Clinical significance of serum HBV RNA in patients with chronic Hepatitis B under anti-viral therapy
| Project/Area Number |
19590757
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Shinshu University |
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Principal Investigator |
TANAKA Eiji Shinshu University, 医学部, 教授 (50163506)
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| Research Collaborator |
MATSUMOTO Akihiro 信州大学, 医学部, 委嘱講師
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | B型肝炎 / RNA遺伝子 / 抗ウイルス療法 |
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| Research Abstract |
HBV RNA/DNA量測定系を開発し、その臨床的意義をHBV DNA量、HBcrAgと比較検討した。B型慢性肝炎のラミブジン治療例を対象とし、治療開始6ヶ月目の測定値でその後の耐性株出現を予測した。HBV DNA量は耐性株が出現しやすい症例の予測に、HBcrAgは耐性株が出現しにくい症例の予測に有用であった。HBV RNA/DNA量はHBV DNAに近い性格を示したが、感度に優れ、精度は3者の中で最も高かった。HBV RNA/DNA量測定系は新しいマーカーとしての可能性が示唆された。
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Guidelines for the treatment of chronic hepatitis and cirrhosis due to hepatitis B virus infection for the fiscal year 2008 in Japan.2010
Author(s)
Kumada H, Okanoue T, Onji M, Moriwaki H, Izumi N, Tanaka E, Chayama K, Sakisaka S, Takehara T, Oketani M, Suzuki F, Toyota J, Nomura H, Yoshioka K, Seike M, Yotsuyanagi H, Ueno Y.
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Journal Title
Hepatol Res 40
Pages: 1-7
NAID
Related Report
Peer Reviewed
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[Journal Article] Distribution of hepatitis B virus genotypes among patients with chronic infection in Japan shifting toward an increase of genotype A.2009
Author(s)
Matsuura K, Tanaka Y, Hige S, Yamada G, Murawaki Y, Komatsu M, Kuramitsu T, Kawata S, Tanaka E, Izumi N, Okuse C, Kakumu S, Okanoue T, Hino K, Hiasa Y, Sata M, Maeshiro T, Sugauchi F, Nojiri S, Joh T, Miyakawa Y, Mizokami M.
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Journal Title
J Clin Microbiol 47
Pages: 1476-1483
Related Report
Peer Reviewed
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[Journal Article] Case-control study for the identification of virological factors associated with fulminant hepatitis B.2009
Author(s)
Kusakabe A, Tanaka Y, Mochida S, Nakayama N, Inoue K, Sata M, IsodaKang J. H, Sumino Y, Yatsuhashi H, Takikawa Y, Kaneko S, Yamada G, KarinY, Tanaka E, Kato J, Sakaida I, Izumi N, Sugauchi F, Nojiri S, Joh T, Miyakawa Y, Mizokami M.
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Journal Title
Hepatol Res 39
Pages: 648-656
NAID
Related Report
Peer Reviewed
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[Journal Article] Low serum level of hepatitis B core-related antigen indicates unlikely reactivation ofhepatitis after cessation of lamivudine therapy.2007
Author(s)
Matsumoto A, Tanaka E, Minami M Okanoue T, Yatsuhashi H, Nagaoka SSuzuki F, Kobayashi M, Chayama K, Imamura M, Yotsuyanagi H, Nakaoka S, Maki N, Kawata S, Kumada H, Iino S, Kiyosawa K.
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Journal Title
Hepatol Res 37
Pages: 661-666
Related Report
Peer Reviewed
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