| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
It is generally accepted that the etiology of nonalcoholic steatohepatitis (NASH) remains to be unknown. The involvement of stress or central neuropeptide on the progression for NASH was investigated in this study. We have demonstrated that restraint stress significantly aggravated liver function on acute fatty liver model in rats and an endogenous corticotropine releasing factor (CRF), which is known as a neuropeptide in the brain was involved. We have also shown that repeated restraint stress has a tendency to make worse fatty change of liver in NASH model. Although the etiology of NASH remains to be elucidated, stress might be involved in the progression for NASH.
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