A clarification of the role of NAD(P)H oxidase of hepatic stellate cell in hepatic fibrosis

• Project/Area Number: 19590747
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Yamagata University
• Principal Investigator: TOGASHI Hitoshi Yamagata University, 保健管理センター, 教授 (60192209)
• Co-Investigator(Kenkyū-buntansha): SUGAHARA Kazuhiko 山形大学, 医学部, 助教 (70333953)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 肝線維化 / NAD(P)H oxidase / 肝星細胞 / ROS / シグナル伝達 / PDGF-BB / TGF-β1 / PDGF / TGF-β

Research Abstract

NAD(P)H oxidase由来のROSの制御が慢性肝疾患の新たな治療法になりうるか研究した。培養肝星細胞において、PDGF-BBは、NAD(P)H oxidase由来のROSを介し細胞増殖をもたらした。ROSは肝星細胞のp38 MAPKのリン酸化を促進し、細胞増殖を引き起こした。in vivoの実験でも、DMNによるマウス肝障害や線維化の進展が、ROS消去剤により抑制された。NAD(P)H oxidaseの制御は、肝線維化の抑制につながり、大変重要であると考えられた。

Research Products

• [Journal Article] インターフェロン療法が著効した特発性血小板減少性紫斑病を合併したC型肝炎の1例 (2009)
  • Author(s): 柄澤哲、冨樫整、他(corresponding author)
  • Journal Title: 日本消化器病学会雑誌 106 Pages: 405-10
  • NAID: 10024850838
  • Peer Reviewed
• [Journal Article] Reply to comments on "What can be revealed by extending the sensitivity of HBsAg detection below the present limit? (2009)
  • Author(s): Togashi H, et.al.
  • Journal Title: J Hepatol 50 Pages: 213-213
  • Peer Reviewed
• [Journal Article] Reply to comments on "What can be revealed by extending the sensitivity of HBsAg detection below the present limit?" (2009)
  • Author(s): Fogashi H, et.al
  • Journal Title: Journal of Hepatology 50 Pages: 213-213
  • Peer Reviewed
• [Journal Article] インターフェロン療法が著効した特発性血小板減少性紫斑病を合併したC型肝炎の1例 (2009)
  • Author(s): 柄澤哲, 冨樫整, 他
  • Journal Title: 日本消化器病学会雑誌 106
  • NAID: 10024850838
  • Peer Reviewed
• [Journal Article] What can be revealed by extending the sensitivity of HBsAg detection to below the present limit? (2008)
  • Author(s): Togashi H, et.al.
  • Journal Title: J Hepatol 49 Pages: 17-24
• [Journal Article] What can be revealed by extending the sensitivity of HBsAg detection to below the present limit? (2008)
  • Author(s): Togashi H, et.al.
  • Journal Title: Journal of Hepatology 49 Pages: 17-24
  • Peer Reviewed
• [Journal Article] Serum levels of stem cell factor and thrombopoietin are markedly decreased in fulminant hepatic failure patients with a poor prognosis (2007)
  • Author(s): Okumoto K, Togashi H, et.al.
  • Journal Title: J Gastroenterol Hepatol 22 Pages: 1265-70
  • Peer Reviewed
• [Journal Article] Risk of hepatocellular carcinoma and secondary structure of hepatitis C virus (HCV) NS3 protein amino-terminus, in patients infected with HCV subtype 1b (2007)
  • Author(s): Nishise Y, Togashi H, et.al.
  • Journal Title: J Infect Dis 196 Pages: 1006-9
  • Peer Reviewed
• [Journal Article] インターフェロン・リバビリン併用療法中に化膿性脊椎炎を合併したC型慢性肝炎の2例 (2007)
  • Author(s): 菅原一彦、冨樫整、他
  • Journal Title: 日本消化器病学会雑誌 104巻 Pages: 1519-25
  • NAID: 10020165111
  • Peer Reviewed
• [Journal Article] Characteristics of three cases of hepatocellular carcinoma showing enhanced technetium-99m-diethylenetriaminepentaacetic acid-galactosyl human serum albumin accumulation by single photon emission computed tomography analysis (2007)
  • Author(s): Suzuki A, Togashi H, et.al.
  • Journal Title: Hepatol Res 37 Pages: 628-36
  • Peer Reviewed
• [Journal Article] Characteristics of three cases of hepatocellular carcinoma showing enhanced techn etium-99m-diethylenetriaminepentaacetic acid-galactosyl human serum albumin acc umulation by single photon emission computed tomography analysis. (2007)
  • Author(s): Suzuki A, Togashi H, et. al.
  • Journal Title: Hepatol Res. 37 Pages: 628-636
  • Peer Reviewed
• [Journal Article] Serum levels of stem cell factor and thrombopoietin are markedly decreased in fulminant hepatic failure patients with a poor prognosis. (2007)
  • Author(s): Okumoto K, Togashi H, et. al.
  • Journal Title: J Gastroenterol Hepatol. 22 Pages: 1265-1270
  • Peer Reviewed
• [Journal Article] Risk of hepatocellular carcinoma and secondary structure of hepatitis C virus (HCV) NS3 protein amino-terminus, in patients infected with HCV subtype 1b. (2007)
  • Author(s): Nishise Y, Togashi H, et. al.
  • Journal Title: J Infect Dis. 196 Pages: 1006-1009
  • Peer Reviewed
• [Presentation] 電子スピン共鳴装置を用いたreactive oxygen speciesの検出と画像化-マウス肝障害モデルを用いた病態解明への応用 (2008)
  • Author(s): 冨樫整
  • Organizer: 第37回日本肝臓学会東部会
  • Place of Presentation: 東京
  • Year and Date: 2008-12-04
• [Presentation] 電子スピン共鳴CT装置を用いたreactive oxygen speciesの検出と画像化-マウス肝障害モデルを用いた病態解明への応用 (2008)
  • Author(s): 冨樫整
  • Organizer: 第37回日本肝臓学会東部会
  • Place of Presentation: 東京
  • Year and Date: 2008-12-04
• [Presentation] What can be revealed by extending the sensitivity of HBsAg detection to below the present limit? (2008)
  • Author(s): Togashi H
  • Organizer: 4^<th> International Infection Control Conference of Theodor Bilharz Research Institute
  • Place of Presentation: Cairo
  • Year and Date: 2008-11-12
• [Presentation] 非B非C型肝細胞癌の臨床像と発癌因子 (2007)
  • Author(s): 菅原一彦、冨樫整、他
  • Organizer: 第43回日本肝臓学会総会
  • Place of Presentation: 東京
  • Year and Date: 2007-06-01
• [Presentation] 非アルコール性脂肪性肝炎(NASH)によるToll様受容体(TLRs)の役割 (2007)
  • Author(s): 鈴木 明彦、冨樫 整, 他
  • Organizer: 第43回日本肝臓学会総会
  • Place of Presentation: 東京
  • Year and Date: 2007-05-31
• [Presentation] 非アルコール性脂肪性肝炎(NASH)におけるToll様受容体(TLRs)の役割 (2007)
  • Author(s): 鈴木明彦、冨樫整、他
  • Organizer: 第43回日本肝臓学会総会
  • Place of Presentation: 東京
  • Year and Date: 2007-05-03
• [Book] 綜合臨床第57巻増刊新版処方計画法、代謝性(遺伝性)肝疾患 (2008)
  • Author(s): 冨樫整、他
  • Publisher: 永井出版
• [Book] 綜合臨床第57巻増刊新版処方計画法代謝性(遺伝性)肝疾患 (2008)
  • Author(s): 冨樫整, 他
  • Publisher: 永井書店