Novel therapeutic strategy for chronic pancreatitis targeting pancreatic stellate cells

• Project/Area Number: 19590786
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Akita University
• Principal Investigator: OHNISHI Hirohide Akita University, 医学部, 教授 (00313023)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 膵臓 / 慢性膵炎 / 膵線維化 / 膵星細胞 / TGF-beta / interleukin-13 / 細胞増殖 / NF-kappaB / Indian hedgehog / 遊走能

Research Abstract

慢性膵炎の主な病理学的現象は膵組織の線維化であり、その線維化の発症伸展の中心的役割を果たすのは活性化膵星細胞である。本研究ではその活性化膵星細胞の増殖や遊走能の分子メカニズムを解明し、それらを抑制する方法を見いだして活性化星細胞の機能を制御する事により、膵線維化の予防ならびに治療法の開発の一助とすべく、本研究を遂行した。

Research Products

• [Journal Article] Indian hedgehog promotes the migration of rat activated pancreatic stellate cells by increasing membrane type-1 matrix metalloproteinase on the plasma membrane (2008)
  • Author(s): Shinozaki S, Ohnishi H et.al.
  • Journal Title: Journal of Cellular Pysiology vol. 216 Pages: 38-46
  • Peer Reviewed
• [Journal Article] Up-regulation of JAM-1 in AR42J cells treated with activin A andbetacellulin and the diabetic regenerating islets (2008)
  • Author(s): Yoshikumi Y, Ohnishi H et.al.
  • Journal Title: Endocirne Journal Vol55 Pages: 757-765
  • Peer Reviewed
• [Journal Article] 膵線維化における膵星細胞機能研究の新しい展開 (2008)
  • Author(s): 大西洋英
  • Journal Title: 膵臓 vol.23 Pages: 124-131
  • NAID: 10024367577
  • Peer Reviewed
• [Journal Article] Indian hedgehog promotes the migration of rat activated pancreatic stellate cells by increas (2008)
  • Author(s): Shinozaki S, Ohnishi H, et.al.
  • Journal Title: J Cell Physiol 216 Pages: 38-46
  • Peer Reviewed
• [Journal Article] Up-regulation of JAM-1 in AR42J cells treated with activin A and betacellulin and the diab (2008)
  • Author(s): Yoshikumi Y, Ohnishi H, et.al.
  • Journal Title: Endocr J 55 Pages: 757-765
  • Peer Reviewed
• [Journal Article] 膵線維化における膵星細胞機能研究の新しい展開 (2008)
  • Author(s): 大西洋英
  • Journal Title: 膵臓 23 Pages: 124-131
  • NAID: 10024367577
• [Journal Article] Cyclooxygenase-2 is required for activated pancreatic stellate cells to respond to proinflammatory cytokines (2007)
  • Author(s): Aoki H, Ohnishi H, et.al.
  • Journal Title: American Journal of Physiology, Cell Physiology vol.292 Pages: 259-268
  • Peer Reviewed
• [Journal Article] 特集 : 膵星細胞「サイトカイン」 (2007)
  • Author(s): 大西洋英
  • Journal Title: 肝胆膵 vol.55 Pages: 1199-1206
  • Peer Reviewed
• [Journal Article] Cox-2 is required for activated pancreatic stellate cells to respond to proinflammatory cytokines (2007)
  • Author(s): Aoki H, Ohnishi H, et. al.
  • Journal Title: Am J Physiol Cell Physiol 292
  • Peer Reviewed
• [Journal Article] Indian hedgehog promotes the migration of rat activated pancreatic stellate cells by increasing membrane type-1 matrix metalloproteinase on the plasma membrane
  • Author(s): Shinozaki S, Ohnishi H, et. al.
  • Journal Title: J Cell Physiol (印刷中)
  • Peer Reviewed
• [Presentation] Molecular mechanism of the regulation of pancreatic stellate cellular functions : Indian Hedg (2009)
  • Author(s): Ohnishi H
  • Organizer: 国際膵臓研究フォーラム
  • Place of Presentation: 東京
  • Year and Date: 2009-03-22
• [Presentation] IL-13の膵星細胞増殖促進作用の検討 (2007)
  • Author(s): 篠崎聡、大西洋英
  • Organizer: 第38回に本膵臓学会大会
  • Place of Presentation: 福岡
  • Year and Date: 2007-06-29
• [Presentation] IL-13 promotes the proliferation of activated rat pancreatic stellate cells through multiple signaling pathways including autocirne TGF-beta/NF-kappaB, Akt-, and S6-dependent pathways (2007)
  • Author(s): Shinozaki S, Ohnishi H.
  • Organizer: 108^<th> Annual Metting of American Gastroenterological Asociation, DDW.
  • Place of Presentation: Waswhington DC, USA
  • Year and Date: 2007-05-20
• [Presentation] IL-13の膵星細胞増殖促進作用における分子機構の解析 (2007)
  • Author(s): 篠崎聡、大西洋英
  • Organizer: 第93回に本消化器病学会総会
  • Place of Presentation: 青森
  • Year and Date: 2007-04-19