| Project/Area Number |
19590796
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
|
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| Research Institution | Kurume University |
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Principal Investigator |
TORIMURA Takuji Kurume University, 医学部, 准教授 (60197986)
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| Co-Investigator(Kenkyū-buntansha) |
UENO Takato 久留米大学, 先端癌治療研究センター, 教授 (70176618)
NAKAMURA Touru 久留米大学, 医学部, 助教 (30341332)
TANIGUCHI Eitaro 久留米大学, 医学部, 助教 (50341318)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKASHIMA Emi 慶応大学, 薬学部, 教授 (90115254)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 肝細胞癌 / 血管新生抑制 / 遺伝子治療 / flk-1 / VEGF / 骨髄細胞 / 平滑筋前駆細胞 / 血管内皮前駆細胞 / 遺伝子 / 移植再生医療 / ウイルス / Soluble flk-1 |
|---|
| Research Abstract |
Mouse bone marrow derived mononuclear cells differentiated to endothelial progenitor cells (EPC) and smooth muscle progenitor cells (SMPC) in vitro. EPC and SMPC injectedvia tail vein selectively migrated to tumor tissue. These cells partly differentiated to endothelial cells and pericytes. Antiangiongenic gene therapy with SMPC transfected flk-1 cDNA by adenovirus vector suppressed vascular development and tumor growth.
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