Elucidation of the roles of an oncogene BCL6 in the adaptation response to hypoxia and its application to the therapy for esophageal cancer
Project/Area Number |
19590707
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Gastroenterology
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Research Institution | Hokkaido University |
Principal Investigator |
SHIMIZU Yuichi Hokkaido University, 北海道大学病院, 講師 (90333608)
|
Co-Investigator(Kenkyū-buntansha) |
小林 正伸 北海道医療大学, 教授 (80241321)
|
Project Period (FY) |
2007 – 2008
|
Project Status |
Completed (Fiscal Year 2008)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 低酸素適応応答 / 低栄養環境 / 癌遺伝子 / BCL6 / 増殖 / 抗癌剤耐性 / 膵癌 / 低酸素 / 低グルコース / 抗癌剤感受性 / 低栄養 / 増殖抑制 / アポトーシス |
Research Abstract |
DNAマイクロアレイ法を用いた網羅的解析とRT-PCR法により、BCL6が低酸素・低グルコース条件下で発現亢進することが確認された.低グルコース環境下で固形癌細胞に発現誘導されるBCL-6蛋白が、固形癌細胞の増殖を促進し、抗癌剤に対する耐性を誘導している可能性を示唆する
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Report
(3 results)
Research Products
(10 results)
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[Journal Article] All-trans retinoic acid enhances murine dendritic cell migration to draining lymph nodes via the balance of matrix metalloproteinases and their inhibitors2007
Author(s)
Darmanin S, Chen J, Zhao S, Cui H, Shirkoohi R, Kubo N, Kuge Y, Tamaki N, Nakagawa K, Hamada J, Moriuti T, Kobayashi M.
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Journal Title
J of Immunol 179
Pages: 4616-4625
Related Report
Peer Reviewed
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[Journal Article] Synergistic up-regulation of Hexokinase 2, glucose transporters and angiogenic factors in pancreatic cancer cells by glucose-deprivation and hypoxia2007
Author(s)
Natsuizaka M, Ozasa M, Darmanin S, Miyamoto M, Kondo S, Kamada S, Shindoh M, Higashino F, Suhara W, Koide H, Aita K, Nakagawa K, Kondo T, Asaka M, Okada F, Kobayashi M.
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Journal Title
Exp. Cell Res. 313
Pages: 3337-48
NAID
Related Report
Peer Reviewed
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[Journal Article] Enhanced expression of asparagine synthetase under glucose-deprived conditions protects pancreatic cancer cells from apoptosis induced by glucose deprivation and cisplatin2007
Author(s)
Cui H, Darmanin S, Natsuisaka M, Kondo T, Asaka M, Shindoh M, Higashino F, Hamuro J, Okada F, Kobayashi M, Nakagawa K, Koide H, Kobayashi M
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Journal Title
Cancer Res. 67
Pages: 3346-3355
Related Report
Peer Reviewed
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[Journal Article] Suppression of tumor growth by intra-muscular transfer of naked DNA encoding adrenomedullin antagonist2007
Author(s)
Miseki T, Kawakami H, Natsuizaka M, Darmanin S, Cui H-Y, Chen J, Fu Q, Okada F, Shindo M, Higashino F, Asaka M, Hamuro J, and Kobayashi M
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Journal Title
Cancer Gene Ther. 14
Pages: 39-44
Related Report
Peer Reviewed
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