Molecular mechanisms for beneficial effects of low-energy shock wave therapy on myocardial ischemia

• Project/Area Number: 19590801
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Tohoku University
• Principal Investigator: ITO Kenta Tohoku University, 大学院・医学系研究科, 准教授 (50375086)
• Co-Investigator(Kenkyū-buntansha): SHIMOKAWA Hiroaki 東北大学, 大学院・医学系研究科, 教授 (00235681)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 血管新生 / 再生医療 / 虚血性心疾患 / 循環器・高血圧 / 再生医学

Research Abstract

私達は、低出力の衝撃波を体外から虚血心筋に照射すると冠動脈の血管新生が効率よく誘導され心筋虚血が改善されることを報告している。本研究により、低出力衝撃波治療が、培養血管内皮細胞において各種血管増殖因子・サイトカインを増減させること、またブタ急性心筋梗塞モデルにおいてeNOS発現を亢進させ梗塞境界領域の毛細血管数を増加することが分かった。本研究により、低出力の衝撃波治療が心筋虚血を改善する機序が明らかになりつつある。

Research Products

• [Journal Article] 現代医学の焦点 : 衝撃波による狭心症治療 (2008)
  • Author(s): 伊藤健太、下川宏明
  • Journal Title: 日本臨床 66 Pages: 2019-2026
• [Journal Article] 低出力体外衝撃波を用いた血管新生療法 (2008)
  • Author(s): 伊藤健太、下川宏明
  • Journal Title: Vascular Medicine 4 Pages: 189-191
• [Journal Article] Extracorporeal cardiac shock wave therapy for ischemic heart disease (2008)
  • Author(s): Shimokawa H, Ito K, Fukumoto Y, Yasuda S
  • Journal Title: Shock Waves 8 Pages: 449-455
  • Peer Reviewed
• [Journal Article] Extracorporeal shock wave therapy ameliorates hindlimb ischemia in rabbits (2008)
  • Author(s): Oi K, Fukumoto Y, Ito K, Uwatoku T, Abe K, Hizume T, Shimokawa H
  • Journal Title: Tohoku J Exp Med 214 Pages: 151-158
  • NAID: 10024166862
  • Peer Reviewed
• [Journal Article] Extracorporeal cardiac shock wave therapy for ischemic heart disease (2008)
  • Author(s): Shimokawa H, Ito K, et.al.
  • Journal Title: Shock Waves 17 Pages: 449-455
  • Peer Reviewed
• [Journal Article] 綜説シリーズ現代医学の焦点 : 衝撃波による狭心症治療 (2008)
  • Author(s): 伊藤健太、下川宏明
  • Journal Title: 日本臨床 66 Pages: 2019-2026
• [Journal Article] Extracorporeal shock wave therapy ameliorates hindlimb ischemia in rabbits. (2008)
  • Author(s): Oi K, Fukumoto Y, Ito K, et. al.
  • Journal Title: Tohoku J Exp Med. 214 Pages: 151-158
  • NAID: 10024166862
  • Peer Reviewed
• [Journal Article] Extracorporeal cardiac shock wave therapy for ischemic heart disease. (2008)
  • Author(s): Shimokawa H, Ito K, et. al.
  • Journal Title: Shock Waves (In press)
  • Peer Reviewed
• [Presentation] Extracorporeal cardiac shock wave therapy ameliorates left ventricular remodeling after myocardial ischemia-reperfusion injury in pigs in vivo (2009)
  • Author(s): Ito Y, Ito K, Shiroto T, Tsuburaya R, Gao JY, Kikuchi Y, Aizawa K, Takeda M, Yasuda H, Shimokawa H
  • Organizer: 第73回日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-03-21
• [Presentation] ブタ心筋虚血再灌流傷害後の左室リモデリングに対する体外衝撃波治療の抑制効果 (2009)
  • Author(s): 伊藤愛剛、伊藤健太、白戸崇、円谷隆治、高軍毅、武田守彦、福本義弘、安田聡、下川宏明
  • Organizer: 第147回日本循環器学会東北地方会
  • Place of Presentation: 仙台
  • Year and Date: 2009-02-14
• [Presentation] Extracorporeal cardiac shock wave therapy ameliorates left ventricular remodeling after myocardial ischemia-reperfusion injury in pigs (2008)
  • Author(s): Ito Y, Ito K, Shiroto T, Tsuburaya R, Gao J, Kikuchi Y, Aizawa K, Takeda M, Yasuda S, Shimokawa H
  • Organizer: American Heart Association Scientific Session 2008
  • Place of Presentation: 米国ニューオーリンズ
  • Year and Date: 2008-11-09
• [Presentation] Extracorporeal cardiac shock wave therapy ameliorates left ventricular remodeling after myocardial ischemia-reperfusion injury in pigs (2008)
  • Author(s): Ito Y, Ito K, et.al.
  • Organizer: American Heart Association Scientific Session 2008
  • Place of Presentation: ニューオーリンズ(米国)
  • Year and Date: 2008-11-09
• [Presentation] 低出力体外衝撃波を用いた非侵襲性血管新生療法の開発 (2008)
  • Author(s): 伊藤健太、福本義弘、安田聡、下川宏明
  • Organizer: 第56回日本心臓病学会学術集会シンポジウム「心血管再生医療の現状と展望」
  • Place of Presentation: 東京
  • Year and Date: 2008-09-11
• [Presentation] Extracorporeal cardiac shock wave therapy ameliorates left ventricular remodeling after myocardial ischemia-reperfusion injury in pigs in vivo (2008)
  • Author(s): Ito Y, Ito K, Shiroto T, Tsuburaya R, Gao JY, Yasuda H, Shimokawa H
  • Organizer: The European Society of Cardiology Congress 2008
  • Place of Presentation: ドイツミュンヘン
  • Year and Date: 2008-08-31
• [Presentation] Extracorporeal cardiac shock wave therapy ameliorates left ventricular remodeling after myocardial ischemia-reperfusion injury in pigs in vivo (2008)
  • Author(s): Ito Y, Ito K, et.al.
  • Organizer: The European Society of Cardiology Congress 2008
  • Place of Presentation: シュンヘン(ドイツ)
  • Year and Date: 2008-08-31
• [Remarks]
  • URL: http://www.cardio.med.tohoku.ac.jp/shockwave/index.html
• [Remarks]
  • URL: http://www.cardio.med.tohoku.ac.jp/shockwave/index.html
• [Remarks] 「体外衝撃波治療:狭心症・急性心筋梗塞や下肢閉塞性動脈硬化症に対する新しい治療法」ホームページ
  • URL: http://www.cardio.med.tohoku.ac.jp/shockwave/index.html