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Mechanism of abrogation of anergy in inflammatory bowel disease

Research Project

Project/Area Number 19590721
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionOsaka University

Principal Investigator

IIJIMA Hideki  Osaka University, 医学系研究科, 助教 (90444520)

Co-Investigator(Kenkyū-buntansha) TSUJII Masahiko  大阪大学, 医学系研究科, 講師 (40303937)
辻 晋吾  大阪大学, 医学系研究科, 講師 (40301262)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords消化器病学(食道、胃、小腸、大腸) / 炎症性腸疾患 / 免疫寛容 / 粘膜免疫 / 潰瘍性大腸炎 / ユビキチン / T細胞 / 医学 / 消化器病学
Research Abstract

炎症性腸疾患である潰瘍性大腸炎では、食事抗原や腸内細菌に対する免疫寛容の破綻が想定されている。炎症性腸疾患を自然発症するIL-10 ノックアウトマウスでは、免疫寛容を誘導すると言われているE3 ユビキチン・リガーゼが有意に低下しており、疾患の制御に重要な働きをしていることが示唆された。さらに、潰瘍性大腸炎患者の末梢血T リンパ球の解析により、免疫寛容関連ユビキチン・リガーゼが潰瘍性大腸炎患者の寛解の維持に重要であることが確認され、新たな治療標的となると考えられた

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (76 results)

All 2008 2007 Other

All Journal Article (18 results) (of which Peer Reviewed: 13 results) Presentation (56 results) Remarks (2 results)

  • [Journal Article] Upregulation of GRAIL is Associated with Remission of Ulcerative Colitis2008

    • Author(s)
      Satoshi Egawa, Hideki Iijima, Shinzaki, S., Nakajima, S., Wang, J., Kondo, J., Ishii, S., Yoshio, T., Irie, T., Nishida, T., Kakiuchi, Y., Yasumaru, M., Yoshihara, H., Kanto, T., Tsujii, M., et.al.
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol 295

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] IgG oligosaccharide alterations are a novel diagnostic marker for disease activity and the clinical course of inflammatory bowel disease2008

    • Author(s)
      Shinichiro Shinzaki, Hideki Iijima, et.al.
    • Journal Title

      Am J Gastroenterol 103

      Pages: 1173-81

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Topical Implantation of Mesenchymal Stem Cells has Beneficial Effects on Healing of Experimental Colitis in Rats2008

    • Author(s)
      Hayashi, Y., Tsuji, S.Tsujii, M., Nishida, T., Ishii, S., Iijima, H., et.al.
    • Journal Title

      J Pharmacol Exp Ther 326

      Pages: 523-31

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Topical transplantation of mesenchymal stem cells accelerates gastric ulcer healing in rats2008

    • Author(s)
      Hayashi, Y., Tsuji, S., Tsujii, M., Nishida, T., Ishii, S., Iijima, H., et.al.
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol 294

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cultured bone marrow cell local implantation accelerates healing of ulcers in mice2008

    • Author(s)
      Nishida, T., Tsuji, S., Tsujii, M., Ishii, S., Yoshio, T., Shinzaki, S., Egawa, S., Irie, T., Kakiuchi, Y., Yasumaru, M., Iijima, H., et.al.
    • Journal Title

      J Gastroenterol 43

      Pages: 124-135

    • NAID

      10021267619

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 他糖尿病におけるGERD : 定量的末梢知覚試験からの検討2008

    • Author(s)
      西田勉, 辻晋吾, 山本克己、飯島英樹
    • Journal Title

      Progress in Medicine 28

      Pages: 706-709

    • Related Report
      2008 Final Research Report
  • [Journal Article] 抗TNFα抗体を用いた炎症性腸疾患の治療2008

    • Author(s)
      中島佐知子、飯島英樹
    • Journal Title

      Clinician 574

      Pages: 1195-1198

    • Related Report
      2008 Final Research Report
  • [Journal Article] 他 CEA高値で発見された非症候性膵2008

    • Author(s)
      西田勉、山本克己、筒井秀作、疋田隼人、飯島英樹
    • Journal Title

      グルカゴノーマの一例膵臓 23

      Pages: 140-145

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Upregulation of GRAIL is Associated with Remission of Ulcerative Colitis.2008

    • Author(s)
      Satoshi Egawa, Hideki Iijima, et al.
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol 295

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IgG oligosaccharide alterations are a novel diagnostic marker for disease activity and the clinical course of inflammatory bowel disease.2008

    • Author(s)
      Shinichiro Shinzaki, Hideki Iijima, et al.
    • Journal Title

      Am J Gastroenterol 103

      Pages: 1173-81

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Topical Implantation of Mesenchymal Stem Cells has Beneficial Effects on Healing of Experimental Colitis in Rats.2008

    • Author(s)
      Hayashi, Y., Tsuji, S. Tsujii, M., Nishida, T., Ishii, S., Iijima, H., et al.
    • Journal Title

      J Pharmacol Exp Ther 326

      Pages: 523-31

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Topical transplantation of mesenchymal stem cells accelerates gastric ulcer healing in rats.2008

    • Author(s)
      Hayashi, Y., Tsuji, S., Tsujii, M., Nishida, T., Ishii, S., Iijima, H., et al.
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol 294

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cultured bone marrow cell local implantation accelerates healing of ulcers in mice.2008

    • Author(s)
      Nishida, T., Tsuji, S., Tsujii, M., Ishii, S., Yoshio, T., Shinzaki, S., Egawa, S., Irie, T., Kakiuchi, Y., Yasumaru, M., Iijima, H., et al.
    • Journal Title

      J Gastroenterol 43

      Pages: 124-135

    • NAID

      10021267619

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 糖尿病におけるGERD : 定量的末梢知覚試験からの検討2008

    • Author(s)
      西田勉, 辻晋吾, 山本克己, 飯島英樹, 他
    • Journal Title

      Progress in Medicine 28

      Pages: 706-709

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 抗T N F α抗体を用いた炎症性腸疾患の治療2008

    • Author(s)
      中島佐知子, 飯島英樹
    • Journal Title

      Clinician 574

      Pages: 1195-1198

    • Related Report
      2008 Annual Research Report
  • [Journal Article] CEA高値で発見された非症候性膵グルカゴノーマの一例2008

    • Author(s)
      西田勉, 山本克己, 筒井秀作, 疋田隼人, 飯島英樹, 他
    • Journal Title

      膵臓 23

      Pages: 140-145

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synergistic antitumor effects of celecoxib with 5-fluorouracil depend on IFN-gamma2007

    • Author(s)
      Irie, T., Tsujii, M., Tsuji, S., Yoshio, T., Ishii, S., Shinzaki, S., Egawa, S., Kakiuchi, Y., Nishida, T., Yasumaru, M., Iijima, H., et.al.
    • Journal Title

      Int J Cancer 121

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 炎症性腸疾患における免疫寛容GRAILの関与2007

    • Author(s)
      飯島英樹、他
    • Journal Title

      消化器発癌における炎症・再生・細胞応答の役割

      Pages: 134-135

    • Related Report
      2007 Annual Research Report
  • [Presentation] Crohn病の診断と治療におけるダブルバル- ン小腸内視鏡の有用性2008

    • Author(s)
      近藤純平、飯島英樹、辻晋吾
    • Organizer
      JDDW2008
    • Place of Presentation
      東京
    • Year and Date
      2008-10-03
    • Related Report
      2008 Final Research Report
  • [Presentation] ビタミンK 欠乏と炎症性腸疾患活動性との関連について2008

    • Author(s)
      中島佐知子、飯島英樹、林紀夫
    • Organizer
      JDDW2008
    • Place of Presentation
      東京
    • Year and Date
      2008-10-03
    • Related Report
      2008 Final Research Report
  • [Presentation] 他 クローン病術後に対する小腸内視鏡検査の有用性と問題点2008

    • Author(s)
      井上隆弘、飯島英樹
    • Organizer
      JDDW2008
    • Place of Presentation
      東京
    • Year and Date
      2008-10-03
    • Related Report
      2008 Final Research Report
  • [Presentation] Crohn病の診断と治療におけるダブルバルーン小腸内視鏡の有用性2008

    • Author(s)
      近藤純平, 飯島英樹, 辻晋吾
    • Organizer
      JDDW2008(第76回消化器内視鏡学会総会)
    • Place of Presentation
      東京
    • Year and Date
      2008-10-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] ビタミンK欠乏と炎症性腸疾患活動性どの関連について2008

    • Author(s)
      中島佐知子, 飯島英樹, 林紀夫
    • Organizer
      JDDW2008
    • Place of Presentation
      東京
    • Year and Date
      2008-10-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] クローン病術後に対する小腸内視鏡検査の有用性と問題点2008

    • Author(s)
      井上隆弘, 飯島英樹, 他
    • Organizer
      JDDW2008
    • Place of Presentation
      東京
    • Year and Date
      2008-10-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] 他マウス炎症性腸疾患におけるT 細胞の免疫寛容の関与についての検討2008

    • Author(s)
      柄川悟志、飯島英樹
    • Organizer
      第36回日本潰瘍学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2008-09-02
    • Related Report
      2008 Final Research Report
  • [Presentation] マウス炎症性腸疾患におけるT細胞の免疫寛容の関与についての検討2008

    • Author(s)
      柄川悟志, 飯島英樹, 他
    • Organizer
      第36回日本潰瘍学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2008-09-02
    • Related Report
      2008 Annual Research Report
  • [Presentation] Alterations in IgG fucosylated oligosaccharides are a novel diagnostic marker for disease activity and the clinical course of inflammatory bowel disease2008

    • Author(s)
      Shinzaki S, Iijima H, et.al.
    • Organizer
      JHUPO conference 2008
    • Place of Presentation
      大阪
    • Year and Date
      2008-07-29
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 他潰瘍性大腸炎患者におけるT 細胞アナジーの検討2008

    • Author(s)
      柄川悟志、飯島英樹
    • Organizer
      第45回日本消化器免疫学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-07-04
    • Related Report
      2008 Final Research Report
  • [Presentation] 潰瘍性大腸炎患者におけるT細胞アナジーの検討2008

    • Author(s)
      柄川悟志, 飯島英樹, 他
    • Organizer
      第45回日本消化器免疫学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-07-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] Chemical intervention reverses oxidative stress-induced epigenetic alterations in colon cancer cells : Clues for new chemopreventive measures against aging and carcinogenesis2008

    • Author(s)
      Masahiko Tsujii, Shingo Tsuji, Hiroshi Eguchi, Shusaku Tsutsui, Hideki Iijima, et. al.
    • Organizer
      Digestive disease week
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2008-05-21
    • Related Report
      2008 Final Research Report
  • [Presentation] Chemical intervention reverses oxidative stress-induced epigenetic alterations in colon cancer cells : Clues for new chemopreventive measures against aging and carcinogenesis.2008

    • Author(s)
      Masahiko Tsujii, Shingo Tsuji, Hiroshi Eguchi, Shusaku Tsutsui, Hideki Iijima, et al.
    • Organizer
      Digestive disease week
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2008-05-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] Agalactosyl IgG observed in inflammatory bowel disease is associated with enhancement of antibody-dependent phagocytosis in human monocytic cell line2008

    • Author(s)
      Hideki Iijima, et.al.
    • Organizer
      Digestive disease week
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2008-05-20
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Upregulation of E3 ubiquitin ligases related to T cell anergy in CD4+ T cells isolated from patients with ulcerative colitis inremission2008

    • Author(s)
      Satoshi Egawa, Hideki Iijima, et.al.
    • Organizer
      Digestive disease week
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2008-05-20
    • Related Report
      2008 Final Research Report
  • [Presentation] Indications And Diagnostic Yield Of Double Balloon Enteroscopy In A Tertiary Care Setting : An Analysis Of 527 Cases With Suspected Small Bowel Diseases2008

    • Author(s)
      10. Jumpei Kondo, Shingo Tsuji, Hideki Iijima, et.al.
    • Organizer
      Digestive disease week
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2008-05-20
    • Related Report
      2008 Final Research Report
  • [Presentation] Bone-marrow cells are able to develop Interstitial Cells of Cajal : Morphologic Evidences in W/Wv mice2008

    • Author(s)
      Shuji Ishii, Shingo Tsuji, Masahiko Tsujii, Jumpei Kondo, Sachiko Nakajima, Toshiyuki Yoshio, Shinichiro Shinzaki, Satoshi Egawa, Tsutomu Nishida, Yoshimi Kakiuchi, Kenji Watabe, Hideki Iijima, et.al.
    • Organizer
      Digestive disease week
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2008-05-20
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Upregulation of E3 ubiquitin 1igases related to T cellanergy in CD4+T cells isolated from patients with ulcerative colitis in remission2008

    • Author(s)
      Satoshi Egawa, Hideki Iijima, et al.
    • Organizer
      Digestive disease week
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2008-05-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] Indications And Diagnostic Yield Of Double Balloon Ente roscopy In A Tertiary Care Setting : An Analysis Of 527 Cases With Suspected Small Bowel Diseases2008

    • Author(s)
      Jumpei Kondo, Shingo Tsuji, Hideki Iijima, et al
    • Organizer
      Digestive disease week
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2008-05-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] Caldesmon suppresses cancer cell invasion by regulating podosome/invadopodium formation2008

    • Author(s)
      Toshiyuki Yoshio, Tsuyoshi Morita, Masahiko Tsujii, Jumpei Kondo, Sachiko Nakajima, Shuji Ishii, Shinichiro Shinzaki, Sato shi Egawa, Tsutomu Nishida, Yoshimi Kakiuchi, Hideki Iijima, et.al
    • Organizer
      Digestive disease week
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2008-05-19
    • Related Report
      2008 Final Research Report
  • [Presentation] Bone mineral density and biochemical markers of bone turnover in patients with inflammatory bowel disease2008

    • Author(s)
      Sachiko Nakajima, Hideki Iijima, et.al.
    • Organizer
      Digestive disease week
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2008-05-19
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Possible roles of let-7 microRNA expression in the Cytotoxin-associated gene A (CagA) associated pathogenesis2008

    • Author(s)
      Jun Wang, Masahiko Tsujii, Shingo Tsuji, Toru Nakamura, Hiroshi Eguchi, Shusaku Tsutsui, Hideki Iijima, et.al.
    • Organizer
      Digestive disease week
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2008-05-19
    • Related Report
      2008 Final Research Report
  • [Presentation] Possible roles of let-7 microRNA expression in the Cyto toxin-associated gene A (CagA) associated pathogenesis2008

    • Author(s)
      Jun Wang, Masahiko Tsujii, Shingo Tsuji, Toru Nakamura, Hiroshi Eguchi, Shusaku Tsutsui, Hideki Iijima, et al.
    • Organizer
      Digestive disease week
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2008-05-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] Caldesmon suppresses cancer cell invasion by regulating podosome/invadopodium formation.2008

    • Author(s)
      Toshiyuki Yoshio, Tsuyoshi Morita, Masahiko Tsujii, Jumpei Kondo, Sachiko Nakajima, Shuji Ishii, Shinichiro Shinzaki, Satoshi Egawa, Tsutomu Nishida, Yoshimi Kakiuchi, Hideki Iijima, et al.
    • Organizer
      Digestive disease week
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2008-05-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] Mesenchymal Stem Cells Transplantation Accelerates Gastric Ulcer Healing in Rats2008

    • Author(s)
      Yujiro Hayashi, Shingo Tsuji, Masahiko Tsujii, Tsutomu Nishida, Shuji Ishii, Hideki Iijima, et.al.
    • Organizer
      Digestive disease week
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2008-05-18
    • Related Report
      2008 Final Research Report
  • [Presentation] Agalactosyl IgG observed in inflammatory bowel disease is associated with enhancement of antibody-dependent phagocytosis in human monocytic cell line.2008

    • Author(s)
      Hideki Iijima, Shinichiro Shinzaki, et al.
    • Organizer
      Digestive disease week
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2008-05-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] Mesenchymal stem Cells Transplantation Accelerates Gastric Ulcer Healing in Rats2008

    • Author(s)
      Yujiro Hayashi*, Shingo Tsuji, Masahiko Tsujii, Tsutomu Nishida, Shuji Ishii, Hideki Iijima, et al.
    • Organizer
      Digestive disease week
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2008-05-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] 炎症性腸疾患に見られるガラクトース欠損IgGによるマクロファージ機能への影響の解析2008

    • Author(s)
      飯島英樹, 他
    • Organizer
      第94回日本消化器病学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2008-05-08
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 林紀夫 骨髄移植モデルを用いた消化管運動障害の改善に関する検討2008

    • Author(s)
      石井修二、辻晋吾、辻井正彦、近藤純平、中島佐知子、由雄敏之、新崎信一郎、柄川悟志、西田勉、垣内佳美、渡部健二、飯島英樹
    • Organizer
      第94回日本消化器病学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2008-05-08
    • Related Report
      2008 Final Research Report
  • [Presentation] 他Caldesmon はinvadopodium/podosomeの形成を阻害する癌細胞浸潤の抑制因子である2008

    • Author(s)
      由雄敏之、森田剛、辻井正彦、近藤純平、中島佐知子、石井修二、新崎信一郎、柄川悟志、山本克己、渡部健二、西田勉、垣内佳美、飯島英樹
    • Organizer
      第94回日本消化器病学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2008-05-08
    • Related Report
      2008 Final Research Report
  • [Presentation] 他 低用量アスピリンによる上部消化管粘膜障害 : 病変予測因子の検討2008

    • Author(s)
      垣内佳美、辻晋吾、辻井正彦、筒井秀作、飯島英樹
    • Organizer
      第94回日本消化器病学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2008-05-08
    • Related Report
      2008 Final Research Report
  • [Presentation] 林紀夫炎症性腸疾患における免疫寛容分子GRAILの関与おけるIgG 糖鎖構造の変化ー血清マーカーとしての可能性2008

    • Author(s)
      新崎信一郎、飯島英樹
    • Organizer
      第94回日本消化器病学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2008-05-08
    • Related Report
      2008 Final Research Report
  • [Presentation] 他 クローン病における悪性腫瘍合併症例の検討2008

    • Author(s)
      井上隆弘、飯島英樹
    • Organizer
      第94回日本消化器病学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2008-05-08
    • Related Report
      2008 Final Research Report
  • [Presentation] 他マウス炎症性腸疾患におけるT 細胞の免疫寛容の関与についての検討2008

    • Author(s)
      柄川悟志、飯島英樹
    • Organizer
      第94回日本消化器病学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2008-05-08
    • Related Report
      2008 Final Research Report
  • [Presentation] 他炎症性腸疾患患者における骨密度および骨代謝マーカーの検討2008

    • Author(s)
      中島佐知子、飯島英樹
    • Organizer
      第94回日本消化器病学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2008-05-08
    • Related Report
      2008 Final Research Report
  • [Presentation] 炎症性腸疾患における免疫寛容分子GRAILの関与おけるIgG糖鎖構造の変化一血清マーカーとしての可能性2008

    • Author(s)
      新崎信一郎, 飯島英樹, 林紀夫
    • Organizer
      第94回日本消化器病学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2008-05-08
    • Related Report
      2008 Annual Research Report
  • [Presentation] クローン病における悪性腫瘍合併症例の検討2008

    • Author(s)
      井上隆弘, 飯島英樹, 他
    • Organizer
      第94回日本消化器病学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2008-05-08
    • Related Report
      2008 Annual Research Report
  • [Presentation] マウス炎症性腸疾患におけるT細胞の免疫寛容の関与についての検討2008

    • Author(s)
      柄川悟志, 飯島英樹, 他
    • Organizer
      第94回日本消化器病学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2008-05-08
    • Related Report
      2008 Annual Research Report
  • [Presentation] 炎症性腸疾患患者における骨密度および骨代謝マーカーの検討2008

    • Author(s)
      中島佐知子, 飯島英樹, 他
    • Organizer
      第94回日本消化器病学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2008-05-08
    • Related Report
      2008 Annual Research Report
  • [Presentation] 骨髄移植モデルを用いた消化管運動障害の改善に関する検討2008

    • Author(s)
      石井修二, 辻晋吾, 辻井正彦, 近藤純平, 中島佐知子, 由雄敏之, 新崎信一郎, 柄川悟志, 西田勉, 垣内佳美, 渡部健二, 飯島英樹, 林紀夫
    • Organizer
      第94回日本消化器病学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2008-05-08
    • Related Report
      2008 Annual Research Report
  • [Presentation] Caldesmonはinvadopodium/podosomeの形成を阻害する癌細胞浸潤の抑制因子である2008

    • Author(s)
      由雄敏之, 森田剛, 辻井正彦, 近藤純平, 中島佐知子, 石井修二, 新崎信一郎, 柄川悟志, 山本克己, 渡部健二, 西田勉, 垣内佳美, 飯島英樹, 他
    • Organizer
      第94回日本消化器病学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2008-05-08
    • Related Report
      2008 Annual Research Report
  • [Presentation] 低用量アスピリンによる上部消化管粘膜障害 : 病変予測因子の検討2008

    • Author(s)
      垣内佳美, 辻晋吾, 辻井正彦, 筒井秀作, 飯島英樹, 他
    • Organizer
      第94回日本消化器病学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2008-05-08
    • Related Report
      2008 Annual Research Report
  • [Presentation] New diagnostic markier in Crohn's disease based on IgG oligosaccharideanalysis2007

    • Author(s)
      Shinichiro Shinzaki, Hideki Iijima, Takatoshi Nakagawa, Satoshi Egawa, Sachiko Nakajima, Jumpei Kondo, ShujiIshii, Tatsuya Kanto, Masahiko Tsujii, et.al
    • Organizer
      The 2nd Korea-Japan IBD symposium
    • Place of Presentation
      東京
    • Year and Date
      2007-12-01
    • Related Report
      2008 Final Research Report
  • [Presentation] Upregulation of GRAIL, an E3 ubiquitin ligase for induction of T cell anergy, in CD4+ Tcells of patients with ulcerative colitis in remission state2007

    • Author(s)
      Satoshi Egawa, Hideki Iijima, Masahiko Tsujii, et.al.
    • Organizer
      13th International congress of mucosal immunology
    • Place of Presentation
      東京
    • Year and Date
      2007-07-10
    • Related Report
      2008 Final Research Report
  • [Presentation] New serologic marker for IBD based on the oligosaccharide analysis2007

    • Author(s)
      Shinichiro Shinzaki, Hideki Iijima, Takatoshi Nakagawa, Satoshi Egawa, Sachiko Nakajima, Tatsuya Kanto, Masahiko Tsujii, et.al.
    • Organizer
      13th International congress of mucosal immunology
    • Place of Presentation
      東京
    • Year and Date
      2007-07-10
    • Related Report
      2008 Final Research Report
  • [Presentation] Upregulation of GRAIL, an E3 ubiquitin ligase for induction of T cell anergy, in CD4^+T cells of patients with ulcerative colitis in remission state2007

    • Author(s)
      柄川悟志、他
    • Organizer
      第13回国際粘膜免疫学会
    • Place of Presentation
      東京
    • Year and Date
      2007-07-10
    • Related Report
      2007 Annual Research Report
  • [Presentation] Expression of Grail, An E3 Ubiquitin Ligase for Induction of T Cell Anergy, in CD4+T Cells of Patients with Ulcerative Colitis ergy, in CD4^+ T cells of patients with ulcerative colitis in remission state2007

    • Author(s)
      柄川悟志、他
    • Organizer
      米国消化器病学会
    • Place of Presentation
      米国Washington DC
    • Year and Date
      2007-05-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] Expression of Grail, An E3 Ubiquitin Ligase for Induction of T Cell Anergy2007

    • Author(s)
      Satoshi Egawa, Hideki Iijima, Shinichiro Shinzaki, Sachiko Nakajima, Jumpei Kondou, Shuji Ishii, Toshiyuki Yoshio, Takanobu Irie, Yoshimi Kakiuchi, Tsutomu Nishida, Masakazu Yasumaru, Masahiko Tsujii, et.al
    • Organizer
      in CD4+ T Cells of Patients with Ulcerative Colitis. DDW2007
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2007-05-17
    • Related Report
      2008 Final Research Report
  • [Presentation] Cyclooxygenase-2 Regulates Toll-Like Receptor(TLR) 2 Expression and TLR2-Mediated Chemokine Production in Intestinal Epithelial Cells2007

    • Author(s)
      Shinichiro Shinzaki, Hideki Iijima, Satoshi Egawa, Sachiko Nakajima, Shuji Ishii, Toshiyuki Yoshio, Takanobu Irie, Yoshimi Kakiuchi, Tsutomu Nishida, Masakazu Yasumaru, Tatsuya Kanto, Masahiko Tsujii, et. al.
    • Organizer
      DDW2007
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2007-05-17
    • Related Report
      2008 Final Research Report
  • [Presentation] Transplantation of Bone Marrow-Derived Mesenchymal Stem Cells Ameliorated 2, 4, 6-Trinitrobenzene Sulfonic Acid (TNBS)-Induced Colitis in Rats2007

    • Author(s)
      Yujiro Hayashi, Shingo Tsuji, Masahiko Tsujii, Tsutomu Nishida, Shuji Ishii, Masato Komori, Takanobu Irie, Hideki Iijima, et.al.
    • Organizer
      DDW2007
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2007-05-17
    • Related Report
      2008 Final Research Report
  • [Presentation] Interferon-Gamma-Dependent Tumor-Suppressive Mechanisms of a COX-2 Inhibitor in Combination with 5-Fluorouracil.2007

    • Author(s)
      Takanobu Irie, Masahiko Tsujii, Shingo Tsuji, Toshiyuki Yoshio, Shuji Ishii, Shinichiro Shinzaki, Satoshi Egawa, Yoshimi Kakiuchi, Tsutomu Nishida, Masakazu Yasumaru, Hideki Iijima, et.al.
    • Organizer
      DDW2007
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2007-05-17
    • Related Report
      2008 Final Research Report
  • [Presentation] DNA Damage-Related Hypomethylation Induced Not Senescence Nor Apoptosis, But Aberrant Hypermethylation in CpG Island Methylator Phenotype-High Colon Cancer Cells Via Aberrant ERK / AKT Activation and Enhanced DNA Methyltransferase Activity2007

    • Author(s)
      Masahiko Tsujii, Shingo Tsuji, Shusaku Tsutsui, Hideki Iijima, et.al.
    • Organizer
      DDW2007
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2007-05-17
    • Related Report
      2008 Final Research Report
  • [Presentation] 他 潰瘍性大腸炎の緩解維持にT 細胞のアナジーが関与する2007

    • Author(s)
      柄川悟志、飯島英樹、新崎信一郎、中島佐知子、考藤達哉、辻井正彦
    • Organizer
      第93回日本消化器病学会総会
    • Place of Presentation
      青森
    • Year and Date
      2007-04-19
    • Related Report
      2008 Final Research Report
  • [Presentation] 林紀夫 レクチンを介した自然免疫系制御による炎症性腸疾患治療の可能性2007

    • Author(s)
      飯島英樹、新崎信一郎
    • Organizer
      第93回日本消化器病学会総会
    • Place of Presentation
      青森
    • Year and Date
      2007-04-19
    • Related Report
      2008 Final Research Report
  • [Presentation] 他 糖鎖解析に基づく炎症性腸疾患の新たな血清マーカー2007

    • Author(s)
      新崎信一郎、飯島英樹、中島佐知子、柄川悟志、考藤達哉、三善英知、辻井正彦
    • Organizer
      第93回日本消化器病学会総会
    • Place of Presentation
      青森
    • Year and Date
      2007-04-19
    • Related Report
      2008 Final Research Report
  • [Presentation] 潰瘍性大腸炎の緩解維持にT細胞のアナジーが関与する2007

    • Author(s)
      柄川悟志、他
    • Organizer
      第93回日本消化器病学会総会
    • Place of Presentation
      青森
    • Year and Date
      2007-04-19
    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.osaka-u.ac.jp/pub/gh/index.Htm

    • Related Report
      2008 Final Research Report
  • [Remarks]

    • URL

      http://www.med.osaka-u.ac.jp/pub/gh/data/relations/study_h.html

    • Related Report
      2008 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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