロームにおける高尿酸血症の意義2007

    • Author(s)
      東浦勝浩, 斎藤重幸, 竹内宏, 高木覚, 浦信行, 島本和明
    • Journal Title

      医学と薬学 57

      Pages: 169-171

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Influence of Hypertension on the Incidence of Cardiovascular Disease in Two Rural Communities in Japan: Tanno-Sobetsu Study2007

    • Author(s)
      Obara F
    • Journal Title

      Hypertens. Research 30

      Pages: 663-682

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Visceral obesity in Japanese patients with metabolic syndrome: Reappraisal of diagnostic criteria by CT scan2007

    • Author(s)
      Eguchi M
    • Journal Title

      Hypertens. Research 30

      Pages: 315-324

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] メタボリックシンドロームの疫学と現状2008

    • Author(s)
      斎藤重幸
    • Organizer
      第29回日本肥満学会
    • Place of Presentation
      大分市
    • Year and Date
      2008-10-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] メタボリックシンドロームの疫学と現状. シンポジウム5メタボリックシンドローム克服へのアプローチ2008

    • Author(s)
      斎藤重幸, 島本和明
    • Organizer
      第29回日本肥満学会
    • Place of Presentation
      大分
    • Related Report
      2008 Final Research Report
  • [Presentation] 端野・壮瞥町研究からみた高血圧・高血圧診療. シンポジウム2日本の高血圧診療のエビデンス2008

    • Author(s)
      斎藤重幸
    • Organizer
      第31回日本高血圧学会総会
    • Place of Presentation
      札幌
    • Related Report
      2008 Final Research Report
  • [Presentation] 高血圧診療ガイドライン. 教育講演III. 高齢者の診療ガイドライン2008

    • Author(s)
      斎藤重幸
    • Organizer
      第50回日本老年医学会学術集
    • Place of Presentation
      幕張
    • Related Report
      2008 Final Research Report
  • [Presentation] The relationship between adipocyte fatty acid binding protein (A-FABP) and insulin resistance in Japanese rural population2008

    • Author(s)
      Yamashita T, Yoshida H, Saitoh N, Yokoyama Y, Akasaka H, Miyazaki Y, Saitoh S, Shimamoto K
    • Organizer
      22nd Scientific Meeting of the International Society of Hypertension
    • Place of Presentation
      Berlin
    • Related Report
      2008 Final Research Report
  • [Presentation] Impact of both chronic kidney diseaseand hypertension on cardiovascular events in rural communities in Japan-The Tanno and Sobetsu study2008

    • Author(s)
      Ohnishi H, Saitoh S, Akasaka H, Mitsumata K, Chiba M, Furugen M, Furukawa T, Mori M, Shimamoto K
    • Organizer
      22nd Scientific Meeting of the International Society of Hypertension
    • Place of Presentation
      Berlin
    • Related Report
      2008 Final Research Report
  • [Presentation] The relationship between hypertension and insulin resistance based on HOMA-Rand Matsuda-DeFronzo index : The Tanno and Sobetsu study2008

    • Author(s)
      Furugen M, Saitoh S, Akasaka H, Miyazaki Y, Ohnishi H, Shimamoto K.
    • Organizer
      22nd Scientific Meeting of the International Society of Hypertension
    • Place of Presentation
      Berlin
    • Related Report
      2008 Final Research Report
  • [Presentation] Cardiovascular mortality in patients with treated hypertension in Japanese general population2008

    • Author(s)
      Saitoh S, Ohonishi H, Shimamoto K, Okamura T, Okayama A, Ueshima H, NIPPON DATA Research Group(Japan)
    • Organizer
      22nd Scientific Meeting of the International Society of Hypertension
    • Place of Presentation
      Berlin
    • Related Report
      2008 Final Research Report
  • [Presentation] Significances of Adiponectin and Fatty Acid Binding Protein as a biomakekers of cardiovascular disease and insulin sensitivity.Roundtable discussin42008

    • Author(s)
      Ura N, Saitoh S, Shimamoto K
    • Organizer
      糖尿病と循環器疾患. 第72回日本循環器学会総会学術集会
    • Place of Presentation
      福岡
    • Related Report
      2008 Final Research Report
  • [Presentation] 糖尿病と循環器疾患の疫学.教育セッションIII2008

    • Author(s)
      斎藤重幸, 島本和明
    • Organizer
      第72回日本循環器学会総会学術集会
    • Place of Presentation
      福岡
    • Related Report
      2008 Final Research Report
  • [Presentation] Consciousness of reduction salt diet and actual achievement of salt reduction estimated from 24hr urinary Na excretions in general population in Japan, PRC, UK and US; the INTERMAP study(3643)2007

    • Author(s)
      Okuda N, Saitoh S, Okayama A, Ueshima H
    • Organizer
      2007American Heart Association Scientific Meeting
    • Place of Presentation
      Orlando, Florida
    • Related Report
      2008 Final Research Report
  • [Presentation] メタボリックシンドロームにおける性差と性ホルモン. シンポジウム9. 循環器領域における性差医療2007

    • Author(s)
      斎藤重幸, 島本和明
    • Organizer
      第55回日本心臓学会学術集会
    • Place of Presentation
      浦安
    • Related Report
      2008 Final Research Report
  • [Presentation] 端野・壮瞥町研究からみたメタボリックシンドロームの予後.シンポジウムIII.メタボリックシンドローム対策の視点2007

    • Author(s)
      斎藤重幸, 大西浩文, 赤坂憲, 島本和明
    • Organizer
      第43回日本循環器病予防学会
    • Place of Presentation
      大津
    • Related Report
      2008 Final Research Report
  • [Presentation] 糖尿病の動脈硬化症予防における高血圧管理の重み.シンポジウム6.糖尿病の動脈硬化症をどう防ぐか2007

    • Author(s)
      斎藤重幸, 島本和明
    • Organizer
      第50回日本糖尿病学会年次学術集会
    • Place of Presentation
      仙台
    • Related Report
      2008 Final Research Report
  • [Presentation] メタボリックシンドロームにおける性差と性ホルモン.2007

    • Author(s)
      斎藤重幸
    • Organizer
      第55回日本心臓学会学術集会
    • Place of Presentation
      千葉
    • Related Report
      2007 Annual Research Report
  • [Book] キーワードでわかるメタボリックシンドローム2008

    • Author(s)
      斎藤重幸
    • Publisher
      中外医学社
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Book] NIPPONDATAからみた循環器疾患のエビデンス2008

    • Author(s)
      斎藤重幸
    • Publisher
      日本医事新報社
    • Related Report
      2008 Final Research Report
  • [Book] 老年医学テキスト改訂第3版2008

    • Author(s)
      斎藤重幸
    • Publisher
      メディカルビュー社
    • Related Report
      2008 Final Research Report
  • [Book] メタボリックシンドロームリスク管理のために健診・保健指導ガイドライン2008

    • Author(s)
      島本和明,斎藤重幸
    • Publisher
      南山堂
    • Related Report
      2008 Final Research Report
  • [Book] 新しい診断と治療のABC,二次性高血圧2008

    • Author(s)
      斎藤重幸, 島本和明
    • Publisher
      最新医学社
    • Related Report
      2008 Final Research Report
  • [Book] 高血圧ナビゲータ.第2版2008

    • Author(s)
      斎藤重幸, 島本和明
    • Publisher
      メディカルビュー社
    • Related Report
      2008 Final Research Report
  • [Book] メタボリックシンドロームと生活習慣病2007

    • Author(s)
      斎藤重幸
    • Publisher
      診断と治療社
    • Related Report
      2008 Final Research Report 2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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