Role of innate immunity in the pathogenesis of autoimmune pancreatitis and analysis of its autoantigens

• Project/Area Number: 19590762
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Kansai Medical University (2008); Kyoto University (2007)
• Principal Investigator: NISHIO Akiyoshi Kansai Medical University, 医学部, 准教授 (50362463)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 自己免疫性膵炎 / 自然免疫 / toll-like receptor / 自己抗体 / 抗原エピトープ膵分泌性トリプシンインヒビター / 膵分泌性トリプシンインヒビター / 内科 / 免疫学 / 動物

Research Abstract

自己免疫性膵炎の病態を解明をするために、マウス膵炎モデルを解析した。各種toll-like receptorリガンドを投与し血清サイトカインの動態と膵炎の発症を検討した結果、インターロイキン10が膵炎の発症抑制に重要と考えられた。さらに、膵分泌性トリプシンインヒビター(PSTI)に対する自己抗体がPSTIのトリプシン結合部と反応してその活性を抑制し、トリプシンの活性化を促進して膵炎を増悪させる可能性を明らかにした。

Research Products

• [Journal Article] Analysis of humoral immune response in experimental autoimmune pancreatitis in mice (2010)
  • Author(s): Masanori Asada, Akiyoshi Nishio, Takuji Akamatsu, 11名、2番目
  • Journal Title: Pancreas 39 Pages: 224-231
  • Peer Reviewed
• [Journal Article] Atypical retroperitoneal fibrosis associated with biliary stricture : IgG4-related sclerosing disease? (2009)
  • Author(s): Mitsunobu Matsushita, Akiyoshi Nishio, Kazuichi Okazaki, 5名、4番目
  • Journal Title: Scand J Gastroenterol 44 Pages: 1146-1147
  • Peer Reviewed
• [Journal Article] Long-term outcome of autoimmune pancreatitis (2009)
  • Author(s): Kazushige Uchida, Akiyoshi Nishio, Kazuichi Okazaki, 12名、3番目
  • Journal Title: J Gastroenterol 44 Pages: 726-732
  • NAID: 10025176191
  • Peer Reviewed
• [Journal Article] Epinephrine sprayed on the papilla for prevention of post-ERCP pancreatitis (2009)
  • Author(s): Mitsunobu Matsushita, Akiyoshi Nishio, Kazuichi Okazaki, 6名、5番目
  • Journal Title: J Gastroenterol 44 Pages: 71-75
  • NAID: 10025173161
  • Peer Reviewed
• [Journal Article] Human TSLP and TLR3 ligands promote differentiation of Th17 cells with a central memory phenotype under Th2-polarizing conditions (2009)
  • Author(s): Junya Tanaka, et al
  • Journal Title: Clin Exp Allergy 39 Pages: 89-100
  • Peer Reviewed
• [Journal Article] Human TSLP and TLR3 ligands promote differentiation of Th17 cells with a central memory phenotype under Th2-polarizing conditions (2008)
  • Author(s): Junya Tanaka, Norihiko Watanabe, Akiyoshi Nishio, 7名、6番目
  • Journal Title: Clin Exp Allergy 39 Pages: 89-100
  • Peer Reviewed
• [Journal Article] Human TSLP directly enhances expansion of CD8+ T cells (2008)
  • Author(s): Takuji Akamatsu, Norihiko Watanabe, Akiyoshi Nishio, 8名、7番目
  • Journal Title: Clin Exp Immunol 154 Pages: 98-106
  • Peer Reviewed
• [Journal Article] Fatal autoimmune hepatitis induced by concurrent loss of naturally arising regulatory T cells and PD-1-mediated Signaling (2008)
  • Author(s): Masahiro Kido, Norihiko Watanabe, Akiyoshi Nishio, 9名、7番目
  • Journal Title: Gastroenterology 154 Pages: 98-106
  • Peer Reviewed
• [Journal Article] Involvement of Smad3 phosphoisoform-mediated signaling in the development of colonic cancer in IL-10-deficient mice (2008)
  • Author(s): Daisaku Hachimine, Akiyoshi Nishio, Kazuichi Okazaki, 13名、4番目
  • Journal Title: Int J Oncol 32 Pages: 1221-1226
  • Peer Reviewed
• [Journal Article] Fatal autoimmune hepatitis induced by concurrent loss of naturally arising reeulatory T cells and PD-1-mediated Signaling (2008)
  • Author(s): Masahiro Kido, et al
  • Journal Title: Gastroenterology 135 Pages: 1333-43
  • Peer Reviewed
• [Journal Article] Human TSLP directly enhances expansion of CD8+ T cells (2008)
  • Author(s): Takuji Akamatsu, et al
  • Journal Title: Clin Exp Immunol 154 Pages: 98-106
  • Peer Reviewed
• [Journal Article] Cross-primed CD8+ cytotoxic T cells induce severe Helicobacter-associated gastritis in the absence of CD4+ T cells (2007)
  • Author(s): Toshiro Fukui, Akiyoshi Nishio, Kazuichi Okazaki, 14名、2番目
  • Journal Title: Helicobacter 12 Pages: 486-497
  • Peer Reviewed
• [Journal Article] Localized cytomegalovirus reactivation after radiotherapy for high-grade gastric lymphoma (2007)
  • Author(s): Kazuyuki Saga, Toshiro Fukui, Akiyoshi Nishio, 8名、7番目
  • Journal Title: Gastrointestinal Endoscopy 65 Pages: 545-547
  • Peer Reviewed
• [Journal Article] Localized cytomegalovirus reactivation after radiotherapy for, high-grade gastric lymphoma. (2007)
  • Author(s): Kazuyuki Saga
  • Journal Title: Gastrointestinal Endoscopy 65 Pages: 545-7
  • Peer Reviewed
• [Journal Article] Cross-primed CD8+ cytotoxic T cells induce severe Helicobacter-associated gastritis in the absence of CD4+ T cells. (2007)
  • Author(s): Toshiro Fukui
  • Journal Title: Helicobacter 12 Pages: 486-97
  • Peer Reviewed
• [Presentation] マウスモデルを用いた自己免疫性膵炎発症における自然免疫の関与 (2009)
  • Author(s): 西尾彰功
  • Organizer: 第51回日本消化器病学会大会
  • Place of Presentation: 京都
  • Year and Date: 2009-10-15
• [Presentation] Fetal autoimmune hepatitis induced by concurrent loss of naturally arising regulatory T cells and PD-1-mediated signaling (2008)
  • Author(s): Masahiro Kido
  • Organizer: 2008年度日本免疫学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-01
• [Presentation] Fatal autoimmune hepatitis induced by concurrent loss of naturally arising regulatory T cells and PD-1-mediated signaling (2008)
  • Author(s): Masahiro Kido, et al
  • Organizer: 2008年度日本免疫学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-01
• [Presentation] Effect of various toll-like receptor stimulation on the development of murine autoimmune pancreatitis (2008)
  • Author(s): Akiyoshi Nishio
  • Organizer: 109th Annual Meeting of the American Gastroenterological Association
  • Place of Presentation: 米国 サンディエゴ
  • Year and Date: 2008-05-20
• [Presentation] Development of a new mouse model of fatal autoimmune hepatitis (2008)
  • Author(s): Norihiko Watanabe
  • Organizer: 109th Annual Meeting of the American Gastroenterological Association
  • Place of Presentation: 米国 サンディエゴ
  • Year and Date: 2008-05-20
• [Presentation] Effect of Various Toll-like Receptor Stimulation On The Development of Murine Autoimmune Pancreatitis (2008)
  • Author(s): Akiyoshi Nishio, et al
  • Organizer: 109th Annual Meeting of the American Gastroenterological Association
  • Place of Presentation: 米国 サンディェゴ
  • Year and Date: 2008-05-20
• [Presentation] Development of a New Mouse Model of Fatal Autoimmune Hepatitis (2008)
  • Author(s): Norihiko Watanabe, et al
  • Organizer: 109th Annual Meeting of the American Gastroenterological Association
  • Place of Presentation: 米国 サンディェゴ
  • Year and Date: 2008-05-20
• [Presentation] The role of innate immunity in the pathogenesis of murine autoimmune pancreatitis (2007)
  • Author(s): Akiyoshi Nishio
  • Organizer: 15th United European Gastroenterology Week
  • Place of Presentation: フランス パリ
  • Year and Date: 2007-10-30
• [Presentation] The role of innate immunity in the pathogenesis of murineautoimmune pancreatitis (2007)
  • Author(s): Akiyoshi Nishio
  • Organizer: 15th United European Gastroenterology Week
  • Place of Presentation: フランス パリ
  • Year and Date: 2007-10-30
• [Presentation] Interleukin 10 is essential for prevention of murine autoimmune pancreatitis induced by poly I:C administration (2007)
  • Author(s): Akiyoshi Nishio
  • Organizer: 108th Annual Meeting of the American Gastroenterological Association
  • Place of Presentation: 米国 ワシントン
  • Year and Date: 2007-05-19
• [Presentation] The role of innate immunity in the pathogenesis of murine experimental model of autoimmune pancreatitis (2007)
  • Author(s): Masanori Asada
  • Organizer: 108th Annual Meeting of the American Gastroenterological Association
  • Place of Presentation: 米国 ワシントン
  • Year and Date: 2007-05-19
• [Presentation] Interleukin 10 is essential for prevention of murineautoimmune pancreatitis induced by poly I:C administration (2007)
  • Author(s): Akiyoshi Nishio
  • Organizer: 08th Annual Meeting of the Americn Gastroneterological Association
  • Place of Presentation: 米国 ワシントン
  • Year and Date: 2007-05-19
• [Presentation] The role of innate immunity in the pathogenesis of murineexperimental model of autoimmune pancreatitis (2007)
  • Author(s): Masanori Asada
  • Organizer: 108th Annual Meeting of the Americn Gastroneterological Association
  • Place of Presentation: 米国 ワシントン
  • Year and Date: 2007-05-19