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Genetic alternation of metastatic and recurrent gastrointestinal stromal tumor (GIST)

Research Project

Project/Area Number 19590743
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionAichi Cancer Center Research Institute

Principal Investigator

SAWAKI Akira  Aichi Cancer Center Research Institute, 分子腫瘍学部, 研究員 (10426489)

Co-Investigator(Kenkyū-buntansha) 近藤 豊  愛知県がんセンター(研究所), 分子腫瘍学部, 室長 (00419897)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Keywords消化管間質腫瘍 / 転移 / 再発 / GIST / DNAメチル化
Research Abstract

(1)当院で治療を行ったGIST患者の臨床情報の整理を行った。凍結組織が保存されているか、パラフィン包埋ブロックが存在しているかを確認した。c-kitおよびPDGFRaの遺伝子変異や臨床のパラメーターとGISTの経時的変化との相関に関して検討を行った。本邦においても欧米と同様にc-kit exon11が最も多く、次にexon9であり、イマチニブの臨床効果もexon11で高かった。
(2)DNAアレイを用いたエピジェネティックに制御されるがん関連遺伝子の解析を行うとともに、凍結組織よりRNAを抽出してcDNAアレイを用いた網羅的発現解析を行ない、細胞接着などの転移・侵潤に関する遺伝子群の発現について検討した。転移・再発を認めたGISTにメチル化の頻度が極めて高い2つの遺伝子を同定した。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (14 results)

All 2009 2008 2007

All Journal Article (6 results) Presentation (7 results) Book (1 results)

  • [Journal Article] 転移・再発GISTに対するイマチニブ治療2009

    • Author(s)
      澤木明,山雄健次
    • Journal Title

      臨床外科(医学書院) 64巻2号

      Pages: 197-183

    • Related Report
      2008 Final Research Report
  • [Journal Article] 消化器 消化管間質腫瘍(GIST)2008

    • Author(s)
      澤木明, 南江堂
    • Journal Title

      内科 101巻6号

      Pages: 1133-1136

    • Related Report
      2008 Final Research Report
  • [Journal Article] 胃と腸(医学書院)2008

    • Author(s)
      澤木明, 水野伸匡, 伯耆徳之, ら
    • Journal Title

      GISTの自然史 43巻2号

      Pages: 199-204

    • Related Report
      2008 Final Research Report
  • [Journal Article] Practical prognostic index for patients with metastatic pancreatic cancer treated with gemcitabine2008

    • Author(s)
      Sawaki A
    • Journal Title

      J Gastroenterol Hepatol. 23

      Pages: 1292-1287

    • Related Report
      2008 Annual Research Report
  • [Journal Article] EUS-guided choledochoduodenostomy for palliative biliary drainage in patients with malignant biliary obstruction : results of long-term follow-up2008

    • Author(s)
      Yamao K
    • Journal Title

      Endoscopy 40

      Pages: 340-342

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Mebio(メジカルビュ一社)2007

    • Author(s)
      澤木明, 水野伸匡, 山雄健次
    • Journal Title

      Gastrointestinal stromal tumorに対するイマチニブ・メシレート療法 24巻5号

      Pages: 50-55

    • Related Report
      2008 Final Research Report
  • [Presentation] Diagnostic Utility of Endoscopic Ultrasound-guided Fine Needle Aspiration for Gastric Submucosal Tumors2009

    • Author(s)
      Akira Sawaki
    • Organizer
      KTSGE2009
    • Place of Presentation
      Seoul
    • Year and Date
      2009-03-28
    • Related Report
      2008 Final Research Report
  • [Presentation] DIAGNOSTIC IMPACT OF ENDOSCOPIC ULTRASOUND GUIDED FINE NEEDLE ASPIRATION FOR GASTRIC SUBMUCOSAL TUMORS2008

    • Author(s)
      Akira Sawaki
    • Organizer
      UEGW2008
    • Place of Presentation
      Wienna
    • Year and Date
      2008-09-21
    • Related Report
      2008 Final Research Report
  • [Presentation] Diagnostic Utility of Endoscopic Ultrasound Guided Fine Needle Aspiration for Gastric Submucosal Tumors2008

    • Author(s)
      Akira Sawaki
    • Organizer
      World Cancer Congress2008
    • Place of Presentation
      Shanghai
    • Year and Date
      2008-06-14
    • Related Report
      2008 Final Research Report
  • [Presentation] Diagnosis of gastric submucosal tumors using endoscopic ultrasound guided fine needle aspiration2008

    • Author(s)
      Akira Sawaki
    • Organizer
      2008ASCO Annual meeting
    • Place of Presentation
      Chicago
    • Year and Date
      2008-06-02
    • Related Report
      2008 Final Research Report
  • [Presentation] Diagnosis of gastric submucosal tumors using endoscopic ultrasound guided fine needle aspiration2008

    • Author(s)
      Sawaki A., et al.
    • Organizer
      2008ASCO Annual Meeting
    • Place of Presentation
      シカゴ(米国)
    • Year and Date
      2008-06-02
    • Related Report
      2008 Annual Research Report
  • [Presentation] Long-term follow-up of patients with gastrointestinal stromal tumors in stomach2008

    • Author(s)
      Akira Sawaki
    • Organizer
      2008 Gastrointestinal cancers symposium
    • Place of Presentation
      Orlando
    • Year and Date
      2008-01-25
    • Related Report
      2008 Final Research Report
  • [Presentation] Long-term follow-up of patients with gastrointestinal stromal tumors in stomach2008

    • Author(s)
      Akira Sawaki
    • Organizer
      2008 Gastrointestinal cancers symposium
    • Place of Presentation
      Orlando in US
    • Year and Date
      2008-01-25
    • Related Report
      2007 Annual Research Report
  • [Book] Mebio2007

    • Author(s)
      澤木 明
    • Total Pages
      6
    • Publisher
      Gastrointestinal stromal tumorに対するイマチニブ・メシレート療法
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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