| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
We have investigated the pathogenesis of Barrett's esophagus focusing on the cellular origin and abnormal differentiation of the original cells. Esophageal fibroblasts, when exposed to acidic gastric contents, secrete various growth factors and cytokines. Especially HB-EGF produced by these acid exposed fibroblasts induced abnormal differentiation of immature esophageal squamous cells to intestinal type columnar cells by inducing Cdx2 expression. Furthermore squamous epithelial cells exposed to bile acids started to differentiate to columnar epithelial cells by the mutual interaction of Cdx1 and Cdx2.
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