• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Studies on wound-healing substances from natural products

Research Project

Project/Area Number 19590694
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General internal medicine (including Psychosomatic medicine)
Research InstitutionEhime University

Principal Investigator

SUMIYOSHI Maho  Ehime University, 大学院・医学系研究科, 研究員 (60444767)

Co-Investigator(Kenkyū-buntansha) 木村 善行  愛媛大学, 大学院・医学系研究科, 講師 (20294796)
Co-Investigator(Renkei-kenkyūsha) KIMURA Yoshiyuki  愛媛大学, 大学院・医学系研究科, 講師 (20294796)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords創傷治癒 / 天然由来化合物 / 紫外線 / 天然物由来化合物 / 血管内皮細胞増殖因子(VEGF)
Research Abstract

低濃度(10pgから100ng/mL)のツボクサ(Centellaasiatica)成分Asiaticosideおよび赤升麻(Astilbethunbergii)成分Eucryphinが、熱傷治癒促進作用をもつことを、マウス熱傷モデル用いて明らかにした。創傷部滲出液の分析、細胞を用いた分析を行い、これら天然物由来化合物が生体の再生能を向上させて創傷治癒を促進していることを明らかにした。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (15 results)

All 2009 2008 2007

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (5 results)

  • [Journal Article] Effects of the nonsugar fraction of brown sugar on chronic ultraviolet B irradiation-induced photoaging in melanin-possessing hairless mice2009

    • Author(s)
      Sumiyoshi M, Hayashi T, Kimura Y
    • Journal Title

      Nat Med(Tokyo) 63

      Pages: 130-136

    • NAID

      10025825902

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of ginseng saponins isolated from red ginseng on ultraviolet B-induced skin aging in hairless mice2009

    • Author(s)
      Kim YG, Sumiyoshi M, Sakanaka M, Kimura Y
    • Journal Title

      Eur J Pharmacol 602

      Pages: 148-156

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of ginseng saponins isolated from red ginseng on ultraviolet B-induced skin aging in hairless mice.2009

    • Author(s)
      Kim YG, Sumiyoshi M, Sakanaka M, Kimura Y
    • Journal Title

      Eur J Pharmacol. 602

      Pages: 148-156

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of the nonsugar fraction of brown sugar on chronic ultraviolet Birradiation-induced photoaging in melanin-possessing hairless mice.2009

    • Author(s)
      Sumiyoshi M, Hayashi T, Kimura Y
    • Journal Title

      Nat Med (Tokyo) 63

      Pages: 130-136

    • NAID

      10025825902

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of Red Ginseng extract on ultraviolet B-irradiated skin change in C57BL mice2008

    • Author(s)
      Kim YG, Sumiyoshi M, Kawahira K, Sakanaka M, Kimura Y
    • Journal Title

      Phytother Res 22

      Pages: 1423-1427

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of ginsenoside Rb_1 at low doses on histamine, substance P, and monocyte chemoattractant protein 1 in the burn wound areas duaring the process of acute burn wound repair2008

    • Author(s)
      Kawahira K, Sumiyoshi M, Sakanaka M, Kimura Y
    • Journal Title

      J Ethnopharmacol 117

      Pages: 278-284

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Facilitationg action of asiaticoside at low doses on burn wound repair and its mechanism2008

    • Author(s)
      Kimura Y, Sumiyoshi M, Samukawa K, Satake N, Sakanaka M
    • Journal Title

      Eur Jpharmacol 584

      Pages: 415-423

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of Red Ginseng extract on ultraviolet B-irradiated skin change in C57BL mice.2008

    • Author(s)
      Kim YG, Sumiyoshi M, Kawahira K, Sakanaka M, Kimura Y
    • Journal Title

      Phytother Res. 22

      Pages: 1423-1427

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of ginsenoside Rb^1 at low doses on histamine,substance P,and monocyte chemoattractant protein 1 in the burn wound areas duaring the process of acute burn wound repair2008

    • Author(s)
      Kawahira K, Sumiyoshi M, Sakanaka M, Kimura Y
    • Journal Title

      J Ethnopharmacol (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Facilitationg action of asiaticoside at low doses on burn wound repair and its mechanism2008

    • Author(s)
      Kimura Y, Sumiyoshi M, Samukawa K, Satake N, Sakanaka M
    • Journal Title

      Eur J Pharmacol 584

      Pages: 415-423

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 低用量長期UVB照射による皮膚老化に対する黒砂糖非ショ糖分画の影響2008

    • Author(s)
      木村善行, 住吉真帆, 林輝明
    • Organizer
      日本生薬学会第55回年会
    • Place of Presentation
      長崎大学
    • Year and Date
      2008-09-20
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 低用量長期UVB照射による皮膚老化に対するウコンCurcumalonga L.抽出物の影響2008

    • Author(s)
      住吉真帆, 木村善行
    • Organizer
      日本生薬学会第55回年会
    • Place of Presentation
      長崎大学
    • Year and Date
      2008-09-19
    • Related Report
      2008 Final Research Report
  • [Presentation] 低用量長期UVB照射による皮膚老化に対するウコンCurcuma longa L. 抽出物の影響2008

    • Author(s)
      住吉真帆, 木村善行
    • Organizer
      日本生薬学会第55回年会
    • Place of Presentation
      長崎大学
    • Year and Date
      2008-09-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] 紅蔘の紫外線B波照射による皮膚老化に及ぼす影響2007

    • Author(s)
      木村善行, 住吉真帆, 金永坤, 河平一宏, 阪中雅広
    • Organizer
      日本生薬薬学会第54回年会
    • Place of Presentation
      愛知学院大学薬学部
    • Year and Date
      2007-09-14
    • Related Report
      2008 Final Research Report
  • [Presentation] 紅參の紫外線B波照射による皮膚老化に及ぼす影響2007

    • Author(s)
      木村 善行, 住吉 真帆, 金 永坤, 河平 一宏, 阪中 雅広
    • Organizer
      日本生薬薬学会第54回年会
    • Place of Presentation
      愛知学院大学薬学部
    • Year and Date
      2007-09-14
    • Related Report
      2007 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi