Interferon-producing killer dendritic cell-based immunotherapy for gastrointestinal cancer
| Project/Area Number |
19590738
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Showa University |
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Principal Investigator |
HIROISHI Kazumasa Showa University, 医学部, 准教授 (80296996)
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| Project Period (FY) |
2007 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 樹状細胞 / ナチュラルキラー細胞 / インターフェロン / 免疫療法 / 抗腫瘍効果 / 腫瘍免疫 / 免疫治療 / 大腸癌 / インターロイキン / TNF / FLT-3リガンド |
|---|
| Research Abstract |
Effective methods for inducing interferon-producing killer dendritic cells (IKDCs) in a mouse model were explored. When murine splenocytes were cultured with CpG, Flt-3 ligand, IL-15, and IL-18, the number of IKDCs was increased to 1.34-6.38 times as much as that in splenocytes without any stimulation. Then, the therapeutic effects of IKDC on the established tumors were assessed using a murine poorly immunogenic colorectal cancer, MC38 model. When IKDCs were inoculated in tumor-bearing mice, the outgrowths of the tumors were significantly suppressed compared with those in mice treated with myeloid dendritic cells. Therefore, IKDC-based immunotherapy should be considered for clinical application.
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Report
(6 results)
Research Products
(22 results)
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[Journal Article] Strong CD8+ T-cell responses against tumor-associated antigens prolong the recurrence-free interval after tumor treatment in patients with hepatocellular carcinoma.2010
Author(s)
Hiroishi K., Eguchi J., Baba T., Shimazaki T., Ishii S., Hiraide A., Sakaki M., Doi H., Uozumi S., Omori R., Matsumura T., Yanagawa T., Ito T., Imawari M
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Journal Title
J Gastroenterol 45(4)
Pages: 451-458
NAID
Related Report
Peer Reviewed
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[Journal Article] Magnitude of CD8+ T-cell responses against hepatitis C virus and severity of hepatitis do not necessarily determine outcomes in acute hepatitis C virus infection2009
Author(s)
Doi H, Hiroishi K, Shimazaki T, Eguchi J, Baba T, Ito T, Matsumura T, Nozawa H, Morikawa K, Ishii S, Hiraide A, Sakaki M, Imawari M.
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Journal Title
Hepatology Research 33
Pages: 256-265
NAID
Related Report
Peer Reviewed
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