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A study of adipocytokines and nutritional in Japanese-Americans in Hawaii and Japanese in Japan for prevention of atherosclerosis

Research Project

Project/Area Number 19590655
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionKyoto Women's University

Principal Investigator

NAKAMURA Yasuyuki  Kyoto Women's University, 家政学部, 教授 (20144371)

Co-Investigator(Kenkyū-buntansha) 上島 弘嗣  滋賀医科大学, 医学部, 教授 (70144483)
岡村 智教  国立循環器病センター, 研究所, 部長 (00324567)
喜多 義邦  滋賀医科大学, 医学部, 助教 (80161462)
Co-Investigator(Renkei-kenkyūsha) UESHIMA Hirotsugu  滋賀医科大学, 医学部, 特任教授 (70144483)
OKAMURA Tomonori  国立循環器病センター, 予防検診部, 部長 (00324567)
KITA Yoshikuni  滋賀医科大学, 医学部, 助教 (80161462)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords動脈硬化 / アディポネクチン / レプチン / 栄養疫学 / 国際共同研究 / アディポサイトカイン / 日系ハワイ人 / 生活習慣 / 肥満 / 地域住民 / 疫学研究
Research Abstract

Differences in adipocytokines between Japanese in Japan and Japanese in Hawaii were largely related to differences in BMI and physical activity in men. In women, specific dietary factors (protein, n-3 PUFA, iron, fiber, alcohol) played some roles in addition.
BMI and log-leptin related significantly and independently to SBP and DBP. These findings are concordant with the inference that leptin is an independent mediator for obesity related adverse BP levels

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (33 results)

All 2010 2009 2008 2007 Other

All Journal Article (18 results) (of which Peer Reviewed: 17 results) Presentation (13 results) Book (2 results)

  • [Journal Article]2010

    • Author(s)
      中村保幸, 他
    • Journal Title

      高コレステロール血症で期江戸肥満の54歳男性「ケースで学ぶ栄養管理の思考プロセス」(In田中清、松末智、本田佳子編)(文光堂)

      Pages: 83-92

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Visceral and Subcutaneous Adiposity and Adiponectin in Middle-aged Japanese Men: The ERA JUMP Study.2009

    • Author(s)
      Nakamura Y, Sekikawa A, Kadowaki T, Kadota A, Kadowaki S, Maegawa H, Kita Y, Evans RW, Edmundowicz D, Curb JD, Ueshima H.
    • Journal Title

      Obesity 17(6)

      Pages: 1269-73

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A Japanese diet and 19-year mortality: NIPPON DATA80.2009

    • Author(s)
      Nakamura Y, Ueshima H, Okamura T, Kadowaki T, Hayakawa T, Kita Y, Robert D Abbott RD, Okayama A.
    • Journal Title

      Brit J Nutr 101

      Pages: 1696-1705

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dietary Habits in Middle Age and Future Changes in Activities of Daily Living-NIPPON DATA80.2009

    • Author(s)
      Nakamura Y, Hozawa A, Turin TC, Takashima N, Okamura T, Hayakawa T, Kita Y, Okayama A, Miura K, Ueshima H.
    • Journal Title

      Gerontology 55(6)

      Pages: 707-13

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relation of Serum Leptin to Blood Pressure of Japanese in Japan and Japanese-Americans in Hawaii: The INTERLIPID Study.2009

    • Author(s)
      Nakamura Y, Ueshima H, Okuda N, Murakami Y, Miura K, Kita Y, Okamura T, Turin TC, Rodriguez B, Curb JD, Stamler J.
    • Journal Title

      Hypertension 54(6)

      Pages: 1416-22

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Visceral and Subcutaneous Adiposity and Adiponectin in Middle-aged Japanese Men : The ERA JUMP Study.2009

    • Author(s)
      Nakamura Y(1), 他10名
    • Journal Title

      Obesity 17

      Pages: 1269-73

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Japanese diet and 19-year mortality : NIPPON DATA802009

    • Author(s)
      Nakamura Y(1), 他8名
    • Journal Title

      Brit J Nutr 101:

      Pages: 1696-1705

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relation of Serum Leptin to Blood Pressure of Japanese in Japan and Japanese in Japan and Japanese-Americans in Hawaii : The INTERLIPID Study.2009

    • Author(s)
      Nakamura Y(1), 他10名
    • Journal Title

      Hypertension 54

      Pages: 1416-22

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relation of dietary and other lifestyle traits to difference in serum adiponectin level of Japanese in Japan and Hawaii: The INTERLIPID Study.2008

    • Author(s)
      Nakamura Y, Ueshima H, Okuda N, Higashiyama A, Kita Y, Kadowaki T, Okamura T, Murakami Y, Okayama A, Choudhury SR, Rodriguez B, Curb JD, Stamler J.
    • Journal Title

      Am J Clin Nutr 88

      Pages: 424-30

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relation of dietary and other lifestyle traits to difference in serum adiponectin level of Japanese in Japan and Hawaii : The INTERLIPID study.2008

    • Author(s)
      Nakamura Y(1), 他11名
    • Journal Title

      Am J Clin Nutr 88

      Pages: 424-430

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cause-specific and all-cause mortality in individuals with low risk status for cardiovascular disease in the Japanese population, NIPPON DATA80.2008

    • Author(s)
      Nakamura Y(2), 他10名
    • Journal Title

      Circ J 72

      Pages: 545-550

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Risk Factor Effects and Total Mortality in Older Japanese Men in Japan and Hawaii.2008

    • Author(s)
      Nakamura Y(8), 他12名
    • Journal Title

      Annal Epidem 18

      Pages: 913-918

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Higher stroke incidence in the spring season regardless of conventionalrisk factors: Takashima Stroke Registry, Japan, 1988-20012008

    • Author(s)
      Turin TC(1), Nakamura Y(9), 他8名
    • Journal Title

      Stroke 39・3

      Pages: 745-752

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Associations of Obesity Measures with the Metabolic Risk Factors in a Community-based Population in Japan2007

    • Author(s)
      Nakamura Y(1), 他8名
    • Journal Title

      Circ J 71・5

      Pages: 776-781

    • NAID

      110006273619

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between metabolic risk factor clustering and cardiovascularmortality stratified by high blood glucose and obesity: NIPPON DATA90, 1990-20002007

    • Author(s)
      Kadota A(1), Nakamura Y(10), 他10名
    • Journal Title

      Diabetes Care 30・6

      Pages: 1533-1538

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alcohol consumption, alcohol-induced flushing and incidence of acutemyocardial infarction among middle-aged men in Japan-Japan Public Health Center-based prospective study.2007

    • Author(s)
      Nakamura Y(1), 他7名
    • Journal Title

      Atherosclerosis 194・2

      Pages: 512-516

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fish consumption and early atherosclerosis in middle-aged men.2007

    • Author(s)
      Nakamura Y(1), 他11名
    • Journal Title

      Metabolism 56・8

      Pages: 1060-1064

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relation of dietary and lifestyle traits to difference in serum leptin of Japanese in Japan and Hawaii: The INTERLIPID Study.

    • Author(s)
      Nakamura Y, Ueshima H, Okuda N, Murakami Y, Miura K, Kita Y, Okamura T, Turin TC, Okayama A, Rodriguez B, Curb JD, Stamler J.
    • Journal Title

      Nutrition, Metabolism and Cardiovascular Diseases (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Presentation] Relation of Serum Leptin to Blood Pressure and Total Dietary Energy Intake of Japanese in Japan and Japanese-Americans in Hawaii : The INTERLIPID Study.2010

    • Author(s)
      中村保幸
    • Organizer
      AHA Cardiovascular Epidemiology
    • Place of Presentation
      サンフランシスコ
    • Year and Date
      2010-03-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] Relation of Serum Leptin to Blood Pressure and Total Dietary Energy Intake of Japanese in Japan and Japanese-Americans in Hawaii: The INTERLIPID Study.2010

    • Author(s)
      Nakamura Y, Ueshima H, Okuda N, Murakami Y, Miura K, Kita Y, Okamura T, Turin TC, Okayama A, Rodriguez BL, Curb JD, Stamler J.
    • Organizer
      AHA Joint Conference 50th Cardiovascular Disease Epidemiology and Prevention- and- Nutrition, Physical Activity and Metabolism
    • Place of Presentation
      San Francisco
    • Related Report
      2009 Final Research Report
  • [Presentation] Factors associated with heart failure and coronary heart disease mortality during 24-years follow-up in Japan : NIPPON DATA80.2009

    • Author(s)
      中村保幸
    • Organizer
      European Society of Cardiology
    • Place of Presentation
      バルセロナ
    • Year and Date
      2009-09-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] Relation of dietary and other lifestyle traits to difference in serum leptin level of Japanese in Japan and Japanese-Americans in Hawaii : The INTERLIPID Study2009

    • Author(s)
      中村保幸
    • Organizer
      AHA Cardiovascular Epidemiology
    • Place of Presentation
      Tampa. Florida
    • Year and Date
      2009-03-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] Relation of Dietary and Other Lifestyle Traits to 5 Difference in Serum Leptin Level of Japanese in Japan and Japanese-Americans in Hawaii: The INTERLIPID Study2009

    • Author(s)
      Nakamura Y, Ueshima H, Okuda N, Miura K, Kita Y, Okamura T, Turin TC, Okayama A, Rodriguez BL, Curb JD, Stamler J.
    • Organizer
      49th Cardiovascular Disease Epidemiology and Prevention Conference 2009
    • Place of Presentation
      Innisbrook Resort and Golf Club, Palm Harbor, Florida
    • Related Report
      2009 Final Research Report
  • [Presentation] Risk Factors for Heart Failure and Coronary Heart Disease Mortality during 24-Years Follow-up in Japan: NIPPON DATA802009

    • Author(s)
      Nakamura Y, Tanvir C Turin, Rumana N, Miura K, Kita Y, Naoyuki Takashima, Hayakawa T, Okamura T, Ueshima H.
    • Organizer
      17th Asian Pacific Congress of Cardiology
    • Place of Presentation
      Kyoto
    • Related Report
      2009 Final Research Report
  • [Presentation] Factors associated with heart failure and coronary heart disease mortality during 24-years follow-up in Japan: NIPPON DATA80.2009

    • Author(s)
      Nakamura Y, Tanvir C Turin, Rumana N, Miura K, Kita Y, Takashima N, Hayakawa T, Okamura T, Ueshima H.
    • Organizer
      European Society of Cardiology Congress 2009
    • Place of Presentation
      Barcelona
    • Related Report
      2009 Final Research Report
  • [Presentation] Visceral and subcutaneous adiposity and serum adiponec-tin in middle-aged Japanese men : the ERA JUMP study2008

    • Author(s)
      中村保幸
    • Organizer
      European Society of Cardiology
    • Place of Presentation
      ミュンヘン
    • Year and Date
      2008-09-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] Alcohol Intake and 19-Year Mortality in Diabetic Men: NIPPON DATA802008

    • Author(s)
      Nakamura Y, Ueshima H, Kadota A, Atsushi Hozawa, Okamura T, Sayaka Kadowaki, Kadowaki T, Hayakawa T, Kita Y, Abbott RD, Okayama A.
    • Organizer
      48th Cardiovascular Disease Epidemiology and Prevention- and- Nutrition, Physical Activity, and Metabolism Conference-
    • Place of Presentation
      Colorado Springs, Colo.
    • Related Report
      2009 Final Research Report
  • [Presentation] Marine-Derived n-3 Fatty Acids and Atherosclerosis in Japanese, Japanese Americans, and Whites.2008

    • Author(s)
      Sekikawa A, Curb JD, Ueshima H, El-Saed A, Kadowaki T, Abbott RD, Evans RW, Rodriguez BL, Okamura T, Sutton-Tyrrell K, Nakamura Y, Masaki K, Edmundowicz D, Kashiwagi A, Willcox BJ, Takamiya T, Mitsunami K, Seto TB, Murata K, White RJ, Kuller LH.
    • Organizer
      48th Cardiovascular Disease Epidemiology and Prevention- and- Nutrition, Physical Activity, and Metabolism Conference-
    • Place of Presentation
      Colorado Springs, Colo.
    • Related Report
      2009 Final Research Report
  • [Presentation] Visceral and subcutaneous adiposity and serum adiponectin in middle-aged Japanese men: the ERA JUMP study.2008

    • Author(s)
      Nakamura Y, Sekikawa A, Kadowaki T, Kadota A, Kadowaki S, Maegawa T, Evans RW, Edmondowicz D, J Curb D, Ueshima H.
    • Organizer
      European Society of Cardiology Congress 2008
    • Place of Presentation
      Munich, Germany
    • Related Report
      2009 Final Research Report
  • [Presentation] A Japanese Diet and 19-Year Mortality: NIPPON DATA80.2007

    • Author(s)
      Nakamura Y(1), 他7名
    • Organizer
      American Heart Association
    • Place of Presentation
      Orland, FL、 USA
    • Year and Date
      2007-11-05
    • Related Report
      2007 Annual Research Report
  • [Presentation] A Japanese Diet and 19-Year Mortality: NIPPON DATA80.2007

    • Author(s)
      Nakamura Y, Ueshima H, Okamura T. Kadowaki T, Hayakawa T, Kita Y, Abbott RD, Okayama A, for NIPPON DATA80 Research Group.
    • Organizer
      American Heart Association Scientific Sessions 2007
    • Place of Presentation
      Orland, FL
    • Related Report
      2009 Final Research Report
  • [Book] NIPPON DATAからみた循環器疾患のエビデンス2008

    • Author(s)
      中村保幸, 他
    • Total Pages
      308
    • Publisher
      日本医事新報社
    • Related Report
      2008 Annual Research Report
  • [Book] 心筋梗塞症の疫学pp15-20 In吉野秀朗編「心筋梗塞症」2007

    • Author(s)
      中村保幸(分担)
    • Total Pages
      351
    • Publisher
      メジカルビュー社、東京
    • Related Report
      2007 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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