The involvement of stress and central neuropeptide on the progression of nonalcoholic steatohepatitis
| Project/Area Number |
19590787
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Aichi Medical University |
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Principal Investigator |
YONEDA Masashi Aichi Medical University, 医学部, 教授 (30261407)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAO Haruhisa 愛知医科大学, 医学部, 教授 (60326139)
NAKADE Yukiomi 愛知医科大学, 医学部, 講師 (70431400)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | NASH / ストレス / CRF / 脂肪肝 / 肝病態 / 神経ペプチド / コリン欠乏食 |
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| Research Abstract |
It is generally accepted that the etiology of nonalcoholic steatohepatitis (NASH) remains to be unknown. The involvement of stress or central neuropeptide on the progression for NASH was investigated in this study. We have demonstrated that restraint stress significantly aggravated liver function on acute fatty liver model in rats and an endogenous corticotropine releasing factor (CRF), which is known as a neuropeptide in the brain was involved. We have also shown that repeated restraint stress has a tendency to make worse fatty change of liver in NASH model. Although the etiology of NASH remains to be elucidated, stress might be involved in the progression for NASH.
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Report
(4 results)
Research Products
(29 results)
