Rapid screening method for drug and poisonous substances by direct mass spectrometry

• Project/Area Number: 19590687
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Legal medicine
• Research Institution: National Research Institute of Police Science
• Principal Investigator: INOUE Hiroyuki National Research Institute of Police Science, 法科学第三部, 室長 (40159992)
• Co-Investigator(Kenkyū-buntansha): 岩田 祐子 (岩田 佑子) 科学警察研究所, 法科学第三部, 主任研究官 (20356190)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2007: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 乱用薬物 / スクリーニング / 質量分析計 / 尿 / 覚せい剤 / MDMA / 医薬品 / 法中毒学

Research Abstract

:直接導入型質量分析計を用いて、エクスタシー錠(MDMA含有錠剤、アンフェタミン及びカフェイン含有錠剤等)や医薬品錠剤(アセトアミノフェン、ジアゼパム等含有)中の成分を迅速に判定する手法を開発した。
また、薬物添加尿についても適用可能であった。本法は、遺留試料や尿試料からの薬毒物スクリーニング法として利用可能であると考えられた。
また、シルデナフィル関連化合物の分析法や覚せい剤の迅速な定量分析法を開発した。

Research Products

• [Journal Article] Simple and simultaneous detection of methamphetamine and dimethyl sulfone in crystalline methamphetamine seizures by fast gas chromatography (2008)
  • Author(s): Inoue, H., Kuwayama, K., Iwata, Y. T., Kanamori, T., Tsujikawa, K., Miyaguchi, H.
  • Journal Title: Forensic Toxicology 26 Pages: 19-22
  • Peer Reviewed
• [Journal Article] Characterization and Profiling of Methamphetamine Seizures (2008)
  • Author(s): Inoue, H., Iwata, Y. T., Kuwayama, K.
  • Journal Title: Journal of Health Science 54 Pages: 615-622
  • NAID: 110007005213
  • Peer Reviewed
• [Journal Article] Chemical profile of sildenafil and related compounds (2008)
  • Author(s): Inoue, H, et. al.
  • Journal Title: 日本法科学技術学会誌 13 Pages: 73-82
  • NAID: 130004942620
  • Peer Reviewed
• [Presentation] 警察関連領域における薬毒物鑑定 (2008)
  • Author(s): 井上博之
  • Organizer: 第1回関西中毒分析研究会
  • Place of Presentation: 大阪府吹田市
  • Year and Date: 2008-09-06
• [Presentation] Rapid and direct analysis of MDMA tablets by atmospheric pressure chemical ionization/ion-trap mass spectrometry (2008)
  • Author(s): Inoue, H., Hashimoto, H., Iwata, Y.T., Kanamori, T., Tsujikawa, K., Miyaguchi, H., Kuwayama, K
  • Organizer: 7^<th> International Symposium ADVANCES IN LEGAL MEDICINE
  • Place of Presentation: 大阪市
  • Year and Date: 2008-09-04
• [Presentation] Rapid and direct analysis of MDMA tablets by atmospheric pressure chemical ionization/ion-trap mass spectrometry (2008)
  • Author(s): Inoue, H., Hashimoto, H., Iwata, Y. T., Kanamori, T., Tsujikawa, K., Miyaguchi, H., Kuwayama, K.
  • Organizer: 7th International Symposium ADVANCES IN LEGAL MEDICINE
  • Place of Presentation: 大阪市
  • Year and Date: 2008-09-04
• [Presentation] 乱用薬物の分析に関する研究 (2008)
  • Author(s): 井上博之
  • Organizer: 日本法中毒学会第27年会
  • Place of Presentation: 東京都品川区
  • Year and Date: 2008-06-13
• [Presentation] Simple and simultaneous detection of methamphetamine and dimethyl sulfone in crystalline methamphetamine seizures by fast gas chromatography (2008)
  • Author(s): Inoue, H., Kuwayama, K., Iwata, Y.T., Kanamori, T., Tsujikawa, K., Miyaguchi, H
  • Organizer: 第46回国際法中毒学会
  • Place of Presentation: フランス領マルティニーク
  • Year and Date: 2008-06-06
• [Presentation] Simultaneous determination of methamphetamine and dimethyl sulfone in crystalline methamphetamine seizures by fast gas chromatography (2008)
  • Author(s): Inoue, H., Kuwayama, K., Iwata, Y.T., Kanamori, T., Tsujikawa, K., Miyaguchi, H
  • Organizer: Pittcon2008
  • Place of Presentation: 米国ニューオーリンズ
  • Year and Date: 2008-03-06
• [Presentation] Simultaneous detemination of methamphetamine and dimethyl sulfone in cstalline methamhetamine seizures by fast gas chromatoaphy (2008)
  • Author(s): Inoue, H, et. al.
  • Organizer: PITTCON2008
  • Place of Presentation: 米国、ニューオリンズ
  • Year and Date: 2008-03-05