Investigation of target molecules involved in enhanced antitumoreffects of chemotherapy for colorectal cancer from the view point of tumor immunity andtumor angiogenesis.

• Project/Area Number: 19590722
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Osaka University
• Principal Investigator: TSUJII Masahiko Osaka University, 医学系研究科, 講師 (40303937)
• Co-Investigator(Kenkyū-buntansha): IIJIMA Hideki 大阪大学, 医学系研究科, 助教 (90444520) ; 辻 晋吾 大阪大学, 医学系研究科, 講師 (40301262)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: COX阻害剤 / 血管新生 / インターフェロン / 悪液質 / VEGF / cyclooxygenase-2 / 5FU / 大腸癌 / インターフェロン-γ / 悪疫質

Research Abstract

疫学的研究からNSAIDs、cylooxygenase-2 阻害剤の腫瘍免疫増強作用・腫瘍血管新生抑制作用を介して抗腫瘍効果を発揮することが明らかにされてきている。本研究では、大腸癌のマウスモデルを用いて、化学療法にcyclooxygenase-2(COX-2)阻害剤を併用した際の抗腫瘍効果に及ぼす影響を検討した。結果はCOX-2 阻害剤は腫瘍内インターフェロンγ産生を誘導し、腫瘍血管新生を抑制することにより、5FU の抗腫瘍効果を増強することが明らかとなった

Research Products

• [Journal Article] Involvement of bone marrow-derived stromal cells in gastrointestinal cancer development and metastasis. J Gastroenterol (2008)
  • Author(s): Ishii S, Tsuji S, Tsujii M, et.al.
  • Journal Title: Hepatol 23
  • Peer Reviewed
• [Journal Article] IgG Oligosaccharide Alterations Are a Novel Diagnostic Marker for Disease Activity and the Clinical Course of Inflammatory Bowel Disease. (2008)
  • Author(s): Shinzaki S, Iijima H, Nakagawa T, Egawa S, Nakajima S, Ishii S, Irie T, Kakiuchi Y, Nishida T, Yasumaru M, Kanto T, Tsujii M, Tsuji S, Mizushima T, Yoshihara H, Kondo A, Miyoshi E, Hayashi N
  • Journal Title: Am J Gastroenterol 103 Pages: 1173-1181
  • Peer Reviewed
• [Journal Article] Topical Transplantation of Mesenchymal Stem Cells Accelerates Gastric Ulcer Healing in Rats (2008)
  • Author(s): Hayashi Y, Tsuji S, Tsujii M, Nishida T, Ishii S, Iijima H, Nakamura T, Eguchi H, Miyoshi E, Hayashi N, Kawano S
  • Journal Title: Am J Physiol Gastrointest Liver Physiol 295
  • Peer Reviewed
• [Journal Article] Upregulation of GRAIL is associated with remission of ulcerative colitis (2008)
  • Author(s): Egawa S, Iijima H, Shinzaki S, et.al.
  • Journal Title: Am H Physiol Gastrointest Liver Physiol 295
  • Peer Reviewed
• [Journal Article] Cultured bone marrow cell local implantation accelerate healing of ulcers in mice (2008)
  • Author(s): Nishida T, Tsuji S, Tsujii M, et.al.
  • Journal Title: J Gastroenterol 43 Pages: 124-135
  • NAID: 10021267619
  • Peer Reviewed
• [Journal Article] Topical Implantation of Mesenchymal Stem Cells has Beneficial Effects on Healing of Experimental Colitis in Rats (2008)
  • Author(s): Hayashi Y, Tsuji S, Tsujii M, Nishi da T, Ishii S, Iijima H, Nakamura T, Eguchi H, Miyoshi E, Hayashi N, Kawano S
  • Journal Title: J Pharmacol Exp Ther 326 Pages: 523-531
  • Peer Reviewed
• [Journal Article] Topical transplantation of mesenchymal stem cells accelerates gastric ulcer healing in rats (2008)
  • Author(s): Hayashi Y, Tsuji S, Tsujii M, et.al.
  • Journal Title: Am J Physiol Gastrointest Liver Physiol 294
  • Peer Reviewed
• [Journal Article] IgG oligosaccharide alterations are a novel diagnostic marker for disease activity and the clinical course of inflammatory bowel disease (2008)
  • Author(s): Shinzaki S, Iijima H, Nakagawa T, et.al.
  • Journal Title: Am J Gastroenterol 103 Pages: 1173-1181
  • Peer Reviewed
• [Journal Article] 糖尿病におけるGERD : 定量的末梢知覚試験からの検討 (2008)
  • Author(s): 西田勉, 辻晋吾, 山本克己、他
  • Journal Title: Progress in Medicine 20 Pages: 706-709
  • Peer Reviewed
• [Journal Article] CEA 高値で発見された非症候性膵 (2008)
  • Author(s): 西田勉、山本克己、筒井秀作、他
  • Journal Title: グルカゴノーマの一例 膵臓 23 Pages: 140-145
  • Peer Reviewed
• [Journal Article] Modified FOLFOX6 was effective for advanced adenocarcinoma with unknown origin in a patient with Crohn's disease (2008)
  • Author(s): Hayashi Y, Nishida T, Kondo J, Yamamoto K, Iijima H, Tsutsui S, Hiramatsu N, Tsujii M, Tsuji S, Ito H, Takehara T, Hayashi N
  • Journal Title: 日本消化器病学会雑誌 106 Pages: 69-76
  • NAID: 10024850279
  • Peer Reviewed
• [Journal Article] Helicobacter pylori infection affects Toll-like receptor 4 expression in human gastric mucosa (2008)
  • Author(s): Asahi K, Fu HY, Hayashi Y, Eguchi H, Murata H, Tsujii M, Tsuji S, Tanimura H, Kawano S
  • Journal Title: Hepatogastroenterology 54 Pages: 1941-1944
  • Peer Reviewed
• [Journal Article] Helicobacter pylori infection induces candidate stem cell marker musashi-1 in the human gastric epithelium (2008)
  • Author(s): Murata H, Tsuji S, Tsujii M, Nakamura T, Fu HY, Eguchi H, Asahi K, Okano H, Kawano S, Hayashi N
  • Journal Title: DigDis Sci 53 Pages: 363-369
  • Peer Reviewed
• [Journal Article] Involvement of bone marrow-derived stromal cells in gast rointestinal cancer development and metastasis. (2008)
  • Author(s): Ishii S, Tsuji S, Tsujii M, et al.
  • Journal Title: J Gastroenterol Hepatol. 23
• [Journal Article] Upregulation of GRAIL is associated with remission of ulcerative colitis. (2008)
  • Author(s): Egawa S, Iijima H, Shinzaki S, et al.
  • Journal Title: Am H Physiol Gastrointest Liver Physiol 295
  • Peer Reviewed
• [Journal Article] Cultured bone marrow cell local implantation accelerate healing of ulcers in mice. (2008)
  • Author(s): Nishida T, Tsuji S, Tsujii M, et al.
  • Journal Title: J Gastroenterol. 43 Pages: 124-135
  • NAID: 10021267619
  • Peer Reviewed
• [Journal Article] Topical Implantation of Mesenchymal stem Cells has Bene ficial Effects on Healing of Experimental Colitis in Rats. (2008)
  • Author(s): Hayashi Y, Tsuji S, Tsujii M, et al.
  • Journal Title: J Pharmacol Exp Ther 326 Pages: 523-531
  • Peer Reviewed
• [Journal Article] Topical transplantation of mesenchymal stem cells accelerates gastric ulcer healing in rats. (2008)
  • Author(s): Hayashi Y, Tsuji S, Tsujii M, et al.
  • Journal Title: Am J Physiol Gastrointest Liver Physiol 294
  • Peer Reviewed
• [Journal Article] IgG oligosaccharide alterations are a novel diagnostic marker for disease activity and the clinical course of inflammatory bowel disease. (2008)
  • Author(s): Shinzaki S, Iijima H, Nakagawa T, et al.
  • Journal Title: Am J Gastroenterol 103 Pages: 1173-1181
  • Peer Reviewed
• [Journal Article] 糖尿病におけるGERD : 定量的末梢知覚試験からの検討 (2008)
  • Author(s): 西田勉, 辻晋吾, 山本克己, 他
  • Journal Title: Progress in Medicine 28 Pages: 706-709
  • Peer Reviewed
• [Journal Article] CEA高値で発見された非症候性膵グルカゴノーマの一例 (2008)
  • Author(s): 西田勉, 山本克己, 筒井秀作, 他
  • Journal Title: Am J Gastroenterol 103 Pages: 1173-1181
  • Peer Reviewed
• [Journal Article] Modified FOLFOX6 was effective for advanced adenocarcinoma with unknown origin in a patient with Crohn's disease (2008)
  • Author(s): Hayashi Y, Nishida T, Kondo J, et al.
  • Journal Title: 日本消化器病学会雑誌 106 Pages: 69-76
  • Peer Reviewed
• [Journal Article] Topical Transplantation of Mesenchymal Stem Cells Accelerates Gastric Ulcer Healing in Rats. (2008)
  • Author(s): Hayashi Y, Tsuji S, Tsujii M, Nishida T, Ishii S, Iijima H, Nakamura T, Eguchi H, Miyoshi E, Hayashi N, Kawano S.
  • Journal Title: Am J Physiol Gastrointest Liver Physiol.
  • Peer Reviewed
• [Journal Article] IgG Oligosaccharide Alterations Are a Novel Diagnostic Marker for Disease Activity and the Clinical Course of Inflammatory Bowel Disease. (2008)
  • Author(s): Shinzaki S, Iijima H, Nakagawa T, Egawa S, Nakajima S, Ishii S, Irie T, Kakiuchi Y, Nishida T, Yasumaru M, Kanto T, Tsujii M, Tsuji S, Mizushima T, Yoshihara H, Kondo A, Miyoshi E, Hayashi N.
  • Journal Title: Am J Gastroenterol.
  • Peer Reviewed
• [Journal Article] Synergistic antitumor effects of celecoxib with 5-fluorouracil depend on IFN-gamma (2007)
  • Author(s): Irie T, Tsujii M, Tsuji S, Yoshio T, Ishii S, Shinzaki S, Egawa S, Kakiuchi Y, Nishida T, Yasumaru M, Iijima H, Murata H, Takehara T, Kawano S, Hayashi N
  • Journal Title: Int J Cancer 121 Pages: 878-883
  • Peer Reviewed
• [Journal Article] Geranylgeranylacetone induces cyclooxygenase-2 expression in cultured rat gastric epithelial cells through NF-kappaB (2007)
  • Author(s): Nishida T, Yabe Y, Fu HY, Hayashi Y, Asahi K, Eguchi H, Tsuji S, Tsujii M, Hayashi N, Kawano S
  • Journal Title: Dig Dis Sci 52 Pages: 1890-1896
  • Peer Reviewed
• [Journal Article] Caldesmon suppresses cancer cell invasion by regulating podosome/invadopodium formation (2007)
  • Author(s): Yoshio T, Morita T, Kimura Y, Tsujii M, Hayashi N, Sobue K
  • Journal Title: FEBS Letter 581 Pages: 37777-3782
  • Peer Reviewed
• [Journal Article] The transdifferentiation of bone-marrow-derived cells in colonic mucosal regeneration after dextran-sulfate-sodium-induced colitis in mice (2007)
  • Author(s): Hayashi Y, Tsuji S, Tsujii M, Nishida T, Ishii S, Nakamura T, Eguchi H, Kawano S
  • Journal Title: Pharmacology 80 Pages: 193-199
  • Peer Reviewed
• [Journal Article] Possibilities of prevention of colonic neoplasms (2007)
  • Author(s): Tsujii M
  • Journal Title: Nippon Naika Gakkai Zasshi 96 Pages: 295-304
  • Peer Reviewed
• [Journal Article] Helicobacter pylori infection affects Toll-like receptor 4 expression in human gastric mucosa. (2007)
  • Author(s): Asahi K, Fu HY, Hayashi Y, Eguchi H, Murata H, Tsujii M, Tsuji S, Tanimura H, Kawano S.
  • Journal Title: Hepatogastroenterology. 54 Pages: 1941-1944
  • Peer Reviewed
• [Journal Article] Helicobacter pylori infection induces candidate stem cell marker musashi-1 in the human gastric epithelium. (2007)
  • Author(s): Murata H, Tsuji S, Tsujii M, Nakamura T, Fu HY, Eguchi H, Asahi K, Okano H, Kawano S, Hayashi N.
  • Journal Title: Dig Dis Sci. 53 Pages: 363-369
  • Peer Reviewed
• [Journal Article] Synergistic antitumor effects of celecoxib with 5-fluorouracil depend on IFN-gamma. (2007)
  • Author(s): Irie T, Tsujii M, Tsuji S, Yoshio T, Ishii S, Shinzaki S, Egawa S, Kakiuchi Y, Nishida T, Yasumaru M, Iijima H, Murata H, Takehara T, Kawano S, Hayashi N.
  • Journal Title: Int J Cancer. 121 Pages: 878-883
  • Peer Reviewed
• [Journal Article] Geranylgeranylacetone induces cyclooxygenase-2 expression in cultured rat gastric epithelial cells through NF-kappaB. (2007)
  • Author(s): Nishida T, Yabe Y, Fu HY, Hayashi Y, Asahi K, Eguchi H, Tsuji S, Tsujii M, Hayashi N, Kawano S.
  • Journal Title: Dig Dis Sci. 52 Pages: 1890-1896
  • Peer Reviewed
• [Journal Article] Caldesmon suppresses cancer cell invasion by regulating podosome/invadopodium formation. (2007)
  • Author(s): Yoshio T, Morita T, Kimura Y, Tsujii M, Hayashi N, Sobue K.
  • Journal Title: FEBS Lett. 581 Pages: 3777-3782
  • Peer Reviewed
• [Journal Article] The transdifferentiation of bone-marrow-derived cells in colonic mucosal regeneration after dextran-sulfate-sodium-induced colitis in mice. (2007)
  • Author(s): Hayashi Y, Tsuji S, Tsujii M, Nishida T, Ishii S, Nakamura T, Eguchi H, Kawano S.
  • Journal Title: Pharmacology. 80 Pages: 193-199
  • Peer Reviewed
• [Journal Article] Possibilities of prevention of colonic neoplasms (2007)
  • Author(s): Tsujii M
  • Journal Title: Nippon Naika Gakkai Zasshi. 96 Pages: 295-304
• [Presentation] 他クローン病術後に対する小腸内視鏡検査の有用性と問題点 (2008)
  • Author(s): 井上隆弘、飯島英樹、中島佐知子
  • Organizer: JDDW2008
  • Place of Presentation: 東京
  • Year and Date: 2008-10-03
• [Presentation] 他進行膵癌(cStageIV)の治療戦略 (2008)
  • Author(s): 西田勉、筒井秀作、山本克己
  • Organizer: JDDW 2008
  • Place of Presentation: 東京
  • Year and Date: 2008-10-03
• [Presentation] クローン病術後に対する小腸内視鏡検査の有用性と問題点 (2008)
  • Author(s): 井上隆弘, 飯島英樹, 中島佐知子, 他
  • Organizer: JDDW 2008
  • Place of Presentation: 東京
  • Year and Date: 2008-10-03
• [Presentation] 進行脚癌(cStageIV)の治療戦略 (2008)
  • Author(s): 西田勉, 筒井秀作, 山本克己, 他
  • Organizer: JDDW 2008
  • Place of Presentation: 東京
  • Year and Date: 2008-10-03
• [Presentation] 他短期間に増大した胃腺内分泌細胞腫の一例 (2008)
  • Author(s): 米本仁史、濱野美奈、西田勉
  • Organizer: 第81回日本消化器内視鏡学会近畿地方会
  • Place of Presentation: 大阪
  • Year and Date: 2008-09-20
• [Presentation] 短期間に増大した胃腺内分泌細胞腫の一例 (2008)
  • Author(s): 米本仁史, 波野美奈, 西田勉, 他
  • Organizer: 第81回日本消化器内視鏡学会近畿地方会
  • Place of Presentation: 大阪
  • Year and Date: 2008-09-20
• [Presentation] 他マウス炎症性腸疾患におけるT細胞の免疫寛容の関与についての検討 (2008)
  • Author(s): 柄川悟志、飯島英樹、新崎信一郎
  • Organizer: 第36回日本潰瘍学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2008-09-05
• [Presentation] マウス炎症性腸疾患におけるT細胞の免疫寛容の関与についての検討 (2008)
  • Author(s): 柄川悟志, 飯島英樹, 新崎信一郎, 他
  • Organizer: 第36回日本潰瘍学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2008-09-05
• [Presentation] Alterations in IgG fucosylated oligosaccharides are a novel diagnostic marker for disease activity and the clinical course of inflammatory bowel disease (2008)
  • Author(s): Shinzaki S, Iijima H, Nakagawa T, et.al.
  • Organizer: JHUPO conference
  • Place of Presentation: 大阪
  • Year and Date: 2008-07-29
• [Presentation] Alterations in IgG fucosylated oligosaccharides are a novel diagnostic marker for disease activity and the clinical course of inflammatory bowel disease (2008)
  • Author(s): Shinzaki S, Iijima H, Nakagawa T, et al.
  • Organizer: JHUPO conference 2008
  • Place of Presentation: 大阪
  • Year and Date: 2008-07-29
• [Presentation] 他潰瘍性大腸炎患者におけるT細胞アナジーの検討 (2008)
  • Author(s): 柄川悟志、飯島英樹、新崎信一郎
  • Organizer: 第45回日本消化器免疫学界総会
  • Place of Presentation: 京都
  • Year and Date: 2008-07-04
• [Presentation] 潰瘍性大腸炎患者におけるT細胞アナジーの検討 (2008)
  • Author(s): 柄川悟志, 飯島英樹, 新崎信一郎, 他
  • Organizer: 第45回日本消化器免疫学界総会
  • Place of Presentation: 福岡
  • Year and Date: 2008-07-04
• [Presentation] Chemical intervention reverses oxidative stress-induced epigenetic alterations in colon cancer cells : Clues for new chemopreventive measures against aging and carcinogenesis (2008)
  • Author(s): Tsujii M, Tsuji S, Eguchi H, et.al.
  • Organizer: 米国消化器病学会
  • Year and Date: 2008-05-21
• [Presentation] IgG oligosaccharidealterations are a novel diagnostic marker for disease activity and the clinical course of inflam matory bowel disease (2008)
  • Author(s): Shinzaki S, Iijima H, Nakagawa T, et.al.
  • Organizer: 米国消化器病学会
  • Place of Presentation: 米国サンディエゴ
  • Year and Date: 2008-05-21
• [Presentation] Mesenchymal Stem Cells Transplantation Accelerates Gastric Ulcer Healing in Rats (2008)
  • Author(s): Hayashi Y, Tsuji S, Tsujii M, et.al.
  • Organizer: 米国消化器病学会
  • Place of Presentation: 米国サンディエゴ
  • Year and Date: 2008-05-21
• [Presentation] Bone mineral density and biochemical markers of bone turnover in patients with in flammatory bowel disease (2008)
  • Author(s): Nakajima S, Iijima H, Shinzaki S, et.al.
  • Organizer: 米国消化器病学会
  • Place of Presentation: 米国サンディエゴ
  • Year and Date: 2008-05-21
• [Presentation] Possible roles of let-7 micro RNA expression in the Cytotoxinassociatedgene A (CagA) associated pathogenesis (2008)
  • Author(s): Wang J, Tsujii M, Tsuji S, et.al.
  • Organizer: 米国消化器病学会
  • Place of Presentation: 米国サンディエゴ
  • Year and Date: 2008-05-21
• [Presentation] Bone-marrow cells are able to develop Interstitial Cells of Cajal : Morphologic Evidences in W/Wv mice (2008)
  • Author(s): Ishii S, Tsuji S, Tsujii M, et.al.
  • Organizer: 米国消化器病学会
  • Place of Presentation: 米国サンディエゴ
  • Year and Date: 2008-05-21
• [Presentation] Caldesmon suppresses cancer cell invasion by regulating podosome/invadopodium formation (2008)
  • Author(s): Yoshio T, Morita T, Tsujii M, , et.al.
  • Organizer: 米国消化器病学会
  • Place of Presentation: 米国サンディエゴ
  • Year and Date: 2008-05-21
• [Presentation] Upregulation of E3 ubiquitin ligases related to T cell anergy in CD4+ T cells isolated from patients with ulcerative colitis in remission (2008)
  • Author(s): Egawa S, Iijima H, Shinzaki S, et.al.
  • Organizer: 米国消化器病学会
  • Place of Presentation: 米国サンディエゴ
  • Year and Date: 2008-05-21
• [Presentation] Indications And Diagnostic Yield Of Double Balloon Enteroscopy In A Tertiary Care Setting : An Analysis Of 527 Cases With Suspected Small Bowel Diseases (2008)
  • Author(s): Kondo J, Tsuji S, Iijima H, et.al.
  • Organizer: 米国消化器病学会
  • Place of Presentation: 米国サンディエゴ
  • Year and Date: 2008-05-21
• [Presentation] Chemical intervention reverses oxidative stress-induced epigenetic alterations in colon cancer cells : Clues for new chemop reventive measures against aging and carcinogenesis. (2008)
  • Author(s): Tsujii M, Tsuji S, Eguchi H, et al.
  • Organizer: 米国消化器病学会
  • Place of Presentation: サン・ディエゴ
  • Year and Date: 2008-05-21
• [Presentation] IgG oligosaccharide alterations are a novel diagnostic marker for disease activity and the clinical course of inflammatory bowel disease (2008)
  • Author(s): Shinzaki S, Iijima H, Nakagawa T, et al.
  • Organizer: 米国消化器病学会
  • Place of Presentation: サン・ディエゴ
  • Year and Date: 2008-05-21
• [Presentation] Mesenchymal Stem Cells Transplantation Accelerates Gastric Ulcer Healing in Rats (2008)
  • Author(s): Hayashi Y, Tsuji S, Tsujii M, et al.
  • Organizer: 米国消化器病学会
  • Place of Presentation: サン・ディエゴ
  • Year and Date: 2008-05-21
• [Presentation] Bone mineral density and biochemical markers of bone turnover in patients with inflammatory bowel disease (2008)
  • Author(s): Nakajima S, Iijima H, Shinzaki S, et al.
  • Organizer: 米国消化器病学会
  • Place of Presentation: サン・ディエゴ
  • Year and Date: 2008-05-21
• [Presentation] Possible roles of let-7 microRNA expression in the Cytotoxin-associated gene A (CagA) associated pathogenesis (2008)
  • Author(s): Wang J, Tsujii M, Tsuji S, et al.
  • Organizer: 米国消化器病学会
  • Place of Presentation: サン・ディエゴ
  • Year and Date: 2008-05-21
• [Presentation] Bone-marrow, cells are able to develop Interstitial Cells of Cajal : Morphologic Evidences in W/Wv mice (2008)
  • Author(s): Ishii S, Tsuji S, Tsujii M, et al.
  • Organizer: 米国消化器病学会
  • Place of Presentation: サン・ディエゴ
  • Year and Date: 2008-05-21
• [Presentation] Caldesmon suppresses cancer cell invasion by regulating podosome/invadopodium formation. (2008)
  • Author(s): Yoshio T, Morita T, Tsuiii M,, et al.
  • Organizer: 米国消化器病学会
  • Place of Presentation: サン・ディエゴ
  • Year and Date: 2008-05-21
• [Presentation] Upregulation of E3 ubiquitin ligases related to T cell anergy in CD4+ T cells isolated from patients with ulcerative colitis in remission (2008)
  • Author(s): Egawa S, Iijima H, Shinzaki S, et al.
  • Organizer: 米国消化器病学会
  • Place of Presentation: サン・ディエゴ
  • Year and Date: 2008-05-21
• [Presentation] Indications And Diagnostic Yield Of Double Balloon Enteroscopy In A Tertiary Care Setting : An Analysis Of 527 Cases With Suspected Small Bowel Diseases (2008)
  • Author(s): Kondo J, Tsuji S, Iijima H, et al.
  • Organizer: 米国消化器病学会
  • Place of Presentation: サン・ディェゴ
  • Year and Date: 2008-05-21
• [Presentation] 他炎症性腸疾患に見られるガラクトース欠損IgGによるマクロファージ機能への影響の解析 (2008)
  • Author(s): 飯島英樹、新崎信一郎、中島佐知子
  • Organizer: 第94回日本消化器病学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2008-05-10
• [Presentation] 他クローン病における悪性腫瘍合併症例の検討 (2008)
  • Author(s): 井上隆弘、飯島英樹、中島佐知子
  • Organizer: 第94回日本消化器病学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2008-05-10
• [Presentation] 他マウス炎症性腸疾患におけるT細胞の免疫寛容の関与についての検討 (2008)
  • Author(s): 柄川悟志、飯島英樹、新崎信一郎
  • Organizer: 第94回日本消化器病学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2008-05-10
• [Presentation] 他炎症性腸疾患患者における骨密度および骨代謝マーカーの検討 (2008)
  • Author(s): 中島佐知子、飯島英樹、新崎信一郎
  • Organizer: 第94回日本消化器病学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2008-05-10
• [Presentation] 他骨髄移植モデルを用いた消化管運動障害の改善に関する検討 (2008)
  • Author(s): 石井修二、辻晋吾、辻井正彦
  • Organizer: 第94回日本消化器病学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2008-05-10
• [Presentation] 他Caldesmonはinvadopodium/podosomeの形成を阻害する癌細胞浸潤の抑制因子である (2008)
  • Author(s): 由雄敏之、森田剛、辻井正彦
  • Organizer: 第94回日本消化器病学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2008-05-10
• [Presentation] 他低用量アスピリンによる上部消化管粘膜障害 : 病変予測因子の検討 (2008)
  • Author(s): 垣内佳美、辻晋吾、辻井正彦
  • Organizer: 第94回日本消化器病学会総会
  • Year and Date: 2008-05-10
• [Presentation] 炎症性腸疾患に見られるガラクトース欠損IgGによるマクロファージ機能への影響の解析 (2008)
  • Author(s): 飯島英樹, 新崎信一郎, 中島佐知子, 他
  • Organizer: 第94回日本消化器病学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2008-05-10
• [Presentation] クローン病における悪性腫瘍合併症例の検討 (2008)
  • Author(s): 井上隆弘, 飯島英樹, 中島佐知子, 他
  • Organizer: 第94回日本消化器病学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2008-05-10
• [Presentation] マウス炎症性腸疾患におけるT細胞の免疫寛容の関与についての検討 (2008)
  • Author(s): 柄川悟志, 飯島英樹, 新崎信一郎, 他
  • Organizer: 第94回日本消化器病学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2008-05-10
• [Presentation] 炎症性腸疾患患者における骨密度および骨代謝マーカーの検討 (2008)
  • Author(s): 中島佐知子, 飯島英樹, 新崎信一郎, 他
  • Organizer: 第94回日本消化器病学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2008-05-10
• [Presentation] 骨髄移植モデルを用いた消化管運動障害の改善に関する検討 (2008)
  • Author(s): 石井修二, 辻晋吾, 辻井正彦, 他
  • Organizer: 第94回日本消化器病学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2008-05-10
• [Presentation] Caldesmonはinvadopodium/podosomeの形成を阻害する癌細胞浸潤の抑制因子である. (2008)
  • Author(s): 由雄敏之, 森田剛, 辻井正彦, 他
  • Organizer: 第94回日本消化器病学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2008-05-10
• [Presentation] 低用量アスピリンによる上部消化管粘膜障害 : 病変予測因子の検討 (2008)
  • Author(s): 垣内佳美, 辻晋吾, 辻井正彦, 他
  • Organizer: 第94回日本消化器病学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2008-05-10
• [Presentation] DNA damage enhanced DNA methyltransferase activity via COX-2 and Erk activation (2007)
  • Author(s): M. Tsujii, S. Tsuji, T.Kanto, T. Takehara, N. Hayashi
  • Organizer: leading to aberrant hypermethylation日本癌学会
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-03
• [Presentation] DNA damage enhanced DNA methyltransferase activity via COX-2 and Erk activation, leading to aberrant hypermethylation (2007)
  • Author(s): M. Tsujii, S. Tsuji, T. Kanto, T. Takehara, N. Hayashi
  • Organizer: 日本がん学会
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-03
• [Presentation] Endoscopic Full-Thickness Resection (EFTR), a New Technique for Treatment of Gastric Malignancy. (2007)
  • Author(s): M Yasumaru, S Tsuji, M Tsujii, S Tsutsui, T Yoshio, S Nakajima, S Ishii, S Shinzaki, S Egawa, T Irie, T Nishida, Y Kakiuchi, H Iijima, S Kawano, N Hayashi
  • Organizer: Digestive Disease Week and 108th Annual Meeting of the AGA Institute
  • Place of Presentation: Washington, DC
  • Year and Date: 2007-05-22
• [Presentation] Expression of Grail, An E3 Ubiquitin-Ligase for Induction of T Cell Anergy, in Cd4+ T Cells of Patients with Ulcerative Colitis. (2007)
  • Author(s): S Egawa, H Iijima, S Shinzaki, S Nakajima, J Kondo, S Ishii, T Yoshio, T Irie, Y Kakiuchi, T Nishida, M Yasumaru, M Tsujii, S Tsuji, N Hayashi.
  • Organizer: Digestive Disease Week and 108th Annual Meeting of the AGA Institute
  • Place of Presentation: Washington, DC
  • Year and Date: 2007-05-21
• [Presentation] Interferon-Gamma-Dependent Tumor-Suppressive Mechanisms of a COX-2 Inhibitor in Combination with 5-Fluorouracil. (2007)
  • Author(s): T Irie, M Tsujii, S Tsuji, S, T Yoshio, S Ishii, S Shinzaki, S Egawa, Y Kakiuchi, T Nishida, M Yasumaru, H Iijima, H Murata, T Takehara, S Kawano, N Hayashi
  • Organizer: Digestive Disease Week and 108th Annual Meeting of the AGA Institute
  • Place of Presentation: Washington, DC
  • Year and Date: 2007-05-21
• [Presentation] Transplantation of Bone Marrow-Derived Mesenchymal Stem Cells Ameliorated 2, 4, 6-Trinitrobenzene Sulfonic Acid (TNBS)-Induced Colitis in Rats (2007)
  • Author(s): Y Hayashi, S Tsuji, M Tsujii, T Nishida, S Ishii, M Komori, T Irie, H I ijima, H Eguchi, N Hayashi, S Kawano
  • Organizer: Digestive Disease Week and 108th Annual Meeting of the AGA Institute
  • Place of Presentation: 米国ワシントンDC
  • Year and Date: 2007-05-20
• [Presentation] N Hayashi Cyclooxygenase-2 Regulates Toll-like Receptor (TLR)2 Expression and Tlr2-Mediated Chemokine Production in Intestinal Epithelial Cells (2007)
  • Author(s): S Shinzaki, H Iijima, S Egawa, S Nakajima, S Ishii, T Yoshio, T Irie, Y Kakiuchi, T Nishida, M Yasumaru, T Kanto, M Tsujii, S Tsuji
  • Organizer: Digestive Disease Week and 108th Annual Meeting of the AGA Institute
  • Place of Presentation: 米国ワシントンDC
  • Year and Date: 2007-05-20
• [Presentation] DNA Damage-Related Hypomethylation Induced Not Senescence Nor Apoptosis, But Aberrant Hypermethylation in CpG Island Methylator Phenotype-High Colon Cancer Cells Via Aberrant Erk/Akt Activation and Enhanced DNA Methyltransferase Activity. (2007)
  • Author(s): M Tsujii, S Tsuji, S Tsutsui, H Iijima, M Yasumaru, T Nishida, T Irie, S Egawa, S Shinzaki, S Ishii, S Nakajima, T Yoshio, J Kondo, H Eguchi, S Kawano, N Hayashi.
  • Organizer: Digestive Disease Week and 108^<th> Annual Meeting of the AGA Institute
  • Place of Presentation: 米国ワシントンDC
  • Year and Date: 2007-05-20
• [Presentation] Expression of Grail, An E3 Ubiquitin-Ligase for Induction of T Cell Anergy, in Cd4+ T Cells of Patients with Ulcerative Colitis (2007)
  • Author(s): S Egawa, H Iijima, S Shinzaki, S Nakajima, J Kondo, S Ishii, T Yoshio, T Irie, Y Kakiuchi, T Nishida, M Yasumaru, M Tsujii, S Tsuji, N Hayashi
  • Organizer: Digestive Disease Week and 108^<th> Annual Meeting of the AGA Institute
  • Place of Presentation: 米国ワシントンDC
  • Year and Date: 2007-05-20
• [Presentation] Interferon-Gamma-Dependent Tumor-Suppressive Mechanisms of a COX-2 Inhibitor in Combination with 5-Fluorouracil (2007)
  • Author(s): T Irie, M Tsujii, S Tsuji, S , T Yoshio, S Ishii, S Shinzaki, S Egawa, Y Kakiuchi, T Nishida, M Yasumaru, H Iijima, H Murata, T Takehara, S Kawano, N Hayashi
  • Organizer: Digestive Disease Week and 108^<th>Annual Meeting of the AGA Institute
  • Place of Presentation: 米国ワシントンDC
  • Year and Date: 2007-05-20
• [Presentation] Endoscopic Full-Thickness Resection (EFTR), a New Technique for Treatment of GastricMalignancy (2007)
  • Author(s): M Yasumaru, S Tsuji, M Tsujii, S Tsutsui, T Yoshio, S Nakajima, S Ishii, S Shinzaki, S Egawa, T Irie, T Nishida, Y Kakiuchi, H Iijima, S Kawano, N Hayashi
  • Organizer: Digestive Disease Week and 108^<th> Annual Meeting of the AGA Institute
  • Place of Presentation: 米国ワシントンDC
  • Year and Date: 2007-05-20
• [Presentation] Transplantation of Bone Marrow-Derived Mesenchymal Stem Cells Ameliorated 2,4,6-Trinitrobenzene sulfonic Acid (TNBS)-Induced Colitis in Rats. (2007)
  • Author(s): Y Hayashi, S Tsuji, M Tsujii, T Nishida, S Ishii, M Komori, T Irie, H Iijima, H Eguchi, N Hayashi, S Kawano.
  • Organizer: Digestive Disease Week and 108th Annual Meeting of the AGA Institute
  • Place of Presentation: Washington, DC
  • Year and Date: 2007-05-20
• [Presentation] Cyclooxygenase-2 Regulates Toll-like Receptor (TLR)2 Expression and Tlr2-Mediated Chemokine Production in Intestinal Epithelial Cells. (2007)
  • Author(s): S Shinzaki, H Iijima, S Egawa, S Nakajima, S Ishii, T Yoshio, T Irie, Y Kakiuchi, T Nishida, M Yasumaru, T Kanto, M Tsujii, S Tsuji, N Hayashi
  • Organizer: Digestive Disease Week and 108th Annual Meeting of the AGA Institute
  • Place of Presentation: Washington, DC
  • Year and Date: 2007-05-20
• [Presentation] DNA Damage-Related Hypomethylation Induced Not Senescence Nor Apoptosis, But Aberrant Hypermethylation in CpG Island Methylator Phenotype-High Colon Cancer Cells Via Aberrant Erk/Akt Activation and Enhanced DNA Methyltransferase Activity. (2007)
  • Author(s): M Tsujii, S Tsuji, S Tsutsui, H Iijima, M Yasumaru, T Nishida, T Irie, S Egawa, S Shinzaki, S Ishii, S Nakajima, T Yoshio, J Kondo, H Eguchi, S Kawano, N Hayashi.
  • Organizer: Digestive Disease Week and 108th Annual Meeting of the AGA Institute
  • Place of Presentation: Washington, DC
  • Year and Date: 2007-05-20
• [Presentation] 林紀夫糖鎖解析に基づく炎症性腸疾患の新たな血清マーカー (2007)
  • Author(s): 新崎信一郎、飯島英樹、中島佐知子、柄川悟志、考藤達哉、三善英知、辻井正彦、辻晋吾、吉原治正
  • Organizer: 第93回日本消化器病学会総会
  • Place of Presentation: 青森
  • Year and Date: 2007-04-20
• [Presentation] 林 紀夫潰瘍性大腸炎患者におけるT細胞不応答性の検討 (2007)
  • Author(s): 柄川悟志、飯島英樹、新崎信一郎、中島佐知子、石井修二、由雄敏之、入江孝延、垣内佳美、安丸正一、考藤達哉、辻井正彦、辻晋吾、吉原治正
  • Organizer: 第93回日本消化器病学会総会
  • Place of Presentation: 青森
  • Year and Date: 2007-04-20
• [Presentation] 糖鎖解析に基づく炎症性腸疾患の新たな血清マーカー (2007)
  • Author(s): 新崎信一郎、飯島英樹、中島佐知子、柄川悟志、考藤達哉、三善英知、辻井正彦、辻 晋吾、吉原治正、林 紀夫
  • Organizer: 第93回日本消化器病学会総会
  • Place of Presentation: 青森
  • Year and Date: 2007-04-20
• [Presentation] 潰瘍性大腸炎患者におけるT細胞不応答性の検討 (2007)
  • Author(s): 柄川悟志、飯島英樹、新崎信一郎、中島佐知子、石井修二、由雄敏之、入江孝延、垣内佳美、安丸正一、考藤達哉、辻井正彦、辻 晋吾、吉原治正、林 紀夫
  • Organizer: 第93回日本消化器病学会総会
  • Place of Presentation: 青森
  • Year and Date: 2007-04-20