Development of novel methods to diagnose cardiovascular diseases with synchrotron radiation in SPring-8

• Project/Area Number: 19590817
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Kobe University
• Principal Investigator: YAMASHITA Tomoya Kobe University, 医学部附属病院, 助教 (90437468)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 心臓病態学 / 血管病態学 / 動脈硬化 / 急性冠症候群 / 不安定粥腫 / 拡張型心筋症 / 位相差CT / X線回折法

Research Abstract

放射光を利用して、循環器疾患の診断に使用できる方法の開発を目指して研究を進めた。動脈硬化不安定粥腫の診断を目標に、位相差X線CTを共同で開発し、動物での撮影に成功し、動脈硬化の質的診断にまで到達した。また、X線回折法にての心筋症の新規診断方法を確率するための動物実験とヒトサンプルでの研究を進めた。

Research Products

• [Journal Article] Plasma tetrahydrobiopterin /dihydrobiopterin ratio (2009)
  • Author(s): Takeda M, Yamashita T, Shinohara M, Sasaki N, Takaya T, Nakajima K, Inoue N, Masano T, Tawa H, Satomi-Kobayashi S, Toh R, Sugiyama D, Nishimura K, Yokoyama M, Hirata K, Kawashima S.
  • Journal Title: Circ J. 73 Pages: 955-62
  • Peer Reviewed
• [Journal Article] Beneficial effects of exogenous tetrahydrobiopterin on left ventricular remodeling after myocardial infarction in rats (2008)
  • Author(s): Masano T, Kawashima S, Toh R, Satomi-Kobayashi S, Shinohara M, Takaya T, Sasaki N Tawa H, Yamashita T, Yokoyama M, Hirata K
  • Journal Title: Circ J. 72 Pages: 1512-1519
  • Peer Reviewed
• [Journal Article] Augmentation of vascular remodeling by uncouled endothelial nitric oxide synthase in a mouse model of diabetes mellitus (2008)
  • Author(s): Sasaki N, Yamashita T, Takaya T, Shinohara M, Shiraki R, Takeda M, Emoto N, Fukatsu A, Hayashi T, Ikemoto K, Nomura T, Yokoyama M, Hirata K, Kawashima S.
  • Journal Title: Arterioscler Thromb Vase Biol. 28 Pages: 1068-1076
  • Peer Reviewed
• [Journal Article] Atherosclerotic Plaque Imaging using Phase-contrast X-ray Computed Tomography (2008)
  • Author(s): Shinohara M, Yamashita T, Tawa H, Takeda M, Sasaki N, Takaya T, Toh R, Takeuchi, A, Ohigashi T, Shinohara K, Yokoyama M, Kawashima S, Hirata K, Momose A.
  • Journal Title: Am J Physiol. 294 Pages: 1094-1100
  • Peer Reviewed
• [Journal Article] Beneficial effects of exogenous tetrahydrobiopterin on left ventricular remodeling after myocardial infarction in rats. (2008)
  • Author(s): 政野 智也 山下 智也
  • Journal Title: Circulation Journal 72 Pages: 1512-1519
  • Peer Reviewed
• [Journal Article] Atherosclerotic Plaque Imaging using Phase-contrast X-ray Computcd Tomography. (2008)
  • Author(s): 篠原 正和, 山下 智也
  • Journal Title: American Journal of Physiology 294
  • Peer Reviewed
• [Journal Article] Augmentation of vascular remodeling by uncouled endothelial nitric oxide synthase in a mouse model of diabetes mellitus. (2008)
  • Author(s): 佐々木 直人. 山下 智也
  • Journal Title: Arterioscler Thromb Vase Biol. 28 Pages: 1068-1076
  • Peer Reviewed
• [Journal Article] Local overexpression of Toll-like Receptors at the vessel wall induces formation of atherosclerotic lesion: Synergism of Toll-like Receptor 2 and Toll-like Receptor 4 (2007)
  • Author(s): Shinohara M, Hirata K, Yamashita T, Takaya T, Sasaki N, Shiraki R, Ueyama T, Emoto N, Inoue N, Yokoyama M, Kawashima S.
  • Journal Title: Arterioscler Thromb Vase Biol. 27 Pages: 2384-2391
  • Peer Reviewed
• [Journal Article] Xenogenic macrophage immunization reduces atherosclerosis in apolipoprotein E knoxkout mice (2007)
  • Author(s): Yamashita T, Kawashima S, Hirase T, Shinohara M, Takaya T, Sasaki N, Takeda M, Tawa H, Inoue N, Hirata K, Yokoyama M.
  • Journal Title: Am J Physiol. 293
  • Peer Reviewed
• [Journal Article] Central Role of Calcium-Dependent Tyrosine Kinase PYK2 in Endothelial Nitric Oxide Synthase Mediated Angiogenic Response and Vascular Function (2007)
  • Author(s): Matsui A, Okigaki M, Amano K, Adachi Y, Jin D, Takai S, Yamashita T, Kawashima S, Kurihara T, Miyazaki M, Tateishi K, Matsunaga S, Katsume A, Honsho S, Takahashi T, Matoba S, Kusaba T, Tatsumi T, Matsubara H.
  • Journal Title: Circulation 116 Pages: 1041-1051
  • Peer Reviewed
• [Journal Article] A specific role for eNOS-derived reactive oxygen species in atherosclerosis progression (2007)
  • Author(s): Takaya T, Hirata K, Yamashita T, Shinohara M, Sasaki N, Inoue N, Yada T, Goto M, Fukatsu A, Hayashi T, Alp NJ, Channon KM, Yokoyama M, Kawashima S.
  • Journal Title: Arterioscler Thromb Vase Biol. 27 Pages: 1632-37
  • Peer Reviewed
• [Journal Article] Atherosclerotic Plaque Imaging using Phase-contrast X-ray Computed Tomography. (2007)
  • Author(s): 篠原 正和, 山下 智也
  • Journal Title: American Journal of Physiology 294 Pages: 1094-1100
  • Peer Reviewed
• [Journal Article] Xenogenic macrophage immunization reduces atherosclerosis in apolipoprotein E knoxkout mice. (2007)
  • Author(s): 山下 智也
  • Journal Title: American Journal of Physiology 293 Pages: 865-873
  • Peer Reviewed
• [Journal Article] Local overexpression of Toll-like Receptors at the vessel wall induces formation of atherosclerotic Iesion: Synergism of Toll-like Receptor 2 and Toll-like Receptor 4. (2007)
  • Author(s): 篠原 正和, 山下 智也
  • Journal Title: Arterioscler Thromb Vasc Biol 27 Pages: 2384-2391
  • Peer Reviewed
• [Presentation] Atherosclerotic Plaque Imaging using Phase-contrast X-ray Computed Tomography. (2007)
  • Author(s): 篠原 正和, 山下 智也
  • Organizer: アメリカ心臓病会議(AHA)
  • Place of Presentation: アメリカ合衆国・オーランド
  • Year and Date: 2007-11-12
• [Presentation] Atheroscletoric Plaque Imaging using Phase-contrast X-ray Computed Tomography (2007)
  • Author(s): Yamashita T
  • Organizer: Orland FL, USA American Heart asociateion, Scientific Seesion