Long-term Inhibition of Rho-kinase Ameliorates Diastolic Heart Failure in Hypertensive Rats
| Project/Area Number |
19590803
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
FUKUMOTO Yoshihiro Tohoku University, 病院, 講師 (70363372)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMOKAWA Hiroaki 東北大学, 大学院・医学系研究科, 教授 (00235681)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 慢性心不全 / 拡張不全 / Rhoキナーゼ / 心筋拡張障害 / 心室線維化 / Rho-キナーゼ |
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| Research Abstract |
慢性心不全は、現在増加傾向にある心臓病終末像であり、中でも左室拡張障害・心筋細胞の硬化・心室線維化を特徴とする拡張不全型心不全に対する薬物療法は確立されていない。
本研究では、心筋拡張障害・心室線維化におけるRhoキナーゼ経路の分子機構の解明および拡張不全型心不全における治療としてのRhoキナーゼ阻害の検討を行い、心筋拡張障害・心室線維化におけるRhoキナーゼ経路の分子機構の解明、拡張不全型心不全における治療としてのRhoキナーゼ阻害の検討を行った。
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Report
(3 results)
Research Products
(29 results)
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[Presentation] Current Status and Future Perspectives of Diastolic Heart Failure in Japan-Possible Importance of Metabolic Syndrome-2009
Author(s)
Yoshihiro Fukumoto, Yutaka Miura, Shigefumi Fukui, Toshiro Miura, Masunori Matsuzaki, Kazunori Shimada, Yoshitaka Iwama, Atsutoshi Takagi, Hiroyuki Daida, Takaki Tsutsumi, Akira Yamada, Shintaro Kinugawa, Hiroyuki Tsutsui, Masanori Asakura, Hitonobu Tomoike, Hiroaki Shimokawa
Organizer
第73回日本循環器学会総会・学術集会
Place of Presentation
大阪
Year and Date
2009-03-21
Related Report
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[Presentation] Evidence for Rho-kinase Activation in Patients with Pulmonary Arterial Hypertension2009
Author(s)
Doe Zhulanqiqige, Yoshihiro Fukumoto, Aya Takaki, Shunsuke Tawara, Junko Ohashi, Makoto Nakano, Tomohiro Tada, Kenya Saji, Kohichiro Sugimura, Hiroshi Fujita, Yasushi Hoshikawa, Jun Nawata, Takashi Kondo, Hiroaki Shimokawa
Organizer
第73回日本循環器学会総会・学術集会
Place of Presentation
大阪
Year and Date
2009-03-20
Related Report
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[Presentation] Evidence for Rho-kinase Activation in Patients with Pulmonary Hypertension2008
Author(s)
Shigefumi Fukui, Yoshihiro Fukumoto, Jun Suzuki, Kenya Saji, Jun Nawata, Zhulanqiqige Do.e, Yoshihiro Fukumoto, Aya Takaki, Shunsuke Tawara, Junko Ohashi, Makoto Nakano, Tomohiro Tada, Kenya Saji, Kohichiro Sugimura, Hiroshi Fujita, Jun Nawata, Yasushi Hoshikawa, Takashi Kondo, Hiroaki Shimokawa
Organizer
Scientific Sessions of the American Heart Association 2008
Place of Presentation
New Orleans
Year and Date
2008-11-11
Related Report
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