Effect of Insulin-like Growth Factor I on Ischemia-Reperfusion Injury in Diabetic Heart

• Project/Area Number: 19590831
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Keio University
• Principal Investigator: TAKAHASHI Toshiyuki Keio University, 医学部, 共同研究員 (20286470)
• Research Collaborator: KANEKO Hidehiro 慶應義塾大学, 医学部, 大学院生 ; H. KIRK Hammond University of California, Professor of Medicine
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 糖尿病 / マウス / 虚血・再灌流障害 / インスリン様成長因子I / アポトーシス / 虚血・再灌流 / 心筋障害

Research Abstract

非糖尿病マウスと比べ糖尿病マウスでは急性期死亡率が高く、再灌流24時間後の梗塞サイズは有意に大きかった。組織学的検討では糖尿病マウスにおいて左室灌流域のアポトーシスがより高率に見られた。虚血後(再灌流前)にヒトインスリン様成長因子I(IGF-I)を投与したところ、糖尿病マウスの急性期死亡率は改善し、IGF-I非投与群に比較して梗塞サイズの縮小およびアポトーシスの抑制が確認された。

Research Products

• [Journal Article] Role of high-mobility group box 1 protein in post-infarction healing process and left ventricular remodelling (2009)
  • Author(s): Kohno T, Anzai T, Naito K, Miyasho T, Okamoto M, Yokota H, Yamada S, Maekawa Y, Takahashi T, Yoshikawa T, Ishizaka A, Ogawa S.
  • Journal Title: Cardiovasc Res 81 Pages: 565-573
• [Journal Article] Activation of cardiac adenylyl cyclase expression increases function of the failing ischemic heart in mice (2008)
  • Author(s): Lai NC, Tang T, Gao MH, Saito M, Takahashi T, Roth DM, Hammond HK
  • Journal Title: J Am Coll Cardiol 51 Pages: 1490-1497
• [Journal Article] Adenylyl cyclase type 6 deletion decreases left ventricular function via impaired calcium handling (2008)
  • Author(s): Tang T, Gao MH, Lai NC, Firth AL, Takahashi T, Guo T, Yuan JX, Roth DM, Hammond HK.
  • Journal Title: Circulation 117 Pages: 61-69
• [Journal Article] Angiotensin-receptor blockade reduces border zone myocardial monocyte chemoattractant protein-1 expression and macrophage infiltration in post-infarction (2008)
  • Author(s): Kohno T, Anzai T, Naito K, Sugano Y, Maekawa Y, Takahashi T, Yoshikawa T, Ogawa S.
  • Journal Title: ventricular remodeling. Circ J 72 Pages: 1685-1692
• [Journal Article] Impact of chronic kidney disease on postinfarction inflammation, oxidative stress, and left ventricular remodeling (2008)
  • Author(s): Naito K, Anzai T, Yoshikawa T, Anzai A, Kaneko H, Kohno T, Takahashi T, Kawamura A, Ogawa S.
  • Journal Title: J Card Fail 14 Pages: 831-838
• [Journal Article] Re-elevation of d-dimer as a predictor of re-dissection or venous thromboembolism during management of stanford type b acute aortic dissection (2008)
  • Author(s): Jo Y, Anzai T, Ueno K, Kohno T, Sugano Y, Maekawa Y, Takahashi T, Yoshikawa T, Ogawa S.
  • Journal Title: Eur Heart J 29(Suppl) Pages: 90-90
• [Journal Article] Increased expression of human C-reactive protein sggravates left ventricular remodeling after myocardial infarction in mice (2008)
  • Author(s): Takahashi T, Anzai T, Kaneko H, Anzai A, Mano Y, Maekawa Y, Ogawa S, Yoshikawa T.
  • Journal Title: Eur Heart J 29(Suppl) Pages: 131-131
• [Journal Article] Increased C-reactive protein expression exacerbates left ventricular function and remodeling after myocardial infarction (2008)
  • Author(s): Takahashi T, Anzai T, Kaneko H, Anzai A, Mano Y, Maekawa Y, Ogawa S, Yoshikawa T.
  • Journal Title: Circulation 118 Pages: 541-541
• [Journal Article] Adenylyl cyclase type 6 deletion decreases left ventricular function via impaired calcium handling (2008)
  • Author(s): Tang T, Gao MH, Lai NC, Firth AL, Takahashi T, Guo T, Yuan JX, Roth DM, Hammond HK
  • Journal Title: Circulation 117 Pages: 61-69
  • Peer Reviewed
• [Journal Article] Early use of beta-blockers attenuates systemic inflammatory response and lung oxygenation impairment after distal type acute aortic dissection (2007)
  • Author(s): Jo Y, Anzai T, Sugano Y, Kaneko H, Naito K, Ueno K, Kohno K, Takahashi T, Yoshikawa T, Ogawa S.
  • Journal Title: Circulation 116(Suppl)
• [Journal Article] Role of ischemic preconditioning and inflammatory response in the development of malignant ventricular arrhythmias after reperfused acute myocardial infarction (2007)
  • Author(s): Kaneko H, Anzai T, Naito K, Ueno K, Jo Y, Takahashi T, Kawamura A, Yoshikawa T, Ogawa S.
  • Journal Title: Circulation 116(Suppl)
• [Journal Article] Intravenous administration of immunoglobulin attenuates myocardial reperfusion injury and improves left ventricular remodeling (2007)
  • Author(s): Ueno K, Anzai T, Jo Y, Naito K, Kohno T, Takahashi T, Yoshikawa T, Ogawa S.
  • Journal Title: Circulation 116(Suppl)
• [Journal Article] Presence of chronic kidney disease is associated with enhanced inflammatory response, oxidative stress and adverse left ventricular remodeling after reperfused acute myocardial infarction (2007)
  • Author(s): Naito K, Anzai T, Yoshikawa T, Kaneko H, Jo Y, Ueno K, Kohno T, Takahashi T, Kawamura A, Ogawa S.
  • Journal Title: Circulation 116(Suppl)