A study of adipocytokines and nutritional in Japanese-Americans in Hawaii and Japanese in Japan for prevention of atherosclerosis

• Project/Area Number: 19590655
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Kyoto Women's University
• Principal Investigator: NAKAMURA Yasuyuki Kyoto Women's University, 家政学部, 教授 (20144371)
• Co-Investigator(Kenkyū-buntansha): 上島 弘嗣 滋賀医科大学, 医学部, 教授 (70144483) ; 岡村 智教 国立循環器病センター, 研究所, 部長 (00324567) ; 喜多 義邦 滋賀医科大学, 医学部, 助教 (80161462)
• Co-Investigator(Renkei-kenkyūsha): UESHIMA Hirotsugu 滋賀医科大学, 医学部, 特任教授 (70144483) ; OKAMURA Tomonori 国立循環器病センター, 予防検診部, 部長 (00324567) ; KITA Yoshikuni 滋賀医科大学, 医学部, 助教 (80161462)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2007: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 動脈硬化 / アディポネクチン / レプチン / 栄養疫学 / 国際共同研究 / アディポサイトカイン / 日系ハワイ人 / 生活習慣 / 肥満 / 地域住民 / 疫学研究

Research Abstract

Differences in adipocytokines between Japanese in Japan and Japanese in Hawaii were largely related to differences in BMI and physical activity in men. In women, specific dietary factors (protein, n-3 PUFA, iron, fiber, alcohol) played some roles in addition.
BMI and log-leptin related significantly and independently to SBP and DBP. These findings are concordant with the inference that leptin is an independent mediator for obesity related adverse BP levels

Research Products

• [Journal Article] (2010)
  • Author(s): 中村保幸, 他
  • Journal Title: 高コレステロール血症で期江戸肥満の54歳男性「ケースで学ぶ栄養管理の思考プロセス」(In田中清、松末智、本田佳子編)(文光堂) Pages: 83-92
• [Journal Article] Visceral and Subcutaneous Adiposity and Adiponectin in Middle-aged Japanese Men: The ERA JUMP Study. (2009)
  • Author(s): Nakamura Y, Sekikawa A, Kadowaki T, Kadota A, Kadowaki S, Maegawa H, Kita Y, Evans RW, Edmundowicz D, Curb JD, Ueshima H.
  • Journal Title: Obesity 17(6) Pages: 1269-73
  • Peer Reviewed
• [Journal Article] A Japanese diet and 19-year mortality: NIPPON DATA80. (2009)
  • Author(s): Nakamura Y, Ueshima H, Okamura T, Kadowaki T, Hayakawa T, Kita Y, Robert D Abbott RD, Okayama A.
  • Journal Title: Brit J Nutr 101 Pages: 1696-1705
  • Peer Reviewed
• [Journal Article] Dietary Habits in Middle Age and Future Changes in Activities of Daily Living-NIPPON DATA80. (2009)
  • Author(s): Nakamura Y, Hozawa A, Turin TC, Takashima N, Okamura T, Hayakawa T, Kita Y, Okayama A, Miura K, Ueshima H.
  • Journal Title: Gerontology 55(6) Pages: 707-13
  • Peer Reviewed
• [Journal Article] Relation of Serum Leptin to Blood Pressure of Japanese in Japan and Japanese-Americans in Hawaii: The INTERLIPID Study. (2009)
  • Author(s): Nakamura Y, Ueshima H, Okuda N, Murakami Y, Miura K, Kita Y, Okamura T, Turin TC, Rodriguez B, Curb JD, Stamler J.
  • Journal Title: Hypertension 54(6) Pages: 1416-22
  • Peer Reviewed
• [Journal Article] Visceral and Subcutaneous Adiposity and Adiponectin in Middle-aged Japanese Men : The ERA JUMP Study. (2009)
  • Author(s): Nakamura Y(1), 他10名
  • Journal Title: Obesity 17 Pages: 1269-73
  • Peer Reviewed
• [Journal Article] A Japanese diet and 19-year mortality : NIPPON DATA80 (2009)
  • Author(s): Nakamura Y(1), 他8名
  • Journal Title: Brit J Nutr 101: Pages: 1696-1705
  • Peer Reviewed
• [Journal Article] Relation of Serum Leptin to Blood Pressure of Japanese in Japan and Japanese in Japan and Japanese-Americans in Hawaii : The INTERLIPID Study. (2009)
  • Author(s): Nakamura Y(1), 他10名
  • Journal Title: Hypertension 54 Pages: 1416-22
  • Peer Reviewed
• [Journal Article] Relation of dietary and other lifestyle traits to difference in serum adiponectin level of Japanese in Japan and Hawaii: The INTERLIPID Study. (2008)
  • Author(s): Nakamura Y, Ueshima H, Okuda N, Higashiyama A, Kita Y, Kadowaki T, Okamura T, Murakami Y, Okayama A, Choudhury SR, Rodriguez B, Curb JD, Stamler J.
  • Journal Title: Am J Clin Nutr 88 Pages: 424-30
  • Peer Reviewed
• [Journal Article] Relation of dietary and other lifestyle traits to difference in serum adiponectin level of Japanese in Japan and Hawaii : The INTERLIPID study. (2008)
  • Author(s): Nakamura Y(1), 他11名
  • Journal Title: Am J Clin Nutr 88 Pages: 424-430
  • Peer Reviewed
• [Journal Article] Cause-specific and all-cause mortality in individuals with low risk status for cardiovascular disease in the Japanese population, NIPPON DATA80. (2008)
  • Author(s): Nakamura Y(2), 他10名
  • Journal Title: Circ J 72 Pages: 545-550
  • Peer Reviewed
• [Journal Article] Risk Factor Effects and Total Mortality in Older Japanese Men in Japan and Hawaii. (2008)
  • Author(s): Nakamura Y(8), 他12名
  • Journal Title: Annal Epidem 18 Pages: 913-918
  • Peer Reviewed
• [Journal Article] Higher stroke incidence in the spring season regardless of conventionalrisk factors: Takashima Stroke Registry, Japan, 1988-2001 (2008)
  • Author(s): Turin TC(1), Nakamura Y(9), 他8名
  • Journal Title: Stroke 39・3 Pages: 745-752
  • Peer Reviewed
• [Journal Article] The Associations of Obesity Measures with the Metabolic Risk Factors in a Community-based Population in Japan (2007)
  • Author(s): Nakamura Y(1), 他8名
  • Journal Title: Circ J 71・5 Pages: 776-781
  • NAID: 110006273619
  • Peer Reviewed
• [Journal Article] Relationship between metabolic risk factor clustering and cardiovascularmortality stratified by high blood glucose and obesity: NIPPON DATA90, 1990-2000 (2007)
  • Author(s): Kadota A(1), Nakamura Y(10), 他10名
  • Journal Title: Diabetes Care 30・6 Pages: 1533-1538
  • Peer Reviewed
• [Journal Article] Alcohol consumption, alcohol-induced flushing and incidence of acutemyocardial infarction among middle-aged men in Japan-Japan Public Health Center-based prospective study. (2007)
  • Author(s): Nakamura Y(1), 他7名
  • Journal Title: Atherosclerosis 194・2 Pages: 512-516
  • Peer Reviewed
• [Journal Article] Fish consumption and early atherosclerosis in middle-aged men. (2007)
  • Author(s): Nakamura Y(1), 他11名
  • Journal Title: Metabolism 56・8 Pages: 1060-1064
  • Peer Reviewed
• [Journal Article] Relation of dietary and lifestyle traits to difference in serum leptin of Japanese in Japan and Hawaii: The INTERLIPID Study.
  • Author(s): Nakamura Y, Ueshima H, Okuda N, Murakami Y, Miura K, Kita Y, Okamura T, Turin TC, Okayama A, Rodriguez B, Curb JD, Stamler J.
  • Journal Title: Nutrition, Metabolism and Cardiovascular Diseases (in press)
  • Peer Reviewed
• [Presentation] Relation of Serum Leptin to Blood Pressure and Total Dietary Energy Intake of Japanese in Japan and Japanese-Americans in Hawaii : The INTERLIPID Study. (2010)
  • Author(s): 中村保幸
  • Organizer: AHA Cardiovascular Epidemiology
  • Place of Presentation: サンフランシスコ
  • Year and Date: 2010-03-02
• [Presentation] Relation of Serum Leptin to Blood Pressure and Total Dietary Energy Intake of Japanese in Japan and Japanese-Americans in Hawaii: The INTERLIPID Study. (2010)
  • Author(s): Nakamura Y, Ueshima H, Okuda N, Murakami Y, Miura K, Kita Y, Okamura T, Turin TC, Okayama A, Rodriguez BL, Curb JD, Stamler J.
  • Organizer: AHA Joint Conference 50th Cardiovascular Disease Epidemiology and Prevention- and- Nutrition, Physical Activity and Metabolism
  • Place of Presentation: San Francisco
• [Presentation] Factors associated with heart failure and coronary heart disease mortality during 24-years follow-up in Japan : NIPPON DATA80. (2009)
  • Author(s): 中村保幸
  • Organizer: European Society of Cardiology
  • Place of Presentation: バルセロナ
  • Year and Date: 2009-09-02
• [Presentation] Relation of dietary and other lifestyle traits to difference in serum leptin level of Japanese in Japan and Japanese-Americans in Hawaii : The INTERLIPID Study (2009)
  • Author(s): 中村保幸
  • Organizer: AHA Cardiovascular Epidemiology
  • Place of Presentation: Tampa. Florida
  • Year and Date: 2009-03-13
• [Presentation] Relation of Dietary and Other Lifestyle Traits to 5 Difference in Serum Leptin Level of Japanese in Japan and Japanese-Americans in Hawaii: The INTERLIPID Study (2009)
  • Author(s): Nakamura Y, Ueshima H, Okuda N, Miura K, Kita Y, Okamura T, Turin TC, Okayama A, Rodriguez BL, Curb JD, Stamler J.
  • Organizer: 49th Cardiovascular Disease Epidemiology and Prevention Conference 2009
  • Place of Presentation: Innisbrook Resort and Golf Club, Palm Harbor, Florida
• [Presentation] Risk Factors for Heart Failure and Coronary Heart Disease Mortality during 24-Years Follow-up in Japan: NIPPON DATA80 (2009)
  • Author(s): Nakamura Y, Tanvir C Turin, Rumana N, Miura K, Kita Y, Naoyuki Takashima, Hayakawa T, Okamura T, Ueshima H.
  • Organizer: 17th Asian Pacific Congress of Cardiology
  • Place of Presentation: Kyoto
• [Presentation] Factors associated with heart failure and coronary heart disease mortality during 24-years follow-up in Japan: NIPPON DATA80. (2009)
  • Author(s): Nakamura Y, Tanvir C Turin, Rumana N, Miura K, Kita Y, Takashima N, Hayakawa T, Okamura T, Ueshima H.
  • Organizer: European Society of Cardiology Congress 2009
  • Place of Presentation: Barcelona
• [Presentation] Visceral and subcutaneous adiposity and serum adiponec-tin in middle-aged Japanese men : the ERA JUMP study (2008)
  • Author(s): 中村保幸
  • Organizer: European Society of Cardiology
  • Place of Presentation: ミュンヘン
  • Year and Date: 2008-09-03
• [Presentation] Alcohol Intake and 19-Year Mortality in Diabetic Men: NIPPON DATA80 (2008)
  • Author(s): Nakamura Y, Ueshima H, Kadota A, Atsushi Hozawa, Okamura T, Sayaka Kadowaki, Kadowaki T, Hayakawa T, Kita Y, Abbott RD, Okayama A.
  • Organizer: 48th Cardiovascular Disease Epidemiology and Prevention- and- Nutrition, Physical Activity, and Metabolism Conference-
  • Place of Presentation: Colorado Springs, Colo.
• [Presentation] Marine-Derived n-3 Fatty Acids and Atherosclerosis in Japanese, Japanese Americans, and Whites. (2008)
  • Author(s): Sekikawa A, Curb JD, Ueshima H, El-Saed A, Kadowaki T, Abbott RD, Evans RW, Rodriguez BL, Okamura T, Sutton-Tyrrell K, Nakamura Y, Masaki K, Edmundowicz D, Kashiwagi A, Willcox BJ, Takamiya T, Mitsunami K, Seto TB, Murata K, White RJ, Kuller LH.
  • Organizer: 48th Cardiovascular Disease Epidemiology and Prevention- and- Nutrition, Physical Activity, and Metabolism Conference-
  • Place of Presentation: Colorado Springs, Colo.
• [Presentation] Visceral and subcutaneous adiposity and serum adiponectin in middle-aged Japanese men: the ERA JUMP study. (2008)
  • Author(s): Nakamura Y, Sekikawa A, Kadowaki T, Kadota A, Kadowaki S, Maegawa T, Evans RW, Edmondowicz D, J Curb D, Ueshima H.
  • Organizer: European Society of Cardiology Congress 2008
  • Place of Presentation: Munich, Germany
• [Presentation] A Japanese Diet and 19-Year Mortality: NIPPON DATA80. (2007)
  • Author(s): Nakamura Y(1), 他7名
  • Organizer: American Heart Association
  • Place of Presentation: Orland, FL、 USA
  • Year and Date: 2007-11-05
• [Presentation] A Japanese Diet and 19-Year Mortality: NIPPON DATA80. (2007)
  • Author(s): Nakamura Y, Ueshima H, Okamura T. Kadowaki T, Hayakawa T, Kita Y, Abbott RD, Okayama A, for NIPPON DATA80 Research Group.
  • Organizer: American Heart Association Scientific Sessions 2007
  • Place of Presentation: Orland, FL
• [Book] NIPPON DATAからみた循環器疾患のエビデンス (2008)
  • Author(s): 中村保幸, 他
  • Total Pages: 308
  • Publisher: 日本医事新報社
• [Book] 心筋梗塞症の疫学pp15-20 In吉野秀朗編「心筋梗塞症」 (2007)
  • Author(s): 中村保幸(分担)
  • Total Pages: 351
  • Publisher: メジカルビュー社、東京