Developmental research on dendritic cell-based immunotherapy against chronic hepatitis C and hepatocellular carcinoma

• Project/Area Number: 19590765
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Osaka University
• Principal Investigator: KANTO Tatsuya Osaka University, 医学系研究科, 寄附講座准教授 (80372613)
• Co-Investigator(Kenkyū-buntansha): TAKEHARA Tetsuo 大阪大学, 医学系研究科, 准教授 (70335355) ; HIRAMATSU Naoki 大阪大学, 医学系研究科, 講師 (30362700)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 樹状細胞 / C型肝炎 / Toll様受容体 / インターフェロンα / リバビリン / HCVプロテアーゼ阻害剤 / Type III IFN / RIG-I

Research Abstract

In hepatitis C virus (HCV) infection, it is well known that the impaired function of dendritic cells (DC) is critically involved in the development of liver disease as well as resistance to anti-viral therapy, such as a combination of peg-interferon-a and ribavirin. We demonstrated in this research project that myeloid DC (MDC) are functionally impaired in the production of type-I IFN and IL-12 in response to Toll-like receptor (TLR) signaling, of which is partly due to reduced expression of TRIF and TRAF6 adaptor molecules. In addition, the treatment of MDC with HCV NS3/4A protease inhibitor restored MDC of stimulatory capacity for CD4+ T cells. Therefore, we demonstrate that MDC could be served as a therapeutic target in order to enhance anti-HCV immune reactions.

Research Products

• [Journal Article] (2010)
  • Author(s): Nalesnik MA, Kanto T
  • Journal Title: Natural killer cells and hepatitis C virus infection. Lotze MT and Thompson AW eds Natural killer cells : Basic science and clinical application(Elsevier London) Pages: 571-587
• [Journal Article] Factors affecting efficacy in patients with genotype 2 chronic hepatitis C treated by pegylated interferon alpha-2b and ribavirin: reducing drug doses has no impact on rapid and susutained virological responses. (2009)
  • Author(s): Inoue, Y., Hiramatsu, N, Oze, T., Yakushijin, T., Mochizuki, K., Hagiwara, H., Oshita, M., Mita, E., Fukui, H., Inada, M., Tamura, S., Yoshihara, H., Hyashi, E., Inoue, A., Imai, Y., Kato, M., Miyagi, T., Hohsui, A., Ishida, M., Kiso, S., Kanto, T., Kasahara, A., Takehara, T., Hayashi, N.
  • Journal Title: Journal of Viral Hepatitis (in press)
  • Peer Reviewed
• [Journal Article] Enhanced ability of regulatory T cells in chronic hepatitis C patients with persistently normal alanine aminotransferase levels than those with active hepatitis. (2009)
  • Author(s): Itose, I., Kanto, T. Kakita, N., Takebe, S., Inoue, M., Higashitani, K., Miyazaki, M., Miyatake, H., Sakakibara, M., Hiramatsu, N., Takehara, T., Kasahara, A., Hayashi, N.
  • Journal Title: Journal of Viral Hepatitis 16 Pages: 846-852
  • Peer Reviewed
• [Journal Article] Anticancer chemotherapy inhibits MHC class I-related chain a ectodomain shedding by downregulating ADAM10 expression in hepatocellular carcinoma. (2009)
  • Author(s): Kohga, K., Takehara, T. Tatsumi, T., Miyagi, T., Ishida, H., Ohkawa, K., Kanto, T., Hiramatsu, N., Hayashi, N.
  • Journal Title: Cancer Resarch 69 Pages: 8050-8057
  • Peer Reviewed
• [Journal Article] Mcl-1 and Bcl-xL cooperatively maintain integrity of hepatocytes in developing and adult murine liver. (2009)
  • Author(s): Hikita H, Takehara T., Shimizu, S., Kodama, T., Li, W., Miyagi, T., Hosui, A., Ishida, H., Ohkawa, K., Kanto, T., Hiramatsu, N., Yin, X.M., Hennighausen, L., Tatsumi, T., Hayashi, N.
  • Journal Title: Hepatology 16 Pages: 1217-1226
  • Peer Reviewed
• [Journal Article] Ribavirin dose reduction raises relapse rate dose-dependently in genotype 1 patients with hepatitis C responding to pegylated interferon alpha-2b plus ribavirin. (2009)
  • Author(s): Hiramatsu, N., Oze, T Yakushijin, T., Inoue, Y., Igura, T., Mochizuki, K., Imanaka, K., Kaneko, A., Oshita, M., Hagiwara, H., Mita, E., Nagase, T., Ito, T., Inui, Y., Hijioka, T., Katayama, K., Tamura, S., Yoshihara, H., Imai, Y., Kato, M., Yoshida, Y., Tatsumi, T., Ohkawa, K., Kiso, S., Kanto, T., Kasahara, A., Takehara, T., Hayashi, N.
  • Journal Title: Journal of Viral Hepatitis 16 Pages: 586-594
  • Peer Reviewed
• [Journal Article] Two types of drug-resistant hepatitis B viral strains emerging alternately and their susceptibility to combination therapy with entecavir and adefovir (2009)
  • Author(s): Kurashige N., Ohkawa, K Hiramatsu, N., Oze, T., Yakushijin, T., Mochizuki, K., Hosui, A., Miyagi, T., Ishida, H., Tatsumi, T., Kanto, T., Takehara, T., Hayashi, N.
  • Journal Title: Antiviral Therapy 14 Pages: 873-877
  • Peer Reviewed
• [Journal Article] Enhanced ability of regulatory T cells in chronic hepatitis C patients with persistently normal alanine aminotransferase levels than those with active hepatitis (2009)
  • Author(s): Itose, I., Kanto, T., et al.
  • Journal Title: Journal of Viral Hepatitis 16 Pages: 846-852
  • Peer Reviewed
• [Journal Article] Anticancer chemotherapy inhibits MHC class I-related chain a ectodomain shedding by downregulating ADAM10 expression in hepatocellular carcinoma (2009)
  • Author(s): Kohga, K., Takehara, T., et al.
  • Journal Title: Cancer Resarch 69 Pages: 8050-8057
  • Peer Reviewed
• [Journal Article] Mcl-1 and Bcl-xL cooperatively maintain integrity of hepatocytes in developing and adult murine liver (2009)
  • Author(s): Hikita H, Takehara T., et al.
  • Journal Title: Hepatology 50 Pages: 1217-1226
  • Peer Reviewed
• [Journal Article] Ribavirin dose reduction raises relapse rate dose-dependently in genotype 1 patients with hepatitis C responding to pegylated interferon alpha-2b plus ribavirin (2009)
  • Author(s): Hiramatsu, N., Oze, T, et al.
  • Journal Title: Journal of Viral Hepatitis 16 Pages: 586-594
  • Peer Reviewed
• [Journal Article] Two types of drug-resistant hepatitis B viral strains emerging alternately and their susceptibility to combination therapy with entecavir and adefovir (2009)
  • Author(s): Kurashige N., Ohkawa, K, et al.
  • Journal Title: Antiviral Therapy 14 Pages: 873-877
  • Peer Reviewed
• [Journal Article] Virus associated innate immunity in liver. (2008)
  • Author(s): Kanto T.
  • Journal Title: Frontiers in Bioscience 13 Pages: 6183-6192
  • Peer Reviewed
• [Journal Article] Impaired cytokine response in myeloid dendritic cells in chronic hepatitis C virusinfection regardless of enhanced expression of Toll-like receptors and retinoic acid inducible gene-I (2008)
  • Author(s): Miyazaki M., Kanto T., Inoue, M., Itose, I., Miyatake, H., Sakakibara, M., Yakushijin, T., Kakita, N., Hiramatsu, N., Takehara, T., Kasahara, A., Hayashi, N.
  • Journal Title: Journal of Medical Virology 80 Pages: 980-988
  • Peer Reviewed
• [Journal Article] Serum levels of soluble major histocompatibility complex (MHC) class I-related chain A in patients with chronic liver diseases and changes during transcatheter arterial embolization for hepatocellular carcinoma. (2008)
  • Author(s): Kohga K., Takehara T., Tatsumi, T., Ohkawa, K., Miyagi, T., Hiramatsu, N., Kanto, T., Kasugai, T., Katayama, K., Kato, M., Hayashi, N.
  • Journal Title: Cancer Science 99 Pages: 1643-1649
  • NAID: 10024010054
  • Peer Reviewed
• [Journal Article] A new prognostic system for hepatocellular carcinoma including recurrent cases: a study of 861 patients in a single institution. (2008)
  • Author(s): Toyama T., Hiramatsu N. Yakushijin, T., Oze, T., Nakanishi, F., Yasumaru, M., Mochizuki, K., Kanto, T., Takehara, T., Kasahara, A., Hayashi, N.
  • Journal Title: Journal of Clinical Gastroenterology 42 Pages: 317-322
  • Peer Reviewed
• [Journal Article] Initial viral response is the most powerful predictor of the emergence of YMDD mutant virus in chronic hepatitis B patients treated with lamivudine. (2008)
  • Author(s): Kurashige N., Hiramatsu N. Ohkawa, K., Oze, T., Inoue, Y., Kurokawa, M., Yakushijin, T., Igura, T., Kiso, S., Kanto, T., Takehara, T., Tamura, S., Kasahara, A., Oshita, M., Hijioka, T., Katayama, K., Yoshihara, H., Hayashi, E., Imai, Y., Kato, M., Hayashi, N.
  • Journal Title: Hepatology Research 38 Pages: 450-456
  • NAID: 10024148320
  • Peer Reviewed
• [Journal Article] Impaired cytokine response in myeloid dendritic cells in chronic hepatitis C virus infection regardless of enhanced expression of Toll-like receptors and retinoic acid inducible gene-I (2008)
  • Author(s): Miyazaki M., Kanto T., et al.
  • Journal Title: Journal of Medical Virology 80 Pages: 980-988
  • Peer Reviewed
• [Journal Article] Serum levels of soluble major histocompatibility complex (MHC)class I-related chain A in patients with chronic liver diseases and changes during transcatheter arterial embolization for hepatocellular carcinoma. (2008)
  • Author(s): Kohga K., Takehara T., et al.
  • Journal Title: Cancer Science 99 Pages: 1643-1649
  • NAID: 10024010054
  • Peer Reviewed
• [Journal Article] Supportive role played by precore and preS2 genomic changes in the establishment of lamivudine-resistant hepatitis B virus. (2008)
  • Author(s): Ohkawa K., Takehara T., et al.
  • Journal Title: Journal of Infectious Diseases 198 Pages: 1150-1158
  • Peer Reviewed
• [Journal Article] A new prognostic system for hepatocellular carcinoma including recurrent cases : a study of 861 patients in a single institution. (2008)
  • Author(s): Toyama T., Hiramatsu N., et al.
  • Journal Title: Journal of Clinical Gastroenterology 42 Pages: 317-322
  • Peer Reviewed
• [Journal Article] Initial viral response is the most powerful predictor of the emergence of YMDD mutant virus in chronic hepatitis B patients treated with lamivudine. (2008)
  • Author(s): Kurashige N., Hiramatsu N., et al.
  • Journal Title: Hepatology Research 38 Pages: 450-456
  • NAID: 10024148320
  • Peer Reviewed
• [Journal Article] Impaired cytokine response in myeloid dendritic cells in chronic hepatitis C virus infection regardless of enhanced expression of Toll-like receptors and retinoic acid inducible gene-I (2008)
  • Author(s): Miyazaki M., Kanto T., et. al.
  • Journal Title: Journal of Medical Virology (In press)
  • Peer Reviewed
• [Journal Article] Impaired ability of interferon-alpha-primed dendritic cells to stimulate Th1-type CD4 T cell response in chronic hepatitis C virus infection. (2007)
  • Author(s): Miyatake H., Kanto T., Inoue, M., Sakakibara, M., Kaimori, A., Yakushijin, T., Itose, I., Miyazaki, M., Kuzushita, N., Hiramatsu, N., Takehara, T., Kasahara, A., Hayashi, N.
  • Journal Title: Journal of Viral Hepatitis 14 Pages: 404-412
  • Peer Reviewed
• [Journal Article] Involvement of dendritic cell frequency and function in virological relapse in pegylated interferon-α2b and ribavirin therapy for chronic hepatitis C patients. (2007)
  • Author(s): Itose I., Kanto T., Inoue, M., Miyazaki, M., Miyatake, H., Sakakibara, M., Yakushijin, T., Oze, T., Hiramatsu, N., Takehara, T., Kasahara, A., Hayashi, N.
  • Journal Title: Journal of Medical Virology 79 Pages: 511-521
  • Peer Reviewed
• [Journal Article] Hepatitis C virus nonstructural protein 5A modulates the toll-like receptor-MyD88-dependent signaling pathway in macrophage cell lines. (2007)
  • Author(s): Abe, T., Kaname, Y., Hamamoto, I., Tsuda, Y., Wen, X., Taguwa, S., Moriishi, K., Takeuchi, O., Kawai, T., Kanto, T., Hayashi, N., Akira, S., Matsuura, Y.
  • Journal Title: Journal of Virology 81 Pages: 8953-8966
  • Peer Reviewed
• [Journal Article] Innate immunity in hepatitis C virus infection: Interplay amongdendritic cells, natural killer cells and natural killer T cells. (2007)
  • Author(s): Kanto, T., Hayashi, N.
  • Journal Title: Hepatolgy Reseach 37Suppl
  • NAID: 10019796655
  • Peer Reviewed
• [Journal Article] Replication-competent recombinant vesicular stomatitis virus encoding hepatitis C virus envelope proteins (2007)
  • Author(s): Tani, H., Komoda, Y., Matsuo, E., Suzuki, K., Hamamoto, I., Yamashita, T., Moriishi, K., Fujiyama, K., Kanto, T., Hayashi, N., Owsianka, A., Patel, A.H., Whitt, M.A., Matsuura, Y.
  • Journal Title: Journal of Virology 81 Pages: 8601-8612
  • Peer Reviewed
• [Journal Article] Natural killer cell and hepatic cell interaction via NKG2A leads to dendritic cell-mediated induction of CD4 CD25 T cells with PD-1-dependent regulatory activities (2007)
  • Author(s): Jinushi, M., Takehara, T., Tatsumi, T., Yamaguchi, S., Sakamori, R., Hiramatsu, N., Kanto, T., Ohkawa, K., Hayashi, N
  • Journal Title: Immunology 120 Pages: 73-82
  • Peer Reviewed
• [Journal Article] Impaired ability of interferon-alpha-primed dendritic cells to stimulate Th1-type CD4 T cell response in chronic hepatitis C virus infection. (2007)
  • Author(s): Miyatake H., Kanto T., et. al.
  • Journal Title: Journal of Viral Hepatitis 14 Pages: 404-412
  • Peer Reviewed
• [Journal Article] Involvement of dendritic cell frequency and function in virological relapse in pegylated interferon-α2b and ribavirin therapy for chronic hepatitis C patients. (2007)
  • Author(s): Itose I., Kanto T., et. al.
  • Journal Title: Journal of Medical Virology 79 Pages: 511-521
  • Peer Reviewed
• [Journal Article] Hepatitis C virus nonstructural protein 5A modulates the toll-like receptor-MyD88-dependent signaling pathway in macrophage cell lines. (2007)
  • Author(s): Abe, T., Kaname, Y., et. al.
  • Journal Title: Journal of Virology 81 Pages: 8953-8966
  • Peer Reviewed
• [Journal Article] Innate immunity in hepatitis C virus infection: Interplay amongdendritic cells, natural killer cells and natural killer T celles. (2007)
  • Author(s): Kanto, T. and Hayashi, N.
  • Journal Title: Hepatolgy Reseach 37Suppl3
  • NAID: 10019796655
  • Peer Reviewed
• [Journal Article] Replication-competent recombinant vesicular stomatitis virus encoding hepatitis C virus envelope proteins (2007)
  • Author(s): Tani, H., Komoda, Y., et. al.
  • Journal Title: Journal of Virology 81 Pages: 8601-8612
  • Peer Reviewed
• [Journal Article] Natural killer cell and hepatic cell interaction via NKG2A leads to dendritic cell-mediated induction of CD4 CD25 T cells with PD-1-dependent regulatory activities (2007)
  • Author(s): Jinushi, M., Takehara, T., et. al.
  • Journal Title: Immunology 120 Pages: 73-82
  • Peer Reviewed
• [Presentation] Dynamics of plasmacytoid dendritic cells as a predictor of relapse regardless of virological response in pegylated interferon-a and ribavirin therapy in chronic hepatitis C patients. (2009)
  • Author(s): Kanto T, et. al.
  • Organizer: The Liver Meeting AASLD 60th Annual Meeting and Postgraduate Course
  • Place of Presentation: Boston, MA, USA
• [Presentation] Feasibility of IL-10-producing regulatory Type 1 cells for the monitoring of viable hepatocellular carcinoma through local ablation therapy. (2009)
  • Author(s): Kakita N, Kanto T, et. al.
  • Organizer: The Liver Meeting AASLD 60th Annual Meeting and Postgraduate Course
  • Place of Presentation: Boston, MA, USA
• [Presentation] Myeloid dendritic cells as a therapeutic target for immune restoration by HCV NS3 protease inhibitor in chronic hepatitis C patients (2009)
  • Author(s): Miyazaki M, Kanto T, et. al.
  • Organizer: The Liver Meeting AASLD 60th Annual Meeting and Postgraduate Course
  • Place of Presentation: Boston, MA, USA
• [Presentation] Therapeutic virological response restores impaired capacity of myeloid dendritic cells in chronic hepatitis B patients (2009)
  • Author(s): Higashitani K, Kanto T, et. al.
  • Organizer: The Liver Meeting AASLD 60th Annual Meeting and Postgraduate Course
  • Place of Presentation: Boston, MA, USA
• [Presentation] Reduced drug doses in genotype 1 patients with chronic hepatitis C during treatment with pegylated interferon alfa-2B plus ribavirin delays the timing of HCVRNA negativity or prevents its attainment; A propensity score-matched study. (2009)
  • Author(s): Son C, Hiramatsu N, et. al.
  • Organizer: The Liver Meeting AASLD 60th Annual Meeting and Postgraduate Course
  • Place of Presentation: Boston, MA, USA
• [Presentation] Prediction of early response to pegylated interferon and ribavirin in chronic hepatitis C based on amino acid substitutions in the viral core region. (2009)
  • Author(s): Inoue Y, Hiramatsu N, et. al.
  • Organizer: The Liver Meeting AASLD 60th Annual Meeting and Postgraduate Course
  • Place of Presentation: Boston, MA, USA
• [Presentation] Dynamics of plasmacytoid dendritic cells as a predictor of relapse regardless of virological response in pegylated interferon-a and ribavirin therapy in chronic hepatitis C patients (2009)
  • Author(s): Kanto T, Itose I, et al.
  • Organizer: The Liver Meeting AASLD 60^<th> Annual Meeting and Postgraduate Course
  • Place of Presentation: Boston, MA, USA
• [Presentation] Feasibility of IL-10-producing regulatory Type 1 cells for the monitoring of viable hepatocellular carcinoma through local ablation therapy (2009)
  • Author(s): Kakita N, Kanto T, et al.
  • Organizer: The Liver Meeting AASLD 60^<th> Annual Meeting and Postgraduate Course
  • Place of Presentation: Boston, MA, USA
• [Presentation] Myeloid dendritic cells as a therapeutic target for immune restoration by HCV NS3 protease inhibitor in chronic hepatitis C patients (2009)
  • Author(s): Miyazaki M, Kanto T, et al.
  • Organizer: The Liver Meeting AASLD 60^<th> Annual Meeting and Postgraduate Course
  • Place of Presentation: Boston, MA, USA
• [Presentation] Therapeutic virological response restores impaired capacity of myeloid dendritic cells in chronic hepatitis B patients (2009)
  • Author(s): Higashitani K, Kanto T, et al
  • Organizer: The Liver Meeting AASLD 60^<th> Annual Meeting and Postgraduate Course
  • Place of Presentation: Boston, MA, USA
• [Presentation] Natural regulatory T cells as biomarker for the assessment of hepatocellular carcinoma in local ablation therapy (2008)
  • Author(s): Kakita N., Kanto T., et al
  • Organizer: The 59^<th> Annual Meeting of the American Association for the Study of Liver Diseases (AASLD)
  • Place of Presentation: San Francisco, CA. USA
  • Year and Date: 2008-11-03
• [Presentation] Dynamic changes of regulatory T cell subsets in patients with chronic HCV infection in relation to the degree of liver inflammation (2008)
  • Author(s): Itose I., Kanto T, et. al.
  • Organizer: The 59th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD)
  • Place of Presentation: San Francisco, CA. USA
  • Year and Date: 2008-11-02
• [Presentation] t al IL-7 as a booster of Th2-differentiation by modulating myeloid dendritic cells in chronic hepatitis C virus infection (2008)
  • Author(s): Takebe S., Kanto T
  • Organizer: The 59th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD)
  • Place of Presentation: San Francisco, CA. USA
  • Year and Date: 2008-11-02
• [Presentation] Natural regulatory T cells as biomarker for the assessment of hepatocellular carcinoma in local ablation therapy (2008)
  • Author(s): Kakita N., Kanto T, et. al
  • Organizer: The 59th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD)
  • Place of Presentation: San Francisco, CA. USA
  • Year and Date: 2008-11-02
• [Presentation] Dynamic changes of regulatory T cell subsets in patients with chronic HCV infection in relation to the degree of liver inflammation (2008)
  • Author(s): Itose I., Kanto T., et al
  • Organizer: The 59^<th> Annual Meeting of the American Association for the Study of Liver Diseases (AASLD)
  • Place of Presentation: San Francisco, CA. USA
  • Year and Date: 2008-11-02
• [Presentation] IL-7 as a booster of Th2-differentiation by modulating myeloid dendritic cells in chronic hepatitis C virus infection (2008)
  • Author(s): Takebe S., Kanto T., et al
  • Organizer: The 59^<th> Annual Meeting of the American Association for the Study of Liver Diseases (AASLD)
  • Place of Presentation: San Francisco, CA. USA
  • Year and Date: 2008-11-02
• [Presentation] NK and NKT-dendritic cell interactions in HCV infection (2008)
  • Author(s): Kanto T.
  • Organizer: Hepatic Inflammation and Immunity 2008
  • Place of Presentation: Galveston, Texas USA
  • Year and Date: 2008-01-27
• [Presentation] Dendritic cell as a versatile controller of innate and adaptive immune response against hepatitis C virus (2008)
  • Author(s): Kanto T.
  • Organizer: The 10th International Symposium on Dendritic Cells
  • Place of Presentation: Kobe, Japan
• [Presentation] Impaired TLR/RIG-I-mediated innate immunity in myeloid dendritic cells in chronic hepatitis C patients (2008)
  • Author(s): Miyazaki M. Kanto T, et. al.
  • Organizer: The 10th International Symposium on Dendritic Cells
  • Place of Presentation: Kobe, Japan
• [Presentation] Novel mature dendritic cells inducible from monocytes with OK432, PGE1 and IFN-a serve as potent vaccine vehicles for gastrointestinal cancers (2008)
  • Author(s): Sakakibara M., Kanto T, et. al.
  • Organizer: The 10th International Symposium on Dendritic Cells
  • Place of Presentation: Kobe, Japan
• [Presentation] NK and NKT-dendritic cell interactions in HCV infection Hepatic (2008)
  • Author(s): Kanto T.
  • Organizer: Inflammation and Immunity 2008
  • Place of Presentation: Galveston, Texas USA
• [Presentation] Dendritic cell as a versatile controller of innate and adaptive immune response against hepatitis C virus (2008)
  • Author(s): Kanto T.
  • Organizer: The 10^<th> International Symposium on Dendritic Cells
  • Place of Presentation: Kobe, Japan
• [Presentation] Impaired TLR/RIG-I-mediated innate immunity in myeloid dendritic cells in chronic hepatitis C patients (2008)
  • Author(s): Miyazaki M., Kanto T, et al.
  • Organizer: The 10^<th> International Symposium on Dendritic Cells
  • Place of Presentation: Kobe, Japan
• [Presentation] Novel mature dendritic cells inducible from monocytes with OK432, PGE1 and IFN-a serve as potent vaccine vehicles for gastrointestinal cancers (2008)
  • Author(s): Sakakibara M., Kanto T, et al.
  • Organizer: The 10^<th> International Symposium on Dendritic Cells
  • Place of Presentation: Kobe, Japan
• [Remarks] 大阪大学大学院医学系研究科消化器内科学ホームページ
  • URL: http://www.med.osaka-u.ac.jp/pub/gh/index.htm
• [Remarks]
  • URL: http://www.med.osaka-u.ac.jp/pub/gh/index.htm
• [Remarks]
  • URL: http://www.med.osaka-u.ac.jp/pub/gh/index.htm
• [Remarks]
  • URL: http://www.med.osaka-u.ac.jp/pub/gh/index.htm