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The new diagnosis and therapy of intractable myocarditis with C type natriuretic peptide

Research Project

Project/Area Number 19590820
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionThe University of Tokushima

Principal Investigator

SOEKI Takeshi  The University of Tokushima, 医学部・歯学部附属病院, 講師 (60393211)

Co-Investigator(Kenkyū-buntansha) KANGAWA Kenji  国立循環器病センター, 研究所, 所長 (00112417)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords循環器・高血圧 / 生理活性 / 薬理学 / 心臓病 / ナトリウム利尿ペプチド / 心筋炎 / 治療 / 診断
Research Abstract

心筋炎に対するC型ナトリウム利尿ペプチド(CNP)の効果とメカニズムの解明を行った。ラットの自己免疫性心筋炎モデルを作製し、2週間CNPまたは5%ブドウ糖液(対照群)の持続静注を行った。CNP投与群において心臓のリモデリングが抑制され、心機能の改善等がみられた。CNP投与群は対照群に比べ左室の線維化が有意に抑制され炎症スコアも低下していた。さらに、CNP投与群の心筋では、自己免疫性心筋炎の発症・進展に関わるとされるヘルパーT細胞のTh1系サイトカイン/Th2系サイトカインのバランスが改善していた。これらのことから、自己免疫性心筋炎に対する心保護薬としてCNPが有用である可能性が示唆された。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (5 results)

All 2008 2007

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (3 results)

  • [Journal Article] hrelin suppresses cardiac sympathetic activity and prevents early left ventricular remodeling in rats with myocardial infarction2008

    • Author(s)
      oeki T, Kishimoto I, Schwenke DO, Tokudame T, Horio T, Yoshida M, Hosoda H, Kangawa K
    • Journal Title

      Am J Physiol Heart Circ Physiol 294

      Pages: 426-32

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] C-type natriuretic peptide is a Schwann cell-derived factor for development and function of sensory neurones2008

    • Author(s)
      Kishimoto I, Tokudome T, Horio T, SoekiT, Chusho H, Nakao K, Kangawa K
    • Journal Title

      J Neuroendocrinol Epub ahead of print

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] C-type natriuretic peptide ameliorates the progression of experimental autoimmune myocarditis2008

    • Author(s)
      Soeki T, et.al.
    • Organizer
      European Society of Cardiology Congress 2008
    • Place of Presentation
      ミュンヘン
    • Year and Date
      2008-09-03
    • Related Report
      2008 Final Research Report
  • [Presentation] C-type natriuretic peptide ameliorates the progression of experimental autoimmune myocarditis2008

    • Author(s)
      添木 武, 他
    • Organizer
      European Society of Cardiology Congress 2008
    • Place of Presentation
      ミュンヘン(ドイツ)
    • Year and Date
      2008-09-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] C型ナトリウム利尿ペプチドは自己免疫性心筋炎の進展を抑制する2007

    • Author(s)
      添木 武, 他
    • Organizer
      日本心臓病学会学術集会
    • Place of Presentation
      千葉(無浜)
    • Year and Date
      2007-09-12
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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