Crosstalk between NRSF-NRSE system and PPAR system contributing to the homeostasis of cardiac myocyte function

• Project/Area Number: 19590814
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Kyoto University
• Principal Investigator: HARADA Masaki Kyoto University, 医学研究科, 助教 (30342695)
• Co-Investigator(Kenkyū-buntansha): KUWAHARA Koichiro 京都大学, 医学研究科, 講師 (30402887)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 心臓病態学 / 心筋細胞 / 代謝 / 転写因子 / PPAR / クロストーク

Research Abstract

本研究では糖尿病などに合併する心筋症の分子メカニズムについて、NRSF-NRSE系とPPAR系に注目して検討した。我々が開発した二つの心不全モデル動物においてその心筋組織所見の解析でミトコンドリアの形態異常が認められたが、このモデル動物の心筋においてPPARγcoactivator-1αmRNA発現が減少していた

Research Products

• [Journal Article] Endogenous cardiac natriuretic peptides protect the heart in a mouse model of dilated cardiomyopathy and sudden death. (2009)
  • Author(s): Yasuno S, et al.
  • Journal Title: Am J Physiol Heart Circ Physiol. 296
  • Peer Reviewed
• [Journal Article] Association of CT dinucleotide repeat polymorphism in the 5'-flanking region of the guanylyl cyclase (GC) -A gene with essential hypertension in the Japanese. (2008)
  • Author(s): Usami S, et. al.
  • Journal Title: Hypertens Res. 31 Pages: 89-96
  • Peer Reviewed
• [Journal Article] Mitochondrial cardiomyopathy evaluated with cardiac magnetic resonance (2007)
  • Author(s): Nakanishi M, Harada M, Tadamura E, Kotani H, Kawakami R, Kuwahara K, Nakagawa Y, Usami S, Kinoshita H, Fujiwara M, Hosoda K, Ueshima K, Nakao K
  • Journal Title: Circulation 116 Pages: 25-26
  • Peer Reviewed
• [Journal Article] Genetic disruption of angiotensin II type 1a receptor improves long-term survival of mice with chronic severe aortic regurgitation (2007)
  • Author(s): Nakanishi M, Harada M, Kishimoto I, Kuwahara K, Kawakami R, Nakagawa Y, Yasuno S, Usami S, Kinoshita H, Adachi Y, Fukamizu A, Saito Y, Nakao K
  • Journal Title: Circ J 71 Pages: 1310-6
  • NAID: 110006368862
  • Peer Reviewed
• [Journal Article] Images in cardiovascular medicine. Mitochondrial cardiomy evaluated with cardiac magnetic resonance. (2007)
  • Author(s): Nakanishi M, et. al.
  • Journal Title: Circulation 116
  • Peer Reviewed
• [Journal Article] Genetic disruption of angiotensin II type la receptor improves long-term survival of mice with chronic severe aortic regurgitation. (2007)
  • Author(s): Nakanishi M, et. al.
  • Journal Title: Circ. J 71 Pages: 1310-6
  • Peer Reviewed
• [Presentation] An Important Role of p300 on Mitochondrial Gene Expression and Function and Tolerance to Ischemia in the heart (2009)
  • Author(s): Nakagawa Y
  • Organizer: The73rd Annual Scientific Meeting of The Japanese Circulation Society
  • Place of Presentation: Osaka International Convention Center
  • Year and Date: 2009-03-20
• [Presentation] Functional inhibition of p300 in the post-natal heart leads to mitochondrial dysfunction and cell death in mice (2008)
  • Author(s): Nakagawa Y, Kuwahara K, Akao M, Katoh M, Takemura G, Takano M, Harada M, Murakami M, Nakanisi M, Usami S, Yasuno S, Kinoshita H, Fuziwara M, Kuwabara Y, Kenj Ueshima K, Nakao K
  • Organizer: The 72nd Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: FUKUOKA
• [Presentation] 心臓ミトコンドリア機能維持における転写共役因子p300の役割 (2008)
  • Author(s): 中川靖章、桑原宏一郎
  • Organizer: 第12回日本心血管内分泌代謝学会学術総会
  • Place of Presentation: 熊本
• [Presentation] Functional inhibition of p300 in the post-natal heart leads to mitochondrial dysfunction and cell death in mice (2008)
  • Author(s): Nakagawa Y, et. al.
  • Organizer: 第72回日本循環器学会学術集会
  • Place of Presentation: 福岡市
• [Presentation] Functional inhibition of p300 leads to mitochondrial dysfunction and autophagic myocardial cell death in the adult heart (2007)
  • Author(s): Yasuaki Nakagawa, Koichiro Kuwahara, Masaki Harada, Genzo Takemura, Masaharu Akao, Masashi Kato, Yuji Arai, Masao Murakami, Michio Nakanishi, Satoru Usami, Hideyuki Kinoshita, Masataka Fujiwara, Kenji Ueshima, Kazuwa Nakao
  • Organizer: American Heart Association Scientific Sessions 2007
  • Place of Presentation: Orlando
  • Year and Date: 2007-11-06
• [Presentation] 心臓ミトコンドリア機能維持におけるp300の重要性 (2007)
  • Author(s): 中川靖章、赤尾昌治、竹村元三、鷹野誠、原田昌樹、中西道郎、宇佐美覚、木下秀之、藤原正隆、上嶋健治、中尾一和
  • Organizer: 第80回日本内分泌学会学術総会
  • Place of Presentation: 東京
• [Presentation] ANP・BNP遺伝子発現抑制因子NRSFの機能阻害による心筋症モデルマウスにおける心室頻拍・突然死発症へのT型カルシウムチャンネルの関与 (2007)
  • Author(s): 木下秀之、桑原宏一郎、原田昌樹、村上政男、中川靖章、中西道郎、保野慎治、宇佐美覚、藤原正隆、上嶋健治、中尾一和
  • Organizer: 第80回日本内分泌学会学術総会
  • Place of Presentation: 東京
• [Presentation] P300 Plays a Critical Role in Post-natal Cardiac Mitochondrial Gene Expression and Myocardial Cell Survival (2007)
  • Author(s): Nakagawa Y, Kuwahara K, Takemura G, Akao M, Harada M, Nakanishi M, Usami S, Kinoshita H, Fujiara M, Ueshima K, Nakao K
  • Organizer: 第11回日本心不全学会学術集会
  • Place of Presentation: 浦安市
• [Book] 心血管リモデリングにおける転写抑制因子NRSFの役割 (2008)
  • Author(s): 桑原宏一郎
  • Publisher: 医学のあゆみ