Development of multi-functional intravascular ultrasound imaging for assessing coronary plaque vulnerability

• Project/Area Number: 19590819
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Nihon University (2008); Yamaguchi University (2007)
• Principal Investigator: HIRO Takafumi Nihon University, 医学部, 准教授 (10294638)
• Co-Investigator(Kenkyū-buntansha): FUJII Takashi 山口大学, 大学院・医学系研究科・器官病態内科学 (60228947)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 血管内エコー法 / 動脈硬化 / プラーク / シェアストレス / 急性冠症候群

Research Abstract

本研究を通じて、血管内エコー法を用いて、血管内腔表面にかかるシェアストレスのカラーマッピングを行うことに成功した。その結果、シェアストレスの局所集中点が将来の破裂点になる可能性が高いことが示唆され、冠動脈粥腫の不安定性を定量評価できる方法の一つを確立したことになる。さらに期間後半では、プラーク破裂の3次元的メカニズムの解明やMDCTの画像上でもシェアストレスの分布を表示できる方法を確立した。

Research Products

• [Journal Article] Localized elevation of shear stress is related to coronary plaque rupture: A three-dimensional intravascular ultrasound study with in vivo color mapping of shear stress distribution (2008)
  • Author(s): Fukumoto Y, Hiro T, Fujii T, Hashimoto G, Fujimura T, Yamada J, Okamura T, Matsuzaki M
  • Journal Title: Journal of the American College of Cardiology 第51巻 Pages: 645-650
  • Peer Reviewed
• [Journal Article] Localized elevation of shear stress is related to coronary plaque rupture:A three-dimensional intravascular ultrasound study with in vivo color mapping of shear stress distribution (2008)
  • Author(s): Yusaku Fukumoto
  • Journal Title: Journal of the American College of Cardiology 51 Pages: 645-650
  • Peer Reviewed
• [Presentation] Asymmetrical distribution of shear stress is related to plaque accumulation in coronary atherosclerosis (2009)
  • Author(s): Yusaku Fukumoto, Takafumi Hiro, 他
  • Organizer: The 58th Annual Scientific Session of the American College of Cardiology
  • Place of Presentation: Orlando, U.S.A.
  • Year and Date: 2009-03-30
• [Presentation] Asymmetrical distribution of shear stress is related to plaque accumulation in coronary atherosclerosis (2009)
  • Author(s): Yusaku Fukumoto, Takafumi Hiro, 他
  • Organizer: The 58^<th> Annual Scientific Session of the American College of Cardiology
  • Place of Presentation: Orlando, U.S.A.
  • Year and Date: 2009-03-30
• [Presentation] Three-dimensional morphologic analysis of ccronary plaque rupture using intravascular ultrasound (2009)
  • Author(s): Tatushiro Fujimura, Takafumi Hiro, 他
  • Organizer: The 58th Annual Scientific Session of the American College of Cardiology
  • Year and Date: 2009-03-29
• [Presentation] Three-dimensional morphologic analysis of coronary plaque rupture using intravascular ultrasound (2009)
  • Author(s): Tatushiro Fujimura, Takafumi Hiro, 他
  • Organizer: The 58^<th> Annual Scientific Session of the American College of Cardiology
  • Place of Presentation: Orlando, U.S.A.
  • Year and Date: 2009-03-29
• [Presentation] Comprehensive multifactorial approach to plaque vulner-ability using a novel modality of intravascular imaging (2009)
  • Author(s): Takafumi Hiro, 他
  • Organizer: The 73rd Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: Osaka
  • Year and Date: 2009-03-21
• [Presentation] Comprehensive multifactorial approach to plaque vulner-ability using a novel modality of intravascular imaging (2009)
  • Author(s): Takafumi Hiro, 他
  • Organizer: The73rd Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: 大阪
  • Year and Date: 2009-03-21
• [Presentation] Seeking New Era of Atherosclerotic Plaque Imaging: An Attempt to Develop a Hybrid IVUS-OCT System (2008)
  • Author(s): Orlando, U.S.Atakafumi Hiro
  • Organizer: The 72nd Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: Fukuoka
  • Year and Date: 2008-03-28
• [Presentation] Seeking New Era of Atherosclerotic Plaque Imaging:An Attempt to Develop a Hybrid IVUS-OCT System (2008)
  • Author(s): Takafumi Hiro
  • Organizer: The 72nd Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: 福岡
  • Year and Date: 2008-03-28