The structure-activity relationship of prodefensin is investigated for a novel therapy of inflammatory bowel disease

• Project/Area Number: 19590708
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Asahikawa Medical College
• Principal Investigator: TANABE Hiroki Asahikawa Medical College, 医学部, 助教 (50396363)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2007: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: 消化器学 / 自然免疫 / Paneth細胞 / DSS腸炎 / defensin / クローン病

Research Abstract

ヒト消化管における抗菌ペプチドに依存する自然免疫機能の感染防御機構を解明し, 炎症性腸疾患の消化管粘膜上皮における自然免疫の関与を検討してきた. ディフェンシンの分子異常と機能異常を検討することによって, 炎症性腸疾患の病因・病態における自然免疫機構異常の関与を解明した. さらに, 内因性抗菌ペプチドをターゲットとする新たな炎症制御の可能性を検討し, 炎症性腸疾患に対する特異的な新規治療法の開発をめざす.

Research Products

• [Journal Article] Functional Role of Metaplastic Paneth Cell Defensins in Helicobacter pylori- Infected Stomach (2008)
  • Author(s): Hiroki Tanabe, Tomonobu Sato, Jiro Watari, Atsuo Maemoto, Mikihiko Fijiya, Toru Kono, Toshifumi Ashida, Tokiyoshi Ayabe, Yutaka Kohgo
  • Journal Title: Helicobacter 13 Pages: 370-379
  • Peer Reviewed
• [Journal Article] Functional Role of Metaplastic Paneth Cell Defensins in Helicobacter pylori-Infected Stomach (2008)
  • Author(s): Hiroki Tanabe
  • Journal Title: Helicobacter 13 Pages: 370-379
  • Peer Reviewed
• [Journal Article] Denatured human alpha-defensin attenuates the bactericidal activity and the stability against enzymatic digestion (2007)
  • Author(s): Tanabe H, Ayabe T, Maemoto A, Ishikawa C, Inaba Y, Sato R, Moriichi K, Okamoto K, Watari J, Kono T, Ashida T, Kohgo Y.
  • Journal Title: Biochem Biophys Res Commun. 358 Pages: 349-55
  • Peer Reviewed
• [Journal Article] クローン病におけるPaneth細胞由来抗菌ペプチドの産生異常 (2007)
  • Author(s): 田邊裕貴, 前本篤男, 綾部時芳, 河野透, 蘆田知史, 高後裕
  • Journal Title: 分子消化器病 4 Pages: 110-115
• [Journal Article] Denatured human alpha-defensin attenuates the bactericidal activity and the stability against enzymatic digestion. (2007)
  • Author(s): Hiroki Tanabe
  • Journal Title: Biochem Biophys Res Commun 358 Pages: 349-355
  • Peer Reviewed
• [Journal Article] クローン病におけるPaneth細胞由来抗菌ペプチドの産生異常 (2007)
  • Author(s): 田邊裕貴
  • Journal Title: 分子消化器病 4 Pages: 110-115
• [Presentation] Precursor processing of human defensin-5 is essential to the physiological functions in vivo and in vitro (2009)
  • Author(s): Hiroki Tanabe
  • Organizer: 2009 International symposium on Regulatory Peptide
  • Place of Presentation: Santa Barbara, CA
  • Year and Date: 2009-01-27
• [Presentation] Precursor processing of human defensin-5 is essential to the physiologic al functions in vivo and in vitro (2009)
  • Author(s): Hiroki Tanabe
  • Organizer: International Symposium on Regulatory Peptide
  • Place of Presentation: Santa Barbara, CA
  • Year and Date: 2009-01-27
• [Presentation] 必須アミノ酸L-isoleucineはβ-defensin 2発現量を増加させる (2008)
  • Author(s): 金野陽高, 田邊裕貴, 前本篤男, 蘆田知史, 高後裕
  • Organizer: 第50回日本消化器病学会
  • Place of Presentation: 東京
  • Year and Date: 2008-10-02
• [Presentation] 必須アミノ酸L-isoleuchleはβ-defensin 2発現量を増加させる (2008)
  • Author(s): 金野陽高
  • Organizer: 第50回日本消化器病学会
  • Place of Presentation: 東京
  • Year and Date: 2008-10-02
• [Presentation] 腸管粘膜における抗菌ペプチドの役割 (2008)
  • Author(s): 田邊裕貴, 藤谷幹浩, 高後裕
  • Organizer: 平成20年度北海道腸内細菌叢研究会
  • Place of Presentation: 札幌
  • Year and Date: 2008-09-19
• [Presentation] ヒト大腸癌におけるα-defensin発現はMAPK阻害剤にて抑制される (2008)
  • Author(s): 田邊裕貴, Zaky Amen, 石川千里, 上野伸展, 金野陽高, 稲場勇平, 伊藤貴博, 盛一健太郎, 岡本耕太郎, 藤谷幹浩, 高後裕
  • Organizer: 第95回北海道癌談話会
  • Place of Presentation: 旭川
  • Year and Date: 2008-09-06
• [Presentation] パネト細胞α-defensinと腸内自然免疫クローン病との関わりを含めて (2008)
  • Author(s): 綾部時芳, 深谷梨恵, 坂井直樹, 前本篤男, 蘆田知史, 河野透, 田邊裕貴, 高後裕
  • Organizer: 第45回補体シンポジウム
  • Place of Presentation: 札幌
  • Year and Date: 2008-07-11
• [Presentation] バネト細胞α-definsinと腸内自然免疫クローン病との関わりを含めて (2008)
  • Author(s): 綾部時芳
  • Organizer: 第45回補体シンポジウム
  • Place of Presentation: 札幌
  • Year and Date: 2008-07-11
• [Presentation] Human enteric defensin induces acquired immunity through activation processing (2007)
  • Author(s): Hiroki Tanabe
  • Organizer: 13th International Congress of Mucosal Immunology
  • Place of Presentation: Tokyo
  • Year and Date: 2007-07-11
• [Presentation] Human enteric defensin induces acquired immunity through activation processing (2007)
  • Author(s): Tanabe H
  • Organizer: 13^<th> International Congress of Mucosal Immunology
  • Place of Presentation: Tokyo
  • Year and Date: 2007-07-10
• [Presentation] Disruption of innate immunity in Crohn's disease (2007)
  • Author(s): Maemoto A, Tanabe H, Inaba Y, Ito T, Ashida T, Ayabe T, Kohgo Y.
  • Organizer: 13^<th> International Congress of Mucosal Immunology
  • Place of Presentation: Tokyo
  • Year and Date: 2007-07-10
• [Presentation] Down-regulation of Paneth cell a-defensin expression and function in patients with Crohn's disease (2007)
  • Author(s): Maemoto A, Ayabe T, Tanabe H, Inaba Y, Ashida T, Fukaya R, Sakai N, Kono T, Kohgo Y.
  • Organizer: American Gastroenterological Association
  • Place of Presentation: Washington DC
  • Year and Date: 2007-05-22
• [Remarks] ホームページ等本研究の一部は旭川医科大学学術成果リポジトリ(AMCoR)から検索が可能である.
  • URL: http://amcor.asahikawa-med.ac.jp/modules/xoonips/