Biological psycho-oncology study on cancer-related psychological stresses and tumor angiogenesis

• Project/Area Number: 19590688
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: Tohoku University
• Principal Investigator: EBIHARA Satoru Tohoku University, 病院, 助教 (90323013)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: ドーパミン / ドーパミントランスポーター / セロトニン / セロトニントランスポーター / 癌 / セロトニントランスポータ / eNOS / セロトニン2B受容体 / 血管新生 / せん妄 / 精神ストレス / 固形腫瘍 / VEGF / ドーパミンD1受容体

Research Abstract

人は癌を告知されたとき様々な精神状態となる。また、癌そのものによっても様々な精神状態をきたす。精神状態は神経伝達物質による神経活動によって規定されるがそのなかでも大きな役割を果たしているのはドーパミンとセロトニンである。そこでドーパミンとセロトニンの変化がどのように腫瘍に影響を与えるか遺伝子改変マウスにて解析した。今回の研究結果は癌患者のせん妄状態や抑うつ状態に対する対処法に示唆を与えるのみならず、新しい分子標的治療法の開発につながる。

Research Products

• [Journal Article] Caregiving Burden for the Oldest Old : A Population Based Study of Centenarian Caregivers in Northern Japan. (2009)
  • Author(s): Freeman S, Kurosawa H, Ebihara S, Kohzuki M
  • Journal Title: Arch Gerontol Geriatr (in press)
  • Peer Reviewed
• [Journal Article] Butler JP. Olfactory stimuli and enhanced postural stability in older adults (2009)
  • Author(s): Freeman S, Ebihara S, Ebihara T, Niu K, Kohzuki M, Arai H
  • Journal Title: Gait Posture(Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Role of ephrinB2 in non-productive angiogenesis induced by Delta-like 4 blockade (2009)
  • Author(s): Yamanda S, Ebihara S, Asada M, Okazaki T, Niu K, Ebihara T, Koyanagi A, Yamaguchi N, Yagita H, Arai H.
  • Journal Title: Blood(Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Depletion of serotonin and selective inhition of 2B receptor suppressed tumor angiogenesis by inhibiting endothelial NOS and ERK1/2 phosphorylation (2009)
  • Author(s): Asada M, Ebihara S, Yamanda S, Niu K, Okazaki T, Sora I and Arai H.
  • Journal Title: Neoplasia 11 Pages: 408-417
  • Peer Reviewed
• [Journal Article] Depletion of serotonin and selective inhibition of 2B receptor suppressed tumor angiogenesis by inhibiting (2009)
  • Author(s): Asada M, Ebihara S, Yama nda S, et.al.
  • Journal Title: Neoplasia 11 Pages: 408-417
  • Peer Reviewed
• [Journal Article] Impaired urge-to-cough in elderly patients with aspiration pneumonia (2008)
  • Author(s): Yamanda S, Ebihara S, Ebihara T, Yamasaki M, Asamura T, Asada M, Une K, Arai H
  • Journal Title: Cough 4 : 11
  • Peer Reviewed
• [Journal Article] Erythropoietin promotes the growth of tumors lacking its receptor and decreases survival of tumor-bearing mice by enhancing angiogenesis (2008)
  • Author(s): Okazaki T, Ebihara S, Asada M, Ymanda S, Niu K, Arai H.
  • Journal Title: Neoplasia 10 Pages: 932-939
  • Peer Reviewed
• [Journal Article] Prospects for health-systems research (2008)
  • Author(s): Ebihara S, Arai H
  • Journal Title: Lancet 7 Pages: 371-371
  • Peer Reviewed
• [Journal Article] Olfactory stimulation using black pepper oil facilitates oral feeding in pediatric patients receiving long-term enteral nutrition (2008)
  • Author(s): Munakata M, Kobayashi K, Niisato-Nezu J, Tanaka S, Kakisaka Y, Ebihara T, Ebihara S, Haginoya K, Tsuchiya S, Onuma A
  • Journal Title: Tohoku J Exp Med 214(4) Pages: 327-332
  • NAID: 10024167604
  • Peer Reviewed
• [Journal Article] Reduced tumor growth in a mouse model of shizophrenia, lacking the dopamine transporter (2008)
  • Author(s): Asada M, Ebihara S, Numachi Y, Okazaki T, Yamanda S, Ikeda K, Yasuda H, Sora I, Arai H
  • Journal Title: Int J Cancer 123(3) Pages: 511-518
  • Peer Reviewed
• [Journal Article] Serum C-reactive protein concentration is associated with physical performance even within very low range in a community-based elderly population aged 70 years and over (2008)
  • Author(s): Niu K, Hozawa A, Guo H, Kuriyama S, Ebihara S, Yamg G, Ohmori-Matsuda K, Nakaya N, Takahashi H, Fujita K, Wen S, Arai H, Tsuji I, Nagatomi R
  • Journal Title: Gerontology 54 Pages: 260-267
  • Peer Reviewed
• [Journal Article] Home blood pressure is associated with depressive symptoms among elderly population aged 70 years and over : a population-based (2008)
  • Author(s): Niu K, Hozawa A, Awata S, Guo H, Kuriyama S, Seki T, Ohmori-Matsuda K, Nakaya N, Ebihara S, Wang Y, Tsuji I, Nagatomi R
  • Journal Title: cross sectional analysis. Hypertension Res 31 Pages: 409-416
  • Peer Reviewed
• [Journal Article] Infection and its control in group homes for the elderly in Japan (2008)
  • Author(s): Ebihara S, Aida J, Freeman S, Osaka K
  • Journal Title: J Hosp Infect 68 Pages: 185-186
  • Peer Reviewed
• [Journal Article] Sex differences in the preference for place of death among community-dwelling elderly people in Japan (2008)
  • Author(s): Yamasaki M, Ebihara S, Freeman S, Ebihara T, Asada M, Yamnda S, Arai H
  • Journal Title: J Am Geriatr Soc 56 Pages: 376-376
  • Peer Reviewed
• [Journal Article] Erythropietin promotes the growth of tumor lacking its receptor and decreases survival of tumor-bearing mice (2008)
  • Author(s): Okazaki T, Ebihara S, As ada M, et.al.
  • Journal Title: Neoplasia 10 Pages: 932-939
  • Peer Reviewed
• [Journal Article] Reduced tumor growth in a mouse model of schizophrenia, lacking dopamine transporter (2008)
  • Author(s): Asada M, Ebihara S, Numa chi Y, et.al.
  • Journal Title: Int J Cancer 123 Pages: 511-518
  • Peer Reviewed
• [Journal Article] Cough reflex and oral chemesthesis induced by capsaicin and capsiate in healthy never-smokers (2007)
  • Author(s): Yamasaki M, Ebihara S, Ebihara T, Freeman S, Yamanda S, Asada M, Yoshida M, Arai H
  • Journal Title: Cough 31(1) : 9
  • NAID: 120002337823
  • Peer Reviewed
• [Journal Article] Contribution of gastric acid in elderly nursing home patients with cough reflex hypersensitivity (2007)
  • Author(s): Ebihara S, Ebihara T, Yamasaki M, Asada M, Yamanda S, Niu K, Sasaki H, Arai H
  • Journal Title: J Am Geriatr Soc 55 Pages: 1686-1688
  • Peer Reviewed
• [Journal Article] Macrophage colony-stimulating factor improves cardiac function after ischemic injury by inducing vascular endothelial growth factor production and survival of cardiomyocytes (2007)
  • Author(s): Okazaki T, Ebihara S, Asada M, Yamanda S, Saijo Y, Shiraishi Y, Ebihara T, Niu K, Mei H, Arai H, Yambe T
  • Journal Title: Am J Pathol 171 Pages: 1093-1103
  • Peer Reviewed
• [Journal Article] Toe clearance rehabilitative slipper for gait disorder in the elderly (2007)
  • Author(s): Sato T, Ebihara S, Kudo H, Fujii M, Sasaki H, Butler JP.
  • Journal Title: Geriatr Gerontol Int 7 Pages: 310-311
  • NAID: 10020021381
  • Peer Reviewed
• [Journal Article] Accidental carbon monoxide poisoning at home in Japan (2007)
  • Author(s): Ohara Y, Ohrui T, Ebihara S, Ebihara T, Sasaki H, Arai H
  • Journal Title: Pediatr Pulmonol 42 Pages: 853-853
  • Peer Reviewed
• [Journal Article] More doctors needed before boosting clinical research in Japan (2007)
  • Author(s): Ebihara S
  • Journal Title: Lancet 369 Pages: 2076-2076
  • Peer Reviewed
• [Journal Article] Angiotensin-converting enzyme inhibitors and smoking cessation (2007)
  • Author(s): Ebihara S, Ebihara T, Yamanda S, Asada M, Arai H
  • Journal Title: Respiration 74 Pages: 478-478
  • Peer Reviewed
• [Journal Article] Mosapride citrate prolongs survival in stroke patients with gastrostomy (2007)
  • Author(s): He M, Ohrui T, Ebihara T, Ebihara S, Sasaki H, Arai H
  • Journal Title: J Am Geriatr Soc 54 Pages: 142-144
  • Peer Reviewed
• [Journal Article] Acid and swallowing reflex (2007)
  • Author(s): Ebihara T, Ebihara S, Ida S, Ohrui T, Yasuda H, Sasaki H, Arai H
  • Journal Title: Geriatr Gerontol Int 7 Pages: 94-95
  • NAID: 10019489828
  • Peer Reviewed
• [Journal Article] Macrophage colony-stimulating factor improves cancer function after ischemic injury by inducing vascular endothelial growth production (2007)
  • Author(s): Okazaki T, Ebihara S, et. al.
  • Journal Title: American Journal of Pathology 171 Pages: 1093-1103
  • Peer Reviewed
• [Journal Article] Contribution of gastric acid in elderly nursing home patients with cough reflex hypersensitivity (2007)
  • Author(s): Ebihara S, et. al.
  • Journal Title: Journal of American Geriatric Society 55 Pages: 1686-1688
  • Peer Reviewed
• [Journal Article] Angiotensin-converting enzyme inhibitors and smoking cessation. (2007)
  • Author(s): Ebihara S, et. al.
  • Journal Title: Respiration 74 Pages: 478-479
  • Peer Reviewed
• [Journal Article] Cough and transdermal long-acting □2 agonist in Japan
  • Author(s): Ebihara S, Ebihara T, Arai H
  • Journal Title: Respir Med Pages: 2102-1497
  • Peer Reviewed
• [Presentation] Notch ligand delta-like 4 blockade suppresses tumor growth in mouse lung carcinoma model. (2007)
  • Author(s): Yamanda S, Ebihara S, et. al.
  • Organizer: ATS 2007 International Conference
  • Place of Presentation: San Francisco, CA, USA
  • Year and Date: 2007-05-20
• [Presentation] Notch ligand delta-like 4 blockade suppresses tumor growth in mouse lung carcinoma model (2007)
  • Author(s): Yamanda S, Ebihara S, et.al.
  • Organizer: ATS 2007 International Conference. H19.5.20 San Francisco
  • Place of Presentation: CA, USA
• [Remarks]
  • URL: http://rounen.med.tohoku.ac.jp/