The role of anti-oxidative enzyme SOD1 on the development of hepatocellular carcinoma from steatohepatitis
| Project/Area Number |
19590790
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Keio University |
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Principal Investigator |
SAITO Hidetsugu Keio University, 医学部, 准教授 (80186949)
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| Co-Investigator(Renkei-kenkyūsha) |
SAKAMOTO Michiie 慶應義塾大学, 医学部, 教授 (40221270)
TSUBOTA Kazuo 慶應義塾大学, 医学部, 教授 (40163878)
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| Research Collaborator |
TAKANO Kakuko 慶應義塾大学, 医学部, 研究助手
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | SODK / Oマウス / 酸化ストレス / 高カロリー(高脂肪)食 / レスベラトロール / DEN / 四塩化炭素 / 胆管細胞癌 / 多方向性分化細胞 / SOD K / SOD1ノックアウトマウス / 脂肪性肝炎 / 発がん / 健康寿命 / 肝線維化 |
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| Research Abstract |
SOD1 K/OヘテロK/Oマウスという酸化ストレスに弱いマウスを使い、様々な方法で脂肪化、線維化、発癌を惹起し、抗酸化剤の抑制効果を検討した. その結果、脂肪化の進展と線維化は相関しないこと、SOD1活性の低下に連れて肝細胞傷害が惹起すること、肝内の抗酸化酵素は特定の酵素活性が弱くなるとそれを補うように他の酵素活性が上昇する「補填効果」を生ずることが示唆された. またDEN濃度による多方向性分化細胞の存在が認められた. 今後ホモK/Oマウス供給の目処がたちSOD-1の作用についてはさらに明らかになる予定である.
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Report
(3 results)
Research Products
(27 results)
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[Journal Article] Treatment of hepatitis C virus with peg-interferon and ribavirin combination therapy significantly affects lipid metabolism2009
Author(s)
S. Tada, H. Saito, H. Ebinuma, K. Ojiro, Y. Yamagishi, N. Kumagai, Y. Inagaki, T. Masuda, J. Nishida, M. Takahashi, H. Nagata, T. hibi
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Journal Title
Hepatol. Res 39(2)
Pages: 195-199
NAID
Related Report
Peer Reviewed
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[Journal Article] Hypofractionated stereotactic radiotherapy with and without transarterial chemo-embolizationfor small hepatocellular carcinoma not eligible for other ablation therapies : Preliminary results for efficacy and toxicity2008
Author(s)
A. Takeda, M. Takahashi, E. Kunieda, T. Takeda, N. Sanuki, Y. Koike, K. Atsukawa, T. Ohashi, H. Saito, N. Shigematsu, A. Kubo
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Journal Title
Hepatol. Res 38(1)
Pages: 60-68
Related Report
Peer Reviewed
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[Journal Article] Transmission of hepatitis B virus (HBV) genotypes among Japanese immigrants and natives in Bolivia2008
Author(s)
A. Khan, Y. Tanaka, H. Saito, H. Ebinuma, H. Sekiguchi, H. Iwama, G. Wakabayashi, T. Kamiya, F. Kurbanov, A. Elkady, M. Mizokami
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Journal Title
Virus Res 132(1-2)
Pages: 174-180
Related Report
Peer Reviewed
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[Journal Article] Rho/Rho kinase is a key enzyme system involved in the angiotensin II signaling pathway of liver fibrosis and steatosis2007
Author(s)
K. Kitamura, S. Tada, N. Nakamoto, K. Toda, H. Horikawa, S. Kurita, S. Tsunematsu, N. Kumagai, H. Ishii, H. Saito, T. Hibi
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Journal Title
J. Gastroenterol. Hepatol 22
Pages: 2022-2033
Related Report
Peer Reviewed
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