Carddiac remodeling therapy due to induced expression by cardiac adiponectin

• Project/Area Number: 19590835
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Kanazawa Medical University
• Principal Investigator: KANDA Tugiyasu Kanazawa Medical University, 医学部, 教授 (40261838)
• Co-Investigator(Kenkyū-buntansha): TAKEDA Kenji 金沢医科大学, 医学部, 助教 (90340009)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2007: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
• Keywords: サイトカイン / 心不全 / 再生医療 / 心筋炎 / アディポネクチン / アンギオテンシン / 心筋肥大 / 糖尿病 / 肥満 / マウス

Research Abstract

アディポネクチンは脂肪細胞から分泌され、抗動脈硬化作用、抗炎症作用を持つサイトカインである。心筋傷害に伴う線維化が心筋内アディポネクチン発現増強に伴い減少している結果をマウス心筋炎モデルで見い出した。
さらに、心不全マウスモデルで、傷害心筋のアディポネクチン発現亢進を認めた。心不全や心肥大で抑制された心筋内アディポネクチンの発現を誘導することが、心筋再生治療の効果を高めることが明らかとなった。

Research Products

• [Journal Article] Silent information regulator, Sirtuin 1, and age-related diseases. (2009)
  • Author(s): Zeng L, Chen R, Liang F, Tsuchiya H, Murai H, Nakahashi T, Iwai K, Takahashi T, Kanda T, Morimoto S.
  • Journal Title: Geriatr Gerontol Int. 9(1) Pages: 7-15
  • NAID: 10025225883
  • Peer Reviewed
• [Journal Article] Silent information regulator, Sirtuin 1, and age-related diseases. (2009)
  • Author(s): Zeng L
  • Journal Title: Geriatr Gerontol Int. 9 Pages: 7-15
  • Peer Reviewed
• [Journal Article] Chronic fatigue syndrome and the central nervous system. (2008)
  • Author(s): Chen R, Liang FX, Moriya J, Yamakawa J, Sumino H, Kanda T, Takahashi T .
  • Journal Title: J Int Med Res. 36(5) Pages: 867-74
  • Peer Reviewed
• [Journal Article] Immobilization stress inhibits intimal fibromuscular proliferation in the process of arterial remodeling in rats. (2008)
  • Author(s): Iwai K, Takahashi T, Nakahashi T, Nomura K, Atsumi M, Zeng L, Ishigami K, Kanda T, Yamaguchi N, Morimoto S.
  • Journal Title: Hypertens Res. 31(5) Pages: 977-86
  • NAID: 10021935807
  • Peer Reviewed
• [Journal Article] Brain Atrophy in a Murine Model of Chronic Fatigue Syndrome and Beneficial Effect of Hochu-ekki-to (TJ-41). (2008)
  • Author(s): Chen R, Moriya J, Yamakawa JI, Takahashi T, Li Q, Morimoto S, Iwai K, Sumino H, Yamaguchi N, Kanda T.
  • Journal Title: Neurochem Res. 33(9) Pages: 1759-67
  • Peer Reviewed
• [Journal Article] Traditional Chinese Medicine for Chronic Fatigue Syndrome. (2008)
  • Author(s): Chen R, Moriya J, Yamakawa JI, Takahashi T, Kanda T.
  • Journal Title: Evid Based Complement Alternat Med.
  • Peer Reviewed
• [Journal Article] Reduced-Energy Diet Improves Survival of Obese KKAy Mice with Viral Myocarditis: Induction of Cardiac Adiponectin Expression (2007)
  • Author(s): T Kanda.
  • Journal Title: Int J Cardiol 119(3) Pages: 310-318
  • Peer Reviewed
• [Journal Article] Candesartan improves myocardial damage in obese mice with viral myocarditis and induces cardiac adiponectin (2007)
  • Author(s): Yu F.
  • Journal Title: Int J Cardiol Nov27(Equib ahead of print)
  • Peer Reviewed
• [Journal Article] Oral administration of candesartan improves the survival of mice with viral myocarditis through modification of cardiac adiponectin expression. (2007)
  • Author(s): Saegusa S.
  • Journal Title: Cardiovasc Drugs Ther 21(3) Pages: 155-160
  • Peer Reviewed
• [Presentation] Candesartan regulates polarization of Th1 and Th2 cytokines in lymphoid organs of obese mice with acute myocarditis (2008)
  • Author(s): T Kanda
  • Organizer: アメリカ心臓病学会 基礎心血管科学カンファランス
  • Place of Presentation: アメリカ合衆国コロラド州キーストーン
  • Year and Date: 2008-07-21
• [Presentation] Candesartan improves myocardial damage in obese mice with viral myocarditis and induces cardiac adiponectin (2007)
  • Author(s): Kanda T.
  • Organizer: 4th Annual symposium of the AHA, Council on Basic Cardiovascular Sciences
  • Place of Presentation: アメリカ合衆国、コロラド州、キーストーン
  • Year and Date: 2007-07-31