Elucidation of the roles of an oncogene BCL6 in the adaptation response to hypoxia and its application to the therapy for esophageal cancer

• Project/Area Number: 19590707
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Hokkaido University
• Principal Investigator: SHIMIZU Yuichi Hokkaido University, 北海道大学病院, 講師 (90333608)
• Co-Investigator(Kenkyū-buntansha): 小林 正伸 北海道医療大学, 教授 (80241321)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 低酸素適応応答 / 低栄養環境 / 癌遺伝子 / BCL6 / 増殖 / 抗癌剤耐性 / 膵癌 / 低酸素 / 低グルコース / 抗癌剤感受性 / 低栄養 / 増殖抑制 / アポトーシス

Research Abstract

DNAマイクロアレイ法を用いた網羅的解析とRT-PCR法により、BCL6が低酸素・低グルコース条件下で発現亢進することが確認された.低グルコース環境下で固形癌細胞に発現誘導されるBCL-6蛋白が、固形癌細胞の増殖を促進し、抗癌剤に対する耐性を誘導している可能性を示唆する

Research Products

• [Journal Article] Long-term outcome after endoscopic resection inpatients with hypopharyngeal carcinoma invading the subepithelium : a case series (2009)
  • Author(s): Simizu Y, Yoshida M, Kato M, Ono SNakagawa M, Homma A, Oridate N, Asaka M.
  • Journal Title: Endoscopy Pages: 374-376
  • Peer Reviewed
• [Journal Article] Endoscopic diagnosis of early squamous neoplasia of the esophagus with iodine attaining high grade intra-epithelial neoplasia turns pink within a few minutes (2008)
  • Author(s): Simizu Y, Omori T, Yokokawa A, Yoshida T, Hirota J, Ono Y, Yamamaoto J, Kato M, Asaka M.
  • Journal Title: J Gastroentero 23(4) Pages: 546-550
  • Peer Reviewed
• [Journal Article] 早期食道癌存在診断・質的診断の進歩 (2008)
  • Author(s): 清水勇一, 他
  • Journal Title: 胃と腸 43 Pages: 1422-1433
  • Peer Reviewed
• [Journal Article] All-trans retinoic acid enhances murine dendritic cell migration to draining lymph nodes via the balance of matrix metalloproteinases and their inhibitors (2007)
  • Author(s): Darmanin S, Chen J, Zhao S, Cui H, Shirkoohi R, Kubo N, Kuge Y, Tamaki N, Nakagawa K, Hamada J, Moriuti T, Kobayashi M.
  • Journal Title: J of Immunol 179 Pages: 4616-4625
  • Peer Reviewed
• [Journal Article] Synergistic up-regulation of Hexokinase 2, glucose transporters and angiogenic factors in pancreatic cancer cells by glucose-deprivation and hypoxia (2007)
  • Author(s): Natsuizaka M, Ozasa M, Darmanin S, Miyamoto M, Kondo S, Kamada S, Shindoh M, Higashino F, Suhara W, Koide H, Aita K, Nakagawa K, Kondo T, Asaka M, Okada F, Kobayashi M.
  • Journal Title: Exp. Cell Res. 313 Pages: 3337-48
  • NAID: 120000971111
  • Peer Reviewed
• [Journal Article] Enhanced expression of asparagine synthetase under glucose-deprived conditions protects pancreatic cancer cells from apoptosis induced by glucose deprivation and cisplatin (2007)
  • Author(s): Cui H, Darmanin S, Natsuisaka M, Kondo T, Asaka M, Shindoh M, Higashino F, Hamuro J, Okada F, Kobayashi M, Nakagawa K, Koide H, Kobayashi M
  • Journal Title: Cancer Res. 67 Pages: 3346-3355
  • Peer Reviewed
• [Journal Article] Elevated oxidative stress in erythrocytes due to a SOD1 deficiency causes anaemia and triggers autoantibody production (2007)
  • Author(s): Iuchi Y, Okada F, Onuma K, Onoda T, Asao H, Kobayashi M, Fujii J.
  • Journal Title: Biochem J. 402 Pages: 219-27
  • Peer Reviewed
• [Journal Article] Suppression of tumor growth by intra-muscular transfer of naked DNA encoding adrenomedullin antagonist (2007)
  • Author(s): Miseki T, Kawakami H, Natsuizaka M, Darmanin S, Cui H-Y, Chen J, Fu Q, Okada F, Shindo M, Higashino F, Asaka M, Hamuro J, and Kobayashi M
  • Journal Title: Cancer Gene Ther. 14 Pages: 39-44
  • Peer Reviewed
• [Presentation] Histological results of EMR for esophageal lesions diagnosed as high-grade intraepithelial squamous neoplasia by endoscopic biopsy (2008)
  • Author(s): Shimizu Y, Yoshida T, Kato M. Asaka M.
  • Organizer: International Society for Esophageal Disease
  • Place of Presentation: Budapest, Hungary
  • Year and Date: 2008-09-20
• [Presentation] Histological results of endoscopic mucosal resection for esophageal lesions diagnosed as high-grade intraepithelial squamous neoplasia by endoscopic biopsy (2008)
  • Author(s): Shimizu Y, et.al.
  • Organizer: The 11^<th> World Congress of the International Society for Disease of the Esophagus
  • Place of Presentation: Budapest, Hungry
  • Year and Date: 2008-09-12