| Project/Area Number |
19590784
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Nara Medical University |
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Principal Investigator |
FUKUI Hiroshi Nara Medical University, 医学部, 教授 (80145838)
福井 博 (2009) Nara Medical University, 医学部, 教授 (80145383)
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| Co-Investigator(Kenkyū-buntansha) |
藤本 正男 奈良県立医科大学, 医学部, 講師 (60295805)
吉治 仁志 奈良県立医科大学, 医学部, 講師 (40336855)
美登路 昭 奈良県立医科大学, 医学部, 助教 (10382285)
辻本 達寛 奈良県立医科大学, 医学部, 助教 (00423921)
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| Co-Investigator(Renkei-kenkyūsha) |
TSUJIMOTO Tatsuhiro
KITAZAWA Hiroyuki
KAWARATANI Hideto
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| Project Period (FY) |
2007 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | Toll-like受容体 / マクロファージ / 非アルコール性脂肪肝炎(NASH) / 急性肝不全 / Kupffer細胞 / TNF-α / エンドトキシン / Toll-like受容体(TLR)4 / アルコール性肝障害 / TLR4アンタゴニスト / ガラクトサミン / Toll-like 受容体 / Kupffer 細胞 |
|---|
| Research Abstract |
Toll-like receptor 4 (TLR4) was upregulated and TNF-α production was increased with the progression of liver injury in the CDAA-fed nonalcoholic steatohepatitis and galactosamine(GalN)-induced acute hepatic failure in rats. Cytokine regulator was effective to NASH rats and alcohol-fed rats. TLR4 inhibitor was effective to AHF and improved survival of GalN/LPS induced lethal AHF in rats.
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