| Project/Area Number |
19590833
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
HONGO Kenichi Jikei University School of Medicine, 医学部, 准教授 (00256447)
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| Co-Investigator(Kenkyū-buntansha) |
KAWAI Makoto 東京慈恵会医科大学, 医学部, 講師 (40277025)
KOMUKAI Kimiaki 東京慈恵会医科大学, 医学部, 講師 (60360145)
OTSU Kinya 大阪大学, 大学院・医学系研究科, 准教授 (20294051)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 心臓病態学 / 細胞内Ca動態 / 筋小胞体機能 / リン酸化調節 / 遺伝子改変 |
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| Research Abstract |
Regulation of intracellular Ca concentration (Ca^<2+>) is important for cardiac contraction. Especially, modulation of sarcoplasmic reticulum (Ca^<2+> store) function has a significant role on cardiac contractility. Selective up-regulation of sarcoplasmic reticulum function improved cardiac function during acidosis (important factor of cardiac dysfunction during ischemia). Ca^<2+> leak from sarcoplasmic reticulum is identified as another important determinant of cardiac function.
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