Mechanism of abrogation of anergy in inflammatory bowel disease
Project/Area Number |
19590721
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Gastroenterology
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Research Institution | Osaka University |
Principal Investigator |
IIJIMA Hideki Osaka University, 医学系研究科, 助教 (90444520)
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Co-Investigator(Kenkyū-buntansha) |
TSUJII Masahiko 大阪大学, 医学系研究科, 講師 (40303937)
辻 晋吾 大阪大学, 医学系研究科, 講師 (40301262)
|
Project Period (FY) |
2007 – 2008
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Project Status |
Completed (Fiscal Year 2008)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Keywords | 消化器病学(食道、胃、小腸、大腸) / 炎症性腸疾患 / 免疫寛容 / 粘膜免疫 / 潰瘍性大腸炎 / ユビキチン / T細胞 / 医学 / 消化器病学 |
Research Abstract |
炎症性腸疾患である潰瘍性大腸炎では、食事抗原や腸内細菌に対する免疫寛容の破綻が想定されている。炎症性腸疾患を自然発症するIL-10 ノックアウトマウスでは、免疫寛容を誘導すると言われているE3 ユビキチン・リガーゼが有意に低下しており、疾患の制御に重要な働きをしていることが示唆された。さらに、潰瘍性大腸炎患者の末梢血T リンパ球の解析により、免疫寛容関連ユビキチン・リガーゼが潰瘍性大腸炎患者の寛解の維持に重要であることが確認され、新たな治療標的となると考えられた
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Report
(3 results)
Research Products
(76 results)
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[Journal Article] Upregulation of GRAIL is Associated with Remission of Ulcerative Colitis2008
Author(s)
Satoshi Egawa, Hideki Iijima, Shinzaki, S., Nakajima, S., Wang, J., Kondo, J., Ishii, S., Yoshio, T., Irie, T., Nishida, T., Kakiuchi, Y., Yasumaru, M., Yoshihara, H., Kanto, T., Tsujii, M., et.al.
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Journal Title
Am J Physiol Gastrointest Liver Physiol 295
Related Report
Peer Reviewed
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[Journal Article] Topical Implantation of Mesenchymal Stem Cells has Beneficial Effects on Healing of Experimental Colitis in Rats2008
Author(s)
Hayashi, Y., Tsuji, S.Tsujii, M., Nishida, T., Ishii, S., Iijima, H., et.al.
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Journal Title
J Pharmacol Exp Ther 326
Pages: 523-31
Related Report
Peer Reviewed
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[Journal Article] Topical transplantation of mesenchymal stem cells accelerates gastric ulcer healing in rats2008
Author(s)
Hayashi, Y., Tsuji, S., Tsujii, M., Nishida, T., Ishii, S., Iijima, H., et.al.
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Journal Title
Am J Physiol Gastrointest Liver Physiol 294
Related Report
Peer Reviewed
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[Journal Article] Cultured bone marrow cell local implantation accelerates healing of ulcers in mice2008
Author(s)
Nishida, T., Tsuji, S., Tsujii, M., Ishii, S., Yoshio, T., Shinzaki, S., Egawa, S., Irie, T., Kakiuchi, Y., Yasumaru, M., Iijima, H., et.al.
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Journal Title
J Gastroenterol 43
Pages: 124-135
NAID
Related Report
Peer Reviewed
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[Journal Article] Topical Implantation of Mesenchymal Stem Cells has Beneficial Effects on Healing of Experimental Colitis in Rats.2008
Author(s)
Hayashi, Y., Tsuji, S. Tsujii, M., Nishida, T., Ishii, S., Iijima, H., et al.
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Journal Title
J Pharmacol Exp Ther 326
Pages: 523-31
Related Report
Peer Reviewed
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[Journal Article] Topical transplantation of mesenchymal stem cells accelerates gastric ulcer healing in rats.2008
Author(s)
Hayashi, Y., Tsuji, S., Tsujii, M., Nishida, T., Ishii, S., Iijima, H., et al.
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Journal Title
Am J Physiol Gastrointest Liver Physiol 294
Related Report
Peer Reviewed
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[Journal Article] Cultured bone marrow cell local implantation accelerates healing of ulcers in mice.2008
Author(s)
Nishida, T., Tsuji, S., Tsujii, M., Ishii, S., Yoshio, T., Shinzaki, S., Egawa, S., Irie, T., Kakiuchi, Y., Yasumaru, M., Iijima, H., et al.
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Journal Title
J Gastroenterol 43
Pages: 124-135
NAID
Related Report
Peer Reviewed
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[Journal Article] Synergistic antitumor effects of celecoxib with 5-fluorouracil depend on IFN-gamma2007
Author(s)
Irie, T., Tsujii, M., Tsuji, S., Yoshio, T., Ishii, S., Shinzaki, S., Egawa, S., Kakiuchi, Y., Nishida, T., Yasumaru, M., Iijima, H., et.al.
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Journal Title
Related Report
Peer Reviewed
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[Presentation] Bone-marrow cells are able to develop Interstitial Cells of Cajal : Morphologic Evidences in W/Wv mice2008
Author(s)
Shuji Ishii, Shingo Tsuji, Masahiko Tsujii, Jumpei Kondo, Sachiko Nakajima, Toshiyuki Yoshio, Shinichiro Shinzaki, Satoshi Egawa, Tsutomu Nishida, Yoshimi Kakiuchi, Kenji Watabe, Hideki Iijima, et.al.
Organizer
Digestive disease week
Place of Presentation
San Diego, USA
Year and Date
2008-05-20
Related Report
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[Presentation] Caldesmon suppresses cancer cell invasion by regulating podosome/invadopodium formation2008
Author(s)
Toshiyuki Yoshio, Tsuyoshi Morita, Masahiko Tsujii, Jumpei Kondo, Sachiko Nakajima, Shuji Ishii, Shinichiro Shinzaki, Sato shi Egawa, Tsutomu Nishida, Yoshimi Kakiuchi, Hideki Iijima, et.al
Organizer
Digestive disease week
Place of Presentation
San Diego, USA
Year and Date
2008-05-19
Related Report
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[Presentation] Caldesmon suppresses cancer cell invasion by regulating podosome/invadopodium formation.2008
Author(s)
Toshiyuki Yoshio, Tsuyoshi Morita, Masahiko Tsujii, Jumpei Kondo, Sachiko Nakajima, Shuji Ishii, Shinichiro Shinzaki, Satoshi Egawa, Tsutomu Nishida, Yoshimi Kakiuchi, Hideki Iijima, et al.
Organizer
Digestive disease week
Place of Presentation
San Diego, USA
Year and Date
2008-05-19
Related Report
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[Presentation] 骨髄移植モデルを用いた消化管運動障害の改善に関する検討2008
Author(s)
石井修二, 辻晋吾, 辻井正彦, 近藤純平, 中島佐知子, 由雄敏之, 新崎信一郎, 柄川悟志, 西田勉, 垣内佳美, 渡部健二, 飯島英樹, 林紀夫
Organizer
第94回日本消化器病学会総会
Place of Presentation
福岡
Year and Date
2008-05-08
Related Report
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[Presentation] Caldesmonはinvadopodium/podosomeの形成を阻害する癌細胞浸潤の抑制因子である2008
Author(s)
由雄敏之, 森田剛, 辻井正彦, 近藤純平, 中島佐知子, 石井修二, 新崎信一郎, 柄川悟志, 山本克己, 渡部健二, 西田勉, 垣内佳美, 飯島英樹, 他
Organizer
第94回日本消化器病学会総会
Place of Presentation
福岡
Year and Date
2008-05-08
Related Report
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[Presentation] Expression of Grail, An E3 Ubiquitin Ligase for Induction of T Cell Anergy2007
Author(s)
Satoshi Egawa, Hideki Iijima, Shinichiro Shinzaki, Sachiko Nakajima, Jumpei Kondou, Shuji Ishii, Toshiyuki Yoshio, Takanobu Irie, Yoshimi Kakiuchi, Tsutomu Nishida, Masakazu Yasumaru, Masahiko Tsujii, et.al
Organizer
in CD4+ T Cells of Patients with Ulcerative Colitis. DDW2007
Place of Presentation
Washington DC, USA
Year and Date
2007-05-17
Related Report
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[Presentation] Cyclooxygenase-2 Regulates Toll-Like Receptor(TLR) 2 Expression and TLR2-Mediated Chemokine Production in Intestinal Epithelial Cells2007
Author(s)
Shinichiro Shinzaki, Hideki Iijima, Satoshi Egawa, Sachiko Nakajima, Shuji Ishii, Toshiyuki Yoshio, Takanobu Irie, Yoshimi Kakiuchi, Tsutomu Nishida, Masakazu Yasumaru, Tatsuya Kanto, Masahiko Tsujii, et. al.
Organizer
DDW2007
Place of Presentation
Washington DC, USA
Year and Date
2007-05-17
Related Report
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[Presentation] Transplantation of Bone Marrow-Derived Mesenchymal Stem Cells Ameliorated 2, 4, 6-Trinitrobenzene Sulfonic Acid (TNBS)-Induced Colitis in Rats2007
Author(s)
Yujiro Hayashi, Shingo Tsuji, Masahiko Tsujii, Tsutomu Nishida, Shuji Ishii, Masato Komori, Takanobu Irie, Hideki Iijima, et.al.
Organizer
DDW2007
Place of Presentation
Washington DC, USA
Year and Date
2007-05-17
Related Report
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[Presentation] Interferon-Gamma-Dependent Tumor-Suppressive Mechanisms of a COX-2 Inhibitor in Combination with 5-Fluorouracil.2007
Author(s)
Takanobu Irie, Masahiko Tsujii, Shingo Tsuji, Toshiyuki Yoshio, Shuji Ishii, Shinichiro Shinzaki, Satoshi Egawa, Yoshimi Kakiuchi, Tsutomu Nishida, Masakazu Yasumaru, Hideki Iijima, et.al.
Organizer
DDW2007
Place of Presentation
Washington DC, USA
Year and Date
2007-05-17
Related Report
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