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The role of anti-oxidative enzyme SOD1 on the development of hepatocellular carcinoma from steatohepatitis

Research Project

Project/Area Number 19590790
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionKeio University

Principal Investigator

SAITO Hidetsugu  Keio University, 医学部, 准教授 (80186949)

Co-Investigator(Renkei-kenkyūsha) SAKAMOTO Michiie  慶應義塾大学, 医学部, 教授 (40221270)
TSUBOTA Kazuo  慶應義塾大学, 医学部, 教授 (40163878)
Research Collaborator TAKANO Kakuko  慶應義塾大学, 医学部, 研究助手
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
KeywordsSODK / Oマウス / 酸化ストレス / 高カロリー(高脂肪)食 / レスベラトロール / DEN / 四塩化炭素 / 胆管細胞癌 / 多方向性分化細胞 / SOD K / SOD1ノックアウトマウス / 脂肪性肝炎 / 発がん / 健康寿命 / 肝線維化
Research Abstract

SOD1 K/OヘテロK/Oマウスという酸化ストレスに弱いマウスを使い、様々な方法で脂肪化、線維化、発癌を惹起し、抗酸化剤の抑制効果を検討した. その結果、脂肪化の進展と線維化は相関しないこと、SOD1活性の低下に連れて肝細胞傷害が惹起すること、肝内の抗酸化酵素は特定の酵素活性が弱くなるとそれを補うように他の酵素活性が上昇する「補填効果」を生ずることが示唆された. またDEN濃度による多方向性分化細胞の存在が認められた. 今後ホモK/Oマウス供給の目処がたちSOD-1の作用についてはさらに明らかになる予定である.

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (27 results)

All 2009 2008 2007

All Journal Article (16 results) (of which Peer Reviewed: 15 results) Presentation (9 results) Book (2 results)

  • [Journal Article] Treatment of hepatitis C virus with peg-interferon and ribavirin combination therapy significantly affects lipid metabolism2009

    • Author(s)
      S. Tada, H. Saito, H. Ebinuma, K. Ojiro, Y. Yamagishi, N. Kumagai, Y. Inagaki, T. Masuda, J. Nishida, M. Takahashi, H. Nagata, T. hibi
    • Journal Title

      Hepatol. Res 39(2)

      Pages: 195-199

    • NAID

      10025324600

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] New mechanism of transforming growth factor-beta signaling in hepatoma : Dramatic up-regulation of tumor initiating cells and epidermal growt hfactor receptor expression2009

    • Author(s)
      T. Nishimura, T. Azuma, A. Yokoyama, H. Ochiai, H. Saito, T. Hibi
    • Journal Title

      Hepatol. Res 39

      Pages: 501-509

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Treatment of hepatitis C virus with peg-interferon and ribavir in combination therapy significantly affects lipid metabolism2009

    • Author(s)
      S. Tada, H. Saito, H. Ebinum a, et al.
    • Journal Title

      Hepatol. Res. 39

      Pages: 195-199

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 飲酒の肝硬変進展への影響-C型肝炎とアルコール性肝硬変の関係について2009

    • Author(s)
      堀江義則, 他
    • Journal Title

      日本アルコール・薬物医学会雑誌 44

      Pages: 38-42

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypofractionated stereotactic radiotherapy with and without transarterial chemo-embolizationfor small hepatocellular carcinoma not eligible for other ablation therapies : Preliminary results for efficacy and toxicity2008

    • Author(s)
      A. Takeda, M. Takahashi, E. Kunieda, T. Takeda, N. Sanuki, Y. Koike, K. Atsukawa, T. Ohashi, H. Saito, N. Shigematsu, A. Kubo
    • Journal Title

      Hepatol. Res 38(1)

      Pages: 60-68

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transmission of hepatitis B virus (HBV) genotypes among Japanese immigrants and natives in Bolivia2008

    • Author(s)
      A. Khan, Y. Tanaka, H. Saito, H. Ebinuma, H. Sekiguchi, H. Iwama, G. Wakabayashi, T. Kamiya, F. Kurbanov, A. Elkady, M. Mizokami
    • Journal Title

      Virus Res 132(1-2)

      Pages: 174-180

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Possible molecular mechanism of the relationship between NS5B polymorphisms and early clearance of hepatitis C virus during interferon plus ribavirin treatment2008

    • Author(s)
      M. Nakamura, H. Saito, M. Ikeda, S. Tada, N. Kumagai, N. Kato, K. Shimotohno, T. Hibi
    • Journal Title

      J. Med. Virol 80(4)

      Pages: 632-663

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reactivation of hepatitis B in a patient with Crohn's disease treated using infliximab2008

    • Author(s)
      K. Ojiro, M. Naganuma, H. Ebinuma, H. Kunimoto, S. Tada, H. Ogata, Y. Iwao, H. Saito, T. Hibi
    • Journal Title

      J. Gastroenterol 43(5)

      Pages: 397-401

    • NAID

      10021268818

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Advances in henomic research on hepatitis C virus with a useful tool2008

    • Author(s)
      M. Nakamura, H. Saito, T. Hibi
    • Journal Title

      replicon system. Keio J. Med 57(2)

      Pages: 75-83

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Possible molecular mechanism of the relationship between NS5B polym orphisms and early clearance of hepatitis C virus during interferon plus ribavirin treatment.2008

    • Author(s)
      M. Nakamura, H. Saito, M. Ikeda, et al.
    • Journal Title

      J. Med. Virol. 80

      Pages: 632-663

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 肝発癌のケモプリベンション:理論と実際2008

    • Author(s)
      斉藤 英胤
    • Journal Title

      日本内科学会雑誌 98

      Pages: 92-98

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Possible Inhibitory Effect of Oral Zinc Supplementation on Hepatic Fibrosis Through Downregulation of TIMP-1 : A Pilot Study2007

    • Author(s)
      M. Takahashi, H. Saito, M. Higashimoto, T. Hibi
    • Journal Title

      Hepatol. Res 37

      Pages: 405-409

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Complexity of the HVR-1 quasispecies and disease activity in patients with hepatitis C2007

    • Author(s)
      N. Kumagai, F. Kaneko, S. Tsunematsu, K. Tsuchimoto, S. Tada, H. Saito, T. Hibi
    • Journal Title

      Eur. J. Clin. Invest 37

      Pages: 566-572

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rho/Rho kinase is a key enzyme system involved in the angiotensin II signaling pathway of liver fibrosis and steatosis2007

    • Author(s)
      K. Kitamura, S. Tada, N. Nakamoto, K. Toda, H. Horikawa, S. Kurita, S. Tsunematsu, N. Kumagai, H. Ishii, H. Saito, T. Hibi
    • Journal Title

      J. Gastroenterol. Hepatol 22

      Pages: 2022-2033

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Possible Inhibitory Effect of Oral Zinc Supplementation on Hepatic Fibrosis Through Downregulation of TIMP-1:A Pilot Study2007

    • Author(s)
      M. Takahashi, H. Saito, et. al.
    • Journal Title

      Hepatology Research 37

      Pages: 405-409

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rho/Rho kinase is a key enzyme system involved in the angiotensin II signaling pathway of liver fibrosis and steatosis2007

    • Author(s)
      K. Kitamura, et. al.
    • Journal Title

      Journal of Gastroenterology and Hepatology 22

      Pages: 2022-2033

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] ^<90m>Tc-フチン酸シンチグラフィー検査を用いたNASH診断の有用性に関する検討2009

    • Author(s)
      菊池真大、富田謙吾、中原理紀、北村直人、寺谷俊昭、押川哲也、鈴木貴博、齋藤英胤、日比紀文
    • Organizer
      第95回日本消化器病学会総会(口演)
    • Place of Presentation
      札幌
    • Year and Date
      2009-05-07
    • Related Report
      2008 Final Research Report
  • [Presentation] NASHに対する、 TelmisartanとPolyenylphosphatidylcholine併用療法の有効性に関する検討2008

    • Author(s)
      富田謙吾, 他
    • Organizer
      第28回日本アルコール医学生物学研究会
    • Place of Presentation
      横浜
    • Year and Date
      2008-09-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] 体成分分析装置によるHCC治療前後での入院患者の体成分パラメータ分析. ワークショップ「肝疾患と栄養(NASHを含めて)」2008

    • Author(s)
      尾城啓輔、齋藤英胤、日比紀文
    • Organizer
      第37回日本肝臓学会東部会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] 非B非Cアルコール性肝疾患における過形成性結節と肝細胞癌の鑑別2008

    • Author(s)
      菊池真大、山岸由幸、尾城啓輔、海老沼浩利、多田慎一郎、堀江義則、齋藤英胤、加藤真三、日比紀文
    • Organizer
      第37回日本肝臓学会東部会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] アルコール性肝硬変の進展に関与する因子の検討2008

    • Author(s)
      堀江義則、山岸由幸、菊池真大、齋藤英胤、加藤真三、石井裕正、日比紀文
    • Organizer
      第28回日本アルコール医学生物学研究会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] 肝癌幹細胞におけるTGF-betaシグナルの二面性-細胞動態・遺伝子プロフィールの観点から2008

    • Author(s)
      西村健、東俊文、齋藤英胤、日比紀文
    • Organizer
      第44回日本肝臓学会総会
    • Place of Presentation
      愛媛
    • Related Report
      2008 Final Research Report
  • [Presentation] 肝線維化の定量的測定におけるElastometerの有用性2008

    • Author(s)
      菊池真大、海老沼浩利、山岸由幸、尾城啓輔、金森英彬、富田謙吾、多田慎一郎、堀江義則、齋藤英胤、加藤真三、日比紀文
    • Organizer
      第94回日本消化器病学会総会
    • Place of Presentation
      福岡
    • Related Report
      2008 Final Research Report
  • [Presentation] マウスNASHモデルにおける亜鉛の抗線維化作用に関する検討2007

    • Author(s)
      熊谷 直樹, 他
    • Organizer
      第11回日本肝臓学会大会(JDDW2007)
    • Place of Presentation
      神戸
    • Year and Date
      2007-10-18
    • Related Report
      2007 Annual Research Report
  • [Presentation] マウスNASHモデルにおける亜鉛の抗線維化作用に関する検討2007

    • Author(s)
      熊谷直樹、杉野陽子、渡辺紗希子、戸田京子、金子文彦、常松令、土本寛二、齋藤英胤、日比紀文
    • Organizer
      第11回日本肝臓学会大会
    • Place of Presentation
      神戸
    • Related Report
      2008 Final Research Report
  • [Book] アンチエイジング医学の基礎と臨床2008

    • Author(s)
      坪田一男, 木下茂, 斎藤一郎 齋藤英胤, 白澤卓二
    • Total Pages
      455
    • Publisher
      メジカルビュー社
    • Related Report
      2008 Annual Research Report
  • [Book] アンチエイジング・ヘルスフードー抗加齢・疾病予防・健康長寿延長への応用-2007

    • Author(s)
      斉藤 英胤, 水島 裕, 監修
    • Publisher
      サイエンスフォーラム
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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