Elucidation of the mechanism of cell adhesion mediated by myocardialinfarction related gene lymphotoxin alpha

• Project/Area Number: 19590816
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Osaka University
• Principal Investigator: SAKATA Yasuhiko Osaka University, 医学系研究科, 助教 (90379206)
• Co-Investigator(Kenkyū-buntansha): SATO Hiroshi 大阪大学, 医学系研究科, 講師 (10294092) ; MIZUNO Hiroya 大阪大学, 医学系研究科, 寄附講座助教 (60437423)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: リンフォトキシン / 細胞接着 / 血管内皮細胞 / 単球細胞 / 動脈硬化 / リンフォトキシンα

Research Abstract

心筋梗塞発症関連遺伝子リンホトキシンα(LTA)による細胞接着の機序を検討した。LTAは接着因子の発現を増強することにより、動脈硬化の初期段階である単球・血管内皮細胞の接着に寄与していた。LTAによる接着因子の発現と細胞接着の増強は、TNF I 型受容体、PI3K-Akt / NFkB 経路 の活性化を介していた。

Research Products

• [Journal Article] SNPs in BRAP associated with risk of myocardial infarction in Asian populations (2009)
  • Author(s): Ozaki K, Sato H, Inoue K, Tsunoda T, Sakata Y, Mizuno H, Lin TH, Miyamoto Y, Aoki A, Onouchi Y, Sheu SH, Ikegawa S, Odashiro K, Nobuyoshi M, Juo SH, Hori M, Nakamura Y, Tanaka T.
  • Journal Title: Nat Genet 2009 41(3) Pages: 329-33
  • Peer Reviewed
• [Journal Article] Impact of Diabetes Mellitus on Rehospitalization for Heart Failure Among Survivors of Acute Myocardial Infarctionin the Percutaneous Coronary Intervention Era (2009)
  • Author(s): Nakatani D, Sakata Y, Mizuno H, Shimizu M, Suna S, Usami M, Ito H, Yasumura Y, Hirayama A, Takeda H, Hori M, Sato H
  • Journal Title: the Osaka Acute Coronary Insufficiency Study (OACIS) Group. Circ J. 73(4) Pages: 662-666
  • Peer Reviewed
• [Journal Article] Lymphotoxin-alpha3 mediates monocyte-endothelial interaction by TNFR I/NF-kappaB signaling (2009)
  • Author(s): Suna S, Sakata Y, Shimizu M, Nakatani D, Usami M, Matsumoto S, Mizuno H, Ozaki K, Takashima S, Takeda H, Tanaka T, Hori M, Sato H.
  • Journal Title: Biochem Biophys Res Commun 379(2) Pages: 374-8
  • Peer Reviewed
• [Journal Article] Lymphotoxin-alpha3 mediates monocyte-endothelial interaction by TNFR I/NF-kappaB signaling. (2009)
  • Author(s): Suna S, Sakata Y, …and, Sato H.
  • Journal Title: Biochem Biophys Res Commun. 379(2) Pages: 374-378
  • Peer Reviewed
• [Journal Article] Triglyceride deposit cardiomyovasculo pathy (2008)
  • Author(s): Hirano K, Ikeda Y, Zaima N, Sakata Y, Matsumiya G.
  • Journal Title: N Engl J Med. 359(22) Pages: 2396-8
  • Peer Reviewed
• [Journal Article] Up-regulation of cell adhesion molecule genes in human endothelial cells stimulated by lymphotoxin alpha : DNA microarray analysis (2008)
  • Author(s): Suna S, Sakata Y, Sato H, Mizuno H, Nakatani D, Shimizu M, Usami M, Takashima S, Takeda H, Hori M.
  • Journal Title: J Atheroscler Thromb 15(3) Pages: 160-5
  • NAID: 10022608417
  • Peer Reviewed
• [Journal Article] Up-regulation of Cell Adhesion Molecule Genes in Human Endothelial Cells Stimulated by Lymphotoxin alpha : a DNA Microarray Analysis. (2008)
  • Author(s): Suna S, Sakata Y, Sato H, et al.
  • Journal Title: J Atheroscler Thromb 15(3) Pages: 160-165
  • NAID: 10022608417
  • Peer Reviewed
• [Presentation] Biomarkers, Single Nucleotide Polymorphisms and Cardiovascular Risk After Acute Myocardial Infarction : Observations from the Osaka Acute Coronary Insufficiency Study (OACIS) (2009)
  • Author(s): 坂田泰彦、佐藤洋
  • Organizer: 第73回日本循環器学会学術集会 シンポジウム1
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2009-03-20
• [Presentation] Lymphotoxin Alpha3 Has a Pivotal Role In Atherosclerosis By Inducing Monocyte-Endothelial Interaction Mediated By Tumor Necrosis Factor Receptor I /Nuclear Factor Kappa B Signaling Pathway (2009)
  • Organizer: 第58回米国心臓病学会議(ACC)
  • Place of Presentation: Orange county convention center, Orlando, USA
• [Presentation] リンホトキシンα(LTA)は血管内皮細胞と単球との接着を増強し、これはNFKB活性化による接着因子の増強を介している (2008)
  • Author(s): 砂真一郎、坂田泰彦、佐藤洋, ほか
  • Organizer: 第28回近畿循環器疾患治療研究会
  • Place of Presentation: ホテルグランヴィア大阪
  • Year and Date: 2008-08-20
• [Presentation] Lymphotoxin-alpha Regulates Monocyte Adhesion to Endothelial Cells by Up-regulation of Cell Adhesion Molecules via PI3 K-Akt-NFkB Pathway in Human Endothelial Cells (2008)
  • Author(s): 砂 真一郎
  • Organizer: 日本循環器学会総会
  • Place of Presentation: マリンメッセ福岡
  • Year and Date: 2008-03-30
• [Presentation] Lymphotoxin-alpha Regulates Monocyte Adhesion to Endothelial Cells by Up-regulation of Cell Adhesion Molecules via PI3K-Akt-NFkB Pathway in Human Endothelial Cells (2008)
  • Author(s): 砂真一郎、坂田泰彦、佐藤洋, ほか
  • Organizer: 第72回日本循環器学会総会・学術集会
  • Place of Presentation: 福岡国際会議場