Study on the pathogenesis of Barrett's esophagus based on stem cell biopsy
Project/Area Number |
19590723
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Gastroenterology
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Research Institution | Shimane University |
Principal Investigator |
KINOSHITA Yoshikazu Shimane University, 医学部, 教授 (30243306)
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Project Period (FY) |
2007 – 2009
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Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | バレット食道 / 胃食道逆流症 / 幹細胞 / 分化 / 腸上皮化生 / パレット食道 / バレット上皮 / 杯細胞 / 骨髄 |
Research Abstract |
We have investigated the pathogenesis of Barrett's esophagus focusing on the cellular origin and abnormal differentiation of the original cells. Esophageal fibroblasts, when exposed to acidic gastric contents, secrete various growth factors and cytokines. Especially HB-EGF produced by these acid exposed fibroblasts induced abnormal differentiation of immature esophageal squamous cells to intestinal type columnar cells by inducing Cdx2 expression. Furthermore squamous epithelial cells exposed to bile acids started to differentiate to columnar epithelial cells by the mutual interaction of Cdx1 and Cdx2.
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Report
(4 results)
Research Products
(55 results)
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[Journal Article] Half-solidification of nutrient does not decrease gastro-esophageal reflux events in patients fed via percutaneous endoscopic gastrostomy.2009
Author(s)
Adachi K, Furuta K, Morita T, Nakata S, Ohara S, Tanimura T, Koshino K, Miki M, Ishimura N, Inoue Y, Ryuko K, Umegae N, Ohhata S, Katoh S, Yamamoto K, Nariai Y, Hashimoto Y, Sumi A, Kawaguchi M, Kinoshita Y.
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Journal Title
Clin Nutr. 28
Pages: 648-651
Related Report
Peer Reviewed
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[Journal Article] IGICS study group. A questionnaire-based survey of GERD and related diseases by physicians in East Asian countries in 2008.2009
Author(s)
Fujiwara Y, Takahashi S, Arakawa T, Sollano JD, Zhu Q, Kachintorn U, Rani AA, Hahm KB, Joh T, Kinoshita Y, Matsumoto T, Naito Y, Takeuchi K, Terano A
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Journal Title
Digestion 80
Pages: 119-128
Related Report
Peer Reviewed
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[Journal Article] Prolactin induces MFG-E8 production in macrophages via transcription factor C/EBPβ-dependent pathway.2008
Author(s)
Aziz MM, Ihishra S, Rumi MAK, Mishima Y, Oshima N, Kadota C, Moriyama I, Yong-Yu Li, Farzana Binte Rahman, Otani A, Oka A, Ishimura N, Kadowaki Y, Amano Y, Kinoshita Y.
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Journal Title
Apoptosis. 13
Pages: 609-620
Related Report
Peer Reviewed
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[Journal Article] Esophageal epithelial surface in patients with gastroesophageal reflux disease: an electron microscopic study.2008
Author(s)
Azumi T, Adachi K, Furuta K, Nakata S, Ohara S, Koshino K, Miki M, Morita T, Tanimura T, Ashizawa N, Kinoshita Y.
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Journal Title
World J Gastroenterol. 14(37)
Pages: 5712-5716
Related Report
Peer Reviewed
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[Journal Article] Comparison of the effects of omeprazole and famotidine in treatment of upper abdominal symptoms in patients with reflux esophagitis.
Author(s)
Kusunoki H, Kusaka M, Kido S, Yamauchi R, Fujimura Y, Watanabe Y, Kobori M, Miwa H, Tomita T, Kin Y, Hori K, Tano N, Sugimoto K, Nakamura Y, Fujimoto K, Oza N, Matsunobu A, Ono N, Fuyuno S, Kinoshita Y, Adachi K, Yuki M, Fujisawa T, Haruma K.
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Journal Title
J Gastroenterol. 44(4)
Pages: 261-270
NAID
Related Report
Peer Reviewed
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