Toxicokinetics of organophosphorus insecticide-Development and application of the analytical method for the metabolites by CE-MS-
| Project/Area Number |
19590678
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Legal medicine
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
FUKE Chiaki University of the Ryukyus, 医学部, 准教授 (60173374)
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| Research Collaborator |
NOGUTI Masamiti 琉球大学, 大学院・医学研究科
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | キャピラリー電気泳動質量分析法 / 有機リン系農薬 / 代謝物 / 生体試料 / 中毒 |
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| Research Abstract |
We developed a determination method for the dialkylphosphates (DAPs), metabolites of organophosphate insecticides, using capillary electrophoresis/mass spectrometer (CE/MS) and applied this method to serum and urine collected from poisoned patients with organophosphate insecticide. The 7 DAPs were detected by CE-MS. In all of 29 caces of organophosphate insecticide poisoning, the expected DAPs were detected using this method. O,S-DMTP was also detected. The phosphate type and single or mix formulation of ingested organophosphate insecticide could be distinguished by determination of DAPs. There was a relation between DMP concentration in the serum and the degree of toxic symptoms.
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Report
(4 results)
Research Products
(4 results)
