Role of myocyte autophagy on cardiac diseases and search for therapeutic target associated with autophagy

• Project/Area Number: 19590837
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Kyoto Pharmaceutical University
• Principal Investigator: KOBARA Miyuki Kyoto Pharmaceutical University, 薬学部, 准教授 (80275198)
• Co-Investigator(Kenkyū-buntansha): MATOBA Satoaki 京都府立医科大学, 医学系研究科, 助教 (10305576)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 心筋細胞 / アポトーシス / オートファジー / チロシンキナーゼ阻害薬 / 培養心筋細胞 / 心アミロイドーシス

Research Abstract

心不全時の病態にかかわる神経体液性因子や、チロシンキナーゼ阻害抗がん剤は、心筋細胞にオートファジーを誘導した。少量のオートファジーは細胞保護的に働き、心筋アポトーシス回避効果を有するが、大量のオートファジーは細胞死を誘導する。

Research Products

• [Journal Article] Spironolactone exhibits direct renoprotective effects and inhibits renal rennin-angiotensin-aldosterone system in diabetic rats (2008)
  • Author(s): Taira M, Toba H, Murakami M, Iga I, Serizawa R, Murata S, Kobara M, and Nakata T
  • Journal Title: Eur. J. Phamacol 589 Pages: 264-271
  • Peer Reviewed
• [Journal Article] Aldosterone nongenomically produces NADPH oxidase-dependent reactive oxygen species and induces myocyte apoptosis (2008)
  • Author(s): Hayashi H, Kobara M (他8人)
  • Journal Title: Hypertens. Res 31 Pages: 363-375
  • NAID: 10024360250
  • Peer Reviewed
• [Journal Article] Apoptotic myocytes generate monocyte chemoattractant protein-1 and mediate macrophage recruitment. J. Appl (2008)
  • Author(s): Kobara M, Sunagawa N, (他8人)
  • Journal Title: hysiol 104 Pages: 601-60
  • Peer Reviewed
• [Presentation] Imatinib Induces Autophagy-Mediated Cell Death in Cardiac Myocytes (2009)
  • Author(s): Miyuki Kobara, Shota Tsujimoto, Yugo Uchida,Kenta Tanaka, Makoto Ohigashi, Hiroe Toba, Tetsuo Nakata
  • Organizer: The 73^<nd> Annual Scientific Meeting of theJapanese Circulation Society
  • Place of Presentation: 大阪
  • Year and Date: 2009-03-21
• [Presentation] Imatinib Induces Autophagy-Mediated Cell Death in Cardiac Myocytes (2009)
  • Author(s): 小原, 辻本, 内田, 田中, 大東, 鳥羽, 中田
  • Organizer: 第73回日本循環器学会
  • Place of Presentation: 大阪
  • Year and Date: 2009-03-21
• [Presentation] Short-Term caloric restriction improves mitochondrial oxidative stress and myocyte apoptosis in cardiac pressure-overload hypertrophy (2008)
  • Author(s): Miyuki Kobara, Mihoko Matsumura, Akiko Furumori, Junichi Hamada, Miho Kitamura, Kazuki Noda,, Hiroe Toba,, Hiroaki Matsubara, and Tetsuo Nakata
  • Organizer: The 72^<nd> Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: 福岡
  • Year and Date: 2008-03-28
• [Presentation] Aldosterone activates apoptosis signal-regulating kinase 1(ASK-1) through nongenomical ROS production and induces myocyte apoptosis (2008)
  • Author(s): Makoto Ohigashi, Miyuki Kobara, Hironori Hayashi, Yuugo Uchida, Kenta Tanaka, Nana Tanaka, Masaki Abe, Hiroe Toba, Hiroaki Matsubara, and Tetsuo Nakata
  • Organizer: The 72^<nd> Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: 福岡
  • Year and Date: 2008-03-28