Association of sleep apnea with metabolic syndrome and cardiovascular risk factors in a general population

• Project/Area Number: 19590662
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: KOKUBO Yoshihiro National Cardiovascular Center Research Institute, 予防検診部, 医長 (20393217)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 睡眠呼吸障害 / 循環器・高血圧 / 代謝症候群 / 血小板凝集能 / 睡眠時呼吸障害 / 循環器疾患 / 動脈硬化 / 炎症反応 / 危険因子 / 肥満指数

Research Abstract

都市部一般住民に対してパルスオキシメトリー検査を実施し、無呼吸低呼吸回数を正常群、軽症群、中程度以上群に分類した。軽症群、中程度群以上はそれぞれ男性で42%、22%、女性で25%、5%であった。睡眠時呼吸障害は、血圧上昇、動脈硬化、炎症反応、肥満、メタボリックシンドロームと関連性が認められ、睡眠時呼吸障害を有している者に対して早期発見することが、動脈硬化、高血圧の予防につながりうると考えられた。

Research Products

• [Journal Article] The Relationship between Waist Circumference and the Risk of Stroke and Myocardial Infarction in a Japanese Urban Cohort : The Suita Study (2010)
  • Author(s): Furukawa Y, Kokubo Y, Okamura T, Watanabe M, Higashiyama A, Ono Y, Kawanishi K, Okayama A, Date C.
  • Journal Title: Stroke 41(in press)
• [Journal Article] The Relationships of Oral Glucose Tolerance Test With All-cause Mortality and Cardiovascular Diseases Mortality in a Prospective Urban Japanese Population : The Suita Study (2009)
  • Author(s): Kokubo Y, Okamura T, Watanabe W, Higashiyama A, Ono Y, Makino H, Miyamoto Y, Furukawa Y, Yoshimasa Y.
  • Journal Title: Circulation 120
• [Journal Article] Association of Carotid Atherosclerosis With Genetic Polymorphisms of Klotho Gene in Patients With Hypertension and in the General Population (2009)
  • Author(s): Oguro R, Kamide K, Kokubo Y, Shimaoka I, Congrains A, Ohishi M, Okamura T, Miyata T, Kawano Y, Rakugi H.
  • Journal Title: Circulation 120
• [Journal Article] Risk of smoking and metabolic syndrome for incidence of cardiovascular disease--comparison of relative contribution in urban Japanese population : the Suita study (2009)
  • Author(s): Higashiyama A, Okamura T, Ono Y, Watanabe M, Kokubo Y, Okayama A.
  • Journal Title: Circ J. 73 Pages: 2258-63
  • NAID: 10025938243
• [Journal Article] Triglycerides and non-high-density lipoprotein cholesterol and the incidence of cardiovascular disease in an urban Japanese cohort : The Suita study (2009)
  • Author(s): Okamura T, Kokubo Y, Watanabe M, Higashiyama A, Ono Y, Miyamoto Y, Yoshimasa Y, Okayama A.
  • Journal Title: Atherosclerosis (in press)
• [Journal Article] High-normal blood pressure and the risk of cardiovascular disease (2009)
  • Author(s): Kokubo Y, Kamide K.
  • Journal Title: Circ J. 73 Pages: 1381-5
  • NAID: 10025933245
• [Journal Article] Elevated serum creatine kinase predicts first-ever myocardial infarction : a 12-year population-based cohort study in Japan, the Suita study (2009)
  • Author(s): Watanabe M, Okamura T, Kokubo Y, Higashiyama A, Okayama A.
  • Journal Title: Int J Epidemiol 38 Pages: 1571-9
• [Journal Article] Association study of 11beta-hydroxysteroid dehydrogenase type 1 gene polymorphisms and metabolic syndrome in urban Japanese cohort (2009)
  • Author(s): Miyamoto Y, Morisaki H, Yamanaka I, Kokubo Y, Masuzaki H, Okayama A, Tomoike H, Nakao K, Okamura T, Yoshimasa Y, Morisaki T.
  • Journal Title: Diabetes Res Clin Pract 85 Pages: 132-8
• [Journal Article] Relationship between blood pressure category and incidence of stroke and myocardial infarction in an urban Japanese population with and without chronic kidney disease : the Suita (2009)
  • Author(s): Kokubo Y, Nakamura S, Okamura T, Yoshimasa Y, Makino H, Watanabe M, Higashiyama A, Kamide K, Kawanishi K, Okayama A, Kawano Y.
  • Journal Title: Stroke 40 Pages: 2674-9
• [Journal Article] Prognostic value of plasma high-sensitivity C-reactive protein levels in Japanese patients with stable coronary artery disease : the Japan NCVC-Collaborative Inflammation Cohort (JNIC) Study (2009)
  • Author(s): Momiyama Y, Kawaguchi A, Kajiwara I, Ohmori R, Okada K, Saito I, Konishi M, Nakamura M, Sato S, Kokubo Y, Mannami T, Adachi H, Kario K, Iso H, Ohsuzu F, Tsushima M.
  • Journal Title: Atherosclerosis 207 Pages: 272-6
• [Journal Article] Identification of genetic markers associated with high-density lipoprotein-cholesterol by genome-wide screening in a Japanese population : the Suita study (2009)
  • Author(s): Hiura Y, Shen CS, Kokubo Y, Okamura T, Morisaki T, Tomoike H, Yoshida T, Sakamoto H, Goto Y, Nonogi H, Iwai N.
  • Journal Title: Circ J. 73 Pages: 1119-26
  • NAID: 10025931682
• [Journal Article] Metabolic syndrome and all-cause and cardiovascular disease mortality : Japan Public Health Center-based Prospective (JPHC) Study (2009)
  • Author(s): Saito I, Iso H, Kokubo Y, Inoue M, Tsugane S.
  • Journal Title: Circ J. 73 Pages: 878-84
  • NAID: 10025930280
• [Journal Article] Low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol and the incidence of cardiovascular disease in an urban Japanese cohort study : The Suita Study (2009)
  • Author(s): Okamura T, Kokubo Y, Watanabe M, Higashiyama A, Miyamoto Y, Yoshimasa Y, Okayama A.
  • Journal Title: Atherosclerosis 203 Pages: 587-92
• [Journal Article] Low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol and the incidence of cardiovascular disease in an urban Japanese cohort study : The Suita study (2009)
  • Author(s): Okamura T, Kokubo Y, Watanabe M, Higashiyama A, Miyamoto Y, Yoshimasa Y, Okayama A.
  • Journal Title: Atherosclerosis 203 Pages: 587-92
  • Peer Reviewed
• [Journal Article] Validation of the association of genetic variants on chromosome 9p21 and 1q41 with myocardial infarction in a Japanese population (2008)
  • Author(s): Hiura Y, Fukushima Y, Yuno M, Sawamura H, Kokubo Y, Okamura T, Tomoike H, Goto Y, Nonogi H, Takahashi R, Iwai N.
  • Journal Title: Circ J. 72 Pages: 1213-7
  • NAID: 110006835717
• [Journal Article] Impact of high-normal blood pressure on the risk of cardiovascular disease in a Japanese urban cohort : The Suita Study (2008)
  • Author(s): Kokubo Y, Kamide K, Okamura T, Watanabe M, Higashiyama A, Kawanishi K, Okayama A, Kawano Y.
  • Journal Title: Hypertension 52 Pages: 652-9
• [Journal Article] Impact of metabolic syndrome components on the incidence of cardiovascular disease in a general urban Japanese population : The Suita Study (2008)
  • Author(s): Kokubo Y, Okamura T, Yoshimasa Y, Miyamoto Y, Kawanishi K, Kotani Y, Okayama A, Tomoike H.
  • Journal Title: Hypertens Res. 31 Pages: 2027-35
  • NAID: 10024828065
• [Journal Article] Leptin gene and leptin receptor gene polymorphisms are associated with sweet preference and obesity (2008)
  • Author(s): Mizuta E, Kokubo Y, Yamanaka I, Miyamoto Y, Okayama A, Yoshimasa Y, Tomoike H, Morisaki H, Morisaki T.
  • Journal Title: Hypertens Res. 31 Pages: 1069-77
  • NAID: 10021936190
• [Journal Article] Associations of hypertension and its complications with variations in the xanthine dehydrogenase gene (2008)
  • Author(s): Yang J, Kamide K, Kokubo Y, Takiuchi S, Horio T, Matayoshi T, Yasuda H, Miwa Y, Yoshii M, Yoshihara F, Nakamura S, Nakahama H, Tomoike H, Miyata T, Kawano Y.
  • Journal Title: Hypertens Res. 31 Pages: 931-40
  • NAID: 10021935610
• [Journal Article] メタボリックシンドロームの概要と現状 (2008)
  • Author(s): 小久保喜弘
  • Journal Title: 生物試料分析 31 Pages: 167-173
• [Journal Article] メタボリックシンドローム予防の教材を用いた実践的プログラム (2008)
  • Author(s): 小久保喜弘
  • Journal Title: 東京内科医会会誌 24 Pages: 30-37
• [Journal Article] 吹田研究 : 都市部一般住民を対象とした循環器疾患リスクの解明 (2008)
  • Author(s): 小久保喜弘
  • Journal Title: 医学のあゆみ 224 Pages: 127-131
• [Journal Article] Impact of high-normal blood pressure on the risk of cardiovascular disease in a Japanese urban cohort : the Suita study (2008)
  • Author(s): Kokubo Y, Kamide K, Okamura T, Watanabe M, Higashiyama A, Kawanishi K, Okayama A, Kawano Y.
  • Journal Title: Hypertension 52 Pages: 652-9
  • Peer Reviewed
• [Journal Article] Impact of metabolic syndrome components on the incidence of cardiovascular disease in a general urban Japanese population : the Suita Study (2008)
  • Author(s): Kokubo Y, Okamura T, Yoshimasa Y, Miyamoto Y, Kawanishi K, Kotani Y, Okayama A, Tomoike H.
  • Journal Title: Hypertens Res 31 Pages: 2027-35
  • NAID: 10024828065
  • Peer Reviewed
• [Journal Article] Protein tyrosine kinase 2beta as a candidate gene for hypertension. (2007)
  • Author(s): Kamide K, Kokubo Y, et. al.
  • Journal Title: Pharmacogenet Genomics. 17 Pages: 931-939
  • Peer Reviewed
• [Journal Article] Age-and gender-related differences of plasma prothrombin activity levels. (2007)
  • Author(s): Sakata T, Okamoto A, Morita T, Kokubo Y, et. al.
  • Journal Title: Thromb Haemost. 97 Pages: 1052-1053
  • Peer Reviewed
• [Journal Article] Sex hormone and gender difference-role of testosterone on male predominance in Brugada syndrome. (2007)
  • Author(s): Shimizu W, Matsuo K, Kokubo Y, et. al.
  • Journal Title: J Cardiovasc Electrophysiol. 18 Pages: 15-21
  • Peer Reviewed
• [Presentation] 高血圧への遺伝素因の関与 疫学研究による家族歴から (2009)
  • Author(s): 小久保喜弘
  • Organizer: 血圧
• [Presentation] 都市部一般住民を対象とした空腹時血糖レベル別にみた血圧と循環器疾患発症との関連 吹田研究での12年間の追跡から (2009)
  • Author(s): 小久保喜弘, 岡村智教, 渡邉至, 東山綾, 宮本恵宏, 小野優, 古川曜子, 川西克幸, 岡山明, 吉政康直
  • Organizer: 日本循環器病予防学会誌
• [Presentation] 都市部一般住民における慢性腎疾患と循環器疾患発症との追跡研究 吹田研究 (2009)
  • Author(s): 小久保喜弘, 中村敏子, 槇野久士, 河野雄平
  • Organizer: 日本腎臓学会誌
• [Presentation] 2型糖尿病患者における血中脳性ナトリウムペプチド (BNP) と糖尿病関連因子の関係 (2009)
  • Author(s): 杉沢貴子, 岸本一郎, 小久保喜弘, 南雲彩子, 槇野久士, 宮本恵宏, 吉政康直
  • Organizer: 糖尿病
• [Presentation] 心不全血中 marker に及ぼすインスリン抵抗性と Adipocytokine の影響 吹田研究データの解析 (2009)
  • Author(s): 岸本一郎, 杉沢貴子, 小久保喜弘, 南雲彩子, 槙野久士, 宮本恵宏, 吉政康直
  • Organizer: 日本内科学会雑誌
• [Presentation] 都市部一般住民における血中脳性ナトリウムペプチド (BNP) と肥満指数の関係 吹田研究データの解析 (2009)
  • Author(s): 杉沢貴子, 岸本一郎, 小久保喜弘, 槙野久士, 宮本恵宏, 吉政康直
  • Organizer: 日本内科学会雑誌
• [Presentation] 都市部一般住民を対象とした睡眠呼吸障害の臨床像に関する断面研究 吹田研究(会議録) (2008)
  • Author(s): 小久保喜弘, 岡村智教, 渡邉至, 東山綾, 古川曜子, 川西克幸, 小谷泰, 谷川武
  • Organizer: 第67回日本公衆衛生学会総会
  • Place of Presentation: 福岡(福岡国際会議場)
  • Year and Date: 2008-11-06
• [Presentation] 日本人における薬物代謝酵素CYP2C9の新規遺伝子多型の機能解析及びロサルタンの血圧降下作用に対する影響 (2008)
  • Author(s): 前川京子, YinTong, 神出計, 斎藤嘉朗, 原川則子, 小久保喜弘, 河野雄平, 峰松一夫, 成冨博章, 宮田敏行, 澤田純一
  • Organizer: 日本薬学会年会要旨集
• [Presentation] 都市部一般住民を対象とした睡眠呼吸障害の臨床像に関する断面研究 吹田研究 (2008)
  • Author(s): 小久保喜弘, 岡村智教, 渡邉至, 東山綾, 古川曜子, 川西克幸, 小谷泰, 谷川武
  • Organizer: 日本公衆衛生学会総会抄録集
• [Presentation] 日本人の血栓症の遺伝的背景に関する調査研究 (2008)
  • Author(s): 宮田敏行, 川崎富夫, 辻肇, 窓岩清治, 坂田洋一, 小嶋哲人, 村田満, 阪田敏幸, 竹下聡, 小久保喜弘, 本田繁則, 小亀浩市, 岡田浩美, 池田康夫
  • Organizer: 臨床血液
• [Presentation] 先天性プロテインCおよびアンチトロンビン欠乏症における動静脈血栓症発症リスクの比較 (2008)
  • Author(s): 阪田敏幸, 岡本章, 小久保喜弘, 塘義明, 竹下聡, 佐野道孝, 苅尾七臣, 宮田敏行
  • Organizer: 日本血栓止血学会誌
• [Presentation] 一般住民を対象としたADAMTS13遺伝子の変異検索 (2008)
  • Author(s): 小亀浩市, 小久保喜弘, 宮田敏行
  • Organizer: 日本血栓止血学会誌
• [Presentation] 先天性アンチトロンビン欠乏症のフェノタイプによる静脈血栓症発症リスクの違い (2008)
  • Author(s): 阪田敏幸, 岡本章, 小久保喜弘, 塘義明, 竹下聡, 佐野道孝, 宮田敏行
  • Organizer: 日本血栓止血学会誌
• [Presentation] PTPN1遺伝子多型は日本人の肥満発症及び減量効果に関連する (2008)
  • Author(s): 佐藤哲子, 宮本恵宏, 森崎裕子, 山中到, 嶋田清香, 島津章, 小久保喜弘, 岡村智教, 吉政康直, 森崎隆幸
  • Organizer: 肥満研究
• [Presentation] 2型糖尿病患者の血中B型ナトリウムペプチド (BNP) 濃度に及ぼす肥満の影響 (2008)
  • Author(s): 岸本一郎, 杉沢貴子, 小久保喜弘, 南雲彩子, 槇野久士, 宮本恵宏, 吉政康直
  • Organizer: 肥満研究
• [Presentation] 2型糖尿病患者の血中脳性ナトリウムペプチド (BNP) に及ぼす体格指数 (BMI) と腹部脂肪面積の影響 (2008)
  • Author(s): 杉沢貴子, 岸本一郎, 小久保喜弘, 南雲彩子, 槇野久士, 宮本恵宏, 吉政康直
  • Organizer: 糖尿病
• [Presentation] 都市部一般住民を対象とした血圧カテゴリー別の空腹時血糖と循環器疾患との関係に関する12年追跡研究 吹田研究
  • Author(s): 小久保喜弘, 岡村智教, 渡邉至, 東山綾, 槇野久士, 宮本恵宏, 神出計, 古川曜子, 川西克幸, 小谷泰, 岡山明, 吉政康直
  • Organizer: 糖尿病